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document
Finglas, P.M. (author), de Meer, K. (author), Molloy, A. (author), Verhoef, P. (author), Pietrzik, K. (author), Powers, H.J. (author), van der Straeten, D. (author), Jägerstad, M. (author), Varela-Moreiras, G. (author), van Vliet, T. (author), Havenaar, R. (author), Buttriss, J. (author), Wright, A.J.A. (author), TNO Kwaliteit van Leven (author)
In the past decade, the understanding of folate bioavailability, metabolism and related health issues has increased, but several problems remain, including the difficulty of delivering the available knowledge to the populations at risk. Owing to the low compliance of taking folic acid supplements, for example, among women of child-bearing age...
article 2006
document
Fox, T.E. (author), van den Heuvel, E.G.H.M. (author), Atherton, C.A. (author), Dainty, J.R. (author), Lewis, D.J. (author), Langford, N.J. (author), Crews, H.M. (author), Luten, J.B. (author), Lorentzen, M. (author), Sieling, F.W. (author), van Aken-Schneyder, P. (author), Hoek, M. (author), Kotterman, M.J.J. (author), van Dael, P. (author), Firweather-Tail, S.J. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)
Objective: To measure the bioavailability of selenium from cooked and raw fish in humans by estimating and comparing apparent absorption and retention of selenium in biosynthetically labelled fish with labelled selenate and biosynthetically labelled selenium in brewers yeast. Design: The intervention study was a parallel, randomised, reference...
article 2004
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van den Heuvel, E.G.H.M. (author), Wils, D. (author), Pasman, W.J. (author), Bakker, M. (author), Saniez, M.-H. (author), Kardinaal, A.F.M. (author), TNO Voeding (author)
Objective: To determine the tolerance of increasing dosages of an incompletely hydrolysed and/or incompletely absorbed food dextrin coming from wheat starch, NUTRIOSE®FB, at daily levels of 10 and 15 g up to 60 and 80 g, respectively. Design: A randomized, double-blind, multiple dose, placebo-controlled, combined crossover and parallel trial....
article 2004
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Lina, B.A.R. (author), Jonker, D. (author), Kozianowski, G. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)
Isomaltulose is a natural occurring disaccharide composed of α-1,6-linked glucose and fructose. Commercial isomaltulose is produced from sucrose by enzymatic rearrangement and has been used as a sugar in Japan since 1985. It is particularly suitable as a non-cariogenic sucrose replacement and is favorable in products for diabetics and...
article 2002
document
Tryfonidou, M.A. (author), Stevenhagen, J.J. (author), van den Bemd, G.J.C.M. (author), Oosterlaken-Dijksterhuis, M.A. (author), Deluca, H.F. (author), Mol, J.A. (author), van den Brom, W.E. (author), van Leeuwen, J.P.T.M. (author), Hazewinkel, H.A.W. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Hormonal regulation of calcium (Ca) absorption was investigated in a cholecalciferol (vitamin D3)supplemented group (hVitD) vs. a control group (cVitD) of growing Great Danes (100 vs. 12.5 μg vitamin D3/kg diet). Although Ca intakes did not differ, fractional Ca absorption was significantly lower in the hVitD group than in the cVitD group. There...
article 2002
document
van den Heuvel, E.G.H.M. (author), Schoterman, M.H.C. (author), Muijs, T. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The aim of this study was to investigate whether a product rich in transgalactooligosaccharides (TOS, Elix'or) stimulates true Ca absorption in postmenopausal women. The study was a double-blind, randomized crossover study, consisting of two 9-d treatment periods separated by a 19-d washout period. During the treatment periods, 12 subjects drank...
article 2000
document
van Dokkum, W. (author), Wezendonk, B. (author), Srikumar, T.S. (author), van den Heuvel, E.G.H.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Objective: To study the effect of the intake of 15 g nondigestible oligosaccharides per day on various parameters of large-bowel function, as well as on blood lipid concentrations and glucose absorption in man. Design: Latin square, randomized, double-blind, diet-controlled. Setting: Metabolic research unit. Subjects: Twelve apparently healthy...
article 1999
document
Duizer, E. (author), Gilde, A.J. (author), Versantvoort, C.H.M. (author), Groten, J.P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
In the present study we characterized the functional and structural disruption of the paracellular barrier of intestinal epithelium in vitro in relation to cytotoxicity after apical Cd2+ exposure. For that purpose filter-grown Caco-2 and IEC-18 cells were apically exposed to 5 to 100 μM CdCl2 for 4 or 14 h. It was found that the effects of Cd2+...
article 1999
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van den Heuvel, E.G.H.M. (author), Muijs, T. (author), van Dokkum, W. (author), Schaafsma, G. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Animal studies have indicated that calcium absorption is increased by lactulose, a synthetic disaccharide. Therefore, the influence of lactulose on calcium absorption was measured in postmenopausal women who may benefit from the possible enhancing effect of lactulose on calcium absorption. Twelve postmenopausal women drank 100 ml of water...
article 1999
document
van den Heuvel, E.G.H.M. (author), Muys, T. (author), van Dokkum, W. (author), Schaafsma, G. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Background: In rats, nondigestible oligosaccharides stimulate calcium absorption. Recently, this effect was also found in human subjects. Objective: The objective of the study was to investigate whether consumption of 15 g oligofructose/d stimulates calcium absorption in male adolescents. Design: Twelve healthy, male adolescents aged 14-16 y...
article 1999
document
van den Berg, H. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)
Chemicals/CAS: Carotenoids, 36-88-4; Chylomicrons
article 1999
document
Knippels, L.M.J. (author), Penninks, A.H. (author), Smit, J.J. (author), Houben, G.F. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Although several in vivo antigenicity assays using parenteral immunization are operational, no full validated enteral models are available to study food allergy and allergenicity of food proteins. To further validate a developed enteral Brown Norway (BN) rat food allergy model, systemic and local immune-mediated reactions were studied upon oral...
article 1999
document
Gerrits, W.J.J. (author), Schrama, J.W. (author), Tamminga, S. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
A previous study showed that the marginal efficiency of utilization of digestible nitrogen for deposition in the body in preruminant calves is only ~30%. The study consisted of two similar experiments that were performed in two live weight ranges: 80-160 and 160-240 kg. In each experiment, 36 calves were allotted to one of twelve dietary...
article 1998
document
de Bie, A.T.H.J. (author), van Ommen, B. (author), Bär, A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The absorption, disposition, metabolism, and excretion of 14C-labeled γ-cyclodextrin ([14C]γ-CD) was examined in four separate experiments with Wistar rats. In experiment 1, [14C]γ-CD (25 μCi, 600 mg/kg body wt) was administered intravenously to four male and four female conventional rats. In experiment 2, [14C]γ- CD (25 μCi, 1000 mg/kg body wt)...
article 1998
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van den Heuvel, E.G.H.M. (author), Schaafsma, G. (author), Muys, T. (author), van Dokkum, W. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The effect of inulin, fructooligosaccharides, and galactooligosaccharides on true intestinal absorption of iron and calcium was measured in men by using double stable-isotope techniques (oral 57Fe and 44Ca and intravenous 58Fe and 48Ca). The incorporation of iron isotopes into erythrocytes and the urinary excretion of calcium isotopes was...
article 1998
document
Duizer, E. (author), van der Wulp, C. (author), Versantvoort, C.H.M. (author), Groten, J.P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Palmitoyl carnitine chloride (PCC) has been shown to be an effective enhancer of intestinal transport of hydrophilic molecules. The exact mechanism by which the epithelial barrier function is decreased is not clear. In an attempt to elucidate the mechanism of action of PCC, we studied the relationship among absorption enhancement, cell viability...
article 1998
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van Vliet, T. (author), TNO Voeding (author)
Objective: To review available information on absorption and further metabolism of different carotenoids in man and to discuss animal models and approaches in the study of carotenoid absorption and metabolism in man. Conclusions: Humans appear to absorb various carotenoids in a relatively non-specific fashion, but absorption kinetics and plasma...
article 1996
document
van Vliet, T. (author), Fentener van Vlissingen, M. (author), van Schaik, F. (author), van den Berg, H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The purpose of this study was to examine whether intestinal β-carotene cleavage activity, measured with the dioxygenase assay, is affected by vitamin A intake and whether this in vitro activity is a determinant of β- carotene cleavage in vivo, measured in lymph-cannulated rats. Six groups of 10-20 rats were fed a diet with a low, normal or high...
article 1996
document
van Vliet, T. (author), Schreurs, W.H.P. (author), van den Berg, H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Postprandial response curves of β-carotene and retinyl esters in a triglyceride-rich lipoprotein (TRL) fraction were evaluated as a potential measure of β-carotene uptake and cleavage. β-Carotene, retinyl ester, and triglyceride concentrations in the TRI, fraction (density < 1.006 kg/L) and plasma were measured in 10 men for 8 or 16 h after an...
article 1995
document
Centraal Instituut voor Voedingsonderzoek TNO (author), Schutte, J.B. (author), Jong, J.de (author), Polziehn, R. (author), Verstegen, M.W.A. (author)
Hemicellulose consists primarily of pentose sugars, joined together in a polysaccharide chain with D-xylose as the most abundant component. Ileal digestibility and urinary excretion of D-xylose and associated effects of this pentose sugar on ileal and faecal digestibility of dry matter (DM), organic matter (OM), gross energy (GE) and nitrogen...
article 1991
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