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Smits, R.C.F. (author), Emmen, H.H. (author), Bertelmans, F.W. (author), Kulig, B.M. (author), van Loenen, A.C. (author), Polman, C.H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
4-Aminopyridine (4-AP) has a favorable effect on the disability of certain patients with MS. We investigated the effect of 4-AP on neuropsychological performance in 20 MS patients using a randomized, double-blind, placebo- controlled, crossover design. Although there was a trend for improved performance with 4-AP for two of the tests, we could...
article 1994
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Vergelli, M. (author), Le, H. (author), van Noort, J.M. (author), Dhib-Jalbut, S. (author), McFarland, H. (author), Martin, R. (author), TNO Preventie en Gezondheid (author)
CD56 is a member of the neural cell adhesion molecule family expressed on cells of the central nervous system and also on NK cells. Previous studies suggest the involvement of CD56 in effector-to-target cell conjugation mediated by NK cells. It was shown recently that CD56 is also expressed by subpopulations of CD8+ and CD4+ T cells. The present...
article 1996
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Nagelkerken, L. (author), Blauw, B. (author), Tielemans, M. (author), TNO Preventie en Gezondheid (author)
IL-10 and IL-4 were studied with respect to their capacity to inhibit experimental allergic encephalomyelitis (EAE) induced in SJL/J mice by immunization with the proteolipid protein peptide PLP139-151. Treatment with 2 μg IL-10/day from day 0 until day 12 delayed onset of disease and inhibited the severity of EAE. By contrast, a daily dose of 0...
article 1997
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van Noort, J.M. (author), TNO Preventie en Gezondheid (author)
Multiple sclerosis is the major neurological disease of young adults in the western world, affecting about 1 per 1,000. It is characterised by chronic or recurrent lesions of inflammatory damage in the white matter of the central nervous system. Within such lesions, the protective myelin sheath is stripped off axons by infiltrated macrophages...
article 1998
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Laman, J.D. (author), Maassen, C.B.M. (author), Schellekens, M.M. (author), Visser, L. (author), Kap, M. (author), de Jong, E. (author), van Puijenbroek, M. (author), van Stipdonk, M.J.B. (author), van Meurs, M. (author), Schwärzler, C. (author), Günthert, U. (author), TNO Preventie en Gezondheid (author)
Interactions between mononuclear cells are required for the formation of inflammatory infiltrates in the CNS and the activation of cellular effector functions provoking demyelination in MS. Membrane-expressed costimulatory molecules are crucial to such interactions. We therefore investigated whether two costimulatory molecules, CD40L (CD154,...
article 1998
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Laman, J.D. (author), van Meurs, M. (author), Schellekens, M.M. (author), de Boer, M. (author), Melchers, B. (author), Massacesi, L. (author), Lassmann, H. (author), Claassen, E. (author), 't Hart, B.A. (author), TNO Preventie en Gezondheid (author)
Accessory molecules and cytokines are involved in the immunopathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) in rodent models, and are potential targets for immunotherapy. Evaluation of such experimental therapies requires appropriate animal models. Therefore, we analysed the expression of selected...
article 1998
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TNO Preventie en Gezondheid (author), Nagelkerken, L. (author)
Evidence is accumulating that Th1 cells play an important role in the development of multiple sclerosis (MS) and experimental allergic encephalomyelitis (EAE), whereas Th2 cells contribute to recovery from disease. A maj or determinant in the development of Th1 and Th2 cells is the type of antigen-presenting cell (APC) involved and its...
article 1998
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Luca, M.E. (author), Visser, L. (author), Lucas, C.J. (author), Nagelkerken, L. (author), TNO Preventie en Gezondheid (author)
In this study, mouse recombinant IFN-β was shown to favor PLP139-151-specific Th2 responses in vitro, by inhibiting IFN-γ production and stimulating IL-4 and IL-10 production. IFN-β (5000 U/day) failed to prevent the development or severity of EAE induced with PLP139-151. Whereas efficacy of IL-10 was found in the B. pertussis assisted but not...
article 1999
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Çelet, B. (author), Akman-Demir, G. (author), Serdaroǧlu, P. (author), Yentür, S.P. (author), Taşci, B. (author), van Noort, J.M. (author), Eraksoy, M. (author), Saruhan-Direskeneli, G. (author), TNO Preventie en Gezondheid (author)
αB-Crystallin, a small heat shock protein, is an immuno-dominant antigen with increased tissue expression in demyelination. To investigate the humoral response against αB-crystallin, the sera and CSF samples of patients with multiple sclerosis (MS), Guillain-Barré syndrome (GBS), neuro-Behçet's disease (NBD) and other non-inflammatory...
article 2000
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Thoua, N.-M. (author), van Noort, J.M. (author), Baker, D. (author), Bose, A. (author), van Sechel, A.C. (author), van Stipdonk, M.J.B. (author), Travers, P.J. (author), Amor, S. (author), TNO Preventie en Gezondheid (author)
The stress protein αB-crystallin is an immunodominant antigen in multiple sclerosis (MS)-affected myelin for human T cells and is expressed at elevated levels in MS lesions. Using bovine αB-crystallin and synthetic peptides based on mouse αB-crystallin the ability of this stress protein to induce experimental allergic encephalomyelitis (EAE) was...
article 2000
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Boxel van-Dezaire, A.H.H. (author), Trigt van-Hoff, S.C.J. (author), Killestein, J. (author), Schrijver, H.M. (author), van Houwelingen, J.C. (author), Polman, C.H. (author), Nagelkerken, L. (author), TNO Preventie en Gezondheid (author)
Interferon (IFN)-β treatment is effective in relapsing-remitting multiple sclerosis (RR-MS) via an as yet unidentified mechanism. In the present study, we investigated whether the expression of messenger RNA (mRNA) encoding the interleukin (IL)-12 subunits p40 and p35, IL-12 receptor chains, IL-18, tumor necrosis factor-α (TNFα), IFNγ, IL-10, IL...
article 2000
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Bajramović, J.J. (author), Plomp, A.C. (author), van der Goes, A. (author), Koevoets, C. (author), Newcombe, J. (author), Cuzner, M.L. (author), van Noort, J.M. (author)
In the development of multiple sclerosis (MS), (re)activation of infiltrating T cells by myelin-derived Ags is considered to be a crucial step. Previously, αB-crystallin has been shown to be an important myelin Ag to human T cells. Since αB-crystallin is an intracellular heat shock protein, the question arises at what stage, if any, during...
article 2000
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van Noort, J.M. (author), Bajramovic, J.J. (author), Plomp, A.C. (author), van Stipdonk, M.J.B. (author)
Several findings indicate that infectious events play a role in the pathogenesis of multiple sclerosis (MS). At the same time, T-cell autoimmunity to myelin antigens is widely believed to be crucial to the development of MS lesions. Several mechanisms have been put forward to explain the presumed link between microbial infections and myelin...
article 2000
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Bajramović, J.J. (author), Bsibsi, M. (author), Geutskens, S.B. (author), Hassankhan, R. (author), Verhulst, K.C. (author), Stege, G.J.J. (author), de Groot, C.J.A. (author), van Noort, J.M. (author), TNO Preventie en Gezondheid (author)
Various lines of evidence suggest a close relationship between heat shock proteins (hsp) and several autoimmune diseases such as arthritis, diabetes and multiple sclerosis. While enhanced expression of hsp in autoimmune diseases is often regarded as a non-specific bystander effect of the inflammatory process, surprisingly little is known on hsp...
article 2000
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van Stipdonk, M.J.B. (author), Willems, A.A. (author), Plomp, A.C. (author), van Noort, J.M. (author), Boog, C.J.P. (author), TNO Preventie en Gezondheid (author)
The myelin-associated protein, αB-crystallin, is considered a candidate autoantigen in multiple sclerosis (MS). In the present study, we examined the potential of αB-crystallin to induce experimental autoimmune encephalomyelitis (EAE) in Lewis rats. Attempts to induce EAE with either bovine, rat or murine αB-crystallin or αB-crystallin peptides...
article 2000
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Lopatinskaya, L. (author), Boxel van-Dezaire, A.H.H. (author), Barkhof, F. (author), Polman, C.H. (author), Lucas, C.J. (author), Nagelkerken, L. (author)
In this longitudinal study, we examined the expression of Fas, FasL, CCR3, CCR5 and CXCR3 mRNA in peripheral blood mononuclear cells (PBMCs) of secondary progressive (SP) and relapsing-remitting (RR) multiple sclerosis (MS) patients. In RR patients, FasL, CCR3 and CCR5 mRNA levels were increased prior to the exacerbations, but these decreased...
article 2003
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Andries, F. (author), Kremer, A.M. (author), Hoogendoorn, W.E. (author), Wevers, C.W.J. (author), van Putten, D.J. (author)
The Work and Handicap Questionnaire (WHQ) was developed to improve the vocational perspectives of patients with a chronic disorder. The WHQ differs from similar instruments in its explicit linkage between disabilities in daily life and job demands. This is an important feature, which allows for the development of specific strategies to counter...
article 2004
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Rieckmann, P. (author), Kruse, N. (author), Nagelkerken, L. (author), Beckmann, K. (author), Miller, D. (author), Polman, C. (author), Dahlke, F. (author), Toyka, K.V. (author), Hartung, H.P. (author), Stürzebecher, S. (author), TNO Preventie en Gezondheid (author)
Background: Subcutaneous IFNβ-1b (Betaferon®) is an established immunomodulatory treatment for relapsing remitting MS and active secondary progressive multiple sclerosis (SPMS). It modulates cytokine and adhesion molecule expression but long term in vivo effects of IFNβ-1b on the immune system are not known in multiple sclerosis. Objective: To...
article 2005
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Wang, C. (author), Chou, Y.K. (author), Rich, C.M. (author), Link, J.M. (author), Afentoulis, M.E. (author), van Noort, J.M. (author), Wawrousek, E.F. (author), Offner, H. (author), van den Bark, A.A. (author), TNO Kwaliteit van Leven (author)
Alpha B-crystallin (αB) is a small heat shock protein that is strongly up-regulated in multiple sclerosis (MS) brain tissue, and can induce strong T cell responses. Assessing a potential encephalitogenic function for αB protein in MS and experimental autoimmune encephalomyelitis (EAE) has been challenging due to its ubiquitous expression that...
article 2006
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Fabriek, B.O. (author), Møller, H.J. (author), Vloet, R.P.M. (author), van Winsen, L.M. (author), Hanemaaijer, R. (author), Teunissen, C.E. (author), Uitdehaag, B.M.J. (author), van den Berg, T.K. (author), Dijkstra, C.D. (author), TNO Kwaliteit van Leven (author)
The scavenger receptor CD163 is selectively expressed on tissue macrophages and human monocytes. CD163 has been implicated to play a role in the clearance of hemoglobin and in the regulation of cytokine production by macrophages. Membrane CD163 can be cleaved by matrix metalloproteinases (MMP) resulting in soluble CD163 (sCD163). In the present...
article 2007
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