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Mpofu, A. (author), Linnemann, A.R. (author), Sybesma, W. (author), Kort, R. (author), Nout, M.J.R. (author), Smid, E.J. (author)
A probiotic dairy product was developed on the basis of a traditional dish called mutandabota to enable resource-poor populations in southern Africa to benefit from a functional food. Mutandabota is widely consumed in rural southern Africa, making it an ideal food matrix to carry probiotics. First, a process to produce probiotic mutandabota was...
article 2014
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Nowack, B. (author), David, R.M. (author), Fissan, H. (author), Morris, H. (author), Shatkin, J.A. (author), Stintz, M. (author), Zepp, R. (author), Brouwer, D. (author)
The expected widespread use of carbon nanotube (CNT)-composites in consumer products calls for an assessment of the possible release and exposure to workers, consumers and the environment. Release of CNTs may occur at all steps in the life cycle of products, but to date only limited information is available about release of CNTs from actual...
article 2013
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Shandilya, N. (author), Morgeneyer, M. (author), Le Bihan, O. (author)
In this work, the particle aerosols emissions during the abrasion of three products – brick, wood and stainless steel – are measured. Owing to different material removal mechanisms in these three products during their abrasions, different quantities and generation rates of aerosols are observed with the brick producing the highest number at a...
article 2015
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Ramirez, T. (author), Daneshian, M. (author), Kamp, H. (author), Bois, F.Y. (author), Clench, M.R. (author), Coen, M. (author), Donley, B. (author), Fischer, S.M. (author), Ekman, D.R. (author), Fabian, E. (author), Guillou, C. (author), Heuer, J. (author), Hogberg, H.T. (author), Jungnickel, H. (author), Keun, H.C. (author), Krennrich, G. (author), Krupp, E. (author), Luch, A. (author), Noor, F. (author), Peter, E. (author), Riefke, B. (author), Seymour, M. (author), Skinner, N. (author), Smirnova, L. (author), Verheij, E. (author), Wagner, S. (author), Hartung, T. (author), van Ravenzwaay, B. (author), Leist, M. (author)
Metabolomics, the comprehensive analysis of metabolites in a biological system, provides detailed information about the biochemical/physiological status of a biological system, and about the changes caused by chemicals. Metabolomics analysis is used in many fields, ranging from the analysis of the physiological status of genetically modified...
article 2013
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Geerling, J.J. (author), Boon, M.R. (author), van der Zon, G.C. (author), van den Berg, S.A.A. (author), van den Hoek, A.M. (author), Lombès, M. (author), Princen, H.M.G. (author), Havekes, L.M. (author), Rensen, P.C.N. (author), Guigas, B. (author)
Metformin is the first-line drug for the treatment of type 2 diabetes. Besides its well-characterized antihyperglycemic properties, metformin also lowers plasma VLDL triglyceride (TG). In this study, we investigated the underlying mechanisms in APOE*3-Leiden.CETP mice, a well-established model for human-like lipoprotein metabolism. We found that...
article 2014
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Shandilya, N. (author), Le Bihan, O. (author), Bressot, C. (author), Morgeneyer, M. (author)
In the present work, we investigate the effect of weathering duration on a commercial photocatalytic nanocoating on the basis of its nanoparticle emission tendency into two media, air and water. It is found that increased weathering duration results in stepwise structural deterioration of the nanocoating, which in turn decreases the nanocoating...
article 2015
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Foti, M.J. (author), Médici, R. (author), Ruijssenaars, H.J. (author)
Pseudomonas putida S12 was engineered for the production of monoethanolamine (MEA) from glucose via the decarboxylation of the central metabolite l-serine, which is catalyzed by the enzyme l-serine decarboxylase (SDC).The host was first evaluated for its tolerance towards MEA as well as its endogenous ability to degrade this alkanolamine. Growth...
article 2013
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Visser, H. (author), Joosten, V. (author), Punt, P.J. (author), Gusakov, A.V. (author), Olson, P.T. (author), Joosten, R. (author), Bartels, J. (author), Visser, J. (author), Sinitsyn, A.P. (author), Emalfarb, M.A. (author), Verdoes, J.C. (author), Wery, J. (author)
The filamentous fungus C1 was developed into an expression platform for screening and production of diverse industrial enzymes. C1 shows a lowviscosity morphology in submerged culture, enabling the use of complex growth and production media. This morphology furthermore allowed C1 to be used as a host for high-throughput robotic screening of gene...
article 2011
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Blaauboer, M.E. (author), Emson, C.L. (author), Verschuren, L. (author), van Erk, M. (author), Turner, S.M. (author), Everts, V. (author), Hanemaaijer, R. (author), Stoop, R. (author)
Collagen deposition is a key process during idiopathic pulmonary fibrosis; however, little is known about the dynamics of collagen formation during disease development. Tissue samples of early stages of human disease are not readily available and it is difficult to identify changes in collagen content, since standard collagen analyses do not...
article 2013
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Atuonwu, J.C. (author), van Straten, G. (author), van Deventer, H.C. (author), van Boxtel, A.J.B. (author)
This work presents a mixed integer nonlinear programming (MINLP) formulation for the design of energy-efficient multistage adsorption dryers within constraints on product temperature and moisture content. Apart from optimizing temperatures and flows, the aim is to select the most efficient adsorbent per stage and product to air flow...
article 2012
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Ahmadi-Abhari, S. (author), Woortman, A.J.J. (author), Hamer, R.J. (author), Oudhuis, A.A.C.M. (author), Loos, K. (author)
Starch is an omnipresent constituent which is used for its nutritional and structuring properties. Recently concerns have been raised since starch is a source of readily available glucose which is tightly correlated with diabetes type II and obesity. For this reason, the possibilities for modulating the digestibility of starch while preserving...
article 2013
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Cobb, Z. (author), de Vries, R. (author), Spooner, N. (author), Williams, S. (author), Staelens, L. (author), Doig, M. (author), Broadhurst, R. (author), Barfield, M. (author), van de Merbel, N. (author), Schmid, B. (author), Siethoff, C. (author), Ortiz, J. (author), Verheij, E. (author), van Baar, B. (author), White, S. (author), Timmerman, P. (author)
Background: At the start of their work, the European Bioanalysis Forum dried blood spots microsampling consortium did not form a dedicated team to investigate the spot homogeneity. However, two teams performed experiments that produced results relating to sample homogeneity. Results: The data, which were produced via two different approaches (a...
article 2013
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van Deun, K. (author), van Mechelen, I. (author), Thorrez, L. (author), Schouteden, M. (author), de Moor, B. (author), van der Werf, M.J. (author), de Lathauwer, L. (author), Smilde, A.K. (author), Kiers, H.A.L. (author)
Background: In systems biology it is common to obtain for the same set of biological entities information from multiple sources. Examples include expression data for the same set of orthologous genes screened in different organisms and data on the same set of culture samples obtained with different high-throughput techniques. A major challenge...
article 2012
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Franken, A.C. (author), Christien Lokman, B. (author), Ram, A.F. (author), van den Hondel, C.A. (author), de Weert, S. (author), Punt, P.J. (author)
To increase knowledge on haem biosynthesis in filamentous fungi like Aspergillus niger, pathway-specific gene expression in response to haem and haem intermediates was analysed. This analysis showed that iron, 5′-aminolevulinic acid (ALA) and possibly haem control haem biosynthesis mostly via modulating expression of hemA [coding for 5′...
article 2012
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Gierman, L.M. (author), Kühnast, S. (author), Koudijs, A. (author), Pieterman, E.J. (author), Kloppenburg, M. (author), van Osch, G.J.V.M. (author), Stojanovic-Susulic, V. (author), Huizinga, T.W.J. (author), Princen, H.M.G. (author), Zuurmond, A.M. (author)
Objective Hypercholesterolaemia, a risk factor for atherosclerosis (ATH), has been suggested to have a role in the development of osteoarthritis (OA). To test this hypothesis, the effect of cholesterol and different cholesterol-lowering treatments on OA was investigated in a mouse model resembling human lipoprotein metabolism. Methods Female...
article 2014
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Piersma, A.H. (author), Bosgra, S. (author), van Duursen, M.B.M. (author), Hermsen, S.A.B. (author), Jonker, L.R.A. (author), Kroese, E.D. (author), van der Linden, S.C. (author), Man, H. (author), Roelofs, M.J.E. (author), Schulpen, S.H.W. (author), Schwarz, M. (author), Uibel, F. (author), van Vugt-Lussenburg, B.M.A. (author), Westerhout, J. (author), Wolterbeek, A.P.M. (author), van der Burg, B. (author)
The application of alternative methods in developmental and reproductive toxicology is challenging in view of the complexity of mechanisms involved. A battery of complementary test systems may provide a better prediction of developmental and reproductive toxicity than single assays. We tested twelve compounds with varying mechanisms of toxic...
article 2013
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Salek, R.M. (author), Neumann, S. (author), Schober, D. (author), Hummel, J. (author), Billiau, K. (author), Kopka, J. (author), Correa, E. (author), Reijmers, T. (author), Rosato, A. (author), Tenori, L. (author), Turano, P. (author), Marin, S. (author), Deborde, C. (author), Jacob, D. (author), Rolin, D. (author), Dartigues, B. (author), Conesa, P. (author), Haug, K. (author), Rocca-Serra, P. (author), O’Hagan, S. (author), Hao, J. (author), van Vliet, M. (author), Sysi-Aho, M. (author), Ludwig, C. (author), Bouwman, J. (author), Cascante, M. (author), Ebbels, T. (author), Griffin, J.L. (author), Moing, A. (author), Nikolski, M. (author), Oresic, M. (author), Sansone, S.A. (author), Viant, M.R. (author), Goodacre, R. (author), Günther, U.L. (author), Hankemeier, T. (author), Luchinat, C. (author), Walther, D. (author), Steinbeck, C. (author)
article 2015
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Aguirre, M. (author), Ramiro-Garcia, J. (author), Koenen, M.E. (author), Venema, K. (author)
This study investigated the stability and the activity of the microbiota from a single and a pool of donors in the TNO in vitro model of the colon (TIM-2 system). Our findings demonstrate the suitability of the preparation of a pool of fecal sample to be used for fermentation experiments. Chemicals/CAS: isobutyric acid, 5711-69-3, 79-31-2;...
article 2014
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Lu, Y. (author), Boekschoten, M.V. (author), Wopereis, S. (author), Müller, M. (author), Kersten, S. (author)
Comparative transcriptomic and metabolomic analysis of fenofibrate and fish oil treatments in mice. Physiol Genomics 43: 1307-1318, 2011. First published September 27, 2011; doi:10.1152/physiolgenomics.00100.2011. Elevated circulating triglycerides, which are considered a risk factor for cardiovascular disease, can be targeted by treatment with...
article 2011
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Dekkers, S. (author), Telman, J. (author), Rennen, M.A.J. (author), Appel, M.J. (author), Buist, H.E. (author), de Heer, C. (author)
article 2006
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