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Germans, F.H. (author), Koster, M.W. (author), Kwee, H.H. (author), Groep Motoriek Revalidatie, Medisch Fysisch Instituut TNO Instituut voor gezondheidstechniek TNO (author)
The merits of the 'vacuum form fixation' are discussed for the production of reliable body impressions of patients suffering from sitting problems. Impressions are taken with the patients seated in the desired posture. The first results are reported, obtained from 4 patients of different categories, fitted with individually moulded seats...
article 1974
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von Lossonczy, T.O. (author), Ruiter, A. (author), Bronsgeest-Schoute, H.C. (author), van Gent, C.M. (author), Hermus, R.J.J. (author)
A cross-over study was done with 19 male and 23 female volunteers living in a monastery and a convent, respectively. The effect of a fat fish (mackerel) diet on the blood serum lipid composition was studied. As the normal diet of these volunteers was of the lacto-ovo-vegetarian type, a control diet in which the fish was replaced by full-fat...
article 1978
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Wolthuis, O. (author), Vanwersch, R.A.P. (author), van der Wiel, H.J. (author), Medisch Biologisch Laboratorium TNO (author)
Previous results had shown that bis-pyridinium oximes, particularly HI-6 are quite effective therapeutically in soman-poisoned rats and mice in vivo and in the rat diaphragm preparation in vitro. The aim of the present study was to investigate the efficacy of bis-pyridinium oximes on soman-inhibited neuromuscular transmission in muscle...
article 1981
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Brommer, E.J.P. (author), Leuven, J.A.G. (author), Barrett-Bergshoeff, M.M. (author), Schouten, J.A. (author), Gaubius instituut TNO (author)
Impairment of fibrinolysis is supposed to contribute to CVD. In 38 hyperlipoproteinemic patients, known to be at risk for early CVD, fibrinolytic activity was measured before and after stimulation with DDAVP. A negative correlation was found between serum triglyceride levels and fibrinolytic activity, both before and after DDAVP. A subnormal...
article 1982
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Vaandrager, G.J. (author), Bruining, G.J. (author), Veenhof, F.J. (author), Drayer, N.M. (author), TNO Preventie en Gezondheid (author)
The incidence of childhood diabetes (0-19 years of age) in The Netherlands, where there is no nationalized health-care system, was investigated retrospectively in the years 1978 to 1980 inclusive. The method chosen was a questionnaire among all Dutch paediatricians and internal physicians acting as consultants. Ascertainment was by the same...
article 1984
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D'Angelo, A. (author), Kluft, C. (author), Verheijen, J.H. (author), Gaubius Instituut TNO (author)
In nine patients with non-malignant diseases undergoing major upper abdominal surgery, the mechanism of the postoperative fibrinolytic shut-down was investigated because of its potential significance for postoperative deep vein thrombosis by employing new and specific methods for assessing and stimulating the fibrinolytic system. The shut-down...
article 1985
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Bos, K.D. (author), Slump, P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Chemicals/CAS: amino acid, 65072-01-7; glutamic acid, 11070-68-1, 138-15-8, 56-86-0, 6899-05-4; glutamine, 56-85-9, 6899-04-3; Glutamates; Glutamic Acid, 56-86-0; Glutamine, 56-85-9
article 1985
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Gaubius instituut TNO (author), Boks, A.L. (author), Brommer, E.J.P. (author), Schalm, S.W. (author), van Vliet, H.H.D.M. (author)
In a study of severe, decompensated liver failure, we tried to find a correlation between hemorrhage and parameters of hemostasis and fibrinolysis. Three groups of patients were studied: alcoholic cirrhosis; nonalcoholic cirrhosis, and acute liver failure without known prior liver disease. The two cirrhotic groups did not differ significantly...
article 1986
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Engesser, L. (author), Brommer, E.J.P. (author), Kluft, C. (author), Briet, E. (author), Gaubius Instituut TNO (author)
Two hundred and three patients with venous thrombophilia were investigated in order to find out whether an elevated plasma concentration of plasminogen activator inhibitor (PAI) could be a cause of their tendency to thrombosis. The patients were studied in an asymptomatic period about 3 months after their last thromboembolic episode. PAI...
article 1989
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Fichtinger-Schepman, A.M.J. (author), Velde van der - Visser, S.D. (author), Dijk van - Knijnenburg, H.C.M. (author), van Oosterom, A.T. (author), Baan, R.A. (author), Berends, F. (author), TNO Voeding Medisch biologisch laboratorium TNO (author)
During chemotherapy with a cisplatin-containing combination of drugs, 217 blood samples from 30 cancer patients were analyzed for the presence of the main cisplatin-DNA adduct cis-Pt(NH3)2d(pGpG) (Pt-GG). Cisplatin was administered during 3-h infusions on each of 5 consecutive days, resulting in increasing adduct levels which, on the average,...
article 1990
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Havenith, G. (author), van Middendorp, H. (author)
An experiment was set up to quantify the relative influence of fitness, acclimatization, gender and anthropometric measures on physiological responses to heat stress. For this purpose, 12 male and 12 female subjects were exposed to a neutral [ambient temperature (T(a)) 21°C, relative humidity (r.h. 50%)], a warm, humid (T(a) 34°C, r.h. 80%) and...
article 1990
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Wertheim, A.H. (author), van Gelder, P. (author)
When the eyes pursue a fixation point that sweeps across a moving background pattern, and the fixation point is suddenly made to stop, the ongoing motion of the background pattern seems to accelerate to a higher velocity. Experiment I showed that this acceleration illusion is not caused by the sudden change in (i) the relative velocity between...
article 1990
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Theeuwes, J. (author)
Three visual search experiments tested whether top-down selectivity toward particular stimulus dimensions is possible during preattentive parallel search. Subjects viewed multielement displays in which two salient items, each unique in a different dimension—that is, color and intensity (Experiment 1) or color and form (Experiments 2 and 3)—were...
article 1991
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Roholl, P.J.M. (author), Weima, S.M. (author), Prinsen, I. (author), de Weger, R.A. (author), den Otter, W. (author), van Unnik, J.A.M. (author), Instituut voor Verouderings- en Vaatziekten Onderzoek TNO Instituut voor Experimentele Gerontologie TNO (author)
The expression of both platelet-derived growth factor (PDGF) and epidermal growth factor (EGF), and of their receptors was examined immunohistochemically in a number of normal tissues as well as in benign and malignant mesenchymal tumors. The benign lesions studied were from the skin: palmar fibromatosis (fibroblastic) and from the uterus:...
article 1991
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Gaubius Instituut TNO (author), de Knijff, P. (author), van den Maagdenberg, A.M.J.M. (author), Stalenhoef, A.F.H. (author), Leuven, J.A.G. (author), Demacker, P.N.M. (author), Kuyt, L.P. (author), Frants, R.R. (author), Havekes, L.M. (author)
By the careful screening of familial dysbetalipoproteinemic (FD) patients, five probands showing heterozygosity for the APOE*3-Leiden allele were found. Genealogical studies revealed that these probands share common ancestry in the 17th century. In a group of 128 family members, spanning three generations, 37 additional heterozygous APOE*3...
article 1991
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Medisch Biologisch Laboratorium TNO (author), de Kort, W.L.A.M. (author), Fransman, L.G. (author), van Dijk, F.J.H. (author)
Several hundreds of thousands of preemployment medical examinations are performed in The Netherlands each year, with the objective of screening for obvious risks for the applicants or others. Neither the efficacy of these examinations nor determinants for rejection are known. Altogether 101,754 preemployment medical examinations of applicants...
article 1991
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Havenith, G. (author), van de Linde, E.J.G. (author), Heus, R. (author)
Hand cooling and resulting comfort and pain were studied in 12 subjects, while touching six different materials (polyurethane foam, wood, nylon, rustproof steel, aluminium, and temperature-controlled metal) which were initially at ambient temperature. This was done for three ambient temperatures (-10°, 0° and 10°C), after pre-exposure exercise...
article 1992
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van de Water, H.P.A. (author), Bijleveld, C.C.J.H. (author), Nederlands Instituut voor Praeventieve Gezondheidszorg TNO (author)
Eind 1990 verschenen in dit tijdschrift twee artikelen over het aantal met HIV geïnfecteerden in Nederland. Hieruit bleek dat het aantal HIV-seropositieven lager lag dan eerder werd aangenomen, maar dat desondanks een stijgend aantal AIDS-patiënten verwacht mocht worden. In uitkomsten liepen de twee onderzoeken niet ver uiteen. Jager et al....
article 1992
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Theeuwes, J. (author)
Three visual-search experiments tested whether the preattentive parallel stage can selectively guide the attentive stage to a particular known-to-be-relevant target feature. Subjects searched multielement displays for a salient green circle that had a unique form when surrounded by green nontarget squares or had a unique color when surrounded by...
article 1992
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van Delft, J.H.M. (author), van den Ende, A.M.C. (author), Keizer, H.J. (author), Ouwerkerk, J. (author), Baan, R.A. (author), Centraal Instituut voor Voedingsonderzoek TNO Medisch Biologisch Laboratorium TNO (author)
An ELISA method was used to determine N7-methylguanine (N7-MeGua) adducts in DNA of white blood cells from cancer patients treated with the methylating antitumor drug dacarbazine by i.v. administration. From four patients who received dacarbazine only, at dosages of 250, 400 or 800 mg/m2, the blood samples were collected before and several days...
article 1992
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