Searched for: +
(21 - 40 of 56)

Pages

document
Essens, P.J.M.D. (author), TNO Technische Menskunde (author)
Two stages for structuring tone sequences have been distinguished by Povel and Essens (1985). In the first, a mental clock segments a sequence into equal time units (clock model); in the second, intervals are specified in terms of subdivisions of these units. The present findings support the clock model in that it predicts human performance...
article 1995
document
Havenith, G. (author), Inoue, Y. (author), Luttikholt, V. (author), Kenny, W.L. (author)
Cross-section comparisons of the effect of age on physiological responses to heat stress have yielded conflicting results, in part because of the inability to separate chronological age from factors which change in concert with the biological aging process. The present study was designed to examine the relative influence of age on cardiovascular...
article 1995
document
Lammers, J.H.C.M. (author), Emmen, H.H. (author), Muijser, H. (author), Hoogendijk, E.M.G. (author), McKee, R.H. (author), Owen, D.E. (author), Kulig, B.M. (author), TNO Kwaliteit van Leven (author)
To evaluate the neurobehavioral effects of hydrocarbon solvents and to establish a working model for extrapolating animal test data to humans, studies were conducted which involved inhalation exposure of rats and humans to white spirit (WS). The specific objectives of these studies were to evaluate the behavioral effects of exposure to WS in...
article 2007
document
van de Kar, N.C.A.J. (author), Kooistra, T. (author), Vermeer, M. (author), Lesslauer, W. (author), Monnens, L.A.H. (author), van Hinsbergh, V.W.M. (author), TNO Preventie en Gezondheid (author)
Infections with verocytotoxin (VT) producing Escherichia coil have been strongly implicated in the epidemic form of hemolytic uremic syndrome (HUS). Endothelial damage plays a central role in the pathogenesis of HUS. In vitro studies have shown that VT can damage endothelial cells after interaction with its cellular receptor...
article 1995
document
Draijer, R. (author), Atsma, D.E. (author), van der Laarse, A. (author), van Hinsbergh, V.W.M. (author), Gaubius Instituut TNO (author)
Previous studies have demonstrated that cGMP and cAMP reduce the endothelial permeability for fluids and macromolecules when the endothelial permeability is increased by thrombin. In this study, we have investigated the mechanism by which cGMP improves the endothelial barrier function and examined whether nitric oxide (NO) can serve as an...
article 1995
document
de Wijk, R.A. (author), Prinz, J.F. (author), TNO Kwaliteit van Leven (author)
Instrumentally measured in vitro friction in semi-solid foods was related to oral texture sensations. Increased fat content resulted in lower sensations of roughness, higher sensations of creaminess, and lower friction, suggesting that lubrication is the mechanism by which fat affects oral texture in low fat foods. Starch breakdown by salivary...
article 2005
document
Bunt, A.A. (author)
Thirty-two subjects had tests of serial recall of visually presented nine-digit lists which were either presented in a single block of trials (constant context) or in between lists of much longer length (variable context). Other variables were vocalization-during-presentation versus silent memorization (within subject) and order of recall ...
article 1976
document
Arts, J. (author), Lansink, T. (author), Grimbergen, J. (author), Toet, K.H. (author), Kooistra, T. (author), Instituut voor verouderings- en vaatziekten onderzoek TNO (author)
We have previously shown that the pleiotropic agent sodium butyrate strongly stimulates tissue-type plasminogen activator (t-PA) expression in human umbilical vein endothelial cells (HUVEC). Here we provide the following evidence that the butyrate-induced t-PA expression in HUVEC involves histone H4 acetylation. (1) t-PA induction by butyrate...
article 1995
document
Verheijen, J.H. (author), Nieuwenhuizen, W. (author), Wijngaards, G. (author), Gaubius instituut TNO (author)
Tissue activator-mediated plasminogen activation is potentiated both by fibrin and by some soluble fibrin(ogen) fragments. The potentiating effect of the different fragments decreases in the order fibrin monomer > D-dimer > Y > D EGTA > Dcate > X. Fibrinogen and the fragments Ecate, E EGTA and E fibrin have almost no effect. The existence of a...
article 1982
document
de Bart, A.C.W. (author), Quax, P.H.A. (author), Löwik, C.W.G.M. (author), Verheijen, J.H. (author), TNO Preventie en Gezondheid (author)
Plasmin-mediated extracellular proteolysis has been implicated in the degradation of bone in normal and pathological conditions. Normal and malignant osteoblasts can produce both tissue-type plasminogen activator (t- PA) and urokinase-type plasminogen activator (u-PA). We have used the osteosarcoma cell line MG63 to address the question of...
article 1995
document
Draijer, R. (author), Vaandrager, A.B. (author), Nolte, C. (author), de Jonge, H.R. (author), Walter, U. (author), van Hinsbergh, V.W.M. (author), Gaubius Instituut TNO (author)
Previous studies demonstrated that the thrombin-induced permeability of endothelial cell monolayers is reduced by the elevation of cGMP. In the present study, the presence of cGMP-dependent protein kinase (cGMP-PK) immunoreactivity and activity in various types of human endothelial cells (ECs) and the role of cGMP-PK in the reduction of thrombin...
article 1995
document
Theeuwes, J. (author)
Three visual-search experiments tested whether the preattentive parallel stage can selectively guide the attentive stage to a particular known-to-be-relevant target feature. Subjects searched multielement displays for a salient green circle that had a unique form when surrounded by green nontarget squares or had a unique color when surrounded by...
article 1992
document
Engelen, L. (author), van den Keybus, P.A.M. (author), de Wijk, R.A. (author), Veerman, E.C.I. (author), Amerongen, A.V.N. (author), Bosman, F. (author), Prinz, J.F. (author), van der Bilt, A. (author), TNO Kwaliteit van Leven (author)
Saliva is expected to be of significance for the perception of food stimuli in the mouth. Mixing the food with saliva, including breakdown and dilution, is considered to be of large importance for semi-solids as these products are masticated without chewing. It is known that there are large variations in composition of saliva originating from...
article 2007
document
Germans, F.H. (author), Koster, M.W. (author), Kwee, H.H. (author), Groep Motoriek Revalidatie, Medisch Fysisch Instituut TNO Instituut voor gezondheidstechniek TNO (author)
The merits of the 'vacuum form fixation' are discussed for the production of reliable body impressions of patients suffering from sitting problems. Impressions are taken with the patients seated in the desired posture. The first results are reported, obtained from 4 patients of different categories, fitted with individually moulded seats...
article 1974
document
Emeis, J.E. (author), Hoekzema, R. (author), de Vos, A.F. (author), TNO Preventie en Gezondheid (author)
In experimental animals and humans, intravenous (IV) injection of endotoxin induces large increases in circulating plasminogen activator inhibitor type-1 (PAI-1), a major inhibitor of blood fibrinolysis. A similar increase is seen after the injection of interleukin-1 (IL-1) or of tumor necrosis factor-α (TNF-α), suggesting that these cytokines...
article 1995
document
Bouman, M.A. (author), Walraven, P.L. (author), Instituut voor Zintuigfysiologie TNO (author)
On the basis of measurements of the achromatic zone for red light in the fovea and for green light in the periphery, a discussion is given on the possible difference in threshold mechanisms for the achromatic (scotopic) and chromatic (photopic) retinal systems. A specific suggestion for this distinction is given that not directly refers to the...
article 1972
document
van Keulen, H.M. (author), Otten, W. (author), Ruiter, R.A.C. (author), van Steenbergen, J. (author), Paulussen, T.W.G.M. (author), Fekkes, M. (author), Paulussen, T.W.G.M. (author)
Onderzoeken welke factoren deelname aan de HPV-vaccinatie bepaalden in 2009 en 2010. Opzet Retrospectief dwarsdoorsnede-onderzoek. Methode Uit een telepanel werden aselecte steekproeven getrokken van Nederlandse meisjes die in 2009 en 2010 werden opgeroepen voor de HPV-vaccinatie, evenals hun moeders. Gegevens werden verzameld via een online...
article 2013
document
Bles, W. (author), Jelmorini, M. (author), Bekkering, H. (author), de Graaf, B. (author), TNO Technische Menskunde (author)
A sensation of linear self-motion can be induced in a blindfolded stationary sitting subject, who keeps contact with a linearly moving platform (acceleration 0.1 m/s²) in the frontoparallel plane by means of a hand-over-hand walking action. When discordant suprathreshold vestibular information from the otoliths is added by moving the subject...
article 1995
document
Bos, J.E. (author), van Erp, J.B.F. (author), Groen, E.L. (author), van Veen, H.J. (author), TNO Defensie en Veiligheid (author)
This paper shows that tactile stimulation can override vestibular information regarding spinning sensations and eye movements. However, we conclude that the current data do not support the hypothesis that tactile stimulation controls eye movements directly. To this end, twenty-four subjects were passively disoriented by an abrupt stop after an...
article 2005
document
Stomp-van den Berg, G.M. (author), Hendriksen, I.J.M. (author), Bruinvels, D.J. (author), Twisk, J.W.R. (author), van Mechelen, W. (author), van Poppel, M.N.M. (author)
The objective of this study was to examine which factors during pregnancy and postpartum predict pelvic girdle pain (PGP) at 12 weeks postpartum among working women. A total of 548 Dutch pregnant employees were recruited in 15 companies, mainly health care, child care, and supermarkets. The definition of PGP was any pain felt in the pelvic...
article 2012
Searched for: +
(21 - 40 of 56)

Pages