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Shandilya, N. (author), Morgeneyer, M. (author), Le Bihan, O. (author)
In this work, the particle aerosols emissions during the abrasion of three products – brick, wood and stainless steel – are measured. Owing to different material removal mechanisms in these three products during their abrasions, different quantities and generation rates of aerosols are observed with the brick producing the highest number at a...
article 2015
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Schoen, E.D. (author), Eendebak, P.T. (author), Goos, P. (author)
A conference design is a rectangular matrix with orthogonal columns, one zero in each column, at most one zero in each row and -1's and +1's elsewhere. A definitive screening design can be constructed by folding over a conference design and adding a row vector of zeroes. We prove that, for a given even number of rows, there is just one...
article 2019
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van der Burg, B. (author), Pieterse, B. (author), Rorije, E. (author), Lewin, G. (author), van der Linden, S.C. (author), Man, H.Y. (author), Piersma, A.H. (author), Mangelsdorf, I. (author), Wolterbeek, A.P.M. (author), Kroese, E.D. (author), van Vugt-Lussenburg, B.M.A. (author)
There is a great need for alternative testing methods for reproductive toxicants that are practical, fast, cost-effective and easy to interpret. Previously we followed a pragmatic approach using readily available tests, which was successful in predicting reproductive toxicity of chemicals [13]. This initial battery still contained apical tests...
article 2015
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Shandilya, N. (author), Le Bihan, O. (author), Bressot, C. (author), Morgeneyer, M. (author)
In the present work, we investigate the effect of weathering duration on a commercial photocatalytic nanocoating on the basis of its nanoparticle emission tendency into two media, air and water. It is found that increased weathering duration results in stepwise structural deterioration of the nanocoating, which in turn decreases the nanocoating...
article 2015
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Klein Entink, R.H. (author), Bekker, C. (author), Fransman, W.F. (author), Brouwer, D.H. (author)
article 2015
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Bekker, C. (author), Kuijpers, E. (author), Brouwer, D.H. (author), Vermeulen, R. (author), Fransman, W. (author)
article 2015
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Kuper, C.F. (author), Bosland, M.C. (author)
article 2019
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van Bilsen, J.H. (author), Knippels, L.M. (author), Penninks, A.H. (author), Nieuwenhuizen, W.F. (author), de Jongh, H.H. (author), Koppelman, S.J. (author)
It is not exactly known why certain food proteins are more likely to sensitize. One of the characteristics of most food allergens is that they are stable to the acidic and proteolytic conditions in the digestive tract. This property is thought to be a risk factor in allergic sensitization. The purpose of the present study was to investigate the...
article 2013
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Burello, E. (author), Worth, A.P. (author)
article 2015
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van der Wielen, N. (author), van Avesaat, M. (author), de Wit, N.J.W. (author), Vogels, J.T.W.E. (author), Troost, F. (author), Masclee, A. (author), Koopmans, S.J. (author), van der Meulen, J. (author), Boekschoten, M.V. (author), Muller, M. (author), Hendriks, Henk F.J. (author), Witkamp, Renger F. (author), Meijerink, Jocelijn (author)
Introduction: Intestinal chemosensory receptors and transporters are able to detect food-derived molecules and are involved in the modulation of gut hormone release. Gut hormones play an important role in the regulation of food intake and the control of gastrointestinal functioning. This mechanism is often referred to as ‘‘nutrient sensing’’....
article 2014
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van den Hout, A. (author), Fox, J.P. (author)
Longitudinal data can be used to estimate the transition intensities between healthy and unhealthy states prior to death. An illness-death model for history of stroke is presented, where time-dependent transition intensities are regressed on a latent variable representing cognitive function. The change of this function over time is described by...
article 2015
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Dano, D. (author), Remington, B.C. (author), Astier, C. (author), Baumert, J.L. (author), Kruizinga, A.G. (author), Bihain, B.E. (author), Taylor, S.L. (author), Kanny, G. (author)
Background: Sesame is a relevant food allergen in France. Compared to other allergens there is a lack of food challenge data and more data could help sesame allergy risk management. The aim of this study is to collect more sesame challenge data and investigate the most efficient food challenge method for future studies. Method: Records of...
article 2015
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Leist, M. (author), Ghallab, A. (author), Graepel, R. (author), Marchan, R. (author), Hassan, R. (author), Bennekou, S.H. (author), Limonciel, A. (author), Vinken, M. (author), Schildknecht, S. (author), Waldmann, T. (author), Danen, E. (author), van Ravenzwaay, B. (author), Kamp, H. (author), Gardner, I. (author), Godoy, P. (author), Bois, F.Y. (author), Braeuning, A. (author), Reif, R. (author), Oesch, F. (author), Drasdo, D. (author), Höhme, S. (author), Schwarz, M. (author), Hartung, T. (author), Braunbeck, T. (author), Beltman, J. (author), Vrieling, H. (author), Sanz, F. (author), Forsby, A. (author), Gadaleta, D. (author), Fisher, C. (author), Kelm, J. (author), Fluri, D. (author), Ecker, G. (author), Zdrazil, B. (author), Terron, A. (author), Jennings, P. (author), van der Burg, B. (author), Dooley, S. (author), Meijer, A.H. (author), Willighagen, E. (author), Martens, M. (author), Evelo, C. (author), Mombelli, E. (author), Taboureau, O. (author), Mantovani, A. (author), Hardy, B. (author), Koch, B. (author), Escher, S. (author), van Thriel, C. (author), Cadenas, C. (author), Kroese, D. (author), van de Water, B. (author), Hengstler, J.G. (author)
Adverse outcome pathways (AOPs) are a recent toxicological construct that connects, in a formalized, transparent and quality-controlled way, mechanistic information to apical endpoints for regulatory purposes. AOP links a molecular initiating event (MIE) to the adverse outcome (AO) via key events (KE), in a way specified by key event...
article 2017
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Sacchettini, G. (author), Calliera, M. (author), Marchis, A. (author), Glass, R. (author), Ellis, C.B. (author), Machera, K. (author), Gerritsen-Ebben, R. (author), Spanoghe, P. (author), Capri, E. (author)
In 2009, the European Union adopted the Directive on Sustainable Use of pesticides (SUD, Directive 2009/128/EC) establishing a framework for achieving a sustainable use of Plant Protection Products (PPPs) through reducing the risks and impacts of PPP use on human health and the environment, promoting integrated pest management and stimulating...
article 2015
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Muller, C. (author), Maldonado, A.G. (author), Varnek, A. (author), Creton, B. (author)
Each oil reservoir could be characterized by a set of parameters such as temperature, pressure, oil composition, and brine salinity, etc. In the context of the chemical enhanced oil recovery (EOR), the selection of high performance surfactants is a challenging and time-consuming task since this strongly depends on the reservoir's conditions. The...
article 2015
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Koivisto, A.J. (author), Aromaa, M. (author), Koponen, I.K. (author), Fransman, W. (author), Jensen, K.A. (author), Mäkelä, J.M. (author), Hämeri, K.J. (author)
Nanoparticle (particles with diameter ≤100 nm) exposure is recognized as a potentially harmful size fraction for pulmonary particle exposure. During nanoparticle synthesis, the number concentrations in the process room may exceed 10 × 106 cm−3. During such conditions, it is essential that the occupants in the room wear highly reliable high...
article 2015
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Friesen, M.C. (author), Shortreed, S.M. (author), Wheeler, D.C. (author), Burstyn, I. (author), Vermeulen, R. (author), Pronk, A. (author), Colt, J.S. (author), Baris, D. (author), Karagas, M.R. (author), Schwenn, M. (author), Johnson, A. (author), Armenti, K.R. (author), Silverman, D.T. (author), Yu, K. (author)
Objectives: Rule-based expert exposure assessment based on questionnaire response patterns in population-based studies improves the transparency of the decisions. The number of unique response patterns, however, can be nearly equal to the number of jobs. An expert may reduce the number of patterns that need assessment using expert opinion, but...
article 2015
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Heeres, H.L. (author)
article 2012
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Rottenkolber, M. (author), Voogd, E. (author), van Dijk, L. (author), Primatesta, P. (author), Becker, C. (author), de Groot, M.C.H. (author), Plana, E. (author), Alvarez, Y. (author), Durand, J. (author), Slattery, J. (author), Afonso, A. (author), Requena, G. (author), Huerta, C. (author), Alvarez, A. (author), de Abajo, F. (author), Tauscher, M. (author), Hasford, J. (author), Fischer, R. (author), Reynolds, R. (author), Schmiedl, S. (author)
Background: For patients with asthma, COPD, or asthma-COPD overlap syndrome (ACOS), inter-country comparisons of seasonal changes in drug prescriptions are scarce or missing. Hence, we aimed to compare seasonal changes in prescription rates of long-acting beta-2-agonist (LABA) in four European countries. Methods: A common study protocol was...
article 2015
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Kuper, C.F. (author), van Bilsen, J. (author), Cnossen, H. (author), Houben, G. (author), Garthoff, J. (author), Wolterbeek, A. (author)
Ahealthyimmunestatus is mostly determined during early life stages andmanyimmune-related diseases may find their origin in utero and the first years of life. Therefore, immune health optimization may be most effective during early life. This review is an inventory of immune organ maturation events in relation
article 2016
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