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document
de Wijn, J.F. (author), Adam, H.F. (author)
article 1967
document
Koëter, H.B.W.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Toxicity data of 37 compounds tested in both a subchronic study and one or more studies focused on reproduction were evaluated to obtain information on the significance of fertility and reproduction parameters in setting no-effect levels (NEL). It appeared that a) the test system aimed at reproduction and development was more sensitive than the...
article 1983
document
Feron, V.J. (author), Kroes, R. (author), Instituut CIVO-Toxicologie en voeding TNO (author)
Despite increasing standardisation and international harmonisation of the long-term carcinogenicity study in rodents there are still areas of controversy such as high-dose selection, duration of the test period, combining or not combining the chronic toxicity and the carcinogenicity study, the use of historical control data, conditions for...
article 1986
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Krasevec, N. (author), van de Hondel, C.A.M.J.J. (author), Komel, R. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
A gene-fusion expression strategy was applied for heterologous expression of human lymphotoxin alpha (LTα) in the Aspergillus niger AB1.13 protease-deficient strain. The LTα gene was fused with the A. niger glucoamylase GII-form as a carrier-gene, behind its transcription control and secretion signals. Special attention was paid to the influence...
article 2000
document
Kruysse, A. (author), Feron, V.J. (author), Immel, H.R. (author), Centraal instituut voor voedingsonderzoek TNO (author)
The inhalation toxicity of peroxyacetyl nitrate (PAN) was examined in acute (single exposure), subacute (4-wk repeated exposure) and subchronic (13-wk repeated exposure) studies in rats. The 4-hr LC50 was found to be 95 ppm. In the 4-wk study rats were exposed to 0, 0.9, 4.1 or 11.8 ppm PAN vapor for 6 hr/day, 5 days/wk. Exposure to 11.8 ppm...
article 1977
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Tüdös, A.J. (author), Stigter, E.C.A. (author), van Hövel tot Westerflier, S.W.F.M. (author), van der Gaag, A. (author), Gaspari, M. (author)
article 2000
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de Wijn, J.F. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Uit de voordrachten gehouden op 4-6 Oktober 1979 te Maastricht.
article 1979
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Hermus, R.J.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
article 1986
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Brussaard, T. (author), Erp-Baart, M.-A. (author), Brants, H. (author), Hulshof, K. (author), Löwik, M. (author)
article 2000
document
Louwman, M.W.J. (author), van Dusseldorp, M. (author), van de Vijver, F.J.R. (author), Thomas, C.M.G. (author), Schneede, J. (author), Ueland, P.M. (author), Refsum, H. (author), van Staveren, W.A. (author)
article 2000
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Egger, R.J. (author), Gooskens, A.C. (author), Huldij, J.C. (author), Wedel, M. (author), Bruning, P.F. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)
article 1987
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Odink, J. (author), Korthals, H. (author), Vette, G.M. (author)
article 1987
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Bloksma, N. (author), v.d. Wiel, P.A. (author), Kuper, C.F. (author), Hofhuis, F.M.A. (author)
article 1988
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Kok, F.J. (author), de Bruijn, A.M. (author), Vermeeren, R. (author), Hoffman, A. (author), van Laar, A. (author), de Bruin, M. (author), Hermus, R.J.J. (author), Valkenburg, H.A. (author), Centraal instituut voor voedingsonderzoek TNO (author)
article 1987
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Koster, E.P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
article 1965
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de Vos, R.H. (author), van Dokkum, W. (author)
article 1989
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van Maanen, J.M.S. (author), de Vries, J. (author), Pappie, D. (author), van de Akker, E. (author), Lafleur, M.V.M. (author), Retel, J. (author), van der Greef, J. (author), Pinedo, H.M. (author)
article 1987
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Dries, W.J.H. (author), Schreurs, W.H.P. (author), Buyze, G. (author), Centraal instituut voor voedingsonderzoek TNO (author)
Pauling introduced the concept of orthomolecular psychiatry. According to this concept, the treatment of mental disease should benefit by optimalisation of the molecular environment of the mind. In this connection, the effect of multiple vitamin administration has been studied in 73 hospitalised psychiatrie patients who were divided in two equal...
article 1978
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Bemelmans, W.J.E. (author), Broer, J. (author), de Vries, J.H.M. (author), Hulshof, K.F.A.M. (author), May, J.F. (author), Meyboom-de Jong, B. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Objective: To investigate the impact of intensive group education on the Mediterranean diet on dietary intake and serum total cholesterol after 16 and 52 weeks, compared to a posted leaflet with the Dutch nutritional guidelines, in the context of primary prevention of cardiovascular disease (CVD). Design: Controlled comparison study of an...
article 2000
document
Carpentier, P. (author), Foquin, A. (author), Rondouin, G. (author), Lerner-Natoli, M. (author), de Groot, D.M.G. (author), Lallement, G. (author)
article 2000
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