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Prins, R.G. (author), Pierik, F. (author), Etman, A. (author), Sterkenburg, R.P. (author), Kamphuis, C.B.M. (author), van Lenthe, F.J. (author)
In choosing appropriate buffer sizes to study environmental influences on physical activity, studies are hampered by insufficient insight into the distance elderly travel actively. This study aims at getting insight into the number of trips walked and cycled within various buffer sizes using GPS measures. Data were obtained from the Elderly And...
article 2014
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Eeftens, M. (author), Hoek, G. (author), Gruzieva, O. (author), Mölter, A. (author), Agius, R. (author), Beelen, R. (author), Brunekreef, B. (author), Custovic, A. (author), Cyrys, J. (author), Fuertes, E. (author), Heinrich, J. (author), Hoffmann, B. (author), De Hoogh, K. (author), Jedynska, A. (author), Keuken, M. (author), Klümper, C. (author), Kooter, I. (author), Krämer, U. (author), Korek, M. (author), Koppelman, G.H. (author), Kuhlbusch, T.A.J. (author), Simpson, A. (author), Smit, H.A. (author), Tsai, M.Y. (author), Wang, M. (author), Wolf, K. (author), Pershagen, G. (author), Gehring, U. (author)
BACKGROUND: Negative effects of long-term exposure to particulate matter (PM) on lung function have been shown repeatedly. Spatial differences in the composition and toxicity of PM may explain differences in observed effect sizes between studies. METHODS: We conducted a multicenter study in 5 European birth cohorts - BAMSE (Sweden), GINIplus and...
article 2014
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de Winkel, K.N. (author), Clément, G. (author), Groen, E.L. (author), Werkhoven, P.J. (author)
Although the mechanisms of neural adaptation to weightlessness and re-adaptation to Earth-gravity have received a lot of attention since the first human space flight, there is as yet little knowledge about how spatial orientation is affected by partial gravity, such as lunar gravity of 0.16. g or Martian gravity of 0.38. g. Up to now twelve...
article 2012
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Jacobs, J.H. (author), Fuertes, E. (author), Krop, E.J.M. (author), Spithoven, J. (author), Tromp, P. (author), Heederik, D.J.J. (author)
Objectives: To describe associations among swimming, respiratory health, allergen sensitisation and Clara cell protein 16 (CC16) levels in Dutch schoolchildren. Trichloramine levels in swimming pool air were determined to assess potential exposure levels. Methods: Respiratory health and pool attendance information was collected from 2359...
article 2012
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Stomp-van den Berg, G.M. (author), Hendriksen, I.J.M. (author), Bruinvels, D.J. (author), Twisk, J.W.R. (author), van Mechelen, W. (author), van Poppel, M.N.M. (author)
The objective of this study was to examine which factors during pregnancy and postpartum predict pelvic girdle pain (PGP) at 12 weeks postpartum among working women. A total of 548 Dutch pregnant employees were recruited in 15 companies, mainly health care, child care, and supermarkets. The definition of PGP was any pain felt in the pelvic...
article 2012
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Terhal, P.A. (author), van Dommelen, P. (author), Le Merrer, M. (author), Zankl, A. (author), Simon, M.E. (author), Smithson, S.F. (author), Marcelis, C. (author), Kerr, B. (author), Kinning, E. (author), Mansour, S. (author), Hennekam, R.C. (author), van der Hout, A.H. (author), Cormier-Daire, V. (author), Lund, A.M. (author), Goodwin, L. (author), Mégarbané, A. (author), Lees, M. (author), Betz, R.C. (author), Tobias, E.S. (author), Coucke, P. (author), Mortier, G.R. (author)
From data collected via a large international collaborative study, we have constructed a growth chart for patients with molecularly confirmed congenital spondylo-epiphyseal dysplasia (SEDC) and other COL2A1 related dysplasias. The growth chart is based on longitudinal height measurements of 79 patients with glycine substitutions in the triple...
article 2012
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Janssens, A.C.J.W. (author), Henneman, L. (author), Detmar, S.B. (author), Khoury, M.J. (author), Steyerberg, E.W. (author), Eijkemans, M.J.C. (author), Mushkudiani, N. (author), Oostra, B.A. (author), van Duijn, C.M. (author), MacKenbach, J.P. (author)
Objective: We investigated the accuracy of self-reported family history for diabetes, hypertension, and overweight against two reference standards: family history based on physician-assessed health status of relatives and on self-reported personal health status of relatives. Study Design and Setting: Subjects were participants from the Erasmus...
article 2012
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Engelen, V. (author), Detmar, S. (author), Koopman, H. (author), Maurice-Stam, H. (author), Caron, H. (author), Hoogerbrugge, P. (author), Egeler, R.M. (author), Kaspers, G. (author), Grootenhuis, M. (author)
Background: The aim of the current study is to investigate the effectiveness of an intervention that provides health-related quality of life (HRQOL) scores of the patient (the QLIC-ON PROfile) to the pediatric oncologist. Procedure: Children with cancer participated in a sequential cohort intervention study: intervention N=94, control N=99....
article 2012
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de Hollander, E.L. (author), Zwart, L. (author), de Vries, S.I. (author), Wendel-Vos, W. (author)
Objective: To examine whether the "Short QUestionnaire to ASsess Health-enhancing physical activity" (SQUASH) and the "Injuries and Physical Activity in the Netherlands" questionnaire ("Ongevallen en Bewegen in Nederland," OBiN) were valid in assessing adherence to physical activity (PA) guidelines. Study Design and Setting: Participants (N =...
article 2012
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Thurlings, M.E. (author), Brouwer, A.M. (author), van Erp, J.B.F. (author), Blankertz, B. (author), Werkhoven, P.J. (author)
Event-related potential (ERP)-based brain–computer interfaces (BCIs) employ differences in brain responses to attended and ignored stimuli. Typically, visual stimuli are used. Tactile stimuli have recently been suggested as a gaze-independent alternative. Bimodal stimuli could evoke additional brain activity due to multisensory integration which...
article 2012
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Liebrechts-Akkerman, G. (author), Lao, O. (author), Liu, F. (author), van Sleuwen, B.E. (author), Engelberts, A.C. (author), L'Hoir, M.P. (author), Tiemeier, H.W. (author), Kayser, M. (author)
Background: Sudden infant death syndrome (SIDS) is the unexpected death of an infant that remains unexplained after a thorough investigation of the circumstances, family history, paediatric investigation and complete autopsy. In Western society, it is the leading cause of post-neonatal death below 1 year of age. In the Netherlands, the SIDS...
article 2011
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Höfer, T. (author), James, D. (author), Syversen, T. (author), Bowmer, T. (author)
Data on acute lethal inhalation toxicity from animal studies are commonly required for assessing the hazards to human health of volatile, gaseous and dusty chemicals or their mixtures. The International Maritime Organisation (IMO) made the provision of acute inhalation toxicity data a mandatory requirement for the carriage of bulk liquid...
article 2011
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Driessen, M.T. (author), Proper, K.I. (author), Anema, J.R. (author), Knol, D.L. (author), Bongers, P.M. (author), van der Beek, A.J. (author)
Objectives: This study investigated the effectiveness of the Stay@Work participatory ergonomics programme to reduce workers9 exposure to psychosocial and physical risk factors. Methods: 37 departments (n=3047 workers) from four Dutch companies participated in this cluster randomised controlled trial; 19 (n=1472 workers) were randomised to an...
article 2011
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Haas, F.J.L.M. (author), Schutgens, R.E.G. (author), Kluft, C. (author), Biesma, D.H. (author)
Introduction. The exclusion of deep venous thrombosis (DVT) by pre-test probability (PTP) and D-dimer in the elderly is safe, but has a low specificity. There is increasing interest in the diagnostic role of thrombin generation in patients with thrombosis. We evaluated the value of thrombin generation in the exclusion of DVT, especially in...
article 2011
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Coenen, P. (author), Kingma, I. (author), Boot, C.R.L. (author), Faber, G.S. (author), Xu, X. (author), Bongers, P.M. (author), van Dieën, J.H. (author)
This study aimed to develop, compare and validate two versions of a video analysis method for assessment of low back moments during occupational lifting tasks since for epidemiological studies and ergonomic practice relatively cheap and easily applicable methods to assess low back loads are needed. Ten healthy subjects participated in a protocol...
article 2011
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Teune, M.J. (author), van Wassenaer, A.G. (author), van Dommelen, P. (author), Mol, B.W.J. (author), Opmeer, B.C. (author)
Objective: Many obstetric interventions are performed to improve long-term neonatal outcome. However, long-term neonatal outcome is usually not a primary outcome because it is time-consuming and expensive. The aim of this project was to identify different perinatal risk indicators and to develop prediction models for neurologic morbidity at 2...
article 2011
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Kleemann, R. (author), Verschuren, L. (author), Morrison, M. (author), Zadelaar, A.S.M. (author), van Erk, M.J. (author), Wielinga, P.Y. (author), Kooistra, T. (author)
Objective: Polyphenols such as quercetin may exert several beneficial effects, including those resulting from anti-inflammatory activities, but their impact on cardiovascular health is debated. We investigated the effect of quercetin on cardiovascular risk markers including human C-reactive protein (CRP) and on atherosclerosis using transgenic...
article 2011
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van Noort, J.M. (author), Bsibsi, M. (author), Gerritsen, W.H. (author), van der Valk, P. (author), Bajramovic, J.J. (author), Steinman, L. (author), Amor, S. (author), TNO Kwaliteit van Leven (author)
We present the first comparative analysis of serum immunoglobulinG reactivity profiles against the full spectrum of human myelin-associated proteins in multiple sclerosis patients and healthy control subjects. In both groups, serum antibodies display a consistent and prominent reaction to αB-crystallin (CRYAB) versus other myelin proteins. As an...
article 2010
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Kälin, S. (author), Amstutz, B. (author), Gastaldelli, M. (author), Wolfrum, N. (author), Boucke, K. (author), Havenga, M. (author), DiGennaro, F. (author), Liska, N. (author), Hemmi, S. (author), Greber, U.F. (author), TNO Kwaliteit van Leven (author)
Human adenovirus serotype 35 (HAdV-35; here referred to as Ad35) causes kidney and urinary tract infections and infects respiratory organs of immunocompromised individuals. Unlike other adenoviruses, Ad35 has a low seroprevalence, which makes Ad35-based vectors promising candidates for gene therapy. Ad35 utilizes CD46 and integrins as receptors...
article 2010
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Eefting, D. (author), Seghers, L. (author), Grimbergen, J.M. (author), de Vries, M.R. (author), de Boer, H.C. (author), Lardenoye, J.W.H.P. (author), Jukema, J.W. (author), van Bockel, J.H. (author), Quax, P.H.A. (author), TNO Kwaliteit van Leven (author)
Aims Matrix metalloproteinases (MMP) and plasminogen activator (PA)/plasmin-mediated proteolysis, especially at the cell surface, play important roles in matrix degeneration and smooth muscle cell migration, which largely contributes to vein graft failure. In this study, a novel hybrid protein was designed to inhibit both protease systems...
article 2010
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