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Centraal Instituut voor Voedingsonderzoek TNO (author), Janbroers, J.M. (author), Sanders, J.C. (author), Til, H.P. (author), Feron, V.J. (author), de Groot, A.P. (author)
Studies in rats on iocetamic acid show that the LD50 levels of this compound compare favorably with those of a number of other oral cholecystographic agents. Pathologic effects are not found in rats and cats in studies of the subacute toxicity. Incompatibility with an anesthetic or a tranquilizer is not found. The elimination pattern of...
article 1969
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Germans, F.H. (author), Koster, M.W. (author), Kwee, H.H. (author), Groep Motoriek Revalidatie, Medisch Fysisch Instituut TNO Instituut voor gezondheidstechniek TNO (author)
The merits of the 'vacuum form fixation' are discussed for the production of reliable body impressions of patients suffering from sitting problems. Impressions are taken with the patients seated in the desired posture. The first results are reported, obtained from 4 patients of different categories, fitted with individually moulded seats...
article 1974
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von Lossonczy, T.O. (author), Ruiter, A. (author), Bronsgeest-Schoute, H.C. (author), van Gent, C.M. (author), Hermus, R.J.J. (author)
A cross-over study was done with 19 male and 23 female volunteers living in a monastery and a convent, respectively. The effect of a fat fish (mackerel) diet on the blood serum lipid composition was studied. As the normal diet of these volunteers was of the lacto-ovo-vegetarian type, a control diet in which the fish was replaced by full-fat...
article 1978
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Gaillard, A.W.K. (author), Varey, C.A. (author), Instituut voor Zintuigfysiologie TNO (author)
The effects (on human beings) of the ACTH analog Org 2766 were investigated for a range of performance tests: complicated serial reaction task, running memory span, verbal learning and non-verbal mental ability tests (closure flexibility and non-verbal abstraction). Subjective ratings on feeling were taken and heart rate was measured. Only the...
article 1979
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Rijken, D.C. (author), Wijngaards, G. (author), Welbergen, J. (author), Gaubius instituut TNO (author)
Human plasminogen activators were compared immunologically in both a double-diffusion technique and quenching experiments on the fibrinolytic activities of the activators. Antisera against HMW and LMW urokinase and an antiserum against highly purified tissue plasminogen activator from human uterus were used. It was found that uterine tissue...
article 1981
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Wolthuis, O. (author), Vanwersch, R.A.P. (author), van der Wiel, H.J. (author), Medisch Biologisch Laboratorium TNO (author)
Previous results had shown that bis-pyridinium oximes, particularly HI-6 are quite effective therapeutically in soman-poisoned rats and mice in vivo and in the rat diaphragm preparation in vitro. The aim of the present study was to investigate the efficacy of bis-pyridinium oximes on soman-inhibited neuromuscular transmission in muscle...
article 1981
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Brommer, E.J.P. (author), Leuven, J.A.G. (author), Barrett-Bergshoeff, M.M. (author), Schouten, J.A. (author), Gaubius instituut TNO (author)
Impairment of fibrinolysis is supposed to contribute to CVD. In 38 hyperlipoproteinemic patients, known to be at risk for early CVD, fibrinolytic activity was measured before and after stimulation with DDAVP. A negative correlation was found between serum triglyceride levels and fibrinolytic activity, both before and after DDAVP. A subnormal...
article 1982
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Vaandrager, G.J. (author), Bruining, G.J. (author), Veenhof, F.J. (author), Drayer, N.M. (author), TNO Preventie en Gezondheid (author)
The incidence of childhood diabetes (0-19 years of age) in The Netherlands, where there is no nationalized health-care system, was investigated retrospectively in the years 1978 to 1980 inclusive. The method chosen was a questionnaire among all Dutch paediatricians and internal physicians acting as consultants. Ascertainment was by the same...
article 1984
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D'Angelo, A. (author), Kluft, C. (author), Verheijen, J.H. (author), Gaubius Instituut TNO (author)
In nine patients with non-malignant diseases undergoing major upper abdominal surgery, the mechanism of the postoperative fibrinolytic shut-down was investigated because of its potential significance for postoperative deep vein thrombosis by employing new and specific methods for assessing and stimulating the fibrinolytic system. The shut-down...
article 1985
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Schreurs, W.H.P. (author), Odink, J. (author), Egger, R.J. (author), Wedel, M. (author), Bruning, P.F. (author), Instituut CIVO-Toxicologie en voeding TNO (author)
Chemicals/CAS: Ascorbic Acid, 50-81-7; Calcifediol, 19356-17-3; Vitamin A, 11103-57-4; Vitamin B 12, 68-19-9; Vitamin E, 1406-18-4; Vitamins
article 1985
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Bos, K.D. (author), Slump, P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Chemicals/CAS: amino acid, 65072-01-7; glutamic acid, 11070-68-1, 138-15-8, 56-86-0, 6899-05-4; glutamine, 56-85-9, 6899-04-3; Glutamates; Glutamic Acid, 56-86-0; Glutamine, 56-85-9
article 1985
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Speek, A.J. (author), Thissen, J.T.N.M. (author), Schrijver, J. (author), Instituut CIVO-Toxicologie en voeding TNO (author)
The urinary excretion of 3-methylhistidine and creatinine and the urinary 3-methylhistidine to creatinine excretion ratio during day and night were investigated in a group of 103 healthy, normally fed Dutch children (52 boys and 51 girls) aged 2-17 years. The 3-methylhistidine to creatinine ratio of the night urine appeared to be significantly...
article 1986
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Gaubius instituut TNO (author), Boks, A.L. (author), Brommer, E.J.P. (author), Schalm, S.W. (author), van Vliet, H.H.D.M. (author)
In a study of severe, decompensated liver failure, we tried to find a correlation between hemorrhage and parameters of hemostasis and fibrinolysis. Three groups of patients were studied: alcoholic cirrhosis; nonalcoholic cirrhosis, and acute liver failure without known prior liver disease. The two cirrhotic groups did not differ significantly...
article 1986
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Gaubius instituut TNO (author), Kempen, H.J.M. (author), Glatz, J.F.C. (author), Gevers Leuven, J.A. (author), van der Voort, H.A. (author), Katan, M.B. (author)
The power of serum lathosterol concentration as an indicator of whole-body cholesterol synthesis was investigated in 47 human volunteers consuming two diets differing in fatty acid composition. The cholesterol balance (fecal excretion of neutral and acid steroids minus cholesterol intake) was strongly correlated with the serum level of total ...
article 1988
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Engesser, L. (author), Brommer, E.J.P. (author), Kluft, C. (author), Briet, E. (author), Gaubius Instituut TNO (author)
Two hundred and three patients with venous thrombophilia were investigated in order to find out whether an elevated plasma concentration of plasminogen activator inhibitor (PAI) could be a cause of their tendency to thrombosis. The patients were studied in an asymptomatic period about 3 months after their last thromboembolic episode. PAI...
article 1989
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Kwekkeboom, J. (author), Princen, H.M.G. (author), van Voorthuizen, E.M. (author), Meijer, P. (author), Kempen, H.J.M. (author), Gaubius Instituut TNO (author)
Intracellular accumulation of 37°C of 50 μM [14C]taurocholic acid by hepatocytes of pig and rat, cultured for 24 hours, and by human hepatocytes, cultured for 12 hours, reached equilibrium after an incubation time of 1 to 2 hours. Maximum capacity to accumulate taurocholate intracellularly was assessed in 3-hour incubations with increasing...
article 1989
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Bloem, M.W. (author), Wedel, M. (author), van Agtmaal, E.J. (author), Speek, A.J. (author), Saowakontha, S. (author), Schreurs, W.H.P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
A group of 134 school children aged 3-9 y, with signs of conjunctival xerosis, from the rural area of Sakorn Nakhon province of Northeast Thailand were selected for a controlled study on the short-term effect (2 wk) of a single, oral high dose of vitamin A on iron metabolism. After collection of the baseline data, children within villages were...
article 1990
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Lowik, M.R.H. (author), Schrijver, J. (author), Odink, J. (author), van den Berg, H. (author), Wedel, M. (author), Hermus, R.J.J. (author), TNO Kwaliteit van Leven (author)
In a nationwide survey the nutritional status was assessed of 539 apparently healthy, independently living elderly aged 65-79 years. Anthropometric data showed no energy deficits. The prevalence of anemia was 4 and 1% among men and women, respectively. Many elderly showed a low level of 25-hydroxyvitamin D in plasma (< 31 nmol/L: men 35%; women...
article 1990
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Kalsbeek, H. (author), Verrips, G.H. (author), TNO Preventie en Gezondheid (author)
Data in a WHO report relating caries prevalence and the use of fluorides in different European countries were compared with data obtained directly from investigators in the field of oral epidemiology. The reliability of DMFT indices of 12-year-old children, mentioned in the WHO report, appeared sufficient to make comparisons between countries on...
article 1990
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Fichtinger-Schepman, A.M.J. (author), Velde van der - Visser, S.D. (author), Dijk van - Knijnenburg, H.C.M. (author), van Oosterom, A.T. (author), Baan, R.A. (author), Berends, F. (author), TNO Voeding Medisch biologisch laboratorium TNO (author)
During chemotherapy with a cisplatin-containing combination of drugs, 217 blood samples from 30 cancer patients were analyzed for the presence of the main cisplatin-DNA adduct cis-Pt(NH3)2d(pGpG) (Pt-GG). Cisplatin was administered during 3-h infusions on each of 5 consecutive days, resulting in increasing adduct levels which, on the average,...
article 1990
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