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Bobeldijk, I. (author), van Dijken, p. (author), van Drumpt, S. (author), van de Sandt, H. (author), Vaes, W. (author)
Our growing understanding of pathological processes is enabling the development of drugs that are ‘tailored’ to specific patients or groups of patients, and hence far more effective. At the same time, developing tomorrow’s medicine is prohibitively expensive, time-consuming and risky. New partnerships and technological developments to speed up...
other 2020
document
Stegehuis, P.L. (author), Boogerd, L.S.F. (author), Inderson, A. (author), Veenendaal, R.A. (author), Bonsing, B.A. (author), Amelink, A. (author), Vahrmeijer, A.L. (author), Dijkstra, J. (author), Robinson, D.J. (author)
EUS-FNA can be used for pathological confirmation of a suspicious pancreatic mass. However, performance depends on an on-site cytologist and time between punction and final pathology results can be long. SFR spectroscopy is capable of extracting biologically relevant parameters (e.g. oxygenation and blood volume) in real-time from a very small...
conference paper 2016
document
Hague Centre for Strategic Studies Nederlandse Organisatie voor Toegepast-Natuurwetenschappelijk Onderzoek (author)
Over the past five years, the pharmaceutical supply chain has grown increasingly unreliable. According to the US Food and Drug Administration (FDA), the figure of drug shortages has tripled between 2006 and 2010 (see Figure 1 and Figure 21). In 2010 alone 211 cases were recorded, while in 2011 up to 89 cases were recorded as early as March.2...
report 2012
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Groenewoud, C.L. (author), Schoen, E.D. (author), Malone, K.M. (author), Jonkers, E. (author), Hoedemaeker, D.M. (author), Hogema, J.H. (author)
Naturalistic driving observation is a relatively new method for studying road safety issues, a method by which one can objectively observe various driver- and accident related behaviour. Typically, participants get their own vehicles equipped with some sort of data logging device that can record various driving behaviours such as speed, braking,...
report 2010
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TNO Defensie en Veiligheid (author), Hoyt, R.W. (author), Buller, M.J. (author), Gunga, H. (author), Werner, A. (author), Sattler, F. (author), Koch, J. (author), Nevola, V.R. (author), Ledderhos, C. (author), Valk, P. (author)
Dismounted warfighting groups are increasingly recognizing the benefits of knowing the medical status information that body-worn computerized physiological sensor systems can provide. This report on real-time physiological and psycho-physiological status monitoring reviews: a) Physiological monitoring system architectures, methods for managing...
report 2010
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Wang, J. (author), van der Heijden, R. (author), Spijksma, G. (author), Reijmers, T. (author), Wang, M. (author), Xu, G. (author), Hankemeier, T. (author), van der Greef, J. (author), TNO Kwaliteit van Leven (author)
A matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS) method was developed for the high throughput and robust qualitative profiling of alkaloids in Fuzi-the processed lateral roots of the Chinese herbal medicine Aconitum carmichaeli Debx (A. carmichaeli). After optimization, powdered roots - without any further sample...
article 2009
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TNO Kwaliteit van Leven (author), Binnendijk, D. (author)
article 2008
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van der Greef, J. (author), Martin, S. (author), Juhasz, P. (author), Adourian, A. (author), Plasterer, T. (author), Verheij, E.R. (author), McBurney, R.N. (author), TNO Kwaliteit van Leven (author)
Systems biology has developed in recent years from a technology-driven enterprise to a new strategic tool in Life Sciences, particularly for innovative drug discovery and drug development. Combining the ultimate in systems phenotyping with in-depth investigations of biomolecular mechanisms will enable a revolution in our understanding of disease...
article 2007
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TNO Defensie en Veiligheid (author), Simons, M. (author)
Onbehandelde luchtwegobstructie leidt in enkele minuten tot de dood en daarom is adequaat pre-hospitaal luchtwegmanagement noodzakelijk bij ernstig gewonde combat slachtoffers. In de civiele of militaire ziekenhuiswereld is endotracheale intubatie (ETI) in handen van ervaren personeel de 'goud standaard' voor controle over de luchtweg. In de pre...
article 2007
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van der Greef, J. (author), TNO Kwaliteit van Leven (author)
The concept of systems-based strategies in medicine is emerging, with systems pathology guiding an understanding of the multidimensional aspects of disease system fingerprints and systems pharmacology providing insight into dynamic system responses upon (multiple) drug perturbations. Knowledge of the changes of system characteristics during...
article 2005
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Centraal Instituut voor Voedingsonderzoek TNO (author), Wijnands, M.V.W. (author)
doctoral thesis 2003
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Jonker, D. (author)
doctoral thesis 2003
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Centraal Instituut voor Voedingsonderzoek TNO (author), Sierksma, A. (author)
doctoral thesis 2003
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Smit, E. (author)
doctoral thesis 2002
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Centraal Instituut voor Voedingsonderzoek TNO (author), Jansen, M.C.J.F. (author)
doctoral thesis 2001
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Centraal Instituut voor Voedingsonderzoek TNO (author), Krul, C.A.M. (author)
doctoral thesis 2001
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Centraal Instituut voor Voedingsonderzoek TNO (author), Vermunt, S.H.F. (author)
doctoral thesis 2001
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Centraal Instituut voor Voedingsonderzoek TNO (author), Arts, J.H.E. (author)
doctoral thesis 2001
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Boelsma, E. (author), Anderson, C. (author), Karlsson, A.M.J. (author), Ponec, M. (author)
article 2000
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Rodenburg, R.J.T. (author), Ganga, A. (author), van Lent, P.L.E.M. (author), van de Putte, L.B.A. (author), van Venrooij, W.J. (author)
Objective. Sulfasalazine (SSZ) is a commonly used drug in the treatment of inflammatory diseases such as rheumatoid arthritis and Crohn's disease. In both diseases, the proinflammatory cytokine tumor necrosis factor α (TNFα) plays a prominent role. In these studies, we investigated the mechanism by which SSZ inhibits TNFα expression in...
article 2000
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