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Koopman, F.W. (author), de Winde, J.H. (author), Ruijssenaars, H.J. (author), TNO Kwaliteit van Leven (author)
The solvent-tolerant bacterium Pseudomonas putida S12 was engineered to efficiently utilize the C1 compounds methanol and formaldehyde as auxiliary substrate. The hps and phi genes of Bacillus brevis, encoding two key steps of the ribulose monophosphate (RuMP) pathway, were introduced to construct a pathway for the metabolism of the toxic...
article 2009
document
Clary, J.J. (author), Feron, V.J. (author), van Velthuijsen, J.A. (author), TNO Voeding (author)
Organo psycho syndrome (OPS) or chronic toxic encephalopathy (CTE) is a neurotoxic condition reported following long-term exposure to paints containing organic solvent and to other solvents. Lactate esters are finding wider use as solvents. Lactate esters have been well studied in standard toxicity tests, but specific neurotoxicity studies have...
article 2001
document
Spoelstra, S. (author), Overbeek, J.P. (author), Hugill, J.A. (author)
To achieve sustainable development in the chemical industry, there is a need for methodologies to assess the eco-efficiency of alternative and novel technologies. The aim of this project was to use a case study to investigate the application of existing tools to assess eco-efficiency. The case study compared the conventional methanol production...
other 2001
document
Spoelstra, S. (author)
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other 2000
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