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Verbeek, R. (author), van der Mark, K. (author), Wawrousek, E.F. (author), Plomp, A.C. (author), van Noort, J.M. (author), TNO Kwaliteit van Leven (author)
Tolerance induction to prevent activation of a naïve T-cell repertoire has been well documented in rodents and can be readily achieved by intravenous, oral or intranasal administration of antigen in the absence of adjuvants. In autoimmune diseases such as multiple sclerosis (MS) the presence of an established memory/effector T-cell repertoire...
article 2007
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Zaadstra, B.M. (author), Chorus, A.M.J. (author), van Buuren, S. (author), Kalsbeek, H. (author), van Noort, J.M. (author), TNO Defensie en Veiligheid TNO Kwaliteit van Leven (author), DenV KvL (author)
Previous studies have suggested an association between multiple sclerosis (MS) and infectious mononucleosis (IM) but data on the exact strength of this association or its selectivity have been conflicting. In this study we have evaluated the association between MS and a variety of common childhood infections and afflictions in a large population...
article 2008
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Dijkstra, S. (author), Kooij, G. (author), Verbeek, R. (author), van der Pol, S.M.A. (author), Amor, S. (author), Geisert Jr., E.E. (author), Dijkstra, C.D. (author), van Noort, J.M. (author), Vries, H.E.D. (author), TNO Kwaliteit van Leven (author)
Leukocyte infiltration is a key step in the development of demyelinating lesions in multiple sclerosis (MS), and molecules mediating leukocyte-endothelial interactions represent prime candidates for the development of therapeutic strategies. Here we studied the effects of blocking the integrin-associated tetraspanin CD81 in in vitro and in vivo...
article 2008
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Pereira, R.R. (author), Draaisma, J.M.T. (author), TNO Kwaliteit van Leven (author)
article 2009
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Ketelslegers, I.A. (author), Boon, M. (author), Pereira, R.R. (author), Hintzen, R.Q. (author), Catsman-Berrevoets, C.E. (author), TNO Kwaliteit van Leven (author)
Acute disseminated encephalomyelitis (ADEM) and multiple sclerosis (MS) in children are relatively rare and the exact incidence is still unknown. There is great variability in clinical presentation and disease course. It is yet unclear which clinical and biological parameters can predict a chronic disease course and progression to multiple...
article 2009
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van Noort, J.M. (author), Bsibsi, M. (author), Gerritsen, W.H. (author), van der Valk, P. (author), Bajramovic, J.J. (author), Steinman, L. (author), Amor, S. (author), TNO Kwaliteit van Leven (author)
We present the first comparative analysis of serum immunoglobulinG reactivity profiles against the full spectrum of human myelin-associated proteins in multiple sclerosis patients and healthy control subjects. In both groups, serum antibodies display a consistent and prominent reaction to αB-crystallin (CRYAB) versus other myelin proteins. As an...
article 2010
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Noga, M.J. (author), Dane, A. (author), Shi, S. (author), Attali, A. (author), van Aken, H. (author), Suidgeest, E. (author), Tuinstra, T. (author), Muilwijk, B. (author), Coulier, L. (author), Luider, T. (author), Reijmers, T.H. (author), Vreeken, R.J. (author), Hankemeier, T. (author)
Experimental Autoimmune Encephalomyelitis (EAE) is the most commonly used animal model for Multiple Sclerosis (MScl). CSF metabolomics in an acute EAE rat model was investigated using targetted LC-MS and GC-MS. Acute EAE in Lewis rats was induced by co-injection of Myelin Basic Protein with Complete Freund's Adjuvant. CSF samples were collected...
article 2012
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Ketelslegers, I.A. (author), Catsman-Berrevoets, C.E. (author), Neuteboom, R.F. (author), Boon, M. (author), van Dijk, K.G.J. (author), Eikelenboom, M.J. (author), Gooskens, R.H.J.M. (author), Niks, E.H. (author), Overweg-Plandsoen, W.C.G. (author), Peeters, E.A.J. (author), Peeters-Scholte, C.M.P.C.D. (author), Poll-The, B.T. (author), de Rijk-Van Andel, J.F. (author), Samijn, J.P.A. (author), Snoeck, I.N. (author), Stroink, H. (author), Vermeulen, R.J. (author), Verrips, A. (author), Vles, J.S.H. (author), Willemsen, M.A.A.P. (author), Rodrigues Pereira, R. (author), Hintzen, R.Q. (author)
Acquired demyelinating syndromes (ADS) can be a first presentation of multiple sclerosis (MS) in children. The incidence of these disorders in Europe is currently unknown. Children (<18 years old) living in the Netherlands who presented with ADS were included from January 1, 2007 to December 31, 2010 by the Dutch pediatric MS study group and the...
article 2012
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Coulier, L. (author), Muilwijk, B. (author), Bijlsma, S. (author), Noga, M. (author), Tienstra, M. (author), Attali, A. (author), van Aken, H. (author), Suidgeest, E. (author), Tuinstra, T. (author), Luider, T.M. (author), Hankemeier, T. (author), Bobeldijk, I. (author)
Analysis of metabolites in biofluids by gas chromatography-mass spectrometry (GC-MS) after oximation and silylation is a key method in metabolomics. The GC-MS method was modified by a modified vial design and sample work-up procedure in order to make the method applicable to small volumes of cerebrospinal fluid (CSF), i. e. 10 μL, with similar...
article 2013
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de Paula Faria, D. (author), Vlaming, M.L.H. (author), Copray, S.C.V.M. (author), Tielen, F. (author), Anthonijsz, H.J.A. (author), Sijbesma, J.W.A. (author), Buchpiguel, C.A. (author), Dierckx, R.A.J.O. (author), van der Hoorn, J.W.A. (author), de Vries, E.F.J. (author)
The experimental autoimmune encephalomyelitis model is a model of multiple sclerosis that closely mimics the disease characteristics in humans. The main hallmarks of multiple sclerosis are neuroinflammation (microglia activation, monocyte invasion, and T-cell infiltration) and demyelination. PET imaging may be a useful noninvasive technique for...
article 2014
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Groothuis-Oudshoorn, C.G.M. (author), Chorus, A.M.J. (author), Verrips, G.H.W. (author), Detmar, S.B. (author)
BACKGROUND: The London Handicap Scale (LHS) was found to be a valid and reliable scale for measuring participation restrictions in adults. OBJECTIVE: This paper describes the development and assesses the construct-related validity of a Dutch version of the London Handicap Scale (DLHS). METHODS: The DLHS was tested in 798 adults (mean age: 50.7...
article 2015
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van der Valk, E.S. (author), Smans, L.C.C.J. (author), Hofstetter, H. (author), Stubbe, J.H. (author), de Vries, M. (author), Backx, F.J.G. (author), Hermus, A.R.M.M. (author), Zelissen, P.M.J. (author)
Background: Health-related quality of life in patients with Addison's disease has been assessed in various European countries, indicating a reduced quality of life. However, no studies have addressed the impact of Addison's disease on physical activity. Objective: The aim of this study was to investigate the quality of life in Dutch patients...
article 2016
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Luijten, M.A.J. (author), Eekhout, I. (author), D'Hooghe, M. (author), Uitdehaag, D.M.J. (author), Mokkink, L.B. (author)
Background: Assessing arm and hand function of multiple sclerosis (MS) patients is important as impaired functioning may impact daily activities and reduce quality of life. Objective: A short-form of the Arm Function in Multiple Sclerosis Questionnaire (AMSQ), a recently developed patient-reported outcome measure containing 31 items, is...
article 2018
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