Searched for: +
(1 - 20 of 165)

Pages

document
Vos, O. (author), Budke, L. (author), Grant, G.A. (author), Medisch Biologisch Laboratorium TNO (author)
In tissue culture, protection against X irradiation by a number of cysteamine derivatives was studied and the results were compared with data obtained in mice. Compounds with a covered SH group, like WR 638, cysteamine phosphate, WR 2721 and AE AE 48527, showed practically no protection when dissolved in tissue culture medium, but developed a...
article 1976
document
Mattern, I.E. (author), Greim, H. (author), Medisch Biologisch Laboratorium TNO (author)
Bacterial systems for the screening of chemical substances for mutagenic potential are receiving widespread attention. Now that many laboratories have introduced these test systems and a large number of substances has been tested, discrepancies in the results have become apparent. To discuss this problem, a workshop was organized at Neuherberg ...
article 1978
document
Gaillard, A.W.K. (author), Varey, C.A. (author), Instituut voor Zintuigfysiologie TNO (author)
The effects (on human beings) of the ACTH analog Org 2766 were investigated for a range of performance tests: complicated serial reaction task, running memory span, verbal learning and non-verbal mental ability tests (closure flexibility and non-verbal abstraction). Subjective ratings on feeling were taken and heart rate was measured. Only the...
article 1979
document
Cocchiarella, L. (author), Mattern, I.E. (author), van Kralingen, C.G. (author), Medisch Biologisch Laboratorium TNO (author)
article 1980
document
Vos, O. (author), Medisch Biologisch Laboratorium TNO (author)
Chemicals/CAS: cysteine, 4371-52-2, 52-89-1, 52-90-4; mercaptamine, 156-57-0, 60-23-1; n (1 adamantylmethyl)thioglycolamidine, 60833-81-0
article 1980
document
Wolthuis, O. (author), Vanwersch, R.A.P. (author), van der Wiel, H.J. (author), Medisch Biologisch Laboratorium TNO (author)
Previous results had shown that bis-pyridinium oximes, particularly HI-6 are quite effective therapeutically in soman-poisoned rats and mice in vivo and in the rat diaphragm preparation in vitro. The aim of the present study was to investigate the efficacy of bis-pyridinium oximes on soman-inhibited neuromuscular transmission in muscle...
article 1981
document
Gaubius instituut TNO (author), Kempen, H.J. (author), Vos Van Holstein, M. (author), Lange, J.de (author)
Chemicals/CAS: cholesterol, 57-88-5; cholic acid, 32500-01-9, 361-09-1, 81-25-4; colestyramine, 11041-12-6, 58391-37-0; compactin, 73573-88-3; lipid, 66455-18-3; tritium oxide, 14940-65-9; Bile Acids and Salts; Cholesterol, 57-88-5; Cholestyramine, 11041-12-6; compactin, 73573-88-3; Lipids; Naphthalenes; Tritium, 10028-17-8
article 1983
document
Prins Maurits Laboratorium TNO Medisch Biologisch Laboratorium TNO (author), Benschop, H.P. (author), Konings, C.A.G. (author), van Genderen, J. (author), de Jong, L.P.A. (author)
The four stereoisomers of the nerve agent pinacolyl methylphosphonofluoridate (soman), designated as C(+)P(+), C(+)P(-), C(-)P(+), and C(-)P(-), have different toxicologic properties due to stereospecific interactions in living organisms. We report the isolation of these stereoisomers with more than 99% optical purity. This result was realized...
article 1984
document
Prins Maurits Laboratorium TNO Medisch Biologisch Laboratorium TNO (author), Benschop, H.P. (author), Bijleveld, E.C. (author), de Jong, L.P.A. (author), van der Wiel, H.J. (author), van Helden, H.P.M. (author)
The toxicokinetics of the four stereoisomers of C(??)P(??)-soman were investigated in anesthetized, atropinized, and artificially ventilated rats at iv doses of 6 (495 ??g/kg) and 3 LD50. By integration of a thermodesorption/cold trap injector into our GLC analysis, the soman stereoisomers could be followed in rat blood down to a minimum...
article 1987
document
Centraal Instituut voor Voedingsonderzoek TNO (author), Jonker, D. (author), Woutersen, R.A. (author), van Bladeren, P.J. (author), Til, H.P. (author), Feron, V.J. (author)
In a 4-wk oral toxicity study, 4-wk-old male and female Wistar rats were exposed to a combination of arbitrarily chosen chemicals comprising sodium metabisulphite, Mirex, Loperamide, metaldehyde, di-n-octyltin dichloride, stannous chloride, lysinoalanine and potassium nitrite. The dose levels used were based on the 'no-observed-adverse-effect...
article 1990
document
van den Berg, K.J. (author), van Raaij, J.A.G.M. (author), Bragt, P.C. (author), Notten, W.R.F. (author), Medisch Biologisch Laboratorium TNO (author)
Previous results in experimental systems have suggested that hydroxylated PCBs may decrease thyroid hormone levels through associative interaction with transthyretin. In the present paper it was investigated whether this property was also shared by various industrial chemicals, mainly pesticides. In total, 65 compounds from 12 chemical groups...
article 1991
document
Brouwer, D.H. (author), Brouwer, E.J. (author), de Vreede, J.A.F. (author), van Welie, R.T.H. (author), Vermeulen, N.P.E. (author), van Hemmen, J.J. (author), Medisch Biologisch Laboratorium TNO (author)
Respiratory occupational exposure to the Z- and E-isomers of 1,3-dichloropropene (DCP) of twelve commercial applicators was assessed. The time-weighted average (TWA) concentrations of DCP ranged from 1.9 to 18.9 mg/m3. On 30% of the observed working days the Dutch occupational exposure limit of 5 mg/m3 was exceeded. Short-term exposure levels...
article 1991
document
Emeis, J.J. (author), van den Hoogen, C.M. (author), Gaubius Laboratory IVVO-TNO, P.O. Box 430, 2300 AK Leiden, Netherlands Instituut voor verouderings- en vaatziekten onderzoek TNO (author)
Pharmacological modulation of the in vivo induction of plasminogen activator inhibitor type-1 (PAI-1) synthesis was studied in rats using the induction of PAI-1 by endotoxin as a model system. Both the cyclooxygenase inhibitors acetylsalicylic acid and indomethacin enhanced PAI-1 induction. The combined cyclooxygenase-lipoxygenase inhibitor,...
article 1992
document
Leenheers, L.H. (author), van Breugel, D.C. (author), Ravensberg, J.C. (author), Meuling, W.J.A. (author), Jongen, M.J.M. (author), Medisch Biologisch Laboratorium TNO (author)
An analytical method for the assessment of the exposure of workers to the pesticide propoxur through biological monitoring has been developed. This study was part of a survey of occupational exposure to pesticides used in greenhouses for the growing of ornamental plants. In order to assess the actual absorbed amount of propoxur in the body, an...
article 1992
document
Brouwer, R. (author), Marquart, H. (author), de Mik, G. (author), van Hemmen, J.J. (author), Medisch Biologisch Laboratorium TNO Instituut CIVO-Toxicologie en Voeding TNO (author)
On 18 farms for rose culture in greenhouses in The Netherlands, dermal exposure of hands and forearms to abamectin (avermectin B1), dodemorph (4- cyclododecyl-2,6-dimethylmorpholinium acetate) and bupirimate (5-butyl-2- (ethylamino)-6-methyl-4-pyrimidinyl dimethylsulphate) was measured during crop activities. Dermal exposure during cutting (75...
article 1992
document
Emeis, J.J. (author), Verheijen, J.H. (author), Instituut voor Verouderings- en Vaatziekten Onderzoek TNO (author)
Chemicals/CAS: Recombinant Proteins; Tissue Plasminogen Activator, EC 3.4.21.68
article 1992
document
Medisch Biologisch Laboratorium TNO (author), Jongen, M.J.M. (author), Engel, R. (author), Leenheers, L.H. (author)
An HPLC method was developed for estimation of dermal exposure of greenhouse workers to the pesticide bupirimate. Chromatography was performed on a cyano-modified silica column with methanol-water (6:4 by volume) containing 5 g/L ammonium sulfate as eluent. UV detection at 310 nm was used for quantitation. Dermal exposure was assessed by letting...
article 1992
document
Vink, A.A. (author), Berg, R.J.W. (author), de Gruijl, F.R. (author), Lohman, P.H.M. (author), Roza, L. (author), Baan, R.A. (author), Centraal Instituut voor Voedingsonderzoek TNO Medisch Biologisch Laboratorium TNO (author)
An immunocytochemical method was developed to study induction and removal of DNA damage in specific cell populations in the epidermis of hairless mice during chronic ultraviolet (UV) exposure. Identification of mouse suprabasal cells was performed with an immunoperoxidase stain. This stain was shown not to affect the fluorescent nuclear stains,...
article 1993
document
Smits, J.P. (author), Knol, W. (author), Bol, J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Two fungal strains, Aspergillus clavatus II-9 and Fusarium oxysporum @ 149, proved to be capable of degrading sinigrin and sinalbin. During the degradation of sinigrin by whole cells of the Aspergillus strain, allylcyanide accumulated in the liquid incubation mixture. After a maximum concentration had been reached, the concentration of...
article 1993
document
Lang, M.S. (author), Oostendorp, R.A.J. (author), Simons, P.J. (author), Boersma, W. (author), Knegt, P. (author), van Ewijk, W. (author)
Both retroviral infections as well as human tumors may cause immunosuppression. One of the factors involved in immunosuppression in patients with squamous cell carcinoma of the head and neck (SCC-HN) is a protein related in the retroviral protein p15E. A conserved, 17-amino acid sequence represents the immunosuppressive epitope of retroviral...
article 1994
Searched for: +
(1 - 20 of 165)

Pages