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Griffiths, J.C. (author), de Vries, J. (author), McBurney, M.I. (author), Wopereis, S. (author), Serttas, S. (author), Marsman, D.S. (author)
Commonly, it is the end of life when our health is deteriorating, that many will make drastic lifestyle changes to improve their quality of life. However, it is increasingly recognized that bringing good health-promoting behaviors into practice as early in life as possible has the most significant impact across the maximal healthspan. The WHO...
article 2020
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Wickramasinghe, K. (author), Mathers, J.C. (author), Wopereis, S. (author), Marsman, D.S. (author), Griffiths, J.C. (author)
Across the globe, there has been a marked increase in longevity, but significant inequalities remain. These are exacerbated by inadequate access to proper nutrition and health care services and to reliable information to make the decisions related to nutrition and health care. Many in economically developing as well as developed societies are...
article 2020
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Wang, L. (author), Jansen, W. (author), van Grieken, A. (author), Vlasblom, J.L.D. (author), Boere-Boonekamp, M.M. (author), L'Hoir, M.P. (author), Raat, H. (author)
BACKGROUND: To identify the patterns of lifestyle behaviours in children aged 3 years, to investigate the parental and child characteristics associated with the lifestyle patterns, and to examine whether the identified lifestyle patterns are associated with child BMI and weight status. METHODS: Cross-sectional data of 2090 children 3 years old...
article 2020
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Yang, C. (author), Hawwash, D. (author), de Baets, B. (author), Bouwman, J. (author), Lachat, C. (author)
Robust recommendations for healthy diets and nutrition require careful synthesis of available evidence. Given the increasing volume of research articles generated, the retrieval and synthesis of evidence are increasingly becoming laborious and time-consuming. Information technology could help to reduce workload for humans. To guide supervised...
article 2020
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Jagadeesan, B. (author), Gerner-Smidt, P. (author), Allard, M.W. (author), Leuillet, S. (author), Winkler, A. (author), Xiao, Y. (author), Chaffron, S. (author), Chaffron, S. (author), Tang, S. (author), Katase, M. (author), McClure, P. (author), Kimura, B. (author), Chai, L. Ching (author), Chapman, J. (author), Grant, K. (author)
Next Generation Sequencing (NGS) combined with powerful bioinformatic approaches are revolutionising food microbiology. Whole genome sequencing (WGS) of single isolates allows the most detailed comparison possible hitherto of individual strains. The two principle approaches for strain discrimination, single nucleotide polymorphism (SNP) analysis...
article 2019
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Lozano-Ojalvo, D. (author), Benede, S. (author), Antunes, C.M. (author), Bavaro, S.L. (author), Bouchaud, G. (author), Costa, A. (author), Denery-Papini, S. (author), Diaz-Perales, A. (author), Garrido-Arandia, M. (author), Gavrovic-Jankulovic, M. (author), Hayen, S. (author), Martinez-Blanco, M. (author), Molina, E. (author), Monaci, L. (author), Pieters, R.H.H. (author), Villemin, C. (author), Wichers, H.J. (author), Wroblewska, B. (author), Willemsen, L.E.M. (author), Roggen, E.L. (author), van Bilsen, J.H.M. (author)
Background: Before introducing proteins from new or alternative dietary sources into the market, a compressive risk assessment including food allergic sensitization should be carried out in order to ensure their safety. We have recently proposed the adverse outcome pathway (AOP) concept to structure the current mechanistic understanding of the...
article 2019
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Houben, G. (author), Blom, M. (author), Alvito, P. (author), Assuncao, R. (author), Crevel, R. (author), Faeste, C.K. (author), Le, T.M. (author), Madsen, C.B. (author), Remington, B. (author), Stroheker, T. (author), Vassilopoulou, E. (author), Verhoeckx, K. (author), Ayiarovska, J. (author), Constable, A. (author)
Many food innovations rely on the introduction and use of new or modified proteins. New or modified food proteins may lead to major health risks due to their inherent potential to cause food allergy. Currently, the pre-market allergenicity assessment for new or modified food proteins and protein sources relies on methods for identifying...
article 2019
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van den Brink, W. (author), van Bilsen, J. (author), Salic, K. (author), Hoevenaars, F.P.M. (author), Verschuren, L. (author), Kleemann, R. (author), Bouwman, J. (author), Ronnett, (author), van Ommen, B. (author), Wopereis, S. (author)
Obesity, type 2 diabetes, and other metabolic disorders have a large impact on global health, especially in Western countries. An important hallmark of metabolic disorders is chronic low-grade inflammation. A key player in chronic low-grade inflammation is dysmetabolism, which is defined as the inability to keep homeostasis resulting in loss of...
article 2019
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Hogenelst, K. (author), Soeter, M. (author), Kallen, V. (author)
Accumulating evidence supports the harmful effects of stress on health, including the development and progress of psychopathology (e.g. anxiety disorders), metabolic disorders (e.g. diabetes type II), inflammatory disturbances, and cardiovascular disease. These harmful effects are often expressed as disturbances in cortisol levels, patterns, or...
article 2019
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Tsakirakis, A.N. (author), Kasiotis, K.M. (author), Anastasiadou, P. (author), Charistou, A.N. (author), Gerritsen-Ebben, R. (author), Glass, C.R. (author), Machera, K. (author)
BACKGROUND: In the present study, the rate of dermal transfer of pesticides to agricultural workers occurring via contact with sprayed hard surfaces was investigated. Cotton gloves were used as dosimeters to collect residues from hard surfaces contaminated by pesticides in greenhouses. Dosimeters, either dry or moistened, were in contact with...
article 2018
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Blom, W.M. (author), Michelsen-Huisman, A.D. (author), van Os-Medendorp, H. (author), van Duijn, G. (author), de Zeeuw-Brouwer, M.L. (author), Versluis, A. (author), Castenmiller, J.J.M. (author), Noteborn, H.P.J.M. (author), Kruizinga, A.G. (author), Knulst, A.C. (author), Houben, G.F. (author)
Background: Accidental allergic reactions to food are frequent and can be severe and even fatal. Objective: We sought to analyze the culprit food products and levels of unexpected allergens in accidental reactions. Methods: A prospective cohort study was conducted in adults (n = 157) with a physician-confirmed diagnosis of food allergy. During a...
article 2018
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Willems, M. (author), Waninge, A. (author), Hilgenkamp, T.I.M. (author), van Empelen, P. (author), Krijnen, W.P. (author), van der Schans, C.P. (author), Melville, C.A. (author)
Background Promotion of a healthy lifestyle for people with intellectual disabilities is important; however, the effectiveness of lifestyle change interventions is unclear. Aims This research will examine the effectiveness of lifestyle change interventions for people with intellectual disabilities. Methods and Procedures Randomized controlled...
article 2018
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Shreffler, W.G. (author), Baumert, J.L. (author), Remington, B.C. (author), Koppelman, S.J. (author), Dinakar, C. (author), Fleischer, D.M. (author), Kim, E. (author), Tilles, S.A. (author), Spergel, J.M. (author)
article 2018
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Koivisto, A.J. (author), Pizzol, L. (author), Basei, G. (author), Zabeo, A. (author), Mackevica, A. (author), Hansen, S.F. (author), Gosens, I. (author), Cassess, F.R. (author), de Jong, W. (author), Koivisto, A.J. (author), Neubauer, N. (author), Sanchaz, J.A. (author), Semenzin, E. (author), Subramanian, V. (author), Fransman, W. (author), Jensen, K.A. (author), Wohlleben, W. (author), Stone, V. (author), Marcomini, A. (author)
The use of nano-scale copper oxide (CuO) and basic copper carbonate (Cu2(OH)2CO3) in both ionic and micronized wood preservatives has raised concerns about the potential of these substances to cause adverse humans health effects. To address these concerns, we performed quantitative (probabilistic) human health risk assessment (HHRA) along the...
article 2018
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Birot, S. (author), Madsen, C.B. (author), Kruizinga, A.G. (author), Crépet, A. (author), Christensen, T. (author), Brockhoff, P.B. (author)
To prevent allergic reactions, food producers have to be able to make a knowledge based decision on whether to label their products with precautionary labelling. As many manufactured food products are sold in different countries across Europe, the allergen risk assessment should be estimated at the European levels. As currently, there are no pan...
article 2018
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Keijser, B.J.F. (author), van den Broek1, T.J. (author), Slot, D.E. (author), van Twillert, L. (author), Kool, J. (author), Thabuis, C. (author), Ossendrijver, M. (author), van der Weijden, F.A. (author), Montijn, R.C. (author)
Background: The oral cavity harbors a complex microbial ecosystem, intimately related to oral health and disease. The use of polyol-sweetened gum is believed to benefit oral health through stimulation of salivary flow and impacting oral pathogenic bacteria. Maltitol is often used as sweetener in food products. This study aimed to establish the...
article 2018
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Whittaker, A.C. (author), Delledonne, M. (author), Finni, T. (author), Garagnani, P. (author), Greig, C.A. (author), Kallen, V. (author), Kokko, K. (author), Lord, J.M. (author), Maier, A.B. (author), Meskers, C. (author), Santos, N.C. (author), Sipila, S. (author), Thompson, J.L. (author), van Riel, N. (author)
Current demographic trends indicate that by the year 2020, almost one in five of the European population will be aged 65 years or over. Although life expectancy is increasing by 2 years per decade, the period of life spent in good health is not keeping pace and most Europeans spend their last decade in poor health. Consequently, there is an...
article 2018
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Luque-Sierra, A. (author), Alvarez-Amor, L. (author), Kleemann, R. (author), Martín, F. (author), Varela, L.M. (author)
Scope: The present study investigates the effect of olive oils with different phenolic content in high-fat diets (HFDs) on hypertrophy and inflammation in adipose tissue and associated atherosclerosis, in the context of obesity. Methods and results: Ldlr−/−.Leiden mice were fed three different HFDs for 32 weeks and were compared with mice fed...
article 2018
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Amoah, B. (author), Giorgi, E. (author), Heyes, D.J. (author), van Buuren, S. (author), Diggle, P.J. (author)
Background: Undernutrition among children under 5 years of age continues to be a public health challenge in many low- and middle-income countries and can lead to growth stunting. Infectious diseases may also affect child growth, however their actual impact on the latter can be difficult to quantify. In this paper, we analyse data from 20...
article 2018
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van Ommen, B. (author), Wopereis, S. (author), van Empelen, P. (author), van Keulen, H.M. (author), Otten, W. (author), Kasteleyn, M. (author), Molema, J.J.W. (author), de Hoogh, I.M. (author), Chavannes, N.H. (author), Numans, M.E. (author), Evers, A.W.M. (author), Pijl, H. (author)
From a biological view, most of the processes involved in insulin resistance, which drives the pathobiology of type 2 diabetes, are reversible. This theoretically makes the disease reversible and curable by changing dietary habits and physical activity, particularly when adopted early in the disease process. Yet, this is not fully implemented...
article 2018
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