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Krishnan, S. (author), Vermeulen, R. (author), Pronk, A. (author), Gyori, B.M. (author), Bachman, J.A. (author), Vlaanderen, J. (author), Stierum, R. (author)BACKGROUND: Mechanistic data is increasingly used in hazard identification of chemicals. However, the volume of data is large, challenging the efficient identification and clustering of relevant data. OBJECTIVES: We investigated whether evidence identification for hazard assessment can become more efficient and informed through an automated...article 2022
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Terluin, B. (author), Terwee, C.B. (author), Eekhout, I. (author)Minimal clinically important difference (MCID) estimates are often used to interpret change scores from measurement instruments. Researchers debate how MCID values should be estimated. In a recent paper, Tenan et al1 recommended adjusting for baseline severity in the analysis to avoid biased MCID estimates due to regression to the mean (RTM)....article 2022
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Scheerman, J.F.M. (author), van Meijel, B. (author), van Empelen, P. (author), Verrips, G.H.W. (author), van Loveren, C. (author), Twisk, J.W.R. (author), Pakpour, A.H. (author), van den Braak, M.C.T. (author), Kramer, G.J.C. (author)[No abstract available]article 2021
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Kocevska, D. (author), Lysen, T.S. (author), Dotinga, A. (author), Koopman-Verhoeff, M.E. (author), Luijk, M.P.C.M. (author), Antypa, N. (author), Biermasz, N.R. (author), Blokstra, A. (author), Brug, J. (author), Burk, W.J. (author), Comijs, H.C. (author), Corpeleijn, E. (author), Dashti, H.S. (author), de Bruin, E.J. (author), de Graaf, R. (author), Derks, I.P.M. (author), Dewald-Kaufmann, J.F. (author), Elders, P.J.M. (author), Gemke, R.J.B.J. (author), Grievink, L. (author), Hale, L. (author), Hartman, C.A. (author), Heijnen, C.J. (author), Huisman, M. (author), Huss, A. (author), Ikram, M.A. (author), Jones, S.E. (author), Klein Velderman, M. (author), Koning, M. (author), Meijer, A.M. (author), Meijer, K. (author), Noordam, R. (author), Oldehinkel, A.J. (author), Groeniger, J.O. (author), Penninx, B.W.J.H. (author), Picavet, H.S.J. (author), Pieters, S. (author), Reijneveld, S.A. (author), Reitz, E. (author), Renders, C.M. (author), Rodenburg, G. (author), Rutters, F. (author), Smith, M.C. (author), Singh, A.S. (author), Snijder, M.B. (author), Stronks, K. (author), ten Have, M, (author), Twisk, J.W.R. (author), van de Mheen, D. (author), van der Ende, J. (author), van der Heijden, K.B. (author), van der Velden, P.G. (author), van Lenthe, F.J. (author), van Litsenburg, R.R.L (author), van Oostrom, S.H. (author), van Schalkwijk, F.J. (author), Sheehan, CM, (author), Verheij, RA, (author), Verhulst, F.C. (author), Vermeulen, M.C.M. (author), Vermeulen, R.C.H. (author), Verschuren, W.M.M. (author), Vrijkotte, T.G.M. (author), Wijga, A.H. (author), Willemen, A.M. (author), ter Wolbeek, M. (author), Wood, A.R. (author), Xerxa, Y. (author), Bramer, W.M. (author), Franco, O.H. (author), Luik, A.I. (author), van Someren, E.J.W. (author), Tiemeier, H. (author)We aimed to obtain reliable reference charts for sleep duration, estimate the prevalence of sleep complaints across the lifespan and identify risk indicators of poor sleep. Studies were identified through systematic literature search in Embase, Medline and Web of Science (9 August 2019) and through personal contacts. Eligible studies had to be...article 2021
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Michaud, P.A. (author), Vervoort, J.P.M. (author), Visser, A. (author), Baltag, V. (author), Reijneveld, S.A. (author), Kocken, P. (author), Jansen, D.E.M.C. (author)Background: School health services (SHS) can be defined as health services provided to enrol pupils by health professionals and/or allied professions. The aim of this study was to explore the current state of the governance, organization and workforce of SHS and their provision of preventive activities in European countries. Methods:...article 2021
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Streekstra, E.J. (author), Russel, F.G.M. (author), van de Steeg, E. (author), de Wildt, S.N. (author)Drug disposition in children is different compared to adults. Growth and developmental change the processes involved in drug disposition and efficacy, including membrane transporters and drug metabolizing enzymes, but for many of these proteins, the exact changes have not been fully elucidated to date. Quantitative proteomics offers a solution...article 2021
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Burger, F. (author), Neerincx, M.A. (author), Brinkman, W.P. (author)The cognitive approach to psychotherapy aims to change patients' maladaptive schemas, that is, overly negative views on themselves, the world, or the future. To obtain awareness of these views, they record their thought processes in situations that caused pathogenic emotional responses. The schemas underlying such thought records have, thus far,...article 2021
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Patel, N. (author), Adelman, D.C. (author), Anagnostou, K. (author), Baumert, J.L. (author), Blom, W.M. (author), Campbell, D.E. (author), Chinthrajah, R.S. (author), Mills, E.N.C. (author), Javed, B. (author), Purington, N. (author), Remington, B.C. (author), Sampson, H.A. (author), Smith, A.D. (author), Yarham, R.A.R. (author), Turner, P.J. (author)Background Eliciting doses (EDs) (eg, ED01 or ED05 values, which are the amounts of allergen expected to cause objective symptoms in 1% and 5% of the population with an allergy, respectively) are increasingly being used to inform allergen labeling and clinical management. These values are generated from food challenge, but the frequency of...article 2021
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Kuper, C.F. (author), Pieters, R.H.H. (author), van Bilsen, J.H.M. (author)The thoracic and peritoneal cavities are lined by serous membranes and are home of the serosal immune system. This immune system fuses innate and adaptive immunity, to maintain local homeostasis and repair local tissue damage, and to cooperate closely with the mucosal immune system. Innate lymphoid cells (ILCs) are found abundantly in the...article 2021
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Glachs, D. (author), Namli, T. (author), Strohmeier, F. (author), Rodríguez Suárez, G. (author), Sluis, M. (author), Delgado-Lista, J. (author), Sont, J.K. (author), de Graaf, A.A. (author), Salzsieder, E. (author), Vogt, L. (author)The main objective of POWER2DM is to develop and validate a personalized self-management support system (SMSS) for T1 and T2 diabetes patients that combines and integrates i) a decision support system (DSS) based on leading European predictive personalized models for diabetes interlinked with predictive computer models, ii) automated e-coaching...bookPart 2021
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Bongers, C.C.W.G. (author), de Korte, J.Q. (author), Catoire, M. (author), Greefhorst, J. (author), Hopman, M.T.E. (author), Kingma, B. (author), Eijsvogels, T.M.H. (author)COVID-19 healthcare personnel (HCP) use personal protective equipment (PPE; ie, isolation gowns, eye protection, facemasks and respirators) to safely perform their medical duties. However, PPE creates a microenvironment around the skin due to a higher thermal resistance and lower water vapour permeability of the materials being used compared...article 2021
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Keemink, A.Q.L. (author), Brug, T.J.H. (author), van Asseldonk, E.H.F. (author), Wu, A.R. (author), van der Kooij, H. (author)Active prosthetic and orthotic devices have the potential to increase quality of life for individuals with impaired mobility. However, more research into human-like control methods is needed to create seamless interaction between device and user. In forward simulations the reflex-based neuromuscular model (RNM) by Song and Geyer shows promising...article 2021
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Bourgonje, A.R. (author), Offringa, A.K. (author), van Eijk, L.E. (author), Abdulle, A.E. (author), Hillebrands, J.L. (author), van der Voort, P.H.J. (author), van Goor, H. (author), van Hezik, E.J. (author)Significance: Hydrogen sulfide (H2S) is one of the three main gasotransmitters that are endogenously produced in humans and are protective against oxidative stress. Recent findings from studies focusing on coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), shifted our attention to a...article 2021
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van Egmond, M.B. (author), Spini, G. (author), van der Galien, O. (author), IJpma, A. (author), Veugen, P.J.M. (author), Kaaij, W. (author), Sangers, A. (author), Rooijakkers, T. (author), Langenkamp, P. (author), Kamphorst, B. (author), van de L'Isle, N. (author), Kooij-Janic, M. (author)Background: Recent developments in machine learning have shown its potential impact for clinical use such as risk prediction, prognosis, and treatment selection. However, relevant data are often scattered across diferent stakehold ers and their use is regulated, e.g. by GDPR or HIPAA. As a concrete use-case, hospital Erasmus MC and health...article 2021
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Stroek, K. (author), Heijboer, A.C. (author), Bouva, M.J. (author), van der Ploeg, C.P.B. (author), Heijnen, M.L.A. (author), Weijman, G. (author), Bosch, A.M. (author), de Jonge, R. (author), Schielen, P.C.J.I. (author), van Trotsenburg, A.S.P. (author), Boelen, A. (author)Objective: Congenital hypothyroidism (CH) is defined as thyroid hormone deficiency at birth due to disorders of the thyroid gland (thyroidal CH, CH-T), or the hypothalamus or pituitary (central CH, CH-C). The Dutch Newborn Screening (NBS) strategy is primarily based on determination of thyroxine (T4) concentrations in dried blood spots followed,...article 2020
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Offringa, A. (author), Montijn, R. (author), Singh, S. (author), Paul, M. (author), Pinto, Y.M. (author), Pinto-Sietsma, S.J. (author)The SARS-CoV-2 pandemic is a healthcare crisis caused by insufficient knowledge applicable to effectively combat the virus. Therefore, different scientific discovery strategies need to be connected, to generate a rational treatment which can be made available as rapidly as possible. This relies on a solid theoretical understanding of the...article 2020
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van den Dries, M.A. (author), Guxens, M. (author), Spaan, S. (author), Ferguson, K.K. (author), Philips, E. (author), Santos, S. (author), Jaddoe, V.W.V. (author), Ghassabian, A. (author), Trasande, L. (author), Tiemeier, H. (author), Pronk, A. (author)BACKGROUND: Prenatal exposures to phthalates and bisphenols are associated with impaired brain development in animals. However, epidemiological studies investigating the association between prenatal phthalate or bisphenol exposure and cognition have produced mixed findings and mostly had modest sample sizes and measured the exposure during the...article 2020
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- Pasma, W. (author), Peelen, L.M. (author), van Buuren, S. (author), van Klei, W.A. (author), de Graaff, J.C. (author) article 2020
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Krone, T. (author), Boessen, R. (author), Bijlsma, S. (author), van Stokkum, R. (author), Clabbers, N.D.S. (author), Pasman, W.J. (author)Background. N-of-1 designs gain popularity in nutritional research because of the improving technological possibilities, practical applicability and promise of increased accuracy and sensitivity, especially in the field of personalized nutrition. This move asks for a search of applicable statistical methods. Objective. To demonstrate the...article 2020
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- Steenhoff, H. (author), Toftum, J. (author), Kingma, B. (author), Daanen, H. (author), Gao, C. (author), Kuklane, K. (author), Garland, S. (author), Alkan Olsson, J. (author), Egli, S. (author), Folkerts, M. (author), Zuurbier, M. (author), Petersson, J. (author), Nybo, L. (author) conference paper 2019