Searched for:
(1 - 15 of 15)
document
Zaadstra, B.M. (author), Chorus, A.M.J. (author), van Buuren, S. (author), Kalsbeek, H. (author), van Noort, J.M. (author), TNO Defensie en Veiligheid TNO Kwaliteit van Leven (author), DenV KvL (author)
Previous studies have suggested an association between multiple sclerosis (MS) and infectious mononucleosis (IM) but data on the exact strength of this association or its selectivity have been conflicting. In this study we have evaluated the association between MS and a variety of common childhood infections and afflictions in a large population...
article 2008
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Zuiderwijk-Sick, E.A. (author), van der Putten, C. (author), Bsibsi, M. (author), Deuzing, I.P. (author), de Boer, W. (author), Persoon-Deen, C. (author), Kondova, I. (author), Boven, L.A. (author), van Noort, J.M. (author), 't Hart, B.A. (author), Amor, S. (author), Bajramovic, J.J. (author), TNO Defensie en Veiligheid TNO Kwaliteit van Leven (author)
Activated microglia are found in a variety of neuroinflammatory disorders where they have attributed roles as effector as well as antigen-presenting cells (APC). Critical determinants for the multifaceted role of microglia are the differentiation potential of microglia and their mode of activation. In this study, we have investigated the effects...
article 2007
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Zafranskaya, M. (author), Oschmann, P. (author), Engel, R. (author), Weishaupt, A. (author), van Noort, J.M. (author), Jomaa, H. (author), Eberl, M. (author), TNO Kwaliteit van Leven (author)
Therapy with interferon-β (IFN-β) has well-established clinical effects in multiple sclerosis (MS), albeit the immunomodulatory mechanisms are not fully understood. We assessed the prevalence and functional capacity of CD4+ and CD8+ T cells in healthy donors, and in untreated and IFN-β-treated MS patients, in response to myelin oligodendrocyte...
article 2007
document
van Noort, J.M. (author), Verbeek, R. (author), Meilof, J.F. (author), Polman, C.H. (author), Amor, S. (author), TNO Kwaliteit van Leven (author)
Human T-cell responses to the stress protein alpha B-crystallin in multiple sclerosis (MS)-affected brain samples are dominant when compared to other myelin antigens. The establishment of the apparent autoimmune repertoire against this antigen has been suggested to involve cross-priming during viral infection. Yet, another possibility would be...
article 2006
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Bsibsi, M. (author), Ravid, R. (author), Gveric, D. (author), van Noort, J.M. (author)
The family of Toll-like receptors (TLRs) plays a key role in controlling innate immune responses to a wide variety of pathogen-associated molecules. In this study we investigated expression of TLRs in vitro by purified human microglia, astrocytes, and oligodendrocytes, and in vivo by immunohistochemical examination of brain and spinal cord...
article 2002
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Thoua, N.-M. (author), van Noort, J.M. (author), Baker, D. (author), Bose, A. (author), van Sechel, A.C. (author), van Stipdonk, M.J.B. (author), Travers, P.J. (author), Amor, S. (author), TNO Preventie en Gezondheid (author)
The stress protein αB-crystallin is an immunodominant antigen in multiple sclerosis (MS)-affected myelin for human T cells and is expressed at elevated levels in MS lesions. Using bovine αB-crystallin and synthetic peptides based on mouse αB-crystallin the ability of this stress protein to induce experimental allergic encephalomyelitis (EAE) was...
article 2000
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Bajramović, J.J. (author), Plomp, A.C. (author), van der Goes, A. (author), Koevoets, C. (author), Newcombe, J. (author), Cuzner, M.L. (author), van Noort, J.M. (author)
In the development of multiple sclerosis (MS), (re)activation of infiltrating T cells by myelin-derived Ags is considered to be a crucial step. Previously, αB-crystallin has been shown to be an important myelin Ag to human T cells. Since αB-crystallin is an intracellular heat shock protein, the question arises at what stage, if any, during...
article 2000
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Bajramović, J.J. (author), Bsibsi, M. (author), Geutskens, S.B. (author), Hassankhan, R. (author), Verhulst, K.C. (author), Stege, G.J.J. (author), de Groot, C.J.A. (author), van Noort, J.M. (author), TNO Preventie en Gezondheid (author)
Various lines of evidence suggest a close relationship between heat shock proteins (hsp) and several autoimmune diseases such as arthritis, diabetes and multiple sclerosis. While enhanced expression of hsp in autoimmune diseases is often regarded as a non-specific bystander effect of the inflammatory process, surprisingly little is known on hsp...
article 2000
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van Stipdonk, M.J.B. (author), Willems, A.A. (author), Verbeek, R. (author), Boog, C.J.P. (author), van Noort, J.M. (author), TNO Preventie en Gezondheid (author)
The myelin-associated stress protein αB-crystallin triggers strong proliferative responses and IFN-γ production by human T cells and it is considered a candidate autoantigen in multiple sclerosis. In this study we examined the capacity of αB-crystallin or peptides derived thereof to induce experimental autoimmune encephalomyelitis (EAE) in SJL...
article 2000
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van Stipdonk, M.J.B. (author), Willems, A.A. (author), Plomp, A.C. (author), van Noort, J.M. (author), Boog, C.J.P. (author), TNO Preventie en Gezondheid (author)
The myelin-associated protein, αB-crystallin, is considered a candidate autoantigen in multiple sclerosis (MS). In the present study, we examined the potential of αB-crystallin to induce experimental autoimmune encephalomyelitis (EAE) in Lewis rats. Attempts to induce EAE with either bovine, rat or murine αB-crystallin or αB-crystallin peptides...
article 2000
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van Stipdonk, M.J.B. (author), Willems, A.A. (author), Amor, S. (author), Persoon-Deen, C. (author), Travers, P.J. (author), Boog, C.J.P. (author), van Noort, J.M. (author), TNO Preventie en Gezondheid (author)
Factors such as developmental stage or physiological and infectious stress may change patterns of post-translational protein modification. In order to determine whether such regulated types of modification may influence T cell responsiveness to self proteins we examined the T cell response of SJL (H-2(S)) mice to αB-crystallin, a small heat...
article 1998
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van Noort, J.M. (author), TNO Preventie en Gezondheid (author)
Multiple sclerosis is the major neurological disease of young adults in the western world, affecting about 1 per 1,000. It is characterised by chronic or recurrent lesions of inflammatory damage in the white matter of the central nervous system. Within such lesions, the protective myelin sheath is stripped off axons by infiltrated macrophages...
article 1998
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Amor, S. (author), Baker, D. (author), Layward, L. (author), McCormack, K. (author), van Noort, J.M. (author), TNO Preventie en Gezondheid (author)
Correlation of the heterogeneic immunopathological profiles of multiple sclerosis (MS) lesions with the paraclinical and clinical markers of disease may be important in the development of therapeutic approaches in MS. This and other issues were discussed at a recent meeting.
article 1997
document
Bajramović, J.J. (author), Lassmann, H. (author), van Noort, J.M. (author), TNO Preventie en Gezondheid (author)
The small heat shock protein αB-crystallin was recently identified as a dominant human T-cell antigen in myelin derived from multiple sclerosis (MS) patients. Using immunohistochemical techniques, oligodendrocytes as well as astrocytes in MS lesions were shown to express α B-crystallin. In the present study we examined the expression of α B...
article 1997
document
van Noort, J.M. (author), TNO Preventie en Gezondheid (author)
The pathogenesis of multiple sclerosis (MS), the major neurological disease of young adults in the Western world, is still poorly understood, and no effective therapy to block MS is available as yet. The clinical symptoms of MS result from inflammatory damage to the insulating myelin sheath of axons in the CNS and - at later stages - to axons...
article 1996
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