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Ly, V. (author), Roijendijk, L.L.M. (author), Hazebroek, H. (author), Tonnaer, C. (author), Hagenaars, M.A. (author)
Freezing is a defensive response to acute stress that is associated with coping and alterations in attentional processing. However, it remains unclear whether individuals in high risk professions, who are skilled at making rapid decisions in emergency situations, show altered threat-induced freezing. Here we investigated the effect of incident...
article 2017
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van Loon, K. (author), Breteler, M.J.M. (author), van Wolfwinkel, L. (author), Rheineck Leyssius, A.T. (author), Kossen, A.S. (author), Kalkman, C.J. (author), van Zaane, B. (author), Peelen, L.M. (author)
Altered respiratory rate is one of the first symptoms of medical conditions that require timely intervention, e.g., sepsis or opioid-induced respiratory depression. To facilitate continuous respiratory rate monitoring on general hospital wards a contactless, non-invasive, prototype monitor was developed using frequency modulated continuous wave...
article 2016
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Breuning-Boers, J.M. (author), Heerdink, M. (author), Kamphuis, M. (author), van Gameren-Oosterom, H. (author), Lanting, C. (author)
The objective of the evidence-based guidelines 'Asthma in children (ages 0-19)' for youth healthcare (CHC) is the prevention and reduction of asthma symptoms. The guidelines contain a lot of recommendations that apply to all disciplines in healthcare that deal with children. Primary prevention (preventing asthma): the main proven effective...
article 2012
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Bakker, G.C.M. (author), van Erk, M.J. (author), Pellis, L. (author), Wopereis, S. (author), Rubingh, C.M. (author), Cnubben, N.H.P. (author), Kooistra, T. (author), van Ommen, B. (author), Hendriks, H.F.J. (author), TNO Kwaliteit van Leven (author)
Background: Low-grade chronic inflammation in overweight subjects is thought to play an important role in disease development. Objective: It was hypothesized that specific dietary components are able to reduce low-grade inflammation as well as metabolic and oxidative stress. Design: Dietary products [resveratrol, green tea extract, α-tocopherol,...
article 2010
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Mulder, S.D. (author), van der Flier, W.M. (author), Verheijen, J.H. (author), Mulder, C. (author), Scheltens, P. (author), Blankenstein, M.A. (author), Hack, C.E. (author), Veerhuis, R. (author), TNO Kwaliteit van Leven (author)
Several studies have shown that reduced amyloid-β 1-42 (Aβ {42}) and increased tau levels in cerebrospinal fluid (CSF) reflect increased Alzheimer's disease (AD) pathology in the brain. β-site APP cleaving enzyme (BACE1) is thought to be the major β-secretase involved in Aβ production in the brain, and therefore we investigated the relation...
article 2010
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Mariani, B. (author), Hoskovec, C. (author), Rochat, S. (author), Büla, C. (author), Penders, J. (author), Aminian, K. (author), Laboratory of Movement Analysis and Measurements, Ecole Polytechnique Fédérale de Lausanne, -STI-IBI2-LMAM, Station 11/ELH 137, CH-1015 Lausanne, Switzerland Service of Geriatric Medicine, CHUV and CUTR Sylvana, Epalinges, Switzerland Holst Centre/IMEC, High Tech Campus 31, Eindhoven, Netherlands (author)
This study describes the validation of a new wearable system for assessment of 3D spatial parameters of gait. The new method is based on the detection of temporal parameters, coupled to optimized fusion and de-drifted integration of inertial signals. Composed of two wirelesses inertial modules attached on feet, the system provides stride length,...
article 2010
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Smits, K.M. (author), Schouten, L.J. (author), Hudak, E. (author), Verhage, B. (author), van Dijk, B.A.C. (author), van de Hulsbergen - Kaa, C.A. (author), Goldbohm, R.A. (author), Oosterwijk, E. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)
Purpose: Body mass index (BMI) is an important risk factor for clear-cell renal cancer (cc-RCC). A common molecular alteration in cc-RCC is loss-of-function of the von Hippel-Lindau (VHL) gene. We evaluated the association between BMI and VHL mutations in cc-RCC by using data from the Netherlands Cohort Study (NLCS), a prospective study, which...
article 2010
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Hogenkamp, P.S. (author), Mars, M. (author), Stafleu, A. (author), de Graaf, C. (author), TNO Kwaliteit van Leven (author)
Background: An important question in the regulation of energy intake is whether dietary learning of energy content depends on the food's characteristics, such as texture. Texture might affect the duration of sensory exposure and eating rate. Objective: The objective was to investigate whether a long sensory exposure, due to differences in means...
article 2010
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Pronk, A. (author), Preller, L. (author), Doekes, G. (author), Wouters, I.M. (author), Rooijackers, J. (author), Lammers, J.-W. (author), Heederik, D. (author), TNO Kwaliteit van Leven (author)
Associations have been observed between exposure to isocyanates, consisting mainly of oligomers, and respiratory symptoms and isocyanate specific sensitisation in spray painters. The aim of the present study was to assess associations between isocyanate exposure and more objective respiratory effect measures such as bronchial hyperresponsiveness...
article 2009
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van den Borne, S.W.M. (author), Cleutjens, J.P.M. (author), Hanemaaijer, R. (author), Creemers, E.E. (author), Smits, J.F.M. (author), Daemen, M.J.A.P. (author), Blankesteijn, W.M. (author), TNO Kwaliteit van Leven (author)
Background: Infarct rupture is a usually fatal complication of myocardial infarction (MI), for which no molecular mechanism has been described in humans. Experimental evidence in mouse models suggests that the degradation of the extracellular matrix by matrix metalloproteinases (MMPs) plays an important role in infarct rupture. The present study...
article 2009
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Berger, M.A.M. (author), Krul, A. (author), Daanen, H.A.M. (author), TNO Defensie en Veiligheid (author)
Finger dexterity tests are generally used to assess performance decrease due to gloves, cold and pathology. It is generally assumed that the O’Connor and Purdue Pegboard test yield similar results. In this experiment we compared these two tests for dry conditions without gloves, and for dry and wet conditions with two types of Nytril gloves. In...
article 2009
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Vogel, I. (author), Verschuure, H. (author), van der Ploeg, C.P.B. (author), Brug, J. (author), Raat, H. (author), TNO Kwaliteit van Leven (author)
OBJECTIVE. The goal was to assess risky and protective listening behaviors of adolescent users of MP3 players and the association of these behaviors with demographic characteristics and frequency of use. METHODS. In 2007, 1687 adolescents (12-19 years of age) in 68 classes in 15 Dutch secondary schools were invited to complete questionnaires...
article 2009
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Hawinkels, L.J.A.C. (author), Verspaget, H.W. (author), van der Reijden, J.J. (author), van der Zon, J.M. (author), Verheijen, J.H. (author), Hommes, D.W. (author), Lamers, C.B.H.W. (author), Sier, C.F.M. (author), TNO Kwaliteit van Leven (author)
Transforming growth factor-β1 (TGF-β1), a cytokine involved in various stages of cancer, is produced as a latent complex and requires processing to become active. We have determined total and active TGF-β1 levels in homogenates of colorectal neoplasia. In contrast to total TGF-β levels, showing a stepwise increase in the mucosa-adenoma-carcinoma...
article 2009
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Koelewijn, T. (author), Bronkhorst, A. (author), Theeuwes, J. (author), TNO Defensie en Veiligheid (author)
There is debate in the crossmodal cueing literature as to whether capture of visual attention by means of sound is a fully automatic process. Recent studies show that when visual attention is endogenously focused sound still captures attention. The current study investigated whether there is interaction between exogenous auditory and visual...
article 2009
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Zekveld, A.A. (author), Kramer, S.E. (author), Kessens, J.M. (author), Vlaming, M.S.M.G. (author), Houtgast, T. (author), TNO Defensie en Veiligheid (author)
This study examined the subjective benefit obtained from automatically generated captions during telephone-speech comprehension in the presence of babble noise. Short stories were presented by telephone either with or without captions that were generated offline by an automatic speech recognition (ASR) system. To simulate online ASR, the word...
article 2009
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Kienhuis, A.S. (author), van de Poll, M.C.G. (author), Wortelboer, H. (author), van Herwijnen, M. (author), Gottschalk, R. (author), de Jong, C.H.C. (author), Boorsma, A. (author), Paules, R.S. (author), Kleinjans, J.C.S. (author), Stierum, R.H. (author), van Delft, J.H.M. (author), TNO Kwaliteit van Leven (author)
The frequent use of rodent hepatic in vitro systems in pharmacological and toxicological investigations challenges extrapolation of in vitro results to the situation in vivo and interspecies extrapolation from rodents to humans. The toxicogenomics approach may aid in evaluating relevance of these model systems for human risk assessment by direct...
article 2009
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van de Vijver, L.P.L. (author), van den Bosch, L.M.C. (author), van den Brandt, P.A. (author), Goldbohm, R.A. (author), TNO Kwaliteit van Leven (author)
Objectives: To assess the association of whole-grain and (cereal) fibre intake with body mass index (BMI) and with the risk of being overweight (BMI ≥ 25) or obese (BMI ≥ 30 kg m-2). Subjects: A total of 2078 men and 2159 women, aged 55-69 years, were included in the analysis, after exclusion of subjects with diagnosed cancer or deceased within...
article 2009
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Graham, J.M.A. (author), Janssen, S.A. (author), Vos, H. (author), Miedema, H.M.E. (author), TNO Bouw en Ondergrond (author)
The relationships between road and rail traffic noise with pre-ejection period (PEP) and with respiratory sinus arrhythmia (RSA) during sleep, as indices of cardiac sympathetic and parasympathetic nervous system tone, were investigated in the field (36 subjects, with 188 and 192 valid subject nights for PEP and RSA, respectively). Two analyses...
article 2009
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Brouwer, A.M. (author), Franz, V.H. (author), Gegenfurtner, K.R. (author), TNO Defensie en Veiligheid (author)
Where exactly do people look when they grasp an object? An object is usually contacted at two locations, whereas the gaze can only be at one location at the time. We investigated participants' fixation locations when they grasp objects with the contact positions of both index finger and thumb being visible and compared these to fixation...
article 2009
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Abdul-Hussien, H. (author), Hanemaaijer, R. (author), Verheijen, J.H. (author), van Bockel, J.H. (author), Geelkerken, R.H. (author), Lindeman, J.H.N. (author), TNO Kwaliteit van Leven (author)
Background: Matrix metalloproteinase-9 (MMP-9) is thought to play a central role in abdominal aortic aneurysm (AAA) initiation. Doxycycline, a tetracycline analogue, has direct MMP-9-inhibiting properties in vitro, and it effectively suppresses AAA development in rodents. Observed inhibition of AAA progression, and contradictory findings in...
article 2009
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