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Michielsen, C.C.J.R. (author), Hangelbroek, R.W.J. (author), Bragt, M.C.E. (author), Verheij, E.R. (author), Wopereis, S. (author), Mensink, R.P. (author), Afman, L.A. (author)
Scope: The drug fenofibrate and dietary fish oils can effectively lower circulating triglyceride (TG) concentrations. However, a detailed comparative analysis of the effects on the plasma metabolome is missing. Methods and Results: Twenty overweight and obese subjects participate in a double-blind, cross-over intervention trial and receive in a...
article 2022
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Grinberg, M. (author), Stöber, R.M. (author), Edlund, K. (author), Rempel, E. (author), Godoy, P. (author), Reif, R. (author), Widera, A. (author), Madjar, K. (author), Schmidt-Heck, W. (author), Marchan, R. (author), Sachinidis, A. (author), Spitkovsky, D. (author), Hescheler, J. (author), Carmo, H. (author), Arbo, M.D. (author), van de Water, B. (author), Wink, S. (author), Vinken, M. (author), Rogiers, V. (author), Escher, S. (author), Hardy, B. (author), Mitic, D. (author), Myatt, G. (author), Waldmann, T. (author), Mardinoglu, A. (author), Damm, G. (author), Seehofer, D. (author), Nüssler, A. (author), Weiss, T.S. (author), Oberemm, A. (author), Lampen, A. (author), Schaap, M.M. (author), Luijten, M. (author), van Steeg, H. (author), Thasler, W.E. (author), Kleinjans, J.C.S. (author), Stierum, R.H. (author), Leist, M. (author), Rahnenführer, J. (author), Hengstler, J.G. (author)
Correction to: Arch Toxicol (2014) 88:2261–2287 https://doi.org/10.1007/s00204-014-1400-x.
article 2022
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Teunissen, L.P.J. (author), Jansen, K.M.B. (author), Janssen, E. (author), Kingma, B.R.M. (author), de Korte, J.Q. (author), Eijsvogels, T.M.H. (author)
Objectives To evaluate how separate and combined climatic parameters affect peak core temperature during exercise in the heat using computer simulations fed with individual data. Methods The impact of eight environmental conditions on rectal temperature (Tre) was determined for exercise under heat stress using the Fiala-thermal-Physiology-and...
article 2022
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Streekstra, E.J. (author), Kiss, M. (author), van den Heuvel, J. (author), Nicolaï, J. (author), van den Broek, P. (author), Botden, S.M.B.I. (author), Stommel, M.W.J. (author), van Rijssel, L. (author), Ungell, A.L. (author), van de Steeg, E. (author), Russel, F.G.M. (author), de Wildt, S.N. (author)
Little is known about the impact of age on the processes governing human intestinal drug absorption. The Ussing chamber is a system to study drug transport across tissue barriers, but it has not been used to study drug absorption processes in children. This study aimed to explore the feasibility of the Ussing chamber methodology to assess...
article 2022
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Fierloos, I.N. (author), Windhorst, D.A. (author), Fang, Y. (author), Bannink, R. (author), Stam, M. (author), Slijkerman, C.A.A. (author), Jansen, W. (author), Raat, H. (author)
Aim: This study examined the association between social support perceived by parents of children aged 1–7 years and the use of additional community youth health care services. Methods: Data of 749 parents of children aged 1–7 years, gathered in the CIKEO cohort study in the Netherlands, were analyzed. Social support was assessed with the...
article 2022
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van Verseveld, M.D.A. (author), Fekkes, M. (author), Fukkink, R.G. (author), Oostdam, R.J. (author)
Although anti-bullying programs often include a component that focuses on strengthening teachers’ abilities in identifying and addressing bullying, it is not clear which bullying situations teachers find difficult to address and what type of support is needed. In the current qualitative study, we investigated what teachers considered difficult...
article 2021
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Kingma, B.R.M. (author), Roijendijk, L.M.M. (author), van Maanen, L. (author), van Rijn, H. (author), Beurden, M.H.P.H. (author)
This study investigates the hypotheses that during passive heat stress, the change in perception of time and change in accuracy of a timed decision task relate to changes in thermophysiological variables gastrointestinal temperature and heart rate (HR), as well as subjective measures of cognitive load and thermal perception. Young adult males (N...
article 2021
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Kox, E.S. (author), Kerstholt, J.H. (author), Hueting, T.F. (author), de Vries, P.W. (author)
The role of intelligent agents becomes more social as they are expected to act in direct interaction, involvement and/or interdependency with humans and other artificial entities, as in Human-Agent Teams (HAT). The highly interdependent and dynamic nature of teamwork demands correctly calibrated trust among team members. Trust violations are an...
article 2021
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Kim, C. (author), Colborn, K. (author), van Buuren, S. (author), Loar, T. (author), Stevens-Lapsley, J.E. (author), Kittelson, A.J. (author)
The purpose of this study was to develop and test personalized predictions for functional recovery after Total Knee Arthroplasty (TKA) surgery, using a novel neighbors-based prediction approach. We used data from 397 patients with TKA to develop the prediction methodology and then tested the predictions in a temporally distinct sample of 202...
article 2021
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Bornet, A. (author), Doerig, A. (author), Herzog, M.H. (author), Francis, G. (author), van der Burg, E. (author)
In crowding, perception of a target deteriorates in the presence of nearby flankers. Traditionally, it is thought that visual crowding obeys Bouma's law, i.e., all elements within a certain distance interfere with the target, and that adding more elements always leads to stronger crowding. Crowding is predominantly studied using sparse displays ...
article 2021
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Piil, J.F. (author), Kingma, B.R.M. (author), Morris, N.B. (author), Christiansen, L. (author), Ioannou, L.G. (author), Flouris, A.D. (author), Nybo, L. (author)
article 2021
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Versluis, A. (author), Knulst, A.C. (author), Michelsen-Huisman, A.D. (author), Houben, G.F. (author), Blom, W.M. (author), Le, T.M. (author), van Os-Medendorp, H. (author)
article 2021
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van Verseveld, M.D.A. (author), Fekkes, M. (author), Fukkink, R.G. (author), Oostdam, R.J. (author)
This study investigates the effectiveness of the PRIMA antibullying program for elementary education using a cluster-randomized trial with two experimental conditions (with and without student lessons) and a control group. Students of 31 schools participated in the study (N = 3,135; Mage = 10 years). Multilevel regression analyses demonstrated...
article 2021
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Regeer, H. (author), Nieuwenhuijse, E.A. (author), Vos, R.C. (author), Kiefte-de Jong, J.C. (author), van Empelen, P. (author), de Koning, E.J.P. (author), Bilo, H.J.G. (author), Huisman, S.D. (author)
Aims: To investigate changes in physical activity (PA) and psychological factors during societal lockdown in people with type 2 diabetes. Methods: A cross-sectional study among Dutch adults with type 2 diabetes. Data were collected using online questionnaires. A multivariate multinomial logistic regression was performed with change in PA during...
article 2021
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van den Dries, M.A. (author), Lamballais, S. (author), El Marroun, H. (author), Pronk, A. (author), Spaan, S. (author), Ferguson, K.K. (author), Longnecker, M.P. (author), Tiemeier, H. (author), Guxens, M. (author)
Background: Prenatal exposure to organophosphate (OP) pesticides associate with impaired neurodevelopment in humans and animal models. However, much uncertainty exists about the brain structural alterations underlying these associations. The objective of this study was to determine whether maternal OP pesticide metabolite concentrations in urine...
article 2020
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Liu, Y. (author), Toet, A. (author), Krone, T. (author), van Stokkum, R. (author), Eijsman, S. (author), van Erp, J.B.F. (author)
The affective appraisal of odors is known to depend on their intensity (I), familiarity (F), detection threshold (T), and on the baseline affective state of the observer. However, the exact nature of these relations is still largely unknown. We therefore performed an observer experiment in which participants (N = 52) smelled 40 different odors ...
article 2020
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Steijn, W.M.P. (author), van Kampen, J.N. (author), van der Beek, D. (author), Groeneweg, J. (author), van Gelder, P.H.A.J.M. (author)
Quantitative Risk Analysis (QRA) is a standard tool in some high-risk industries (such as the on- and offshore exploration and production and chemical industry). Presently, existing knowledge concerning human error likelihood and human reliability assessment is insufficiently represented in QRAs. In this paper we attempt to implement the...
article 2020
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Folkerts, M.A. (author), Gerrett, N. (author), Kingma, B.R.M. (author), Zuurbier, M. (author), Daanen, H.A.M. (author)
Young children are vulnerable to extreme temperatures due to their physiological and anatomical characteristics and behavioural dependability. The latter is a relatively unexplored area. Therefore, the current study investigated the skin temperature as a proxy of the thermal state of children and care providers in day-care centers, the ability...
article 2020
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Müller, R.A.J. (author), von Benda-Beckmann, A.M. (author), Halvorsen, M.B. (author), Ainslie, M.A. (author)
Regulations for underwater anthropogenic noise are typically formulated in terms of peak sound pressure, root-mean-square sound pressure, and (weighted or unweighted) sound exposure. Sound effect studies on humans and other terrestrial mammals suggest that in addition to these metrics, the impulsiveness of sound (often quantified by its kurtosis...
article 2020
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Stevens, L.J. (author), Donkers, J.M. (author), Dubbel, J. (author), Vaes, W.H.J. (author), van de Steeg, E. (author), Knibbe, C.A.J. (author), Alwayn, I.P.J. (author), van de Steeg, E. (author)
To predict the absorption, distribution, metabolism and excretion (ADME) profile of candidate drugs a variety of preclinical models can be applied. The ADME and toxicological behavior of newly developed drugs are often investigated prior to assessment in humans, which is associated with long time-lines and high costs. Therefore, good predictions...
article 2020
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