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van Groen, B.D. (author), van de Steeg, E. (author), Mooij, M.G. (author), van Lipzig, M.M.H. (author), de Koning, B.A.E. (author), Verdijk, R.M. (author), Wortelboer, H.M. (author), Gaedigk, R. (author), Bi, C. (author), Leeder, S. (author), van Schaik, R.H.N. (author), van Rosmalen, J. (author), Tibboel, D. (author), Vaes, W.H. (author), de Wildt, S.N. (author)
Background Hepatic membrane transporters are involved in the transport of many endogenous and exogenous compounds, including drugs. We aimed to study the relation of age with absolute transporter protein expression in a cohort of 62 mainly fetus and newborn samples. Methods Protein expressions of BCRP, BSEP, GLUT1, MCT1, MDR1, MRP1, MRP2, MRP3,...
article 2018
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Hayes, D.J. (author), van Buuren, S. (author), ter Kuile, F.O. (author), Stasinopoulos, D.M. (author), Rigby, R.A. (author), Terlouw, D.J. (author)
Methods: A weight-for-age database was constructed from pre-existing population-based anthropometric data obtained from household surveys and research groups. It contained data collected between 1995 and 2012 on 1 263 119 individuals (909 368 female, 353 751 male) older than 14 days and younger than 50 years in 64 malaria-endemic countries....
article 2015
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van Dommelen, P. (author), Verkerk, P.H. (author), van Straaten, H.L. (author)
Objective To gain insight into health and related costs associated with very preterm births, one needs accurate information about the prevalence of the disabling conditions, including neonatal hearing loss (NHL). Study design We assessed the prevalence of NHL by week of gestation and categories of birth weight in very preterm neonates. Results...
article 2015
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MacDorman, M.F. (author), Mathews, T.J. (author), Mohangoo, A.D. (author), Zeitlin, J. (author)
OBJECTIVES: This report investigates the reasons for the United States' high infant mortality rate when compared with European countries. Specifically, the report measures the impact on infant mortality differences of two major factors: the percentage of preterm births and gestational age-specific infant mortality rates. METHODS: Infant...
article 2014
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Mooij, M.G. (author), van Duijn, E. (author), Knibbe, C.A.J. (author), Windhorst, A.D. (author), Hendrikse, N.H. (author), Vaes, W.H.J. (author), Spaans, E. (author), Fabriek, B.O. (author), Sandman, H. (author), Grossouw, D. (author), Hanff, L.M. (author), Janssen, P.J.J.M. (author), Koch, B.C.P. (author), Tibboel, D. (author), de Wildt, S.N. (author)
Results: Ten infants (aged 0.1–83.1 months) were included; one was excluded as he vomited shortly after administration. In nine patients, [14C]AAP and metabolites in blood samples were detectable at expected concentrations: median (range) maximum concentration (Cmax) [14C]AAP 1.68 (0.75–4.76) ng/L, [14C]AAP-Glu 0.88 (0.34–1.55) ng/L, and [14C...
article 2014
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Deurloo, J.A. (author), van Gameren-Oosterom, H.B.M. (author), Kamphuis, M. (author)
There is a high incidence of skin disorders; these are also frequently encountered within Youth Healthcare (YHC). Some skin disorders are caused by an underlying disease, syndrome or child abuse. Therefore, detection of these causes in an early stage is important. Skin disorders can have a huge psychosocial impact on both child and parents. This...
article 2012
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van Dommelen, P. (author), van Straaten, H.L.M. (author), Verkerk, P.H. (author)
Aim: To evaluate 10-year quality assurance of newborn hearing screening (NHS) in Dutch neonatal intensive care units (NICU). Methods: Results of the two-stage automated auditory brainstem response (AABR) screening and diagnostic examination in NICU graduates were centrally registered between October 1998 and December 2008. This registration...
article 2011
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Schönbeck, Y. (author), Talma, H. (author), van Dommelen, P. (author), Bakker, B. (author), Buitendijk, S.E. (author), HiraSing, R.A. (author), van Buuren, S. (author)
To assess the prevalence of overweight and obesity among Dutch children and adolescents, to examine the 30-years trend, and to create new body mass index reference charts. Design: Nationwide cross-sectional data collection by trained health care professionals. Participants: 10,129 children of Dutch origin aged 0-21 years. Main Outcome Measures:...
article 2011
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Kamphuis, M. (author), Obenhuijsen, N.H. (author), van Dommelen, P. (author), van Buuren, S. (author), Verkerk, P.H. (author), TNO Kwaliteit van Leven (author)
The main goal of this guideline for preventive child health care (PCHC) is to improve early detection of disorders that induce short stature. Based on research, evidence-based referral criteria for children aged 0-10 years with a short stature were formulated. These criteria are important for all professionals working with children, such as PCHC...
article 2010
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Anthony, S. (author), Jacobusse, G.W. (author), van der Pal-De Bruin, K.M. (author), Buitendijk, S. (author), Zeitlin, J. (author), TNO Kwaliteit van Leven (author)
Perinatal mortality rates differ markedly between countries in Europe. If population characteristics, such as maternal age, parity or multiple births, contribute to these differences, standardised rates may be useful for international comparisons of health status and especially quality of care. This analysis used aggregated population-based data...
article 2009
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van der Pal, S.M. (author), Walther, F.J. (author), TNO Kwaliteit van Leven (author)
Objective and design. The Leiden Developmental Care Project explored the effects of the basic elements of developmental care (DC: the use of incubator covers and nests) and the Newborn Individualized Developmental Care and Assessment Program (NIDCAP) with individual behavior observations for very premature infants less than 32 weeks of gestation...
article 2008
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Vančíková, Z. (author), Lodinová-Žádníková, R. (author), Radl, J. (author), Tlaskalová-Hogenová, H. (author)
The development of levels of secretory immunoglobulins (SIgs) in newborns' saliva was examined under physiological conditions and after artificial colonization with nonpathogenic, probiotic bacterial strain E. coli O83. Higher levels of secretory immunoglobulin M (SIgM) and secretory immunoglobulin A (SIgA) were detected in the saliva of breast...
article 2003
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Hirasing, R.A. (author), Rodrigues Pereira, R. (author)
The Dutch Paediatric Surveillance System was initiated by the Dutch Paediatric Society and is housed within the TNO Prevention and Health office. The purpose of the surveillance system is (a) to gain insight on a population level into the prevalence of rare and new diseases in youths (0-18 year), and (b) to promote scientific research addressing...
article 2002
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Centraal Instituut voor Voedingsonderzoek TNO (author), Oostenbrug, G.S. (author), Mensink, R.P. (author), Al, M.D.M. (author), van Houwelingen, A.C. (author), Hornstra, G. (author)
During pregnancy, maternal plasma concentrations of the peroxidation-susceptible polyunsaturated fatty acids (polyenes) increase. In addition, the proportion of polyenes is higher in neonatal plasma than in maternal plasma. To study whether these increased amounts of polyenes affect antioxidant levels, we measured lipid-soluble antioxidants in...
article 1998
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Hirasing, R.A. (author), TNO Preventie en Gezondheid (author)
Objective: To determine if the incidence of insulin-dependent diabetes mellitus (IDDM) in the age group of 0-19 years in the Netherlands in the period 1988-1990 had changed in comparison with the period 10 years before. Design: Retrospective. Setting: The Netherlands. Method: In 1991 a questionnaire was sent to all paediatricians and internists...
article 1995
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Kwan, A.L. (author), Verloove-Vanhorick, S.P. (author), Verwey, R.A. (author), Brand, R. (author), Ruys, J.H. (author), TNO Preventie en Gezondheid (author)
Objective. To analyse whether the conventional so-called Kloosterman charts for birthweight of preterm infants based on data from 1931-1965 are still valid. Design. Descriptive investigation. Location. The Netherlands. Methods. Data were obtained from the 'project of the premature and small for gestational age' (POPS) survey in 1983. The...
article 1994
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Hille, E.T.M. (author), den Ouden, A.L. (author), Bauer, L. (author), van den Oudenrijn, C. (author), Brand, R. (author), Verloove-Vanhorick, S.P. (author), Nederlands Instituut voor Praeventieve Gezondheidszorg TNO (author)
To assess the impact of both perinatal disorders and developmental problems identified at preschool age on school performance, we followed a virtually complete birth cohort of very premature (<32 completed weeks of gestation) and very low birth weight infants until they were 9 years of age. In 84% of the survivors (n = 813), data on school...
article 1994
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Verkerk, P.H. (author), Buitendijk, S.E. (author), Verloove-Vanhorick, S.P. (author)
Background. The validity of the results of studies using retrospectively collected information on exposures is often criticized, because cases may report differently from controls even if their true exposure status is the same. This study was performed to quantify the extent to which this effect (differential misclassification) may occur for...
article 1994
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Verkerk, P.H. (author), Derksen-Lubsen, G. (author), Vulsma, T. (author), Loeber, J.G. (author), de Vijlder, J.J.M. (author), Verbrugge, H.P. (author), Nederlands Instituut voor Praeventieve Gezondheidszorg TNO (author)
Doel. Evaluatie van de Nederlandse screening op congenitale hypothyreoïdie (CHT). Opzet. Descriptief. Plaats. Landelijk. Methoden. Gegevens over de screening in de periode 1 januari 1981-31 december 1990 werden verkregen van de entadministraties, van laboratoria en van kinderartsen naar wie kinderen met afwijkende uitslagen verwezen werden....
article 1993
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Meijer, W.J. (author), Verloove-Vanhorick, S.P. (author), Brand, R. (author), van den Brande, J.L. (author), TNO Preventie en Gezondheid (author)
In 563 surviving very preterm (<32 weeks gestational age) and/or very low birthweight (<1500 g) infants the relationship between neonatal thyroxine concentration and psychomotor development at 2 years of age (corrected for preterm birth) was studied. A significant association was found between low neonatal thyroxine concentration and a negative...
article 1992
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