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(1 - 16 of 16)
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Leenheers, L.H. (author), van Breugel, D.C. (author), Ravensberg, J.C. (author), Meuling, W.J.A. (author), Jongen, M.J.M. (author), Medisch Biologisch Laboratorium TNO (author)
An analytical method for the assessment of the exposure of workers to the pesticide propoxur through biological monitoring has been developed. This study was part of a survey of occupational exposure to pesticides used in greenhouses for the growing of ornamental plants. In order to assess the actual absorbed amount of propoxur in the body, an...
article 1992
document
Cashman, J.R. (author), Xiong, Y. (author), Lin, J. (author), Verhagen, H. (author), van Poppel, G. (author), van Bladeren, P.J. (author), Larsen-Su, S. (author), Williams, D.E. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The effect of consumption of glucosinolate-containing Brussels sprouts on flavin-containing monooxygenase functional activity in humans was investigated in 10 healthy, male, non-smoking volunteers. After a 3-week run-in period, 5 volunteers continued on a glucosinolate-free diet for 3 weeks (control group), and 5 others consumed 300 g of cooked...
article 1999
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Knebel, N.G. (author), Grieb, S. (author), Winkler, M. (author), Locher, M. (author), van der Vlis, E. (author), Verheij, E.R. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
An HPLC assay with tandem mass spectrometric detection in the positive-ion Turbo-Ion-Spray((TM)) (TISP) mode for the fast and sensitive determination of perifosine ((I), D-21266) in human plasma was developed, utilising the structural analogue, miltefosine ((II), D-18506), as internal standard. Automated solid-phase extraction of diluted plasma...
article 1999
document
Fidder, A. (author), Noort, D. (author), Hulst, A.G. (author), de Jong, L.P.A. (author), Benschop, H.P. (author), Prins Maurits Laboratorium TNO (author)
The development of a procedure for retrospective detection and quantitation of exposure to the arsenical dichloro(2-chlorovinyl)arsine (lewisite; L1) has been initiated. Upon incubation of human blood with [14C]L1 (20 nM-0.2 mM) in vitro, more than 90% of the total radioactivity was found in the erythrocytes and 25-50% of the radioactivity...
article 2000
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Degenhardt, C.E.A.M. (author), Pleijsier, K. (author), van der Schans, M.J. (author), Langenberg, J.P. (author), Preston, K.E. (author), Solano, M.I. (author), Maggio, V.L. (author), Barr, J.R. (author), Prins Maurits Laboratorium TNO (author)
One of the most appropriate biomarkers for the verification of organophosphorus nerve agent exposure is the conjugate of the nerve agent to butyrylcholinesterase (BuChE). The phosphyl moiety of the nerve agent can be released from the BuChE enzyme by incubation with fluoride ions, after which the resulting organophosphonofluoridate can be...
article 2004
document
van Baar, B.L.M. (author), Hulst, A.G. (author), de Jong, A.L. (author), Wils, E.R.J. (author), Prins Maurits Laboratorium TNO (author)
In a follow-up of the earlier characterisation of botulinum toxins type A and B (BTxA and BTxB) by mass spectrometry (MS), types C, D, E, and F (BTxC, BTxD, BTxE, BTxF) were now investigated. Botulinum toxins are extremely neurotoxic bacterial toxins, likely to be used as biological warfare agent. Biologically active BTxC, BTxD, BTxE, and BTxF...
article 2004
document
Verhoeckx, K.C.M. (author), Bijlsma, S. (author), Jespersen, S. (author), Ramaker, R. (author), Verheij, E.R. (author), Witkamp, R.F. (author), van der Greef, J. (author), Rodenburg, R.J.T. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)
The discovery of new anti-inflammatory drugs is often based on an interaction with a specific target, although other pathways often play a primary or secondary role. Anti-inflammatory drugs can be categorized into classes, based on their mechanism of action. In this article we investigate the possibility to characterize novel anti-inflammatory...
article 2004
document
Wang, M. (author), Lamers, R.J.A.N. (author), Korthout, H.A.A.J. (author), van Nesselrooij, J.H.J. (author), Witkamp, R.F. (author), van der Heijden, R. (author), Voshol, P.J. (author), Havekes, L.M. (author), Verpoorte, R. (author), van der Greef, J. (author), TNO Kwaliteit van Leven (author)
The introduction of the concept of systems biology, enabling the study of living systems from a holistic perspective based on the profiling of a multitude of biochemical components, opens up a unique and novel opportunity to reinvestigate natural products. In the study of their bioactivity, the necessary reductionistic approach on single active...
article 2005
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Coulier, L. (author), Bas, R. (author), Jespersen, S. (author), Verheij, E. (author), van der Werf, M.J. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven TNO Voeding (author)
We have developed an analytical method, consisting of ion-pair liquid chromatography coupled to electrospray ionization mass spectrometry (IP-LC-ESI-MS), for the simultaneous quantitative analysis of several key classes of polar metabolites, like nucleotides, coenzyme A esters, sugar nucleotides, and sugar bisphosphates. The use of the ion-pair...
article 2006
document
Bobeldijk, I. (author), Karlsson, D. (author), Pronk, A. (author), Gonsalves, J. (author), Hekman, M. (author), van de Lagemaat, D. (author), Preller, L. (author), Heederik, D. (author), Skarping, G. (author), TNO Kwaliteit van Leven (author)
An adapted method for the quantitative determination of isocyanates in air was implemented and validated in-house. The method was based on air sampling using an impinger flask containing di-n-butylamine (DBA) in toluene and a glass fibre filter in series. The DBA derivatives were determined using liquid chromatography and tandem mass...
article 2008
document
Gozalpour, E. (author), Greupink, R. (author), Wortelboer, H.M. (author), Bilos, A. (author), Schreurs, M. (author), Russel, F.G.M. (author), Koenderink, J.B. (author)
Digitalis-like compounds (DLCs) such as digoxin, digitoxin, and ouabain, also known as cardiac glycosides, are among the oldest pharmacological treatments for heart failure. The compounds have a narrow therapeutic window, while at the same time, DLC pharmacokinetics is prone to drug-drug interactions at the transport level. Hepatic transporters...
article 2014
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Jónasdóttir, H.S. (author), Ioan-Facsinay, A. (author), Kwekkeboom, J. (author), Brouwers, H. (author), Zuurmond, A.M. (author), Toes, R. (author), Deelder, A.M. (author), Giera, M. (author)
Here we present an advanced platform for the analysis of specialized pro-resolving mediators (SPM), including a set of pro-inflammatory lipids and respective biochemical pathway markers. The platform is characterized by a largely simplified sample preparation protocol, employing methanol protein-precipitation instead of solid phase extraction....
article 2014
document
Nohynek, G.J. (author), Skare, J.A. (author), Meuling, W.J.A. (author), Wehmeyer, K.R. (author), de Bie, A.T.H.J. (author), Vaes, W.H.J. (author), Dufour, E.K. (author), Fautz, R. (author), Steiling, W. (author), Bramante, M. (author), Toutain, H. (author)
Systemic exposure was measured in humans after hair dyeing with oxidative hair dyes containing 2.0% (A) or 1.0% (B) [14C]-p-phenylenediamine (PPD). Hair was dyed, rinsed, dried, clipped and shaved; blood and urine samples were collected for 48 hours after application. [14C] was measured in all materials, rinsing water, hair, plasma, urine and...
article 2015
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Garner, C.R. (author), Park, K.B. (author), French, N.S. (author), Earnshaw, C. (author), Schipani, A. (author), Selby, A.M. (author), Byrne, L. (author), Siner, S. (author), Crawley, F.P. (author), Vaes, W.H.J. (author), van Duijn, E. (author), de ligt, R. (author), Varendi, H. (author), Lass, J. (author), Grynkiewicz, G. (author), Maruszak, W. (author), Turner, M.A. (author)
Aims The aims of the study were to compare [14C]-paracetamol ([14C]-PARA) paediatric pharmacokinetics (PK) after administration mixed in a therapeutic dose or an isolated microdose and to develop further and validate accelerator mass spectrometry (AMS) bioanalysis in the 0-2 year old age group. Methods [14C]-PARA concentrations in 10-15 μl...
article 2015
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Hulst, A.G. (author), Verstappen, D.R.W. (author), van der Riet-van Oeveren, D. (author), Vermeulen, N.P.E. (author), Noort, D. (author)
In the current paper we show that exposure of human callus to isocyanates leads to covalent modifications within keratin proteins. Mass spectrometric analyses of pronase digests of keratin isolated from exposed callus show that both mono- and di-adducts (for di-isocyanates) are predominantly formed on the ε-amino group of lysine. In addition,...
article 2015
document
Kasiotis, K.M. (author), Tsakirakis, A.N. (author), Richard Glass, C. (author), Charistou, A.N. (author), Anastassiadou, P. (author), Gerritsen-Ebben, R. (author), Machera, K. (author)
A dislodgeable foliar residue study was conducted in greenhouse pepper and tomato on the island of Crete, Greece, following the spray application of an SC insecticide (with active substance (a.s.) tebufenozide) and an EC fungicide (a.s. bupirimate). Furthermore, for the assessment of worker exposure to pesticides – as a result of re-entering the...
article 2017
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