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Scholtes-Timmerman, M.J. (author), Bijlsma, S. (author), Fokkert, M.J. (author), Slingerland, R. (author), van Veen, S.J.F. (author)
Self-monitoring of glucose is important for managing diabetes. Noninvasive glucose monitors are not yet available, but patients would benefit highly from such a device. We present results that may lead to a novel, point-of-care noninvasive system to measure blood glucose based on Raman spectroscopy. A hospitalized cohort of 111 subjects was...
article 2014
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van Dijk, C.E. (author), de Boer, M.R. (author), Koppes, L.L.J. (author), Roos, J.C. (author), Lips, P. (author), Twisk, J.W.R. (author), TNO Kwaliteit van Leven (author)
Introduction: Studies on the association of vitamin D and bone mineral density (BMD) in adolescence and young adults have shown contrasting results. None of these studies have examined the course and baseline in vitamin D intake. The purpose of this study was to examine the association between baseline and the course of dietary vitamin D intake...
article 2009
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Kersten, S. (author), Lichtenstein, L. (author), Steenbergen, E. (author), Mudde, K. (author), Hendriks, H.F.J. (author), Hesselink, M.K. (author), Schrauwen, P. (author), Müller, M. (author), TNO Kwaliteit van Leven (author)
OBJECTIVE-: Plasma lipoprotein levels are determined by the balance between lipoprotein production and clearance. Recently, angiopoietin-like protein 4 (ANGPTL4) was uncovered as a novel endocrine factor that potently raises plasma triglyceride levels by inhibiting triglyceride clearance. However, very little is known about ANGPTL4 in human....
article 2009
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Vermeulen, M. (author), Klöpping-Ketelaars, I.W.A.A. (author), van den Berg, R. (author), Vaes, W.H.J. (author), TNO Kwaliteit van Leven (author), KvL (author)
The aim of this study was to determine the bioavailability and kinetics of the supposed anticarcinogen sulforaphane, the hydrolysis product of glucoraphanin, from raw and cooked broccoli. Eight men consumed 200 g of crushed broccoli, raw or cooked, with a warm meal in a randomized, free-living, open cross-over trial. Higher amounts of...
article 2008
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Stuurman, B. (author), Meijster, T. (author), Heederik, D. (author), Doekes, G. (author), TNO Kwaliteit van Leven (author)
Objectives: To obtain an overview of inhalable β(1→3)glucans levels in Dutch industrial bakeries and explore possible associations with reported respiratory health effects in bakery workers. Methods: β(1→3)glucan levels were analysed in 186 personal inhalable dust measurements obtained from a random population of bakery workers. Association...
article 2008
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de Wijk, R.A. (author), Zijlstra, N. (author), Mars, M. (author), de Graaf, C. (author), Prinz, J.F. (author), TNO Kwaliteit van Leven (author)
Two studies investigated the effect of a food's viscosity on bite size, bite effort and food intake using a standardized protocol in which subjects sipped through a straw every 20 s for a period of 15 min from one of two products, a chocolate-flavored dairy drink and a chocolate-flavored dairy semi-solid, matched for energy density. In the first...
article 2008
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Koushik, A. (author), Hunter, D.J. (author), Spiegelman, D. (author), Beeson, W.L. (author), van den Brandt, P.A. (author), Buring, J.E. (author), Calle, E.E. (author), Cho, E. (author), Fraser, G.E. (author), Freudenheim, J.L. (author), Fuchs, C.S. (author), Giovannucci, E.L. (author), Goldbohm, R.A. (author), Harnack, L. (author), Jacobs Jr., D.R. (author), Kato, I. (author), Krogh, V. (author), Larsson, S.C. (author), Leitzmann, M.F. (author), Marshall, J.R. (author), McCullough, M.L. (author), Miller, A.B. (author), Pietinen, P. (author), Rohan, T.E. (author), Schatzkin, A. (author), Sieri, S. (author), Virtanen, M.J. (author), Wolk, A. (author), Zeleniuch-Jacquotte, A. (author), Zhang, S.M. (author), Smith-Warner, S.A. (author), TNO Kwaliteit van Leven (author)
Background Fruit and vegetable intakes have been associated with a reduced risk of colon cancer; however, in more recent studies associations have been less consistent. Statistical power to examine associations by colon site has been limited in previous studies. Methods Fruit and vegetable intakes in relation to colon cancer risk were examined...
article 2007
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Peeters, K.A.B.M. (author), Nordlee, J.A. (author), Penninks, A.H. (author), Chen, L. (author), Goodman, R.E. (author), Bruijnzeel-Koomen, C.A.F.M. (author), Hefle, S.L. (author), Taylor, S.L. (author), Knulst, A.C. (author), TNO Kwaliteit van Leven (author)
Background: Reports of lupine allergy are increasing as its use in food products increases. Lupine allergy might be the consequence of cross-reactivity after sensitization to peanut or other legumes or de novo sensitization. Lupine allergens have not been completely characterized. Objectives: We sought to identify allergens associated with...
article 2007
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Houben, E. (author), Uchida, Y. (author), Nieuwenhuizen, W.F. (author), de Paepe, K. (author), Vanhaecke, T. (author), Holleran, W.M. (author), Rogiers, V. (author), TNO Kwaliteit van Leven (author)
It has recently become evident that at least five ceramidase (CDase) isoforms are present in human epidermis, and that specifically acidic CDase (aCDase) and alkaline CDase (alkCDase) activities increase during keratinocyte differentiation, and thus might play a pivotal role(s) in permeability barrier function. Prior to investigating their...
article 2007
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Flinterman, A.E. (author), van Hoffen, E. (author), den Hartog Jager, C.F. (author), Koppelman, S. (author), Pasmans, S.G. (author), Hoekstra, M.O. (author), Bruijnzeel-Koomen, C.A. (author), Knulst, A.C. (author), Knol, E.F. (author), TNO Kwaliteit van Leven (author)
Background: In peanut-allergic adults, IgE is mainly directed to Ara h1 and Ara h2. More recently, a role for Ara h6 has been suggested. In contrast to adults, IgE in children can fluctuate over time. Therefore, children may have a more dynamic reactivity to peanut. Objective: To examine the IgE reactivity to major peanut allergens in peanut...
article 2007
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Nohynek, G.J. (author), Meuling, W.J.A. (author), Vaes, W.H.J. (author), Lawrence, R.S. (author), Shapiro, S. (author), Schulte, S. (author), Steiling, W. (author), Bausch, J. (author), Gerber, E. (author), Sasa, H. (author), Nau, H. (author), TNO Kwaliteit van Leven (author)
Background: Vitamin A is widely used in cosmetic preparations. Given that oral Vitamin A and its metabolites present a potential reproductive risk, the present study investigated the effect of topical Vitamin A on human endogenous plasma levels of Vitamin A and its metabolites. Methods: Two groups of 14 female volunteers of child-bearing age...
article 2006
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Wiefferink, C.H. (author), Peters, L. (author), Hoekstra, F. (author), Ten Dam, G. (author), Buijs, G.J. (author), Paulussen, T.G.W.M. (author), TNO Kwaliteit van Leven (author)
Characterizing school health promotion is its category-by-category approach, in which each separate health-related behavior is addressed independently. Such an approach creates a risk that extra-curricular activities become overloaded, and that teaching staff are distracted by continuous innovations. Within the health promotion sector there are...
article 2006
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van Erk, M.J. (author), Blom, W.A.M. (author), van Ommen, B. (author), Hendriks, H.F.J. (author), TNO Kwaliteit van Leven (author)
Background: Application of transcriptomics technology in human nutrition intervention studies would allow for genome-wide screening of the effects of specific diets or nutrients and result in biomarker profiles. Objective: The aim was to evaluate the potential of gene expression profiling in blood cells collected in a human intervention study...
article 2006
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Blom, W.A.M. (author), Mars, M. (author), Hendriks, H.F.J. (author), de Groot, L.C.P.G.M. (author), Stafleu, A. (author), Kok, F.J. (author), de Graaf, C. (author), TNO Kwaliteit van Leven (author)
Objective: To study the role of ghrelin as a hunger signal during energy restriction and to test the hypothesis that changes in fasting leptin concentrations during energy restriction are associated with changes in fasting ghrelin concentrations. Research Methods and Procedures: Thirty-five healthy, lean men (23 ± 3 years of age; BMI: 22.3 ±1.6...
article 2006
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Smeets, P.A.M. (author), de Graaf, C. (author), Stafleu, A. (author), van Osch, M.J.P. (author), Nievelstein, R.A.J. (author), van der Grond, J. (author), TNO Kwaliteit van Leven (author)
Background: The brain plays a crucial role in the decision to eat, integrating multiple hormonal and neural signals. A key factor controlling food intake is selective satiety, ie, the phenomenon that the motivation to eat more of a food decreases more than does the motivation to eat foods not eaten. Objective: We investigated the effect of...
article 2006
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van de Laar, F.A. (author), van de Lisdonk, E.H. (author), Lucassen, P.L.B.J. (author), Stafleu, A. (author), Mulder, J. (author), van den Hoogen, H.J.M. (author), Rutten, G.E.H.M. (author), van Weel, C. (author), TNO Kwaliteit van Leven (author)
Aims: To assess restrained, emotional and external eating behaviour in patients newly diagnosed with Type 2 diabetes compared with the general population, and to assess the relationship of eating behaviour to changes in fat and energy. Methods: We assessed emotional, external, and restrained eating behaviour and measured fat and energy intake in...
article 2006
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Mojet, J. (author), Köster, E.P. (author), Prinz, J.F. (author), TNO Kwaliteit van Leven (author)
The stimuli used in taste research are usually considered to be odourless. This was tested in two experiments with aqueous solutions of two representative compounds for each of the five taste qualities including umami. In the first experiment elderly and young subjects rated the intensity and pleasantness of three concentrations of the stimuli,...
article 2005
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Fox, T.E. (author), van den Heuvel, E.G.H.M. (author), Atherton, C.A. (author), Dainty, J.R. (author), Lewis, D.J. (author), Langford, N.J. (author), Crews, H.M. (author), Luten, J.B. (author), Lorentzen, M. (author), Sieling, F.W. (author), van Aken-Schneyder, P. (author), Hoek, M. (author), Kotterman, M.J.J. (author), van Dael, P. (author), Firweather-Tail, S.J. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)
Objective: To measure the bioavailability of selenium from cooked and raw fish in humans by estimating and comparing apparent absorption and retention of selenium in biosynthetically labelled fish with labelled selenate and biosynthetically labelled selenium in brewers yeast. Design: The intervention study was a parallel, randomised, reference...
article 2004
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Verhoef, P. (author), Steenge, G.R. (author), Boelsma, E. (author), van Vliet, T. (author), Olthof, M.R. (author), Katan, M.B. (author), TNO Voeding (author)
Background: A high plasma total homocysteine (tHcy) concentration is a risk factor for cardiovascular disease. The increase in tHcy induced by methionine, the sole dietary precursor of homocysteine, might be modulated by other amino acids present in dietary proteins. Objectives: Our objectives were to compare the postprandial effect of free and...
article 2004
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Koppelman, S.J. (author), Wensing, M. (author), Ertmann, M. (author), Knulst, A.C. (author), Knol, E.F. (author), TNO Voeding (author)
Background: A number of allergenic proteins in peanut has been described and the relative importance of these allergens is yet to be determined. Objectives: We have investigated the relevance of previously identified peanut allergens in well-characterized peanut-allergic patients by in vitro, ex vivo and in vivo assays. Methods: Thirty-two adult...
article 2004
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