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Gaubius instituut TNO (author), Kempen, H.J.M. (author), Glatz, J.F.C. (author), Lange, J.de (author), Veerkamp, J.H. (author)
Cholestyramine feeding of rats increased the rate of palmitate and glycerol incorporation into triacylglycerols of isolated hepatocytes. Concomitantly an increase of fatty-acid binding by hepatic cytosolic proteins was observed, which could be attributed to an elevation of the content of the fatty-acid-binding protein (M(r) 12,000). The...
article 1983
document
Prins Maurits Laboratorium TNO (author), Ligtenstein, D.A. (author), Kossen, S.P. (author)
The kinetic profile of the oxime HI-6, a potent cholinesterase reactivator, after iv administration of 0.1325 mmol/kg (50 mg/kg) to rats is described. The blood concentrations measured over a period of 300 min can be described by a two-compartment open model. Excretion occurred only by the kidney. Approximately 60% was excreted in unmetabolized...
article 1983
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Bergshoeff, G. (author), Lanting, R.W. (author), van Ham, J. (author), Instituut voor Milieuhygiëne en Gezondheidstechniek TNO (author)
A simple, inexpensive and reliable manual spectrophotometric method for the determination of ozone in ambient air is evaluated. The air is passed through the blue solution of indigo disulphonate (IDS) in a special double sintered disc absorber. The resulting partly bleached solution is very stable. The discoloration is measured at 610 nm. The...
article 1984
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Kuiper, J. (author), Hanstveit, A.O. (author), Centraal laboratorium TNO (author)
The fate and effects of 4-chlorophenol (4CP) and 2,4-dichlorophenol (DCP) added to North Sea coastal plankton communities enclosed by large plastic bags were studied in three experiments of 4 to 6 weeks duration. The biodegredation of the compounds was studied in laboratory experiments using water from the enclosed ecosystems 4CP and DCP, added...
article 1984
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Speek, A.J. (author), Temalilwa, C.R. (author), Schrijver, J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
A fast and sensitive high-performance liquid chromatographic (HPLC) method for the determination of the provitamin A, ??-carotene, in vegetables is described. After alkaline saponification and organic extraction ??-carotene is separated from other carotenoids on a reversed-phase HPLC column and determined by measurement of its absorbance at 445...
article 1986
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Radiobiologisch Instituut TNO (author), Varekamp, A.E. (author), de Vries, A.J. (author), Hagenbeek, A. (author)
Interstitial pneumonitis (IP) is one of the major complications after allogeneic bone marrow transplantation (incidence: 30 to 50%, fatality rate: 50 to 60%). Cytomegalovirus is associated with 60% of the cases. When no infectious agent can be detected, it is classified as idiopathic IP (IIP). Factors related to IIP are: remission induction...
article 1986
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Radiobiologisch Instituut TNO (author), van Rongen, E. (author), Tan, C. (author), Zurcher, C. (author)
article 1986
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Radiobiologisch Instituut TNO (author), Hermens, A.F. (author), Korving, R. (author), de Leeuw, A.M. (author), van den Berg, K.J. (author)
article 1986
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Zwart, A. (author), Woutersen, R.A. (author), Wilmer, J.W.G.M. (author), Spit, B.J. (author), Feron, V.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
To study in detail possible effects of low concentrations of formaldehyde on the nasal epithelium, Wistar rats were exposed to 0, 0.3, 1 and 3 ppm formaldehyde vapour for 6 h/day, 5 days/week during 3 days or 13 weeks, using in vivo [3H]thymidine labeling for cell proliferation studies, and light and electron microscopy for detecting...
article 1988
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de Groot, A.P. (author), Feron, V.J. (author), Immel, H.R. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
In previous studies we observed an increased incidence of hyperplasia in the epithelium of the urinary bladder of rats fed cereal-based stock diet supplemented with 6% monosodium glutamate (MSG) for 3 months. Hyperplasia was not enhanced, however, when 6% MSG was fed in a purified casein diet. Further studies have been conducted to identify the...
article 1988
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Feron, V.J. (author), Bruyntjes, J.P. (author), Woutersen, R.A. (author), Immel, H.R. (author), Appelman, L.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Male Wistar rats were exposed to 0, 10 or 20 ppm formaldehyde vapour for 4, 8 or 13 weeks (6 h/day; 5 days/week), and were then observed for periods up to 126 weeks. Transient growth retardation occurred in both test groups. Death rate was not noticeably affected by formaldehyde. Despite recovery periods of at most 126 weeks, the nasal...
article 1988
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Rutten, A.A.J.J.L. (author), Wilmer, J.W.G.M. (author), Beems, R.B. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The effects of cigarette smoke condensate (CSC) and all-trans retinol on the cell proliferative activity of vitamin A-deprived hamster tracheal epithelium have been studied in vitamin A-deficient, serum-free, hormone-supplemented medium in organ culture. In the absence of retinol, CSC induced a dose-dependent increase in labelig index (LI)...
article 1988
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Radl, J. (author), Croese, J.W. (author), Zurcher, C. (author), van den Enden-Vieveen, M.H.M. (author), de Leeuw, A.M. (author), Instituut voor Experimentele Gerontologie TNO (author)
Animal models of spontaneous and induced plasmacytomas in some inbred strains of mice have proven to be useful tools for different studies on tumorigenesis and immunoregulation. Their wide applicability and the fact that after their intravenous transplantation, the recipient mice developed bone lesions, led in some instances to an incorrect use...
article 1988
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Rutten, A.A.J.J.L. (author), Beems, R.B. (author), Wilmer, J.W.G.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The effects of all-trans retinol and cigarette smoke condensate (CSC) on tissue morphology and cellular differentiation were investigated in vitamin A-deprived tracheal epithelium cultured in vitamin A- and serum-free hormone-supplemented medium. Physiological retinol concentrations prevented the development of hyperplasia and squamous...
article 1988
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Rutten, A.A.J.J.L. (author), Jongen, W.M.F. (author), de Haan, L.H.J. (author), Hendriksen, E.G.J. (author), Koeman, J.H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The dye-coupled intercellular communication across gap junctions in primary hamster tracheal epithelial cells has been studied in serum-free, hormone-supplemented medium. In the absence of vitamin A, non-cytotoxic concentrations of cigarette-smoke condensate (CSC) inhibited intercellular communication between tracheal epithelial cells in a...
article 1988
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Tranquille, N. (author), Emeis, J.J. (author), Gaubius Instituut TNO (author)
The acute release of tissue-type plasminogen activator (t-PA) was studied in perfused rat hindlegs. Pretreatment of rats with the protein synthesis inhibitor cycloheximide (2 mg/kg) at 1, 3 or 5 h prior to perfusion of rat hindlegs did not influence the amount of t-PA released by platelet-activating factor (20 nM) or bradykinin (1 μM). The...
article 1989
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Kwekkeboom, J. (author), Princen, H.M.G. (author), van Voorthuizen, E.M. (author), Meijer, P. (author), Kempen, H.J.M. (author), Gaubius Instituut TNO (author)
Intracellular accumulation of 37°C of 50 μM [14C]taurocholic acid by hepatocytes of pig and rat, cultured for 24 hours, and by human hepatocytes, cultured for 12 hours, reached equilibrium after an incubation time of 1 to 2 hours. Maximum capacity to accumulate taurocholate intracellularly was assessed in 3-hour incubations with increasing...
article 1989
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Gaubius Instituut TNO (author), Princen, H.M.G. (author), Meijer, P. (author), Hofstee, B. (author)
To study the effect of steroid hormones on bile acid synthesis by cultured rat hepatocytes, cells were incubated with various amounts of these compounds during 72 h and conversion of [4-14C]cholesterol into bile acids was measured. Bile acid synthesis was stimulated in a dose-dependent way by glucocorticoids, but not by sex steroid hormones,...
article 1989
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Instituut CIVO-Toxicologie en Voeding TNO (author), van Ommen, B. (author), Hendriks, W. (author), Bessems, J.G.M. (author), Geesink, G. (author), Muller, F. (author), van Bladeren, P.J. (author)
The relation between the major toxic effect of hexachlorobenzene, hepatic porphyria, and its oxidative biotransformation was studied in vivo, by observing the effect of modulating its biotransformation on the expression of porphyria. This modulation was achieved by selective in vivo inhibition of the major cytochrome P450 isoenzyme involved in...
article 1989
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van der Hoeven, N. (author), Hemerik, L. (author)
A stochastic model is formulated to determine the optimal strategy for a solitary parasitoid which has discovered an already parasitized host. The model assumes that the parasitoid can count both the number of eggs already present in a host and the number of conspecifics searching in the same patch. The survival probability of an egg is assumed...
article 1990
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