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Huisman, L.G.M. (author), Meijer, P. (author), van Griensven, J. (author), Kluft, C. (author), Gaubius Laboratory Instituut voor verouderings- en vaatziekten onderzoek TNO (author)
t-PA depleted citrated plasma was used to prepare standards of different molecular forms of plasminogen activator inhibitor 1 (PAI-1). These standards were used to evaluate the specificity of two new PAI-1 antigen assays: the TintElize PAI-1 antigen assay (cat. no. 210221) and the Innotest PAI-1. Differences in specificity were apparent: the...
article 1992
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Hennis, B.C. (author), Boomsma, D.I. (author), van Boheemen, P.A. (author), Engesser, L. (author), Kievit, P. (author), Dooijewaard, G. (author), Kluft, C. (author), TNO Preventie en Gezondheid (author)
A pedigree-based maximum likelihood method developed by Lange et al. (12) was used to study the contribution of a newly defined di-allelic polymorphism in histidine-rich glycoprotein (HRG) to the plasma levels of HRG. In four families (n = 99) and 20 volunteers we found a heritability of 70%, an age effect of 3% and an effect of individual...
article 1995
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Ceconi, C. (author), Fox, K.M. (author), Remme, W.J. (author), Simoons, M.L. (author), Deckers, J.W. (author), Bertrand, M. (author), Parrinello, G. (author), Kluft, C. (author), Blann, A. (author), Cokkinos, D. (author), Ferrari, R. (author), TNO Kwaliteit van Leven (author)
The PERTINENT study measured biomarkers of atherosclerosis and thrombosis in a stable coronary artery disease population from EUROPA receiving ACE inhibition with perindopril 8 mg/day or placebo. Biomarkers of inflammation, C-reactive protein (CRP), fibrinogen, and tumor necrosis factor-alpha (TNF-α), and a biomarker of thrombosis, d-dimer, were...
article 2009
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Kluft, C. (author), Meijer, P. (author), LaGuardia, K.D. (author), Fisher, A.C. (author), TNO Kwaliteit van Leven (author)
Purpose: The aim of this study was to compare effects of the transdermal contraceptive patch, a desogestrel/ethinyl estradiol (EE)-containing, monophasic combination oral contraceptive (COC) and a levonorgestrel/EE-containing, triphasic COC on hemostasis variables. Study Design: This was a randomized, open-label study of 104 young women who...
article 2008
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de Maat, M.P.M. (author), de Knijff, P. (author), Green, F.R. (author), Thomas, A.E. (author), Jespersen, J. (author), Kluft, C. (author), TNO Preventie en Gezondheid (author)
Elevated plasma fibrinogen levels represent an increased risk for cardiovascular diseased, but the mechanism explaining this association is still not clear. Genetic differences may play a role, because it has been shown that individuals who carry the rare alleles of polymorphisms in the genes for the Bβ-chain (Bcl I and G/A 455) and the Aα-chain...
article 1995
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de Maat, M.P.M. (author), Arnold, A.E.R. (author), van Buuren, S. (author), Wilson, J.H.P. (author), Kluft, C. (author), Gaubius Instituut TNO (author)
Elevated plasma fibrinogen levels are associated with an increased risk for cardiac events. Ticlopidine is a drug that inhibits the ADP-induced aggregation of blood platelets and it also has been described that ticlopidine can decrease the plasma fibrinogen level in patients with vascular diseases. The mechanism of this decrease has not yet been...
article 1996
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te Velthuis - Wierik, E.J.M. (author), Kluft, C. (author), van den Berg, H. (author), Weststrate, J.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
A high fat intake has been associated with the high prevalence of coronary heart disease (CHD) in most Western countries. Consumption of reduced-fat products might reduce fat intake and beneficially affect markers of CHD risk. Therefore, the effects of 6 months of realistic consumption of reduced-fat products on energy and fat intake,...
article 1996
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Slagboom, P.E. (author), Kluft, C. (author), Gaubius Laboratory TNO Preventie en Gezondheid (author)
article 1996
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Verheijen, J.H. (author), Chang, G.T.G. (author), Kluft, C. (author), Gaubius Instituut TNO (author)
Human plasma contains a fast-acting t-PA inhibitor, which is not identical with ??2-antiplasmin or ??2-macroglobulin. The concentration of this inhibitor in normal plasma is highly variable, much lower than that of known plasma protease inhibitors, and in the range of physiologically occurring plasma concentrations of t-PA (0-2 IU/ml). The...
article 1984
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Alizadeh Dehnavi, R. (author), Beishuizen, E.D. (author), van de Ree, M.A. (author), Le Cessie, S. (author), Huisman, M.V. (author), Kluft, C. (author), Princen, H.M.G. (author), Tamsma, J.T. (author), TNO Kwaliteit van Leven (author)
Background: The burden of cardiovascular disease in diabetes mellitus type 2 (DM2) patients is variable. We hypothesize that metabolic syndrome (MS) and low-grade systemic inflammation modify the extent of atherosclerosis in DM2. Methods: Vascular phenotype was determined using the following endothelium-related, hemostatic, and sonographic...
article 2008
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Myrup, B. (author), Rossing, P. (author), Jensen, T. (author), Gram, J. (author), Kluft, C. (author), Jespersen, J. (author), Gaubius instituut TNO (author)
Objective: To investigate protein concentration changes during venous occlusion of proteins with reported affinity for extracellular matrix (plasminogen activator inhibitor type 1, antithrombin III, fibronectin and von Willebrand factor) in comparison with proteins with no reported affinity (albumin, tissue-type plasminogen activator,...
article 1999
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Sitruk-Ware, R.L. (author), Menard, J. (author), Rad, M. (author), Burggraaf, J. (author), de Kam, M.L. (author), Tokay, B.A. (author), Sivin, I. (author), Kluft, C. (author), TNO Kwaliteit van Leven (author)
Objective: We evaluated the effects of a new combined hormonal contraceptive vaginal ring (CVR) delivering the nonandrogenic progestin Nestorone® (NES) and ethinyl estradiol (EE) on several key estrogen-sensitive hepatic proteins that may be markers for the risk of arterial or venous disease events and on blood pressure (BP). Because the...
article 2007
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Haider, A.W. (author), Andreotti, F. (author), Hackett, D.R. (author), Tousoulis, D. (author), Kluft, C. (author), Maseri, A. (author), Davies, G.J. (author), Gaubius Instituut TNO (author)
Objectives. This study investigated the influence of early spontaneous intermittent reperfusion on the extent of myocardial damage and its relation to endogenous hemostatic activity, Background. In the early phase of acute myocardial infarction coronary occlusion is often intermittent, even before thrombolytic therapy is administered. The...
article 1995
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Haas, F.J.L.M. (author), Schutgens, R.E.G. (author), Kluft, C. (author), Biesma, D.H. (author)
Introduction. The exclusion of deep venous thrombosis (DVT) by pre-test probability (PTP) and D-dimer in the elderly is safe, but has a low specificity. There is increasing interest in the diagnostic role of thrombin generation in patients with thrombosis. We evaluated the value of thrombin generation in the exclusion of DVT, especially in...
article 2011
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Boomsma, D.I. (author), Willemsen, G. (author), Sullivan, P.F. (author), Heutink, P. (author), Meijer, P. (author), Sondervan, D. (author), Kluft, C. (author), Smit, G. (author), Nolen, W.A. (author), Zitman, F.G. (author), Smit, J.H. (author), Hoogendijk, W.J. (author), van Dyck, R. (author), de Geus, E.J.C. (author), Penninx, B.W.J.H. (author), TNO Kwaliteit van Leven (author)
To identify the genomic regions that confer risk and protection for major depressive disorder (MDD) in humans, large-scale studies are needed. Such studies should collect multiple phenotypes, DNA, and ideally, biological material that allows gene expression analysis, transcriptomic, proteomic, and metabolomic studies. In this paper, we briefly...
article 2008
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Pikaar, N.A. (author), Wedel, M. (author), van der Beek, E.J. (author), van Dokkum, W. (author), Kempen, H.J.M. (author), Kluft, C. (author), Ockhuizen, T. (author), Hermus, R.J.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
To investigate the effect of moderate alcohol consumption on blood constituents related to cardiovascular disease, 12 male volunteers consumed (instead of their usual alcoholic drinks) four different standardized amounts of red wine in addition to their habitual diet. Each dose was given to the subjects during a period of 5 weeks in a randomized...
article 1987
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Hellgren, M. (author), Conard, J. (author), Norris, L. (author), Kluft, C. (author), TNO Kwaliteit van Leven (author)
Objective: To study cardiovascular risk markers in women taking estradiol/trimegestone or estradiol/dydrogesterone. Design: Multicenter, randomized, prospective, double-blind study of 184 healthy post-menopausal women randomized to 6 cycles of either estradiol (2 mg) + trimegestone (0.5 mg) (T-group) or estradiol (2 mg) + dydrogesterone (10 mg) ...
article 2009
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de Lau, L.M.L. (author), Cheung, E.Y.L. (author), Kluft, C. (author), Leebeek, F.W.G. (author), Meijer, P. (author), Laterveer, R. (author), Dippel, D.W.J. (author), de Maat, M.P.M. (author), TNO Kwaliteit van Leven (author)
Ischemic stroke is associated with leucocyte activation. Activated leucocytes release elastase, an enzyme that can degrade fibrinogen. Fibrinogen elastase degradation products (FgEDP) may serve as a specific marker of elastase proteolytic activity. In a case-control study of 111 ischemic stroke patients and 119 controls, significantly higher...
article 2008
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Myrup, B. (author), Hansen, P.M. (author), Jensen, T. (author), Kofoed-Enevoldsen, A. (author), Feldt-Rasmussen, B. (author), Gram, J. (author), Kluft, C. (author), Jespersen, J. (author), Deckert, T. (author), Gaubius Instituut TNO (author)
We investigated the effect of heparin on urinary albumin excretion in patients with insulin-dependent diabetes mellitus. 39 patients with persistent urinary albumin excretion of 30-300 mg/24 h were randomly treated for 3 months with subcutaneous injections twice daily of isotonic saline, 5000 IU unfractionated heparin, or 2000 anti-Xa IU low...
article 1995
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Hemelaar, M. (author), van der Mooren, M.J. (author), Rad, M. (author), Kluft, C. (author), Kenemans, P. (author), TNO Kwaliteit van Leven (author)
Objective: To review the effects of non-oral administration of postmenopausal hormone therapy (HT) on risk markers for atherosclerotic and venous thromboembolic disease.Non-oral postmenopausal HT appears not to increase venous thromboembolic risk, whereas the effect on coronary heart disease risk is less clear. Design: Systematic review of...
article 2008
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