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Gaubius Instituut TNO (author), Brama, P.A.J. (author), TeKoppele, J.M. (author), Beekman, B. (author), van Weeren, P.R. (author), Barneveld, A. (author)
Objective - To investigate the influence of age, osteoarthritis (OA), and osteochondrosis (OC) on the matrix metalloproteinase (MMP) activity in the synovial fluid (SF) of equine joints. Methods - SF was collected from normal and osteoarthritic metacarpophalangeal joints (normal: 14 adult, 28 juvenile; OA: 22 adult). And from normal and...
article 1998
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Beekman, B. (author), Drijfhout, J.W. (author), Ronday, H.K. (author), TeKoppele, J.M. (author), Gaubius instituut TNO (author)
Elevated MMP activities are implicated in tissue degradation in, e.g., arthritis and cancer. The present study was designed to measure MMP enzyme activity in plasma. Free active MMP is unlikely to be present in plasma: upon entering the circulation, active MMP is expected to be captured by the proteinase inhibitor α2-macroglobulin (α2M)....
article 1999
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Beekman, B. (author), van El, B. (author), Drijfhout, J.W. (author), TeKoppele, J.M. (author)
article 1999
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Verdonk, J.M.A.J. (author), Gerrits, W.J.J. (author), Beekman, S.P.A. (author), Spanhaak, S. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
bookPart 1999
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TNO Preventie en Gezondheid (author), Brama, P.A.J. (author), TeKoppele, J.M. (author), Beekman, B. (author), van El, B. (author), Barneveld, A. (author), van Weeren, P.R. (author)
Objective - To investigate the role of stromelysin (MMP-3) activity in synovial fluid (SF) at different stages of development and in common joint disorders in the horse. Methods - Stromelysin activity was determined with a fluorogenic enzyme activity assay in SF of normal joints of fetal, juvenile and adult horses, and in SF of horses suffering...
article 2000
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Gaubius Instituut TNO (author), Braat, E.A.M. (author), Jie, A.F.H. (author), Ronday, H.K. (author), Beekman, B. (author), Rijken, D.C. (author)
Background - Excessive fibrin deposition within the inflamed joints of rheumatoid arthritis (RA) patients suggests that local fibrinolysis is inefficient, which seems to be in contrast with the observed increased levels of urokinase type plasminogen activator (u-PA). Thrombin-mediated inactivation of single chain u-PA (scu-PA) into an inactive...
article 2000
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Huebner, J.L. (author), Hanes, M.A. (author), Beekman, B. (author), TeKoppele, J.M. (author), Kraus, V.B. (author), Gaubius Instituut (author)
Objective: To evaluate the interaction of bone and cartilage in knee osteoarthritis (OA) pathogenesis in two guinea-pig strains with appreciable differences in bone metabolism. Design: Two guinea-pig strains were evaluated for their susceptibilities to OA using semi-quantitative histological grading of knee joints and quantification of...
article 2002
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Beekman, M. (author), Heijmans, B.T. (author), Martin, N.G. (author), Whitfield, J.B. (author), Pedersen, N.L. (author), de Faire, U. (author), Snieder, H. (author), Lakenberg, N. (author), Suchiman, H.E.D. (author), de Knijff, P. (author), Frants, R.R. (author), van Ommen, G.J.B. (author), Kluft, C. (author), Vogler, G.P. (author), Boomsma, D.I. (author), Slagboom, P.E. (author)
The genetic basis of cardiovascular disease (CVD) with its complex etiology is still largely elusive. Plasma levels of lipids and apolipoproteins are among the major quantitative risk factors for CVD and are well-established intermediate traits that may be more accessible to genetic dissection than clinical CVD end points. Chromosome 19 harbors...
article 2003
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Beekman, M. (author), Heijmans, B.T. (author), Martin, N.G. (author), Whitfield, J.B. (author), Pedersen, N.L. (author), de Faire, U. (author), Snieder, H. (author), Lakenberg, N. (author), de Knijff, P. (author), Frants, R.R. (author), van Ommen, G.J.B. (author), Kluft, C. (author), Vogler, G.P. (author), Slagboom, P.E. (author), Boomsma, D.I. (author)
Plasma levels of lipoprotein(a) - Lp(a) - are associated with cardiovascular risk (Danesh et al., 2000) and were long believed to be influenced by the LPA locus on chromosome 6q27 only. However, a recent report of Broeckel et al. (2002) suggested the presence of a second quantitative trait locus on chromosome 1 influencing Lp(a) levels. Using a...
article 2003
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Beekman, M. (author), Posthuma, D. (author), Heijmans, B.T. (author), Lakenberg, N. (author), Suchiman, H.E.D. (author), Snieder, H. (author), de Knijff, P. (author), Frants, R.R. (author), van Ommen, G.J.B. (author), Kluft, C. (author), Vogler, G.P. (author), Slagboom, P.E. (author), Boomsma, D.I. (author)
Combined association and linkage analysis is a powerful tool for pinpointing functional quantitative traits (QTLs) responsible for regions of significant linkage identified in genome-wide scans. We applied this technique to apoE plasma levels and the APOEε2/ε3/ε4 polymorphism in two Dutch twin cohorts of different age ranges. Across chromosome...
article 2004
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Cloetingh, S. (author), Cornu, T. (author), Ziegler, P.A. (author), Beekman, F. (author), Ustaszewski, K. (author), Schmid, S.M. (author), Dèzes, P. (author), Hinsch, R. (author), Decker, K. (author), Lopes Gardozo, G. (author), Granet, M. (author), Bertrand, G. (author), Behrmann, J. (author), van Balen, R. (author), Michon, L. (author), Pagnier, H. (author), Rozsa, S. (author), Heck, B. (author), Tesauro, M. (author), Kahle, H.G. (author), Dewez, T. (author), Carretier, S. (author), Winter, T. (author), Hardebol, N. (author), Bada, G. (author), Dost, B. (author), van Eck, T. (author), TNO Bouw en Ondergrond (author)
Research on neotectonics and related seismicity has hitherto been mostly focused on active plate boundaries that are characterized by generally high levels of earthquake activity. Current seismic hazard estimates for intraplate domains are mainly based on probabilistic analyses of historical and instrumental earthquake catalogues. The accuracy...
article 2006
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TNO Kwaliteit van Leven (author), Klein, E. (author), Maathuis, E. (author), Wever, C. (author), van der Greft, A. (author), Tas, W. (author), Beekman, V. (author), Gilissen, L. (author), van Gorcom, R. (author), Jansman, A. (author), Kardinaal, A. (author), te Koppele, J. (author), Schenk, E. (author), van der Sluis, A. (author), Teeuw, J. (author), Verhagen, H. (author), van Zandvoort, C. (author), Zondervan, C. (author)
ZonMw heeft samen met Wageningen UR, TNO en RIVM een programmeringsstudie over voeding en gezondheid uitgebracht. De studie doet onder meer aanbevelingen voor het werken aan preventie van chronische ziekten (te beginnen bij kinderen), de verbetering van de kwaliteit van leven (te beginnen bij de doelgroep ouderen en patiënten) en het...
book 2007
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van Wees, J.D. (author), van Bergen, F. (author), David, P. (author), Nepveu, M. (author), Beekman, F. (author), Cloetingh, S. (author), Bonté, D. (author), TNO Bouw en Ondergrond (author)
Tectonic modeling is often neglected in the basin modeling workflow and heat flow is most times considered a user input. Such heat flows can, therefore, result in erroneous basin modeling outcomes, resulting in false overoptimistic identification of prospective areas or failure to identify prospects. This is particularly true for areas with...
article 2009
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van Wees, J.D. (author), Cloetingh, S. (author), Ziegler, P.A. (author), Lenkey, L. (author), Beekman, F. (author), Tesauro, M. (author), Förster, A. (author), Norden, B. (author), Kaban, M. (author), Hardebol, N. (author), Voorde, M.T. (author), Willingshofer, E. (author), Cornu, T. (author), Bonté, D. (author), TNO Bouw en ondergrond (author)
For geothermal exploration and the development of enhanced geothermal systems (EGS) knowlegde of temperature at drillable depth is a prerequisite for site selection. Equally important is the thermo-mechanical signature of the lithosphere and crust which allow to obtain critical constraints for the crustal stress field and basement temperatures...
conference paper 2009
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Cloetingh, S. (author), van Wees, J.D. (author), Ziegler, P.A. (author), Lenkey, L. (author), Beekman, F. (author), Tesauro, M. (author), Förster, A. (author), Norden, B. (author), Kaban, M. (author), Hardebol, N. (author), Bonté, D. (author), Genter, A. (author), Guillou-Frottier, L. (author), ter Voorde, M. (author), Sokoutis, D. (author), Willingshofer, E. (author), Cornu, T. (author), Worum, G. (author), TNO Bouw en Ondergrond (author)
Knowledge of temperature at drillable depth is a prerequisite in site selection for geothermal exploration and development of enhanced geothermal systems (EGS). Equally important, the thermo-mechanical signature of the lithosphere and crust provides critical constraints for the crustal stress field and basement temperatures where borehole...
article 2010
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Vlasveld, M.C. (author), van der Feltz-Cornelis, C.M. (author), Bültmann, U. (author), Beekman, A.T.F. (author), van Mechelen, W. (author), Hoedeman, R. (author), Anema, J.R. (author)
article 2012
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Kruisdijk, F.R. (author), Hendriksen, I.J.M. (author), Tak, E.C.P.M. (author), Beekman, A.T.F. (author), Hopman-Rock, M. (author)
Background. The societal and personal burden of depressive illness is considerable. Despite the developments in treatment strategies, the effectiveness of both medication and psychotherapy is not ideal. Physical activity, including exercise, is a relatively cheap and non-harmful lifestyle intervention which lacks the side-effects of medication...
article 2012
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Guigas, B. (author), de Leeuw van Weenen, J.E. (author), van Leeuwen, N. (author), Simonis-Bik, A.M. (author), van Haeften, T.W. (author), Nijpels, G. (author), Houwing-Duistermaat, J.J. (author), Beekman, M. (author), Deelen, J. (author), Havekes, L.M. (author), Penninx, B.W.J.H. (author), Vogelzangs, N. (author), van 't Riet, E. (author), Dehghan, A. (author), Hofman, A. (author), Witteman, J.C. (author), Uitterlinden, A.G. (author), Grarup, N. (author), Jørgensen, T. (author), Witte, D.R. (author), Lauritzen, T. (author), Hansen, T. (author), Pedersen, O. (author), Hottenga, J. (author), Romijn, J.A. (author), Diamant, M. (author), Kramer, M.H.H. (author), Heine, R.J. (author), Willemsen, G. (author), Dekker, J.M. (author), Eekhoff, E.M. (author), Pijl, H. (author), de Geus, E.J. (author), Slagboom, P.E. (author), 't Hart, L.M. (author)
Aims: Modulation of dopamine receptor D2 (DRD2) activity affects insulin secretion in both rodents and isolated pancreatic β-cells. We hypothesized that single nucleotide polymorphisms in the DRD2/ANKK1 locus may affect susceptibility to Type 2 diabetes in humans. Methods: Four potentially functional variants in the coding region of the DRD2...
article 2014
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Wiggelinkhuizen, E.J. (author), van der Welle, A.J. (author), Papathanasiou, F. (author), Beekman, L. (author), Boxem, T. (author), Koornneef, J. (author), Faaij, A. (author)
System integration between the offshore gas infrastructure and offshore wind, can offer significant economic and ecologic benefits compared to separate development. These result from lower development and operational costs for both offshore wind and gas, a higher market value through increased flexibility, reduced greenhouse gas emissions and...
other 2016
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Wiggelinkhuizen, E.J. (author), Papathanasiou, F. (author), Beekman, L. (author), Boxem, T. (author), Koornneef, J. (author), Faaij, A. (author)
nvt
public lecture 2017
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