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Smits, R.C.F. (author), Emmen, H.H. (author), Bertelmans, F.W. (author), Kulig, B.M. (author), van Loenen, A.C. (author), Polman, C.H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
4-Aminopyridine (4-AP) has a favorable effect on the disability of certain patients with MS. We investigated the effect of 4-AP on neuropsychological performance in 20 MS patients using a randomized, double-blind, placebo- controlled, crossover design. Although there was a trend for improved performance with 4-AP for two of the tests, we could...
article 1994
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van Noort, J.M. (author), van Sechel, A.C. (author), Bajramovic, J.J. (author), El Quagmiri, M. (author), Polman, C.H. (author), Lassmann, H. (author), Ravid, R. (author), TNO Preventie en Gezondheid (author)
The identification of key antigens in human autoimmune diseases is a crucial step towards the development of specific intervention. The autoantigen(s) relevant to multiple sclerosis (MS) probably reside in myelin of the central nervous system, the target of the disease. Here we examine proliferative responses of human peripheral blood T cells to...
article 1995
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van Noort, J.M. (author), TNO Preventie en Gezondheid (author)
The pathogenesis of multiple sclerosis (MS), the major neurological disease of young adults in the Western world, is still poorly understood, and no effective therapy to block MS is available as yet. The clinical symptoms of MS result from inflammatory damage to the insulating myelin sheath of axons in the CNS and - at later stages - to axons...
article 1996
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Gaubius Instituut TNO (author), Gerritse, K. (author), Laman, J.D. (author), Noelle, R.J. (author), Aruffo, A. (author), Ledbetter, J.A. (author), Boersma, W.J.A. (author), Claassen, E. (author)
We investigated the role of CD40-CD40 ligand (CD40L) interactions in multiple sclerosis (MS) and experimental allergic encephalomyelitis (EAE). Activated helper T cells expressing CD40L (gp39) surface protein were found in MS patient brain sections, but not in brain tissue sections of normal controls or patients with other neurological diseases....
article 1996
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Amor, S. (author), Baker, D. (author), Layward, L. (author), McCormack, K. (author), van Noort, J.M. (author), TNO Preventie en Gezondheid (author)
Correlation of the heterogeneic immunopathological profiles of multiple sclerosis (MS) lesions with the paraclinical and clinical markers of disease may be important in the development of therapeutic approaches in MS. This and other issues were discussed at a recent meeting.
article 1997
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Bajramović, J.J. (author), Lassmann, H. (author), van Noort, J.M. (author), TNO Preventie en Gezondheid (author)
The small heat shock protein αB-crystallin was recently identified as a dominant human T-cell antigen in myelin derived from multiple sclerosis (MS) patients. Using immunohistochemical techniques, oligodendrocytes as well as astrocytes in MS lesions were shown to express α B-crystallin. In the present study we examined the expression of α B...
article 1997
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Laman, J.D. (author), de Boer, M. (author), 't Hart, B.A. (author), TNO Preventie en Gezondheid (author)
The interactions of CD40 and CD40L have been known for some time to critically regulate B-cell responses with respect to proliferation, isotype switching, antibody production, and memory formation. More recent findings demonstrated that CD40 can be expressed on several other antigen-presenting cell (APC) types such as macrophages, dendritic...
article 1998
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Laman, J.D. (author), Thompson, E.J. (author), Kappos, L. (author), TNO Preventie en Gezondheid (author)
The need for reliable markers of disease activity in multiple sclerosis (MS) to better guide basic research, diagnosis, treatment, and monitoring of therapy is well-recognized. A recent European Charcot Foundation Symposium (Body fluid markers for course and activity of disease in multiple sclerosis (Madrid, Spain, October 2-4, 1997) organized...
article 1998
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van Noort, J.M. (author), TNO Preventie en Gezondheid (author)
Multiple sclerosis is the major neurological disease of young adults in the western world, affecting about 1 per 1,000. It is characterised by chronic or recurrent lesions of inflammatory damage in the white matter of the central nervous system. Within such lesions, the protective myelin sheath is stripped off axons by infiltrated macrophages...
article 1998
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Laman, J.D. (author), Thompson, E.J. (author), Kappos, L. (author), TNO Preventie en Gezondheid (author)
article 1998
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Laman, J.D. (author), van Meurs, M. (author), Schellekens, M.M. (author), de Boer, M. (author), Melchers, B. (author), Massacesi, L. (author), Lassmann, H. (author), Claassen, E. (author), 't Hart, B.A. (author), TNO Preventie en Gezondheid (author)
Accessory molecules and cytokines are involved in the immunopathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) in rodent models, and are potential targets for immunotherapy. Evaluation of such experimental therapies requires appropriate animal models. Therefore, we analysed the expression of selected...
article 1998
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TNO Preventie en Gezondheid (author), Nagelkerken, L. (author)
Evidence is accumulating that Th1 cells play an important role in the development of multiple sclerosis (MS) and experimental allergic encephalomyelitis (EAE), whereas Th2 cells contribute to recovery from disease. A maj or determinant in the development of Th1 and Th2 cells is the type of antigen-presenting cell (APC) involved and its...
article 1998
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van Boxel-Dezaire, A.H.H. (author), Hoff, S.C.J. (author), van Oosten, B.W. (author), Verweij, C.L. (author), Dräger, A.M. (author), Adèr, H.J. (author), van Houwelingen, J.C. (author), Barkhof, F. (author), Polman, C.H. (author), Nagelkerken, L. (author), TNO Preventie en Gezondheid (author)
It has been shown that proinflammatory and antiinflammatory cytokines correlate with disease activity in multiple sclerosis (MS). To establish whether such correlations depend on the disease stage, we assessed in a longitudinal fashion the expression of interleukin (IL)-12 (p40 and p35), tumor necrosis factor- 1/4 , interferon-γ, and IL-10 mRNA...
article 1999
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Maassen, C.B.M. (author), Laman, J.D. (author), Heijne den Bak-Glashouwer, M.J. (author), Tielen, F.J. (author), van Holten-Neelen, J.C.P.A. (author), Hoogteijling, L. (author), Antonissen, C. (author), Leer, R.J. (author), Pouwels, P.H. (author), Boersma, W.J.A. (author), Shaw, D.M. (author)
Lactobacillus strains possess properties that make them attractive candidates as vehicles for oral administration of therapeutics. In this report we describe the construction and analysis of recombinant Lactobacillus casei applicable in oral vaccination against an infectious disease (tetanus) and in oral tolerance induction for intervention in...
article 1999
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Feltkamp, T.E.W. (author), Aarden, L.A. (author), Lucas, C.J. (author), Verweij, C.L. (author), de Vries, R.R.P. (author), TNO Preventie en Gezondheid (author)
In most autoimmune diseases multigenic factors play a significant role in pathogenesis. Progress in identifying these genetic factors, many of which are located outside the major histocompatibility complex, was the subject of a recent meeting. Chemicals/CAS: Interleukin-10, 130068-27-8; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha
article 1999
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TNO Preventie en Gezondheid (author), Howard, L.M. (author), Miga, A.J. (author), Vanderlugt, C.L. (author), Dal Canto, M.C. (author), Laman, J.D. (author), Noelle, R.J. (author), Miller, S.D. (author)
Relapsing experimental autoimmune encephalomyelitis (R-EAE) in the SJL mouse is a Th1-mediated autoimmune demyelinating disease model for human multiple sclerosis and is characterized by infiltration of the central nervous system (CNS) by Th1 cells and macrophages. Disease relapses are mediated by T cells specific for endogenous myelin epitopes...
article 1999
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TNO Preventie en Gezondheid (author), van Sechel, A.C. (author), Bajramovic̀, J.J. (author), van Stipdonk, M.J.B. (author), Persoon-Deen, C. (author), Geutskens, S.B. (author), van Noort, J.M. (author)
The development of multiple sclerosis is most likely influenced by autoimmune responses to central nervous system myelin proteins as well as by infections with common viruses such as EBV and human herpesvirus-6. However, much remains to be established on how these factors interact. In this study, we show that upon EBV infection, human B cells...
article 1999
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Çelet, B. (author), Akman-Demir, G. (author), Serdaroǧlu, P. (author), Yentür, S.P. (author), Taşci, B. (author), van Noort, J.M. (author), Eraksoy, M. (author), Saruhan-Direskeneli, G. (author), TNO Preventie en Gezondheid (author)
αB-Crystallin, a small heat shock protein, is an immuno-dominant antigen with increased tissue expression in demyelination. To investigate the humoral response against αB-crystallin, the sera and CSF samples of patients with multiple sclerosis (MS), Guillain-Barré syndrome (GBS), neuro-Behçet's disease (NBD) and other non-inflammatory...
article 2000
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Bajramović, J.J. (author), Plomp, A.C. (author), van der Goes, A. (author), Koevoets, C. (author), Newcombe, J. (author), Cuzner, M.L. (author), van Noort, J.M. (author)
In the development of multiple sclerosis (MS), (re)activation of infiltrating T cells by myelin-derived Ags is considered to be a crucial step. Previously, αB-crystallin has been shown to be an important myelin Ag to human T cells. Since αB-crystallin is an intracellular heat shock protein, the question arises at what stage, if any, during...
article 2000
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van Noort, J.M. (author), Bajramovic, J.J. (author), Plomp, A.C. (author), van Stipdonk, M.J.B. (author)
Several findings indicate that infectious events play a role in the pathogenesis of multiple sclerosis (MS). At the same time, T-cell autoimmunity to myelin antigens is widely believed to be crucial to the development of MS lesions. Several mechanisms have been put forward to explain the presumed link between microbial infections and myelin...
article 2000
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