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Majchrzykiewicz-Koehorst, J.A. (author), Heikens, E. (author), Trip, H. (author), Hulst, A.G. (author), de Jong, A.L. (author), Viveen, M.C. (author), Sedee, N.J.A. (author), van der Plas, J. (author), Coenjaerts, F.E.J. (author), Paauw, A. (author)
The rapid identification of existing and emerging respiratory viruses is crucial in combating outbreaks and epidemics. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a rapid and reliable identification method in bacterial diagnostics, but has not been used in virological diagnostics. Mass...
article 2015
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Coenen, P. (author), Kingma, I. (author), Boot, C.R.L. (author), Bongers, P.M. (author), van Dieën, J.H. (author)
The trade-off between feasibility and accuracy of measurements of physical exposure at the workplace has often been discussed, but is unsufficiently understood. We therefore explored the effect of two low-back loading measurement tools with different accuracies on exposure estimates and their associations with low-back pain (LBP). Low-back...
article 2015
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van Lint, C.L. (author), van der Boog, P.J.M. (author), Romijn, F.P.H.T.M. (author), Schenk, P.W. (author), van Dijk, S. (author), Rövekamp, T.J.M. (author), Kessler, A. (author), Siekmann, L. (author), Rabelink, T.J. (author), Cobbaert, C.M. (author)
Background: The StatSensor® Xpress-i™, a point-of-care system for blood creatinine measurement, offers patients the possibility of self-monitoring creatinine. In this study, the analytical performance of the StatSensor® for both detecting current renal function and monitoring renal (dys)function in kidney transplant patients was examined....
article 2015
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Majchrzykiewicz-Koehorst, J.A. (author), Heikens, E. (author), Trip, H. (author), Hulst, A.G. (author), de Jong, A.L. (author), Viveen, M.C. (author), Sedee, N.J.A. (author), van der Plas, J. (author), Coenjaerts, F.E.J. (author), Paauw, A. (author)
Tested respiratory viruses: influenza A virus, respiratory syncytial virus (RSV) and human metapneumovirus (hMPV), were successfully identified directly from crude cell cultures using liquid chromatography-tandem MS (LC-MS/MS). The identification was preceded with the simple, generic and fast sample preparation method. The determined...
conference paper 2014
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Fieten, K.B. (author), Zijlstra, W.T. (author), van Os-Medendorp, H. (author), Meijer, Y. (author), Venema, M.U. (author), Rijssenbeek-Nouwens, L. (author), l' Hoir, M.P. (author), Bruijnzeel-Koomen, C.A. (author), Pasmans, S.G.M.A. (author)
Background: About 10 to 20% of children in West European countries have atopic dermatitis (AD), often as part of the atopic syndrome. The full atopic syndrome also consists of allergic asthma, allergic rhinitis and food allergy. Treatment approaches for atopic dermatitis and asthma include intermittent anti-inflammatory therapy with...
article 2014
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Perez, J. (author), de Looze, M.P. (author), Bosch, T. (author), Neumann, W.P. (author)
This methodological paper presents a novel approach to predict operator's mechanical exposure and fatigue accumulation in discrete event simulations. A biomechanical model of work-cycle loading is combined with a discrete event simulation model which provides work cycle patterns over the shift resulting in a load-time trace for the entire shift....
article 2014
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TNO Kwaliteit van Leven (author), Molag, M.L. (author), de Vries, J.H.M. (author), Duif, N. (author), Ocké, M.C. (author), Dagnelie, P.C. (author), Goldbohm, R.A. (author), van 't Veer, P. (author)
The authors automated the selection of foods in a computer system that compiles and processes tailored FFQ. For the selection of food items, several methods are available. The aim of the present study was to compare food lists made by MOM2, which identifies food items with highest between-person variance in intake of the nutrients of interest...
article 2010
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de Kraker, H. (author), de Korte, E. (author), van Mil, F. (author), Rijs, B. (author), Bongers, P. (author), TNO Kwaliteit van Leven (author)
The aim of this study was to determine the effect of a tactile feedback signal on hovering behaviour, productivity, usability and comfort after 1 week of using an experimental mouse. In a randomized controlled trial, a regular computer mouse was compared to a new developed mouse with a tactile, vibrating feedback signal to prevent unnecessary...
article 2008
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TNO Kwaliteit van Leven (author), Prenafeta-Boldú, F.X. (author), Illa, J. (author), van Groenestijn, J.W. (author), Flotats, X. (author)
The biodegradation of toluene was studied in two lab-scale air biofilters operated in parallel, packed respectively with perlite granules (PEG) and polyurethane foam cubes (PUC) and inoculated with the same toluene-degrading fungus. Differences on the material pore size, from micrometres in PEG to millimetres in PUC, were responsible for...
article 2008
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van Rhenen, W. (author), Blonk, R.W.B. (author), Schaufeli, W.B. (author), van Dijk, F.J.H. (author), TNO Kwaliteit van Leven (author)
Objectives: The aim of the study was to evaluate the effectiveness of two brief preventive stress reduction programs - a cognitive focused program and a combined intervention of physical exercise and relaxation - on sickness absence in stressed and non-stressed employees working in various jobs in a telecom company. Methods: The study was...
article 2007
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Blonk, R.W.B. (author), Brenninkmeijer, V. (author), Lagerveld, S.E. (author), Houtman, I.L.D. (author), TNO Kwaliteit van Leven (author), KvL (author)
We investigated the effectiveness of cognitive behavioural therapy (CBT) and a combined intervention of workplace- and individual-focused techniques among self-employed people on sick leave owing to work-related psychological complaints (such as anxiety, depression, and burnout). Both interventions were based on CBT; however, one was conducted...
article 2006
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Jansen, J.J. (author), Hoefsloot, H.C.J. (author), van der Greef, J. (author), Timmerman, M.E. (author), Smilde, A.K. (author), TNO Kwaliteit van Leven (author)
Genomics-based technologies in systems biology have gained a lot of popularity in recent years. These technologies generate large amounts of data. To obtain information from this data, multivariate data analysis methods are required. Many of the datasets generated in genomics are multilevel datasets, in which the variation occurs on different...
article 2005
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Guimarães, A.H.C. (author), van Tilburg, N.H. (author), Vos, H.L. (author), Bertina, R.M. (author), Rijken, D.C. (author)
Thrombin activatable fibrinolysis inhibitor (TAFI) antigen levels exhibit a large interindividual variability in which genetic control seems to play a major role. However, recent reports have questioned the association between TAFI concentration and genotype, suggesting that variable antibody reactivity towards TAFI isoforms, particularly the...
article 2004
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Twisk, J. (author), Proper, K. (author)
The most common way to evaluate the effect of an intervention is to compare the intervention and non-intervention groups regarding the change in the outcome variable between baseline and follow-up; however, there are many different ways to define "changes". The purpose of this article is to demonstrate how different definitions of "change" used...
article 2004
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Rennen, M.A.J. (author), Bouwman, T. (author), Wilschut, A. (author), Bessems, J.G.M. (author), de Heer, C. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)
Due to a lack of route-specific toxicity data, the health risks resulting from occupational exposure are frequently assessed by route-to-route (RtR) extrapolation based on oral toxicity data. Insight into the conditions for and the uncertainties connected with the application of RtR extrapolation has not been clearly described in a systematic...
article 2004
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Hoogendoorn, W.E. (author), Bongers, P.M. (author), de Vet, H.C.W. (author), Twisk, J.W.R. (author), van Mechelen, W. (author), Bouter, L.M. (author), TNO Arbeid (author)
Aims: To compare the results of a traditional approach using standard regression for the analysis of data from a prospective cohort study with the results of generalised estimating equations (GEE) analysis. Methods: The research was part of a three year prospective cohort study on work related risk factors for low back pain. The study population...
article 2002
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Kemme, M.J.B. (author), Faaij, R.A. (author), Schoemaker, R.C. (author), Kluft, C. (author), Meijer, P. (author), Cohen, A.F. (author), Burggraaf, J. (author), Gaubius Instituut TNO (author)
During studies on warfarin, heparin and various anticoagulants with novel mechanisms of action, the activated partial thromboplastin time (aPTT) and the (apparent) international normalized ratio (INR) from a bedside monitor (Coagucheck Plus®) were compared with laboratory assay results. Data were compared using the Bland and Altman method of...
article 2001
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Hildebrandt, V.H. (author), Proper, K.I. (author), van den Berg, R. (author), Douwes, M. (author), van den Heuvel, S.G. (author), van Buuren, S. (author), TNO Preventie en Gezondheid (author)
Objective. To determine the effectiveness of a special form of exercise therapy ('Cesar therapy') on self reported recovery and improvement of posture amongst patients with chronic aspecific lower back pain. Design. Prospective randomized controlled and blinded investigation. Method. After informed consent had been obtained, patients with...
article 2000
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de Boer, P. (author), Duim, B. (author), Rigter, A. (author), van der Plas, J. (author), Jacobs-Reitsma, W.F. (author), Wagenaar, J.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
For epidemiological tracing of the thermotolerant Campylobacter species C. jejuni and C. coli, reliable and highly discriminatory typing techniques are necessary. In this study the genotyping techniques of flagellin typing (flaA typing), pulsed-field gel electrophoresis (PFGE), automated ribotyping, and amplified fragment length polymorphism ...
article 2000
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TNO Biomedical Instrumentation (author), van Popele, N.M. (author), Bos, W.J.W. (author), de Beer, N.A.M. (author), van der Kuip, D.A.M. (author), Hofman, A. (author), Grobbee, D.E. (author), Witteman, J.C.M. (author)
Oscillometric blood pressure devices tend to overestimate systolic blood pressure and underestimate diastolic blood pressure compared with sphygmomanometers. Recent studies indicate that discrepancies in performance between these devices may differ between healthy and diabetic subjects. Arterial stiffness in diabetics could be the underlying...
article 2000
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