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Ostendorf, R. (author), Erpelinck, S. (author)
The Organ-on-a-Chip Early Research Program enables TNO to offer state-of-the-art technologies that help the pharmaceutical industry advance drug development. An accurate, viable alternative to animal testing, on-a-chip technologies model human tissue functioning and accelerate compound development and testing. The Intestinal Epithelial Barrier...
other 2022
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Ostendorf, R. (author)
The Organ-on-a-Chip Early Research Program (ERP) has enabled TNO to offer a number of state-of-the-art technologies to help pharmaceutical and biotech companies advance and accelerate drug development. An accurate, viable alternative to animal testing, on-a-chip technologies model the workings of human tissue and accelerate compound development...
other 2022
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Steenhoff, H. (author), Toftum, J. (author), Kingma, B. (author), Daanen, H. (author), Gao, C. (author), Kuklane, K. (author), Garland, S. (author), Alkan Olsson, J. (author), Egli, S. (author), Folkerts, M. (author), Zuurbier, M. (author), Petersson, J. (author), Nybo, L. (author)
conference paper 2019
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Nybo, L. (author), Flouris, A.D. (author), Morabito, M. (author), Messeri, A. (author), Casanueva, A. (author), Kotlarski, S. (author), Spirig, C. (author), Schwierz, C. (author), Toftum, J. (author), Daanen, H. (author), Steenhoff, H. (author), Kingma, B. (author), Gao, C. (author)
conference paper 2019
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Bogerd, C.P. (author), Velt, K.B. (author), Annaheim, S. (author), Bongers, C.C.W.G. (author), Eijsvogels, T.M.H. (author), Daanen, H.A.M. (author)
OBJECTIVE: The discomfort caused by rectal probes and esophageal probes for the estimation of body core temperature has triggered the development of gastrointestinal (GI) capsules that are easily accepted by athletes and workers due to their non-invasive characteristics. We compare two new GI capsule devices with rectal temperature during cycle...
article 2018
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Berendsen, J. (author), Bonifacio, C. (author), van Gemert-Schriks, M. (author), van Loveren, C. (author), Verrips, E. (author), Duijster, D. (author)
Objectives: This study aimed to evaluate parents’ Willingness to Invest (WTI) in their children's oral health in terms of money, visits to a dental practice, and brushing minutes. Objectives were to assess the association between parents’ WTI and a) children's dental caries experience, b) children's oral hygiene behavior (OHB), and c) maternal...
article 2018
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de Wind, A. (author), Burr, H. (author), Pohrt, A. (author), Hasselhorn, H.M.S. (author), van der Beek, A.J. (author), Rugulies, R. (author)
Objectives: The aims of this article are to (1) determine whether and to what extent general perceived health and quality of supervision predict voluntary early retirement pension (VERP) and (2) assess whether quality of supervision modifies the association between general perceived health and VERP. Methods: Employees aged 49–64 years who...
article 2017
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Diepeveen, F.B. (author), Dusseldorp, E. (author), Bol, G.W. (author), Oudesluys-Murphy, A.M. (author), Verkerk, P.H. (author)
This study established predictive properties of single language milestones for specific language impairment (SLI) after the age of four, as these had not previously been reported in the literature. Methods In this nested case-control study, children attending special needs schools for severe speech and language difficulties were matched with...
article 2016
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van Buuren, S. (author), Bezemer, R.A. (author), Reijneveld, S.A. (author), L' Hoir, M.P. (author)
Curve matching is a new big data technique to predict an outcome given earlier measurements. Here we apply curve matching to predict the future growth of a specific child, the target child. The method searches in large datasets of longitudinal growth data for other children who are similar to the target child in terms of factors that influence...
article 2015
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Zwaveling-Soonawala, N. (author), Trotsenburg, A.S. (author), Verkerk, P.H. (author)
Congenital hypothyroidism (CH) may be of thyroidal (CHT) or central origin (CHC). Worldwide, most neonatal screening programs are TSH based and effectively detect CHT. Only a few screening programs measure total or free T4 and TSH simultaneously or stepwise, enabling detection of CHT as well as CHC. A frequently used argument against screening...
article 2015
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Kamphuis, M. (author), van de Nieuwegiessen, A.I. (author), Span, P.M. (author)
Background Dutch Youth health care is an easily accessible service where parents can ask for support for the healthy development of their children. The majority of the screenings and medical examinations show no abnormalities. Sometimes there is doubt about the severity of symptoms: the line between healthy variation and diseases or...
article 2014
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van der Pal-de Bruin, K.M. (author), Heerdink, N. (author), Kamphuis, M. (author), Pols, M.A. (author)
Conflict of interest and financial support: disclosure forms provided by the authors are available along with the full text of this article at www.ntvg.nl, search for A6745; click on ‘Belangenverstrengeling’ (‘Conflict of interest’). The Netherlands Organization for Health Research and Development provided a subsidy (subsidy no 156000009) to the...
article 2014
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Iyer, V. (author), Waldram-Nienhuis, A. (author), Boland, N. (author), Kamphuis, M. (author)
The Dutch Youth Act (2015) has to resolve serious problems among young people, prevent inappropriate medicalisation, and realise efficiency. Participation and empowerment are terms often used. At the moment Dutch youth healthcare doctors monitor children on a regular basis and assess situations based on the national Public Health Status and...
article 2014
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Diepeveen, F.B. (author), de Kroon, M.L. (author), Dusseldorp, E. (author), Snik, A.F. (author)
The purpose of this study was to assess the relation of perinatal risk factors with later development of specific language impairment (SLI). METHOD: In a case-control study, 179 children attending special needs schools for SLI were matched with non-affected children attending mainstream schools. Both groups consisted of 134 males and 45 females ...
article 2013
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Koeman, T. (author), Slottje, P. (author), Kromhout, H. (author), Schouten, L.J. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), Vermeulen, R. (author)
Objectives Although a study among utility workers found an increased risk for acute myocardial infarction and arrhythmia-related deaths associated with occupational extremely low-frequency magnetic fields (ELF-MF) exposure, later studies largely failed to replicate these findings. This study investigated the association between occupational ELF...
article 2013
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van Keulen, H.M. (author), Otten, W. (author), Ruiter, R.A.C. (author), van Steenbergen, J. (author), Paulussen, T.W.G.M. (author), Fekkes, M. (author), Paulussen, T.W.G.M. (author)
Onderzoeken welke factoren deelname aan de HPV-vaccinatie bepaalden in 2009 en 2010. Opzet Retrospectief dwarsdoorsnede-onderzoek. Methode Uit een telepanel werden aselecte steekproeven getrokken van Nederlandse meisjes die in 2009 en 2010 werden opgeroepen voor de HPV-vaccinatie, evenals hun moeders. Gegevens werden verzameld via een online...
article 2013
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Geybels, M.S. (author), Verhage, B.A.J. (author), van Schooten, F.J. (author), Goldbohm, A. (author), van den Brandt, P.A. (author)
BACKGROUND: Selenium may prevent advanced prostate cancer (PCa), but most studies on this topic were conducted in populations with moderate to high selenium status. We investigated the association of toenail selenium, reflecting long-term selenium exposure, and advanced PCa risk in a population from the Netherlands where low selenium status is...
article 2013
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Breuning-Boers, J.M. (author), Heerdink, M. (author), Kamphuis, M. (author), van Gameren-Oosterom, H. (author), Lanting, C. (author)
The objective of the evidence-based guidelines 'Asthma in children (ages 0-19)' for youth healthcare (CHC) is the prevention and reduction of asthma symptoms. The guidelines contain a lot of recommendations that apply to all disciplines in healthcare that deal with children. Primary prevention (preventing asthma): the main proven effective...
article 2012
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Beltman, M. (author), Deurloo, J.A. (author), van Leerdam, F.J.M. (author), Wierenga-van der Hoeven, C.J. (author), Bulk-Bunschoten, A.M.W. (author), Kamphuis, M. (author)
Continence problems can occur during childhood. This guideline is for the Dutch Youth Health Care (JGZ) and gives recommendations for the prevention, early detection and treatment of these problems. As a preventative measure advices for potty training should be started in children aged 18-24 months. If incontinence is present, it is important to...
article 2012
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Steevens, J. (author), Schouten, L.J. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author)
Prospective epidemiologic data on vegetables and fruits consumption and risk of subtypes of esophageal and gastric cancer are sparse. We studied the association between vegetables and fruits consumption and risk of esophageal squamous cell carcinoma (ESCC), esophageal adenocarcinoma (EAC), gastric cardia adenocarcinoma (GCA) and gastric...
article 2011
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