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van Kempen, E. (author), van Kamp, I. (author), Nilsson, M. (author), Lammers, J. (author), Emmen, H. (author), Clark, C. (author), Stansfeld, S. (author), TNO Kwaliteit van Leven (author)
On the basis of this study it cannot be ruled out that the appraisal of the noise affects the association between air and road traffic noise exposure and children's health and cognition. However, the conclusion is limited due to the relatively small group of annoyed children, which may have influenced our group comparisons. Furthermore, the...
article 2010
document
Krekora, K. (author), Lacoviello, L. (author), de Lucia, L. (author), Amore, C. (author), Doojewaard, G. (author), Consoli, F.J. (author), Capani, F. (author), Donati, M.B. (author), TNO Preventie en gezondheid (author)
article 1996
document
Jonge, G.D. (author), Dienske, H. (author), Luxemburg, E.A.V. (author), Ribbens, L. (author), Primatencentrum TNO (author)
Social play between two rhesus monkey (Macaca mulatta) infants takes place mainly when they are both not in body contact with their mothers. This suggests that social play and mother-infant body contact are potential competitors in the infants' time budgets. We investigated whether the presence of a playmate changed the duration of mother-infant...
article 1981
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Lee, J. (author), Tomchick, D.R. (author), Brautigam, C.A. (author), Machius, M. (author), Kort, R. (author), Hellingwerf, K.J. (author), Gardner, K.H. (author), TNO Kwaliteit van Leven (author), KvL (author)
The Bacillus subtilis KinA protein is a histidine protein kinase that controls the commitment of this organism to sporulate in response to nutrient deprivation and several other conditions. Prior studies indicated that the N-terminal Per-ARNT-Sim domain (PAS-A) plays a critical role in the catalytic activity of this enzyme, as demonstrated by...
article 2008
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Padro, T. (author), Quax, P.H.A. (author), van den Hoogen, C.M. (author), Roholl, P. (author), Verheijen, J.H. (author), Emeis, J.J. (author), Gaubius Instituut TNO (author)
Plasminogen activator (PA) and PA inhibitor (PAI) antigen, activity, and mRNA were analyzed in the three layers of rat aorta, and the effect of endotoxin on PA and PAI was studied. All PA activity in aorta was identified as tissue-type PA (TPA) activity; no urokinase-type PA was detected. In the tunica adventitia TPA activity, TPA antigen, and...
article 1994
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Zdzienicka, M.Z. (author), Jasprs, N.G.J. (author), van der Schans, G.P. (author), Natarajan, A.T. (author), Simons, J.W.I.M. (author), Medisch Biologisch Laboratorium TNO (author)
article 1989
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Kienhuis, A.S. (author), Wortelboer, H.M. (author), Hoflack, J.C. (author), Moonen, E.J. (author), Kleinjans, J.C.S. (author), van Ommen, B. (author), van Delft, J.H.M. (author), Stierum, R.H. (author), TNO Kwaliteit van Leven (author)
Sandwich-cultured primary rat hepatocytes are often used as an in vitro model in toxicology and pharmacology. However, loss of liver-specific functions, in particular, the decline of cytochrome P450 (P450) enzyme activity, limits the value of this model for prediction of in vivo toxicity. In this study, we investigated whether a hepatic in vitro...
article 2006
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Shandilya, N. (author), Le Bihan, O. (author), Bressot, C. (author), Morgeneyer, M. (author)
In the present work, we investigate the effect of weathering duration on a commercial photocatalytic nanocoating on the basis of its nanoparticle emission tendency into two media, air and water. It is found that increased weathering duration results in stepwise structural deterioration of the nanocoating, which in turn decreases the nanocoating...
article 2015
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van Noort, J.M. (author), Bsibsi, M. (author), Gerritsen, W.H. (author), van der Valk, P. (author), Bajramovic, J.J. (author), Steinman, L. (author), Amor, S. (author), TNO Kwaliteit van Leven (author)
We present the first comparative analysis of serum immunoglobulinG reactivity profiles against the full spectrum of human myelin-associated proteins in multiple sclerosis patients and healthy control subjects. In both groups, serum antibodies display a consistent and prominent reaction to αB-crystallin (CRYAB) versus other myelin proteins. As an...
article 2010
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Reinhold, H.S. (author), Radiobiologisch Instituut TNO (author)
The response of the tumour micro-circulation of a mouse mammary tumour to fractionated irradiation was investiagted by the quantitative analysis of cinematographically recorded micro-angiograms made of tumours, growing in a sheet-like fashion with a thickness of about 50 μ. The results indicate that, during a course of fractionated radiotherapy...
article 1971
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Huisman, J. (author), de Vries, P.H.U. (author), van Weerden, E.J. (author), Bertram, H.L. (author), Instituut voor Landbouwkundig Onderzoek en Biochemische Produkten TNO (author)
article 1986
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van Bekkum, D.W. (author), Medisch Biologisch Laboratorium TNO (author)
article 1958
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de Maat, M.P.M. (author), Kodex, M. (author), Kastelein, J.J.P. (author), Gaubius Laboratory TNO Preventie en Gezondheid (author)
Elevated plasma fibrinogen levels represent an increased risk for cardiac events. This has enhanced the interest in identifying agents that can normalize elevated plasma fibrinogen levels. Agents that have this capacity are the lipid lowering fibric acid derivatives (e.g. ciprofibrate) and the platelet aggregation inhibitor ticlopidine....
article 1996
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Eefting, D. (author), Bot, I. (author), de Vries, M.R. (author), Schepers, A. (author), van Bockel, J.H. (author), van Berkel, T.J.C. (author), Biessen, E.A.L. (author), Quax, P.H.A. (author), TNO Kwaliteit van Leven (author)
Objective: Inflammatory responses to vascular injury are key events in vein graft disease and accelerated atherosclerosis, which may result in bypass failure. The monocyte chemoattractant protein-1 (MCP-1)/CC-chemokine receptor (CCR)-2 pathway is hypothesized to play a central role. A murine model for vein graft disease was used to study the...
article 2009
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Lamers, R.-J.A.N. (author), de Groot, J. (author), Spies-Faber, E.J. (author), Jellema, R.H. (author), Kraus, V.B. (author), Verzijl, N. (author), te Koppele, J.M. (author), Spijksma, G.K. (author), Vogels, J.T.W.E. (author), van der Greef, J. (author), van Nesselrooij, J.H.J. (author)
Osteoarthritis (OA), one of the most common diseases among the elderly, is characterized by the progressive destruction of joint tissues. Its etiology is largely unclear and no effective disease-modifying treatment is currently available. Metabolic fingerprinting provides a novel tool for the identification of biomarkers. A metabolic fingerprint...
article 2003
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Barendsen, G.W. (author), Radiobiologisch instituut TNO (author)
Als gevolg van ontwikkelingen in de geneeskunde en techniek wordt de bevolking minder blootgesteld aan risico's. Mede als gevolg hiervan is de gemiddelde levensduur sterk gestegen tot boven de 70 jaar en de gemiddelde kans op overlijden door alle oorzaken samen is gedaald tot ongeveer 10^-3 per jaar voor de bevolkingsgroep tussen 15 en 40 jaar....
article 1980
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van Hinsbergh, V.W.M. (author), Collen, A. (author), Koolwijk, P. (author), Gaubius instituut TNO (author)
Angiogenesis is the formation of new blood vessels from preexisting ones. Many solid tumors depend on an extensive newly formed vascular network to become nourished and to expand. Tumor cells induce the formation of an extensive but aberrant vascular network by the secretion of angiogenic factors. A proper context is needed for the endothelial...
article 1999
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Landegent, J.E. (author), Baan, R.A. (author), Hoeijmakers, J.H.J. (author), Raap, A.K. (author), van der Ploeg, M. (author), Medisch Biologisch Laboratorium TNO (author)
article 1984
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van Luijk, N. (author), Stierli, M.P. (author), Schwenninger, S.M. (author), Hervé, C. (author), Dasen, G. (author), Jore, J.P.M. (author), Pouwels, P.H. (author), van der Werf, M.J. (author), Teuber, M. (author), Meile, L. (author), TNO Voeding (author)
article 2002
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Rumbold, K. (author), van Buijsen, H.J.J. (author), Gray, V.M. (author), van Groenestijn, J.W. (author), Overkamp, K.M. (author), Slomp, R.S. (author), van der Werf, M.J. (author), Punt, P.J. (author), TNO Kwaliteit van Leven (author)
Increasingly lignocellulosic biomass hydrolysates are used as the feedstock for industrial fermentations. These biomass hydrolysates consist of complex mixtures of different fermentable sugars, but also contain inhibitors and salts that affect the performance of the productgenerating microbes. The performance of six industrially relevant...
article 2010
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