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Loomans, M.G.L.C. (author), Jacobs, P. (author)De inzet van stromingssimulaties is in verschillende projecten binnen TNO Bouw regelmatig noodzakelijk. Dit vanwege de complexe stromingstechnische vraagstukken die aan de orde zijn. Het stromingssimulatieprogramma Computational Fluid Dynamics (CFD) levert hierin zijn bijdrage. CFD is echter als ontwerp-hulpmiddel vaak minder goed bruikbaar...article 2003
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Meijboom, L.J. (author), Westerhof, B.E. (author), Nollen, G.J. (author), Spaan, J.A.E. (author), de Mol, B.A.J.M. (author), Jacobs, M.J.H.M. (author), Mulder, B.J.M. (author), TNO Biomedical Instrumentation (author)Objective: β-blocking therapy is the standard therapy in non-operated Marfan patients, however its efficacy after entire aortic replacement is unknown. The aim of this study was to describe the influence of (nearly) entire aortic replacement and β-blocking therapy on blood pressure and wave reflections in Marfan patients. Methods: Four Marfan...article 2004
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de Groot, J. (author), Verzijl, N. (author), van Wenting-Wijk, M.J.G. (author), Jacobs, K.M.G. (author), van El, B. (author), van Roermund, P.M. (author), Bank, R.A. (author), Bijlsma, J.W.J. (author), TeKoppele, J.M. (author), Lafeber, F.P.J.G. (author), TNO Preventie en Gezondheid (author)Objective. Osteoarthritis (OA) is one of the most prevalent and disabling chronic conditions affecting the elderly. Its etiology is largely unknown, but age is the most prominent risk factor. The current study was designed to test whether accumulation of advanced glycation end products (AGEs), which are known to adversely affect cartilage...article 2004
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Jacobs, J.J.L. (author), Lehé, C.L. (author), Cammans, K.D.A. (author), Das, P.K. (author), Elliott, G.R. (author)The human organotypic skin explant culture (hOSEC) model is a promising alternative in vitro model for screening contact allergens. In this model, the chemical-induced migration of Langerhans cells (LCs) out of the epidermis, evaluated after a 24-h exposure period, is used as a measure of sensitizer potential. As skin irritants can also induce...article 2004
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TNO Fysisch en Elektronisch Laboratorium (author), Kraemer, M.C.J.C.M. (author), Jacobs, B. (author), Kwaspen, J.J.M. (author), Suijker, E.M. (author), de Hek, A.P. (author), Karouta, F. (author), Kaufmann, L.M.F. (author), Hoskens, R.C.P. (author)We present dispersion free pulsed current voltage (I-V) and radio frequency (RF) power results of undoped and doped AlGaN/GaN HEMTs on sapphire and SiC substrates. The most significant processing step leading to these results is the application of a reactive ion etching (RIE) argon (Ar) plasma (10sccm, 40mTorr, 20W, t=30s, DC bias = -167V, 20gr....conference paper 2004
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TNO Preventie en Gezondheid (author), Vernooy, J.H.J. (author), Lindeman, J.H.N. (author), Jacobs, J.A. (author), Hanemaaijer, R. (author), Wouters, E.F.M. (author)Background: The increased expression of matrix metalloproteinases (MMPs) is considered to be a key factor in the development of COPD. Net MMP activity represents a tightly regulated process, which is not addressed by conventional investigation methods such as messenger RNA or protein expression. Yet, quantitative data on MMP activity in the...article 2004
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Park, Y. (author), Hunter, D.J. (author), Spiegelman, D. (author), Bergkvist, L. (author), Berrino, F. (author), van den Brandt, P.A. (author), Buring, J.E. (author), Colditz, G.A. (author), Freudenheim, J.L. (author), Fuchs, C.S. (author), Giovannucci, E. (author), Goldbohm, R.A. (author), Graham, S. (author), Harnack, L. (author), Hartman, A.M. (author), Jacobs, D.R. (author), Kato, I. (author), Krogh, V. (author), Leitzmann, M.F. (author), McCullough, M.L. (author), Miller, A.B. (author), Pietinen, P. (author), Rohan, T.E. (author), Schatzkin, A. (author), Willett, W.C. (author), Wolk, A. (author), Zeleniuch-Jacquotte, A. (author), Zhang, S.M. (author), Smith-Warner, S.A. (author), TNO Kwaliteit van Leven (author)Context: Inconsistent findings from observational studies have continued the controversy over the effects of dietary fiber on colorectal cancer. Objective: To evaluate the association between dietary fiber intake and risk of colorectal cancer. Design, Setting, and Participants: From 13 prospective cohort studies included in the Pooling Project...article 2005
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Herlaar, K. (author), van der Jagt-Deutekom, M.J. (author), Jacobs, M.J.N. (author)The use of lightweight composite armour concepts is essential for the protection of future combat systems, both vehicles and personal. The design of such armour systems is challenging due to the complex material behaviour. Finite element simulations can be used to help understand the important design parameters. A material model of Dyneema, a...conference paper 2005
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Jacobs, M.A. (author), Breeuwer, R. (author), Kemmere, M.F. (author), Keurentjes, J.T.F. (author), TNO Industrie en Techniek (author)Contactless fluid level detection in process equipment is an important challenge for the process automation industry, especially under high-pressure conditions. In this study, a method is presented, which permits the contactless measurement of liquid levels in thin opaque capillaries at high pressures. The method is based on the mass dependence...article 2005
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TNO Defensie en Veiligheid (author), Gehr, S.E. (author), Schurig, M. (author), Jacobs, L.R.M.A. (author), van der Pal, J. (author), Bennett, W. (author), Schreiber, B. (author)Exercise First WAVE (EFW) was conducted in November 2004 and was the first large-scale NATO MTDS event that focused on investigating and providing COMAO training for warfighters and mission support staff in a distributed synthetic environment. To assess the training potential of EFW, the NATO partners of the seven countries participating in EFW...conference paper 2005
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Jacobs, J. (author), Verhoeve, R. (author), Cappon, H.J. (author), Rutjes, N. (author), Wismans, J.S.H.M. (author), TNO Industrie en Techniek (author)Physical crash test dummies of one type, such as the ES-2 side impact dummy, are not perfectly reproducible due to production and certification tolerances. This means that similar crash tests with various ES2 dummies will have varying results, called experimental scatter. New car designs should be insensitive to this scatter, thus the design is...conference paper 2006
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Jacobs, L.R.M.A. (author), Cornelisse, E. (author), Schavemaker-Piva, O. (author), TNO Defensie en Veiligheid (author)To enhance and improve the quality of mission training and simulation for fighter pilots, TNO and the Royal Netherlands Air Force (RNLAF) investigate various innovative debrief concepts. In this paper we will describe our work on Innovative Debrief Solutions for Mission Training through Distributed Simulation (MTDS). Mission training and...conference paper 2006
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Jacobs, P. (author), Kerstholt, K. (author), TNO Bouw en Ondergrond (author)Hybridge ventilatie heeft naast een laag energiegebruik een positieve invloed op de gebruiker. Toepassing vraagt echter om een andere benadering van het ontwerpproces. Dit blijkt uit recente publicaties. Hierbij wordt het ontbreken van een integrale aanpak als oorzaak genoemd. Om meer samenwerking tussen partijen te realiseren zijn TNO en...article 2006
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Blootstelling aan tabaksrook in de horeca: Reductie van 90 tot 99 procent met verdringingsventilatieJacobs, P. (author), de Gids, W.F. (author), TNO Bouw en Ondergrond (author)De rook behoeften in de horeca en zorginstellingen beperken de mogelijkheden voor rookvrije werkplekken. In opdracht van het Ministerie van VWS is onderzocht in hoeverre ventilatie en luchtreiniging de blootstelling aan tabaksrook kan reduceren. Naast een literatuurstudie en praktijktest is er ook simulatie gebruikt om de reductie van de...article 2006
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Lehé, C.L. (author), Jacobs, J.J.L. (author), Hua, C.M. (author), Courtellemont, P. (author), Elliott, G.R. (author), Das, P.K. (author), TNO Defensie en Veiligheid (author)The accelerated migration of Langerhans cells (LCs) out of the epidermis and up-regulation of maturation markers, upon treatment with subtoxic concentrations of chemicals, were used as the criteria to determine the potential of allergenic chemicals capable of inducing a hapten-specific delayed-type hypersensitivity reaction. Here we report the...article 2006
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Jacobs, P. (author), de Gids, W.F. (author), TNO Bouw en Ondergrond (author)A new concept for aircraft cabin climatisation has been developed in which the seat is the main Indoor Air Quality (IAQ) and temperature control system for the passengers containing provisions for local supply and local exhaust of air. Direct supply of clean outside air in the breathing zone, through the headrest of the seat, yields a high...article 2006
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Jacobs, J.J.L. (author), Lehé, C.L. (author), Hasegawa, H. (author), Elliott, G.R. (author), Das, P.K. (author), TNO Defensie en Veiligheid (author)Skin irritants and contact allergens reduce the number of Langerhans cells (LCs). It has been assumed that this reduction is due their migration to the draining lymph node (LN) for initiating immune sensitization in a host. Skin irritation, however, as opposed to contact allergy is not considered to be an immunological disease. Nevertheless,...article 2006
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van Vliet, T. (author), Jacobs, R.G.J.M. (author), de Deckere, E. (author), van den Berg, H. (author), de Bree, A. (author), van der Put, N.M.J. (author), TNO Kwaliteit van Leven (author)Objective: To determine the effect of folic acid, vitamin B6 and B12 fortified spreads on the blood concentrations of these vitamins and homocysteine. Design and setting: A 6-week randomized, double-blinded, placebo-controlled, parallel trial carried out in a clinical research center. Subjects: One hundred and fifty healthy volunteers (50% males...article 2007
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- Bouvier D'Yvoire, M. (author), Prieto, P. (author), Blaauboer, B.J. (author), Bois, F.Y. (author), Boobis, A. (author), Brochot, C. (author), Coecke, S. (author), Freidig, A. (author), Gundert-Remy, U. (author), Hartung, T. (author), Jacobs, M.N. (author), Lavé, T. (author), Leahy, D.E. (author), Lennernäs, H. (author), Loizou, G.D. (author), Meek, B. (author), Pease, C. (author), Rowland, M. (author), Spendiff, M. (author), Yang, J. (author), Zeilmaker, M. (author), TNO Kwaliteit van Leven (author) article 2007
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Jacobs, P. (author)Ventilatie in scholen heeft invloed op de leerprestaties en de overdracht van infectieziekten. Op basis van literatuuronderzoek zijn prestatie-eisen voorgesteld voor de ventilatie. Voor de beperking van infectieziekten moet de co2 concentratie niet meer dan 400 tot 1000 ppm boven de buitenconcentratie liggen. Voor optimale leerprestaties kan...article 2007