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document
Snelten, H. (author), te Wierik, E. (author), Veenstra, J. (author), Schaafsma, G. (author)
article 1991
document
Schaafsma, G. (author)
article 1989
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Luyken, R. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
article 1979
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Schrikker, A.C.M. (author), de Vries, W.R. (author), Zwart, A. (author), Luijendijk, S.C.M. (author)
We have investigated the slope of the alveolar plateau for inert tracer gases that were washed out from mixed venous blood. Two pairs of tracer gases were used (He, SFe) and (C2H2, Freon 22). The gases of each pair share almost the same blood-gas partition coefïicient but they have different diffusive properties in the gas phase. The experiments...
article 1989
document
Boelsma, E. (author), Anderson, C. (author), Karlsson, A.M.J. (author), Ponec, M. (author)
article 2000
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Zwart, A. (author), Arts, J.H.E. (author), ten Berge, W.F. (author), Appelman, L.M. (author)
A new design for acute inhalation toxicity testing was evaluated and compared with results obtained according to OECD guideline 403. The new design consists of a range-finding test, which is compatible with a conventional limit test, and can be followed by determination of a concentration-time-mortality relationship, enabling calculation of LC50...
article 1992
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Beems, R.B. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)
article 1986
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Egger, R.J. (author), Meulmeester, J.F. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
article 1985
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Arts, C.J.M. (author), Govers, C.A.R.L. (author), van den Berg, H. (author), Wolters, M.G.E. (author), van Leeuwen, P. (author), Thijsen, J.H. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)
Within the framework of experiments related to the association between dietary fiber and breast cancer an in vitro test system was used to study the binding of estrogens to various fibers (e.g. cholestyramin, lignin and cellulose) and fiber sources (e.g. wheat bran, cereals, seeds and legumes). Furthermore, the in vivo apparent digestibility of...
article 1991
document
Satterlee, L.D. (author), Slump, P. (author)
article 1982
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Hooftman, R.N. (author), Kuper, C.F. (author), Appelman, L.M. (author), Hoofdgroep Maatschappelijke Technologie TNO (author)
The sensitivity of different parameters for the determination of lung injury caused by nitrogen dioxide (NO2) was investigated. Male rats were exposed to concentrations of 0, 4, 10 or 25 ppm NO2 for 6 h/day, for 7, 14 or 21 days. Histopathology of the nasal cavity, larynx, trachea and lungs was compared with the changes in macrophage function...
article 1988
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Groenen, P.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
article 1973
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Rodenburg, R.J.T. (author), Ganga, A. (author), van Lent, P.L.E.M. (author), van de Putte, L.B.A. (author), van Venrooij, W.J. (author)
Objective. Sulfasalazine (SSZ) is a commonly used drug in the treatment of inflammatory diseases such as rheumatoid arthritis and Crohn's disease. In both diseases, the proinflammatory cytokine tumor necrosis factor α (TNFα) plays a prominent role. In these studies, we investigated the mechanism by which SSZ inhibits TNFα expression in...
article 2000
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Feron, V.J. (author), Kruysse, A. (author), Til, H.P. (author), Immel, H.R. (author), Centraal instituut voor voedingsonderzoek TNO (author)
The subacute inhalation toxicity of acrolein was examined in 4 groups of 20 hamsters, 12 rats and 4 rabbits each, exposed repeatedly to acrolein vapour at concentrations of 0, 0.4, 1.4 and 4.9 ppm (6 hr/day, 5 days/week) for a 13-week period. The most important effects found at the highest level included mortality in rats, ocular and nasal...
article 1978
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Krul, C.A.M. (author), Luiten-Schuite, A. (author), Baan, R. (author), Verhagen, H. (author), Mohn, G. (author), Feron, V. (author), Havenaar, R. (author)
The TNO gastro-Intestinal tract Model (TIM) is a dynamic computer-controlled in vitro system that mimics the human physiological conditions in the stomach and small intestine. In the current TIM physiological parameters such as pH, temperature, peristaltic movements, secretion of digestion enzymes, bile and pancreatic juices, and absorption of...
article 2000
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Hautvast, J.G.A.J. (author), Hermus, R.J.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
article 1979
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van 't Veer, P. (author), Kolb, C.M. (author), Verhoef, P. (author), Kok, F.J. (author), Schouten, E.G. (author), Hermus, R.J.J. (author), Sturmans, F. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)
To study the association between dietary fiber, beta-carotene and breast cancer, the average daily intake of these dietary components was compared among 133 incident breast cancer cases and 238 population controls. Average daily intake of cereal products, fruit and vegetables was also studied. A statistically significant lower energy-adjusted...
article 1990
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Gibney, M.J. (author), Serra-Majem, L. (author), Kearney, J.M. (author), Becker, W. (author), Löwik, M.R.H. (author)
article 2000
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Löwik, M.R.H. (author), Hofman, Z. (author), Kok, F.J. (author), Wedel, M. (author), Hulshof, K.F.A.M. (author), Odink, J. (author), Schaafsma, G. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)
Associations between blood pressure and nutrition-related variables (body mass index, dietary intake, and 24-hr excretion of sodium, potassium, magnesium, and calcium in the urine) were investigated in men (n = 138) and women (n = 117) 65-79 years old not using drugs known to affect blood pressure and not on a diet. Among men, body mass index...
article 1991
document
Zeijdner, E.E. (author), Havenaar, R. (author)
article 2000
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