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- Kastelein, J. (author), Northolt, M.D. (author), TNO Voeding (author) article 1996
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von Benda-Beckmann, A.M. (author), Aarts, G. (author), Sertlek, H.O. (author), Lucke, K. (author), Verboom, W.C. (author), Kastelein, R.A. (author), Ketten, D.R. (author), van Bemmelen, R. (author), Lam, F.P.A. (author), Kirkwood, R. (author), Ainslie, M.A. (author)(UXO) are still present in the North Sea. UXO are frequently accidentally encountered by fishermen and dredging vessels. Out of concern for human safety and to avoid damage to equipment and infrastructure from uncontrolled explosions, most reported UXO found in the Dutch Continental Shelf (DCS) are detonated in a controlled way. These underwater...article 2015
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Kastelein, R.A. (author), Wensveen, P.J. (author), Hoek, L. (author), Au, W.W.L. (author), Terhune, J.M. (author), de Jong, C.A.F. (author), TNO Industrie en Techniek (author)A psychoacoustic behavioral technique was used to determine the critical ratios (CRs) of two harbor porpoises for tonal signals with frequencies between 0.315 and 150 kHz, in random Gaussian white noise. The masked 50% detection hearing thresholds were measured using a "go/no-go" response paradigm and an up-down staircase psychometric method....article 2009
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de Beer, F. (author), Stalenhoef, A.F.H. (author), Hoogerbrugge, N. (author), Kastelein, J.J.P. (author), Leuven, J.A.G. (author), van Duijn, C.M. (author), Havekes, L.M. (author), Smelt, A.H.M. (author), Gaubius Instituut TNO (author)Type III hyperlipoproteinemia (HLP) is mainly found in homozygous carriers of apolipoprotein E2 (apoE2, Arg158→Cys). Only a small percentage (<5%) of these apoE2 homozygotes develops hyperlipidemia, indicating that additional environmental and genetic factors contribute to the expression of type III HLP. In the present study, first, the...article 2002
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Kastelein, R.A. (author), Hoek, L. (author), Wensveen, P.J. (author), Terhune, J.M. (author), de Jong, C.A.F. (author), TNO Industrie en techniek (author)The underwater hearing sensitivities of two 2-year-old female harbor seals were quantified in a pool built for acoustic research by using a behavioral psycho-acoustic technique. The animals were trained only to respond when they detected an acoustic signal (“go/no-go” response). Detection thresholds were obtained for pure tone signals ...article 2010
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Kastelein, R.A. (author), van Schie, R. (author), Verboom, W.C. (author), de Haan, D. (author), TNO Defensie en Veiligheid (author)The unmasked underwater hearing sensitivities of an 8-year-old male and a 7-year-old female Steller sea lion were measured in a pool, by using behavioral psychophysics. The animals were trained with positive reinforcement to respond when they detected an acoustic signal and not to respond when they did not. The signals were narrow-band,...article 2005
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Kastelein, R.A. (author), de Haan, D. (author), Verboom, W.C. (author), TNO Defensie en Veiligheid (author)It is unclear how well harbor porpoises can locate sound sources, and thus can locate acoustic alarms on gillnets. Therefore the ability of a porpoise to determine the location of a sound source was determined. The animal was trained to indicate the active one of 16 transducers in a 16-m -diam circle around a central listening station. The...article 2007
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Kastelein, R.A. (author), Janssen, M. (author), Verboom, W.C. (author), de Haan, D. (author), TNO Defensie en Veiligheid (author)Receiving beam patterns of a harbor porpoise were measured in the horizontal plane, using narrow-band frequency modulated signals with center frequencies of 16, 64, and 100 kHz. Total signal duration was 1000 ms, including a 200 ms rise time and 300 ms fall time. The harbor porpoise was trained to participate in a psychophysical test and...article 2005
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Kastelein, R.A. (author), Verboom, W.C. (author), Muijsers, M. (author), Jennings, N.V. (author), van der Heul, S. (author)To prevent grounding of ships and collisions between ships in shallow coastal waters, an underwater data collection and communication network is currently under development: Acoustic Communication network for Monitoring of underwater Environment in coastal areas (ACME). Marine mammals might be affected by ACME sounds since they use sounds of...article 2005
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Kastelein, R.A. (author), van der Heul, S. (author), Verboom, W.C. (author), Triesscheijn, R.J.V. (author), Jennings, N.V. (author), TNO Defensie en Veiligheid (author)To prevent grounding of ships and collisions between ships in shallow coastal waters, an underwater data collection and communication network (ACME) using underwater sounds to encode and transmit data is currently under development. Marine mammals might be affected by ACME sounds since they may use sound of a similar frequency (around 12 kHz)...article 2006
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Kastelein, R.A. (author), Gransier, R. (author), Hoek, L. (author), de Jong, C.A.F. (author)The distance at which harbor porpoises can hear underwater detonation sounds is unknown, but depends, among other factors, on the hearing threshold of the species for impulsive sounds. Therefore, the underwater hearing threshold of a young harbor porpoise for an impulsive sound, designed to mimic a detonation pulse, was quantified by using a...article 2012
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Kastelein, R.A. (author), Wensveen, P.J. (author), Terhune, J.M. (author), de Jong, C.A.F. (author)Equal-loudness functions describe relationships between the frequencies of sounds and their perceived loudness. This pilot study investigated the possibility of deriving equal-loudness contours based on the assumption that sounds of equal perceived loudness elicit equal reaction times (RTs). During a psychoacoustic underwater hearing study, the...article 2011
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Kastelein, J. (author), van der Vossen, J.M.B.M. (author)Kimguard One-Step sterilisation wrap has regulatory approval as a Class I medical device suitable for packaging terminally sterilised medical items. In this study, we evaluated the performance of five different grades of Kimguard One-Step sterilisation wrap after prion sterilisation cycle (134 °C for 18 minutes) using the final pack test method....article 2013
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- Kastelein, J. (author), Northolt, M.D. (author), Centraal Instituut voor Voedingsonderzoek TNO (author) article 1995
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Kastelein, R.A. (author), Hoek, L. (author), Gransier, R. (author), de Jong, C.A.F. (author), Terhune, J.M. (author), Jennings, N. (author)Acoustic Mitigation Devices (AMDs) are used to deter marine mammals from construction sites, in order to prevent hearing injury by offshore pile driving noise. To estimate the distance at which two AMDs designed as ‘seal scarers’ (Ace Aquatec and Lofitech) are detected by harbor porpoises, the 50% hearing detection thresholds for playbacks of...article 2015
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Hoffer, M.J.V. (author), Bredie, S.J.H. (author), Snieder, H. (author), Reymer, P.W.A. (author), Demacker, P.N.M. (author), Havekes, L.M. (author), Boomsma, D.I. (author), Stalenhoef, A.F.H. (author), Frants, R.R. (author), Kastelein, J.J.P. (author), Gaubius Instituut TNO (author)Familial combined hyperlipidemia (FCHL) is a frequent cause of premature coronary artery disease. Affected family members are characterized by different combinations of elevated cholesterol and/or triglyceride levels. A reduction in lipoprotein lipase (LPL) activity has been observed in a subgroup of FCHL patients. Recently, we have demonstrated...article 1998
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Kastelein, R.A. (author), Hoek, L. (author), de Jong, C.A.F. (author)The distance at which active naval sonar signals can be heard by harbor porpoises depends, among other factors, on the hearing thresholds of the species for those signals. Therefore the hearing sensitivity of a harbor porpoise was determined for 1 s up-sweep and down-sweep signals, mimicking mid-frequency and low-frequency active sonar sweeps ...article 2011
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Boekholdt, S.M. (author), Peters, R.J.G. (author), de Maat, M.P.M. (author), Zwinderman, A.H. (author), van der Wall, E.E. (author), Reitsma, P.H. (author), Jukema, J.W. (author), Kastelein, J.J.P. (author), Gaubius Instituut TNO (author)Background: The PlA1A2 polymorphism of glycoprotein IIIa (GPIIIa), which affects postoccupancy signaling by the platelet fibrinogen receptor IIbIIIa, has been investigated as a potential genetic risk factor for cardiovascular events in numerous studies, without consistent results. We investigated whether the effect of this genetic variant of the...article 2004
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Kastelein, R.A. (author), Hoek, L. (author), de Jong, C.A.F. (author), Wensveen, P.J. (author), TNO Industrie en techniek (author)The underwater hearing sensitivity of a young male harbor porpoise for tonal signals of various signal durations was quantified by using a behavioral psychophysical technique. The animal was trained to respond only when it detected an acoustic signal. Fifty percent detection thresholds were obtained for tonal signals (15 frequencies between 0.25...article 2010
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Kockx, M. (author), de Maat, M.P.M. (author), Knipscheer, H.C. (author), Kastelein, J.P. (author), Kluft, C. (author), Princen, H.M.G. (author), Kooistra, T. (author), Gaubius Instituut TNO (author)Evaluation of fibrate treatment in humans has focused primarily on its anti-lipidaemic effects. A potentially favourable haemostasis-modulating activity of fibrates has also been recognized but the data are not consistent. We sought to learn more about this variability by examining the effects of gemfibrozil and ciprofibrate on plasma levels of...article 1997