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Tielman, M.L. (author), Neerincx, M.A. (author), van Meggelen, M. (author), Franken, I. (author), Brinkman, W.P. (author)
BACKGROUND AND OBJECTIVE: With the rise of autonomous e-mental health applications, virtual agents can play a major role in improving trustworthiness, therapy outcome and adherence. In these applications, it is important that patients adhere in the sense that they perform the tasks, but also that they adhere to the specific recommendations on...
article 2017
document
Damsten, M.C. (author), Commandeur, J.N.M. (author), Fidder, A. (author), Hulst, A.G. (author), Touw, D. (author), Noort, D. (author), Vermeulen, N.P.E. (author), TNO Defensie en Veiligheid (author)
Covalent binding of reactive electrophilic intermediates to proteins is considered to play an important role in the processes leading to adverse drug reactions and idiosyncratic drug reactions. Consequently, both for the discovery and the development of new drugs, there is a great interest in sensitive methodologies that enable the detection of...
article 2007
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Meijer, C. (author), Timmer, A. (author), de Vries, E.G.E. (author), Groten, J.P. (author), Knol, A. (author), Zwart, N. (author), Dam, W.A. (author), Sleijfer, D.Th. (author), Mulder, N.H. (author)
Cisplatin (CDDP) is an extremely active drug in the treatment of germ- cell tumours. Earlier, we found an unexpected inverse correlation between the total amount of sulfhydryl groups and CDDP sensitivity in a panel of 3 human germ-cell tumour and 3 colon-carcinoma cell lines. Major components of the sulfhydryl groups are glutathione and...
article 2000
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Sartorelli, P. (author), Andersen, H.R. (author), Angerer, J. (author), Corish, J. (author), Drexler, H. (author), Göen, T. (author), Griffin, P. (author), Hotchkiss, S.A.M. (author), Larese, F. (author), Montomoli, L. (author), Perkins, J. (author), Schmelz, M. (author), van de Sandt, J. (author), Williams, F. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
During the last few years the general interest in the percutaneous absorption of chemicals has increased. It is generally accepted that there is very few reliable quantitative and qualitative data on dermal exposure to chemicals in the general population and in occupationally exposed workers. In order to predict the systemic risk of dermally...
article 2000
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Korst, A.E.C. (author), Boven, E. (author), van der Sterre, M.L.T. (author), Fichtinger-Schepman, A.M.J. (author), van der Vijgh, W.J.F. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Amifostine (Ethyol, WR-2721) is in use in the clinic as a protector against platinum-induced toxicities. We have previously reported that amifostine induced a potentiation of the antitumour activity of carboplatin in human ovarian cancer xenografts. An influence of amifostine on the pharmacokinetics of carboplatin, resulting in higher platinum...
article 1998
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Braakhuis, B.J.M. (author), Welters, M.J.P. (author), Cloos, J. (author), Pankras, J.E. (author), Smeets, S.J. (author), Fichtinger-Schepman, A.-M.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The aim of the present study was to investigate how normal head and neck epithelial cells (NHNEC) respond to cisplatin compared to their neoplastic counterparts with respect to intracellular platinum (Pt) levels and growth inhibition. A colorimetric assay was used to assess growth inhibition after exposure to cisplatin for 72 h. Growth...
article 1999
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Proper, K. (author), Hildebrandt, V. (author), van der Beek, A. (author), Green, B.B. (author)
Chemicals/CAS: cholesterol, 57-88-5
article 2003
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Emmen, H.H. (author), Hoogendijk, E.M.G. (author), Klöpping-Ketelaars, W.A.A. (author), Muijser, H. (author), Duistermaat, E. (author), Ravensberg, J.C. (author), Alexander, D.J. (author), Borkhataria, D. (author), Rusch, G.M. (author), Schmit, B. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
HFC 134a (1,1,1,2-tetrafluoroethane) and HFC 227 (1,1,1,2,3,3,3-heptafluoropropane) are used to replace chlorofluorocarbons (CFCs) in refrigerant and aerosol applications, including medical use in metered-dose inhalers. Production and consumption of CFCs are being phased out under the Montreal Protocol on Substances that Deplete the Ozone Layer....
article 2000
document
Fransson, E.I. (author), Nyberg, S.T. (author), Heikkilä, K. (author), Alfredsson, L. (author), Bjorner, J.B. (author), Borritz, M. (author), Burr, H. (author), Dragano, N. (author), Geuskens, G.A. (author), Goldberg, M. (author), Hamer, M. (author), Hooftman, W.E. (author), Houtman, I.L. (author), Joensuu, M. (author), Jokela, M. (author), Knutsson, A. (author), Koskenvuo, M. (author), Koskinen, A. (author), Kumari, M. (author), Leineweber, C. (author), Lunau, T. (author), Madsen, I.E.H. (author), Hanson, L.L.M. (author), Nielsen, M.L. (author), Nordin, M. (author), Oksanen, T. (author), Pentti, J. (author), Pejtersen, J.H. (author), Rugulies, R. (author), Salo, P. (author), Shipley, M.J. (author), Steptoe, A. (author), Suominen, S.B. (author), Theorell, T. (author), Toppinen-Tanner, S. (author), Vahtera, J. (author), Virtanen, M. (author), Väänänen, A. (author), Westerholm, P.J.M. (author), Westerlund, H. (author), Zins, M. (author), Britton, A. (author), Brunner, E.J. (author), Singh-Manoux, A. (author), Batty, G.D. (author), Kivimäki, M. (author)
BACKGROUND AND PURPOSE: Psychosocial stress at work has been proposed to be a risk factor for cardiovascular disease. However, its role as a risk factor for stroke is uncertain. METHODS: We conducted an individual-participant-data meta-analysis of 196 380 males and females from 14 European cohort studies to investigate the association between...
article 2015
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van Loon, A.A.W.M. (author), Timmerman, A.J. (author), van der Schans, G.P. (author), Lohman, P.H.M. (author), Baan, R.A. (author), Medisch Biologisch Laboratorium TNO (author)
Exposure of cells to ionizing radiation gives rise to DNA damage, comprising strand breaks and base modifications. All these lesions may contribute to cell death, mutagenesis and/or carcinogenesis, but their relative contributions are likely to be different. It is important, therefore, to study the various damages with respect to their abundance...
article 1992
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Bogaards, J.J.P. (author), Hissink, E.M. (author), Briggs, M. (author), Weaver, R. (author), Jochemsen, R. (author), Jackson, P. (author), Bertrand, M. (author), van Bladeren, P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
A strategy is presented to predict interindividual variation in drug plasma levels in vivo by the use of physiologically based pharmacokinetic modeling and human in vitro metabolic parameters, obtained through the combined use of microsomes containing single cytochrome P450 enzymes and a human liver microsome bank. The strategy, applied to the...
article 2000
document
van Poppel, G. (author), Verhoeven, D.T.H. (author), Verhagen, H. (author), Goldbohm, R.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
This paper first gives an overview of the epidemiological data concerning the cancer-preventive effect of brassica vegetables, including cabbages, kale, broccoli, Brussels sprouts, and cauliflower. A protective effect of brassicas against cancer may be plausible due to their relatively high content of glucosinolates. Certain hydrolysis products...
article 2000
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van Beijsterveldt, A.M. (author), Steffen, K. (author), Stubbe, J.H. (author), Frederiks, J.E. (author), van de Port, I.G.L. (author), Backx, F.J.G. (author)
OBJECTIVE:: To describe characteristics of outdoor soccer injury and recovery among Dutch soccer players. DESIGN:: Prospective cohort study. SETTING:: The 2009-2010 competitive season (33 weeks). PARTICIPANTS:: Four hundred fifty-six Dutch male soccer players of 23 amateur teams. MAIN OUTCOME MEASURES:: Coaches recorded individual exposure to...
article 2014
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Wenczl, E. (author), van der Schans, G.P. (author), Roza, L. (author), Kolb, R.M. (author), Timmerman, A.J. (author), Smit, N.P.M. (author), Pavel, S. (author), Schothorst, A.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The question of whether melanins are photoprotecting and/or photosensitizing in human skin cells continues to be debated. To evaluate the role of melanin upon UVA irradiation, DNA single-strand breaks (ssb) were measured in human melanocytes differing only in the amount of pigment produced by culturing at two different concentrations, basic (0...
article 1998
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Molhoek, E.M. (author), den Hertog, A.L. (author), de Vries, A.M.B.C. (author), Nazmi, K. (author), Veerman, E.C.I. (author), Hartgers, F.C. (author), Yazdanbakhsh, M. (author), Bikker, F.J. (author), van der Kleij, D. (author), TNO Defensie en Veiligheid (author)
Cathelicidins are effector molecules of the innate host defense system that establish an antimicrobial barrier at epithelial interfaces. The human cathelicidin LL-37, in addition to its antimicrobial activity, also exhibits immunomodulatory effects, such as inhibition of pro-inflammatory responses to bacterial LPS in human monocytic cells. In...
article 2009
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Mol, M.A.E. (author), de Vries-Van de Ruit, A.M.B.C. (author), Medisch Biologisch Laboratorium TNO (author)
The concentration- and time-dependent effects of sulphur mustard on cultured human epidermal keratinocyte function were investigated with respect to cell proliferation, DNA and protein synthesis, the level of NAD+ and ATP, and the intracellular activity of lactate dehydrogenase. If human epidermal keratinocytes were stimulated to proliferate by...
article 1992
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Leenheers, L.H. (author), van Breugel, D.C. (author), Ravensberg, J.C. (author), Meuling, W.J.A. (author), Jongen, M.J.M. (author), Medisch Biologisch Laboratorium TNO (author)
An analytical method for the assessment of the exposure of workers to the pesticide propoxur through biological monitoring has been developed. This study was part of a survey of occupational exposure to pesticides used in greenhouses for the growing of ornamental plants. In order to assess the actual absorbed amount of propoxur in the body, an...
article 1992
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Boer, J.M.A. (author), Ehnholm, C. (author), Menzel, H.J. (author), Havekes, L.M. (author), Rosseneu, M. (author), O'Reilly, D.S.J. (author), Tiret, L. (author), Gaubius Instituut TNO (author)
To elucidate how the apolipoprotein (apo)E polymorphism and modifiable factors interact in explaining plasma lipid and apolipoprotein levels, we studied 1448 young adults (18 to 26 years old), participating in the European Atherosclerosis Research Study (EARS). Venous blood was collected after an overnight fast. Modifiable factors, eg, body mass...
article 1997
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van der Gaag, M.S. (author), Ubbink, J.B. (author), Sillanaukee, P. (author), Nikkari, S. (author), Hendriks, H.F.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Serum homocysteine increases after moderate consumption of red wine and spirits, but not after moderate consumption of beer. Vitamin B6 in beer seems to prevent the alcohol-induced rise in serum homocysteine. Chemicals/CAS: Homocysteine, 454-28-4; Pyridoxine, 65-23-6
article 2000
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Bobeldijk, I. (author), Hekman, M. (author), van der Vries de- Weij, J. (author), Coulier, L. (author), Ramaker, R. (author), Kleemann, R. (author), Kooistra, T. (author), Rubingh, C. (author), Freidig, A. (author), Verheij, E. (author), TNO Kwaliteit van Leven (author)
We report a sensitive, generic method for quantitative profiling of bile acids and other endogenous metabolites in small quantities of various biological fluids and tissues. The method is based on a straightforward sample preparation, separation by reversed-phase high performance liquid-chromatography mass spectrometry (HPLC-MS) and electrospray...
article 2008
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