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Hollander, C.F. (author), Instituut voor experimentele gerontologie TNO (author), GO RBI IVEG (author)
Cartilaginous tissue in the heart of rat has been described in literature by some as an ageing phenomenon, while others have observed it in young animals. Hearts of rats of different ages were studied for the occurence and localization of cartilaginous tissue. A cartilaginous focus has been regularly found in rats as young as 1 week old. This...
article 1968
document
Centraal Instituut voor Voedingsonderzoek TNO (author), Janbroers, J.M. (author), Sanders, J.C. (author), Til, H.P. (author), Feron, V.J. (author), de Groot, A.P. (author)
Studies in rats on iocetamic acid show that the LD50 levels of this compound compare favorably with those of a number of other oral cholecystographic agents. Pathologic effects are not found in rats and cats in studies of the subacute toxicity. Incompatibility with an anesthetic or a tranquilizer is not found. The elimination pattern of...
article 1969
document
Centraal Instituut voor Voedingsonderzoek TNO (author), Janbroers, J.M. (author), Sanders, J.C. (author), Til, H.P. (author), Feron, V.J. (author), de Groot, A.P., (author)
A new oral cholecystographic medium called iocetamicacid was submitted to a toxicologic study in rats and dogs. Dosages, which were equivalent to 200 and 1000 mg of the compound per kilogram of body weight per day and were 5 times and 25 times the human routine dose, were administered daily for 3 weeks in order to establish whether the substance...
article 1969
document
van Putten, L.M. (author), Lelieveld, P. (author), Radiobiologisch Instituut TNO (author)
The sensitivity of resting spleen colony-forming cells in normal mouse bone marrow and of rapidly-proliferating spleen colony-forming cells in repopulating mouse spleen to a number of bis-chloro-aethyl-amines was determined. The rapidly-growing cells were more sensitive to each of the agents than the resting cells. The equal degree of...
article 1971
document
van den Berg, K.J. (author), Betel, I. (author), Radiobiologisch Instituut TNO (author)
Chemicals/CAS: 2 amino 2 methylpropionic acid, 62-57-7; carbon, 7440-44-0; thymidine, 50-89-5; tritium, 10028-17-8; Aminoisobutyric Acids; Carbon Isotopes; Lectins; Thymidine, 50-89-5; Tritium, 10028-17-8
article 1971
document
Ormai, S. (author), Hagenbeek, A. (author), Palkovits, M. (author), van Bekkum, D.W. (author), Radiobiologisch Instituut TNO (author)
The changes in lymphocyte kinetics induced by the lymphocyte mobilizing agent polymethacrylic acid (PMAA) were studied in the normal rat. Quantitative data are presented concerning the degree of lymphocyte mobilization in the spleen and in various lymph nodes at different times after PMAA administration. Data were also obtained regarding the...
article 1973
document
Boorman, G.A. (author), Zurcher, C. (author), Hollander, C.F. (author), Feron, V.J. (author), Centraal instituut voor voedingsonderzoek Instituut voor experimentele gerontologie TNO Radiobiologisch Instituut (author)
article 1973
document
Germans, F.H. (author), Koster, M.W. (author), Kwee, H.H. (author), Groep Motoriek Revalidatie, Medisch Fysisch Instituut TNO Instituut voor gezondheidstechniek TNO (author)
The merits of the 'vacuum form fixation' are discussed for the production of reliable body impressions of patients suffering from sitting problems. Impressions are taken with the patients seated in the desired posture. The first results are reported, obtained from 4 patients of different categories, fitted with individually moulded seats...
article 1974
document
van Beek, L. (author), Feron, V.J. (author), de Groot, A.P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Alkali treated spun soy isolate was fed to rats at dietary levels of 5, 10, and 20% for a period of 90 days. The results failed to reveal any adverse effects on general appearance, growth, feeding efficiency, hematological indices, blood serum values, urine composition, kidney function, organ weights, and gross and microscopic pathology except...
article 1974
document
Radiobiologisch Instituut TNO (author), Sindram, P.J. (author), Snow, G.B. (author), van Putten, L.M. (author)
Chemicals/CAS: folinate calcium, 1492-18-8, 51057-63-7; folinic acid, 58-05-9, 68538-85-2; methotrexate, 15475-56-6, 59-05-2, 7413-34-5; Leucovorin, 58-05-9; Methotrexate, 59-05-2
article 1974
document
van Putten, L.M. (author), Kram, L.K.J. (author), van Dierendonck, H.H.C. (author), Radiobiologisch Instituut TNO (author)
In studies on a model of induced pulmonary metastasis in mice a tumour host system was analysed which was not affected by immunogenicity of the tumour for the host; neither intensive immunosuppression nor immunization caused a significant change in the quantity of pulmonary metastatic nodules. In contrast the application of cytostatic drugs and...
article 1975
document
Wolthuis, O.L. (author), Clason-van der Wiel, H.J. (author), Visser, R.P.L.S. (author), Medisch Biologisch Laboratorium TNO Chemisch Laboratorium TNO (author)
Atropinised anaesthetised rats were injected i.v. with 4, 6 or 8 x LD50 of the organophosphorous anticholinesterase soman. Subsequent treatment with one dose of HS 6 (100 mg/kg, i.v.) delayed respiratory failure by 1 h or more; a further postponement was obtained when an additional HS 6 infusion was given. At the same infusion rate, HS 6 blood...
article 1976
document
Nickolson, V.J. (author), Wolthuis, O.L. (author), Medisch Biologisch Laboratorium TNO (author)
The effects of Piracetam, Naftidrofuryl and methamphetamine on several parameters of cerebral energy metabolism have been studied. At variance with some reports in the literature neither Piracetam nor Naftidrofuryl affected the cerebral contents of adenine nucleotides and, accordingly, both substances were without effect on the adenylate energy...
article 1976
document
de Groot, A.P. (author), Slump, P. (author), Feron, V.J. (author), van Beek, L. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
To find out whether alkali treated proteins possess nephrotoxic properties, feeding studies were conducted with drastically treated soybean protein and casein, and also with lysinoalanine (LAL), the amino acid known to be formed in proteins subjected to high pH at an elevated temperature. The feeding of synthesized LAL to rats at dietary levels...
article 1976
document
Nickolson, V.J. (author), Wolthuis, O.L. (author), Medisch Biologisch Laboratorium TNO (author)
The effect of Piracetam on rat cerebral protein metabolism in vivo and in vitro was studied. It was found that the drug stimulates the uptake of labelled leucine by cerebral cortex slices, has no effect on the incorporation of leucine into cerebral protein, neither in slices nor in vivo, but inhibits the breakdown of newly formed protein in...
article 1976
document
Vos, O. (author), Grant, G.A. (author), Budke, L. (author), Medisch Biologisch Laboratorium RVO-TNO (author)
The effect of diamide on the radiosensitivity of T cells was investigated under oxic and anoxic conditions. The compound was found to sensitize the cells under both conditions. Under oxic conditions, exposure for 10 min before and during irradiation to 0.1, 0.5 and 1.0 mM diamide produced dose modifying factors of 0.81, 0.60 and 0.55,...
article 1976
document
Wolthuis, O.L. (author), de Wied, D. (author), Medisch Biologisch Laboratorium TNO Chemisch Laboratorium TNO (author)
Averaged visual evoked responses (VER) in cortical area 17 were recorded one hour after the administration of 7-l-phe ACTH(4-10) or 7-d-phe ACTH(4-10) to artificially ventilated rats, paralysed with gallamine. In addition, the effects of these peptides on spontaneous motor behavior were analyzed. The results show that the latencies of all VER...
article 1976
document
Kruysse, A. (author), Feron, V.J. (author), Immel, H.R. (author), Centraal instituut voor voedingsonderzoek TNO (author)
The inhalation toxicity of peroxyacetyl nitrate (PAN) was examined in acute (single exposure), subacute (4-wk repeated exposure) and subchronic (13-wk repeated exposure) studies in rats. The 4-hr LC50 was found to be 95 ppm. In the 4-wk study rats were exposed to 0, 0.9, 4.1 or 11.8 ppm PAN vapor for 6 hr/day, 5 days/wk. Exposure to 11.8 ppm...
article 1977
document
van Velsen, F.L. (author), Nickolson, V.J. (author), Medisch Biologisch Laboratorium TNO Medisch Fysisch Instituut TNO (author)
The effects of the myotonic agent, 9-anthroic acid (ANCA), and the acetylcholinesterase (AChE) inhibitor, soman, on the isolated phrenic nerve-diaphragm preparation of the rat were studied. ANCA induced after-contractions which followed the twitches evoked by either direct or indirect stimulation. In the intermittently stimulated muscle the...
article 1977
document
Jonkman, E.J. (author), Mosmans, P.C.M. (author)
other 1977
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