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Zito, F. (author), di Castelnuovo, A. (author), Amore, C. (author), D'Orazio, A. (author), Donati, M.B. (author), Iacoviello, L. (author), Gaubius Instituut TNO (author)The aim of this study was to investigate the association of the Bcl I β-chain fibrinogen polymorphism with the risk of acute myocardial infarction (AMI) and its relationship with fibrinogen levels in the Italian population. We studied 102 AMI patients, selected within the framework of the GISSI-2 trial, who had a familial history of arterial...article 1997
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Delaney, B. (author), Carlson, T. (author), Zheng, G.-H. (author), Hess, R. (author), Knutson, N. (author), Frazer, S. (author), Ostergren, K. (author), van Zijverden, M. (author), Knippels, L. (author), Jonker, D. (author), Penninks, A. (author), TNO Voeding (author)The cholesterol-lowering effect observed following consumption of oats and barley is attributable to the β-glucan component of the soluble fiber fraction of these cereal grains. β-Glucan has also been reported to modulate immune activity, however, few studies have evaluated the hematological effects of β-glucan following oral exposure. In the...article 2003
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Hyperlipidemia and cutaneous abnormalities in transgenic mice overexpressing human apolipoprotein C1Jong, M.C. (author), Gijbels, M.J.J. (author), Dahlmans, V.E.H. (author), van Gorp, P.J.J. (author), Koopman, S.-J. (author), Ponec, M. (author), Hofker, M.H. (author), Havekes, L.M. (author), Gaubius instituut TNO (author)Transgenic mice were generated with different levels of human apolipoprotein C1 (APOC1) expression in liver and skin. At 2 mo of age, serum levels of cholesterol, triglycerides (TG), and FFA were strongly elevated in APOC1 transgenic mice compared with wild-type mice. These elevated levels of serum cholesterol and TG were due mainly to an...article 1998
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Smith-Warner, S.A. (author), Spiegelman, D. (author), Yaun, S.-S. (author), Albanes, D. (author), Beeson, W.L. (author), van den Brandt, P.A. (author), Feskanich, D. (author), Folsom, A.R. (author), Fraser, G.E. (author), Freudenheim, J.L. (author), Giovannucci, E. (author), Goldbohm, R.A. (author), Graham, S. (author), Kushi, L.H. (author), Miller, A.B. (author), Pietinen, P. (author), Rohan, T.E. (author), Speizer, F.E. (author), Willett, W.C. (author), Hunter, D.J. (author)Inverse associations between fruit and vegetable consumption and lung cancer risk have been consistently reported. However, identifying the specific fruits and vegetables associated with lung cancer is difficult because the food groups and foods evaluated have varied across studies. We analyzed fruit and vegetable groups using standardized...article 2003
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Kamphuis, M. (author), van de Nieuwegiessen, A.I. (author), Span, P.M. (author)Background Dutch Youth health care is an easily accessible service where parents can ask for support for the healthy development of their children. The majority of the screenings and medical examinations show no abnormalities. Sometimes there is doubt about the severity of symptoms: the line between healthy variation and diseases or...article 2014
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de Looze, M.P. (author), Steenhuizen, S. (author), Boeken-Kruger, M.C. (author), Baten, C.T.M. (author), Kingma, I. (author), van Dieën, J.H. (author)People who know the actual mass of an object to be lifted normally prepare themselves before attempting a lift to control the movement and to minimize low back loading. In this study, the trunk muscular reactions and low back torque were investigated in the situation in which the individual did not know the actual mass but only had some idea of...article 2000
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Tielman, M.L. (author), Neerincx, M.A. (author), van Meggelen, M. (author), Franken, I. (author), Brinkman, W.P. (author)BACKGROUND AND OBJECTIVE: With the rise of autonomous e-mental health applications, virtual agents can play a major role in improving trustworthiness, therapy outcome and adherence. In these applications, it is important that patients adhere in the sense that they perform the tasks, but also that they adhere to the specific recommendations on...article 2017
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Stiggelbout, M. (author), Popkema, D.Y. (author), Hopman-Rock, M. (author), de Greef, M. (author), van Mechelen, W. (author)Objectives: To determine the effects of gymnastics on the health related quality of life (HRQoL) and functional status of independently living people, aged 65 to 80 years. Gymnastics formed part of the More Exercise for Seniors (MBvO in Dutch) programme, a group based exercise programme for older adults in the Netherlands. It has been widely...article 2004
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Hosli, E. (author), Detmar, S. (author), Raat, H. (author), Bruil, J. (author), Vogels, T. (author), Verrips, E. (author), TNO Kwaliteit van Leven (author)The Child Health Questionnaire (CHQ)-87-item child and adolescent self-report (CF87) is an increasingly used health-related quality-of-life instrument for measuring the self-perceived physical and psychosocial well-being of children aged 10 years and older. The aims of this study were to evaluate structure, reliability and validity of the Dutch...article 2007
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van den Heuvel, E.G.H.M. (author), Wils, D. (author), Pasman, W.J. (author), Saniez, M.H. (author), Kardinaal, A.F.M. (author), TNO Kwaliteit van Leven (author)Background: It is well documented that fermentation of carbohydrates that escape digestion exert several effects supposed to be beneficial for (colonic) health, including an increase in stool volume, a shorter intestinal transit time, production of short chain fatty acids and a decrease of colonic pH (Kritchevsky 1988). NUTRIOSE®FB is a dextrin...article 2005
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Kitayama, K. (author), Nakai, D. (author), Kono, K. (author), van der Hoop, A.G. (author), Kurata, H. (author), de Wit, E.C. (author), Cohen, L.H. (author), Inaba, T. (author), Kohama, T. (author), TNO Preventie en Gezondheid (author)1-{7-[(1-(3,5-Diethoxyphenyl)-3-{[(3,5-difluorophenyl)(ethyl)amino]carbo nyl}-4-oxo-1,4-dihydroquinolin-7-yl)oxy]heptyl}-1-methylpiperidinium bromide, R-146224, is a potent, specific ileum apical sodium-dependent bile acid transporter (ASBT) inhibitor; concentrations required for 50% inhibition of [3H]taurocholate uptake in human ASBT-expressing...article 2006
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Ruwaard, D. (author), Gijsen, R. (author), Bartelds, A.I.M. (author), Hirasing, R.A. (author), Verkleij, H. (author), Kromhout, D. (author), TNO Preventie en Gezondheid (author)OBJECTIVE - To assess possible changes in the incidence of diabetes in all age-groups in The Netherlands during a 10-year period (1980-1983/1990-1992). RESEARCH DESIGN AND METHODS - Since 1970, a network of sentinel stations (the Dutch Sentinel Practice Network) consisting of ∼1% of the Dutch population has been in operation to gain insight into...article 1996
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Hopman-Rock, M. (author), Stiggelbout, M. (author), Popkema, D.Y. (author), de Greef, M. (author), TNO Kwaliteit van Leven (author)Since 1980, More Exercise for Seniors (MBvO in Dutch) has provided a number of special physical activities for the elderly. The aim is to improve social participation and integration, and to prevent a need for care. Despite the fact that MBvO has been active for more than 25 years, and weekly 300,000 people participate in gymnastics, swimming,...article 2006
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de Jong-de Vos Van Steenwijk, C.C.E. (author), Wieling, W. (author), Harms, M.P.M. (author), Wesseling, K.H. (author), TNO Biomedical Instrumentation (author)1. Fainting is a common phenomenon in young subjects, but the final events before the actual faint are not well known. The aim of the present study was to study the inter-individual variability of haemodynamic events associated with near-fainting in children and teenagers. 2. Sixty-eight healthy subjects (aged 6-16 years) performed a 70°tilt-up...article 1997
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- Reijneveld, S.A. (author), de Meer, G. (author), Wiefferink, C.H. (author), Crone, M.R. (author), TNO Kwaliteit van Leven (author) article 2008
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Böhm, F.J. (author), Hirasing, R.A. (author), Vaandrager, G.J. (author), Reeser, H.M. (author), Bijlsma, F. (author), de Groot, R.M. (author), TNO Preventie en Gezondheid (author)Objective. To determine the mortality of insulin-dependent diabetes mellitus in the age group of 0-19 year over the period 1988-1990 and to compare these data with those of ten years ago. Design. Retrospective. Setting. The Netherlands. Method. The number of deaths was obtained by using the data of the death certificate registers of the Central...article 1996
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Rijnkels, J.M. (author), Hollanders, V.M.H. (author), Woutersen, R.A. (author), Koeman, J.H. (author), Alink, G.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The potential inhibitory effects of a vegetables-fruit mixture on the initiation and promotion phases of azoxymethane-induced colorectal carcinogenesis were examined in rats fed low- or high-fat diets. Rats were fed low-fat diets (20 energy percent, Diets A and B) or high-fat diets (40 energy percent, Diets C and D), supplemented with a...article 1998
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Meijer, C. (author), Timmer, A. (author), de Vries, E.G.E. (author), Groten, J.P. (author), Knol, A. (author), Zwart, N. (author), Dam, W.A. (author), Sleijfer, D.Th. (author), Mulder, N.H. (author)Cisplatin (CDDP) is an extremely active drug in the treatment of germ- cell tumours. Earlier, we found an unexpected inverse correlation between the total amount of sulfhydryl groups and CDDP sensitivity in a panel of 3 human germ-cell tumour and 3 colon-carcinoma cell lines. Major components of the sulfhydryl groups are glutathione and...article 2000
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Schulter, V. (author), Koolwijk, P. (author), Peters, E. (author), Frank, S. (author), Hrzenjak, A. (author), Graier, W.F. (author), van Hinsbergh, V.W.M. (author), Kostner, G.M. (author), Gaubius Instituut TNO (author)Angiostatin, which consists of the kringle I-IV domains of plasminogen and which is secreted into urine, is an efficient inhibitor of angiogenesis and tumor growth. Because N-terminal apolipoprotein(a) [apo(a)] fragments, which also contain several types of kringle IV domains, are found in urine as well, we evaluated the potential angiostatic...article 2001
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Haan, J. (author), Kluft, C. (author), Leebeek, F.W.G. (author), de Bart, A.C.W. (author), Buruma, O.J. (author), Roos, R.A.C. (author)In view of reported associations between increased bleeding tendency and systemically decreased alpha 2-antiplasmin in patients with systemic amyloid deposition we studied alpha 2-antiplasmin, fibrinogen, C-reactive protein and blood levels of locally produced endothelial hemostasis factors in the acute and quiescent phase in 16 patients with...article 1992