Searched for:
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document
Zaadstra, B.M. (author), Chorus, A.M.J. (author), van Buuren, S. (author), Kalsbeek, H. (author), van Noort, J.M. (author), TNO Defensie en Veiligheid TNO Kwaliteit van Leven (author), DenV KvL (author)
Previous studies have suggested an association between multiple sclerosis (MS) and infectious mononucleosis (IM) but data on the exact strength of this association or its selectivity have been conflicting. In this study we have evaluated the association between MS and a variety of common childhood infections and afflictions in a large population...
article 2008
document
Fabriek, B.O. (author), Møller, H.J. (author), Vloet, R.P.M. (author), van Winsen, L.M. (author), Hanemaaijer, R. (author), Teunissen, C.E. (author), Uitdehaag, B.M.J. (author), van den Berg, T.K. (author), Dijkstra, C.D. (author), TNO Kwaliteit van Leven (author)
The scavenger receptor CD163 is selectively expressed on tissue macrophages and human monocytes. CD163 has been implicated to play a role in the clearance of hemoglobin and in the regulation of cytokine production by macrophages. Membrane CD163 can be cleaved by matrix metalloproteinases (MMP) resulting in soluble CD163 (sCD163). In the present...
article 2007
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van Noort, J.M. (author), Verbeek, R. (author), Meilof, J.F. (author), Polman, C.H. (author), Amor, S. (author), TNO Kwaliteit van Leven (author)
Human T-cell responses to the stress protein alpha B-crystallin in multiple sclerosis (MS)-affected brain samples are dominant when compared to other myelin antigens. The establishment of the apparent autoimmune repertoire against this antigen has been suggested to involve cross-priming during viral infection. Yet, another possibility would be...
article 2006
document
Andries, F. (author), Kremer, A.M. (author), Hoogendoorn, W.E. (author), Wevers, C.W.J. (author), van Putten, D.J. (author)
The Work and Handicap Questionnaire (WHQ) was developed to improve the vocational perspectives of patients with a chronic disorder. The WHQ differs from similar instruments in its explicit linkage between disabilities in daily life and job demands. This is an important feature, which allows for the development of specific strategies to counter...
article 2004
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Bsibsi, M. (author), Ravid, R. (author), Gveric, D. (author), van Noort, J.M. (author)
The family of Toll-like receptors (TLRs) plays a key role in controlling innate immune responses to a wide variety of pathogen-associated molecules. In this study we investigated expression of TLRs in vitro by purified human microglia, astrocytes, and oligodendrocytes, and in vivo by immunohistochemical examination of brain and spinal cord...
article 2002
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Bajramović, J.J. (author), Plomp, A.C. (author), van der Goes, A. (author), Koevoets, C. (author), Newcombe, J. (author), Cuzner, M.L. (author), van Noort, J.M. (author)
In the development of multiple sclerosis (MS), (re)activation of infiltrating T cells by myelin-derived Ags is considered to be a crucial step. Previously, αB-crystallin has been shown to be an important myelin Ag to human T cells. Since αB-crystallin is an intracellular heat shock protein, the question arises at what stage, if any, during...
article 2000
document
van Boxel-Dezaire, A.H.H. (author), Hoff, S.C.J. (author), van Oosten, B.W. (author), Verweij, C.L. (author), Dräger, A.M. (author), Adèr, H.J. (author), van Houwelingen, J.C. (author), Barkhof, F. (author), Polman, C.H. (author), Nagelkerken, L. (author), TNO Preventie en Gezondheid (author)
It has been shown that proinflammatory and antiinflammatory cytokines correlate with disease activity in multiple sclerosis (MS). To establish whether such correlations depend on the disease stage, we assessed in a longitudinal fashion the expression of interleukin (IL)-12 (p40 and p35), tumor necrosis factor- 1/4 , interferon-γ, and IL-10 mRNA...
article 1999
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Laman, J.D. (author), de Boer, M. (author), 't Hart, B.A. (author), TNO Preventie en Gezondheid (author)
The interactions of CD40 and CD40L have been known for some time to critically regulate B-cell responses with respect to proliferation, isotype switching, antibody production, and memory formation. More recent findings demonstrated that CD40 can be expressed on several other antigen-presenting cell (APC) types such as macrophages, dendritic...
article 1998
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Laman, J.D. (author), Thompson, E.J. (author), Kappos, L. (author), TNO Preventie en Gezondheid (author)
The need for reliable markers of disease activity in multiple sclerosis (MS) to better guide basic research, diagnosis, treatment, and monitoring of therapy is well-recognized. A recent European Charcot Foundation Symposium (Body fluid markers for course and activity of disease in multiple sclerosis (Madrid, Spain, October 2-4, 1997) organized...
article 1998
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van Noort, J.M. (author), TNO Preventie en Gezondheid (author)
Multiple sclerosis is the major neurological disease of young adults in the western world, affecting about 1 per 1,000. It is characterised by chronic or recurrent lesions of inflammatory damage in the white matter of the central nervous system. Within such lesions, the protective myelin sheath is stripped off axons by infiltrated macrophages...
article 1998
document
Laman, J.D. (author), Thompson, E.J. (author), Kappos, L. (author), TNO Preventie en Gezondheid (author)
article 1998
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Laman, J.D. (author), van Meurs, M. (author), Schellekens, M.M. (author), de Boer, M. (author), Melchers, B. (author), Massacesi, L. (author), Lassmann, H. (author), Claassen, E. (author), 't Hart, B.A. (author), TNO Preventie en Gezondheid (author)
Accessory molecules and cytokines are involved in the immunopathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) in rodent models, and are potential targets for immunotherapy. Evaluation of such experimental therapies requires appropriate animal models. Therefore, we analysed the expression of selected...
article 1998
document
Amor, S. (author), Baker, D. (author), Layward, L. (author), McCormack, K. (author), van Noort, J.M. (author), TNO Preventie en Gezondheid (author)
Correlation of the heterogeneic immunopathological profiles of multiple sclerosis (MS) lesions with the paraclinical and clinical markers of disease may be important in the development of therapeutic approaches in MS. This and other issues were discussed at a recent meeting.
article 1997
document
Bajramović, J.J. (author), Lassmann, H. (author), van Noort, J.M. (author), TNO Preventie en Gezondheid (author)
The small heat shock protein αB-crystallin was recently identified as a dominant human T-cell antigen in myelin derived from multiple sclerosis (MS) patients. Using immunohistochemical techniques, oligodendrocytes as well as astrocytes in MS lesions were shown to express α B-crystallin. In the present study we examined the expression of α B...
article 1997
document
van Noort, J.M. (author), TNO Preventie en Gezondheid (author)
The pathogenesis of multiple sclerosis (MS), the major neurological disease of young adults in the Western world, is still poorly understood, and no effective therapy to block MS is available as yet. The clinical symptoms of MS result from inflammatory damage to the insulating myelin sheath of axons in the CNS and - at later stages - to axons...
article 1996
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