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Appelman, L.M. (author), ten Berge, W.F. (author), Reuzel, P.G.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The acute inhalation toxicity of ammonia was examined in rats using various exposure concentrations and exposure periods. Groups of male and female rats were exposed to dynamic atmospheres containing different concentrations of ammonia for 10, 20, 40 or 60 min. The aim of the study was to establish the relationship between exposure concentration...
article 1982
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Feron, V.J. (author), Immel, H.R. (author), Spit, B.J. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)
The trachea of Syrian golden hamsters was injured by electrocoagulation. The lesions induced as well as the repair process were studied by light and scanning electron microscopy. The changes observed were considered to create the proper conditions for studying the significance of severe focal damage to the respiratory tract for the formation of...
article 1984
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Speek, A.J. (author), Thissen, J.T.N.M. (author), Schrijver, J. (author), Instituut CIVO-Toxicologie en voeding TNO (author)
The urinary excretion of 3-methylhistidine and creatinine and the urinary 3-methylhistidine to creatinine excretion ratio during day and night were investigated in a group of 103 healthy, normally fed Dutch children (52 boys and 51 girls) aged 2-17 years. The 3-methylhistidine to creatinine ratio of the night urine appeared to be significantly...
article 1986
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Lowik, M.R.H. (author), Schrijver, J. (author), Odink, J. (author), van den Berg, H. (author), Wedel, M. (author), Hermus, R.J.J. (author), TNO Kwaliteit van Leven (author)
In a nationwide survey the nutritional status was assessed of 539 apparently healthy, independently living elderly aged 65-79 years. Anthropometric data showed no energy deficits. The prevalence of anemia was 4 and 1% among men and women, respectively. Many elderly showed a low level of 25-hydroxyvitamin D in plasma (< 31 nmol/L: men 35%; women...
article 1990
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Goldbohm, R.A. (author), van den Brandt, P.A. (author), van 't Veer, P. (author), Dorant, E. (author), Sturmans, F. (author), Hermus, R.J.J. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)
The association between alcohol consumption and cancer of the colon and rectum was investigated in a prospective cohort study, conducted in the Netherlands from 1986 onwards among 120,852 men and women, aged 55 to 69 years. During 3.3 years of follow-up, 312 and 166 cases of colon and rectal cancer had accumulated, respectively. After exclusion...
article 1994
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van Ree, J.H. (author), van den Broek, W.J.A.A. (author), Dahlmans, V.E.H. (author), Groot, P.H.E. (author), Vidgeon-Hart, M. (author), Frants, R.R. (author), Wieringa, B. (author), Havekes, L.M. (author), Hofker, M.H. (author), TNO Preventie en Gezondheid (author)
Apolipoprotein (apo) E is a ligand for the receptor-mediated uptake of lipoprotein remnant particles. Complete absence of apo E in humans leads to a severe form of type III hyperlipoproteinemia. We have used targeted inactivation in murine embryonic stem cells, as also described by others, to specifically study the effects of heterozygous Apoe...
article 1994
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Goldbohm, R.A. (author), van 't Veer, P. (author), van den Brandt, P.A. (author), van 't Hof, M.A. (author), Brants, H.A.M. (author), Sturmans, F. (author), Hermus, R.J.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Objectives: In studies on diet and cancer, diet assessment should address long-term intake. Therefore, the authors determined the 5-year reproducibility of a self-adminstered 150-item food frequency questionnaire (FFQ) used to assess dietary habits in the Netherlands Cohort Study on diet and cancer. Since the FFQ was repeated more than once, the...
article 1995
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Grootenhuis, P.A. (author), Westenbrink, S. (author), Sie, C.M.T.L. (author), de Neeling, J.N.D. (author), Kok, F.J. (author), Bouter, L.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
A self-administered semiquantitative food frequency questionnaire including 75 food items and providing information on the habitual intake of 31 nutritional parameters, based on the intake of protein, fat, carbohydrate, fiber and 11 vitamins and minerals, was developed for use in epidemiologic research on chronic disease among the elderly, such...
article 1995
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Brussaard, J.H. (author), Hulshof, K.F.A.M. (author), Löwik, M.R.H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
To estimate the effect of possible goitre prophylactic measures on the intake of iodine among population groups, simulation studies, based on the first Dutch National Food Consumption Survey, were carried out. Iodine intake figures and prevalence of low intakes were calculated after fictively iodizing either bread, a combination of industrial...
article 1995
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Dirven, H.A.A.M. (author), Dictus, E.L.J.T. (author), Broeders, N.L.H.L. (author), van Ommen, B. (author), van Bladeren, P.J. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)
Nonenzymatic and glutathione S-transferase (GST) catalyzed glutathione (GSH) conjugation has been postulated as a mechanism by which alkylating cytostatic drugs can be inactivated intracellularly. In this study, we describe studies on the glutathione-dependent biotransformation of thiotepa (tris(1-aziridinyl)phosphine sulfide), a trifunctional...
article 1995
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de Heer, C. (author), Schuurman, H.J. (author), Houben, G.F. (author), Pieters, R.H.H. (author), Penninks, A.H. (author), van Loveren, H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
SCID mice engrafted with human fetal thymus and liver tissue fragments (SCID-hu mice) are currently considered as a new tool in human immunotoxicological risk assessment. Testing of various immunotoxicants exerting thymotoxicity via different intrathymic target cell types is necessary for validation of this model. Therefore, SCID-hu mice were...
article 1995
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Kardinaal, A.F.M. (author), van 't Veer, P. (author), Brants, H.A.M. (author), van den Berg, H. (author), van Schoonhoven, J. (author), Hermus, R.J.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
For an evaluation of fat-soluble vitamin concentrations in adipose tissue as biomarkers of intake, estimates of usual intake of β-carotene, total vitamin A, and vitamin E (assessed by food frequency questionnaire) were compared with plasma and adipose tissue concentrations of β-carotene, retinol, and α-tocopherol, respectively. Data were...
article 1995
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Virtanen, S.M. (author), van 't Veer, P. (author), Kok, F. (author), Kardinaal, A.F.M. (author), Aro, A. (author), EURAMIC Study Group (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Objective: To evaluate the levels of adipose tissue alpha-tocopherol, gamma-tocopherol, and toenail selenium and their determinants. Design: Control subjects from multicentre case-control study on antioxidants, myocardial infarction and cancer of the breast. Subjects and setting: 686 male and 339 female middle-aged and elderly subjects from...
article 1996
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Brussaard, J.H. (author), van Dokkum, W. (author), van der Paauw, C.G. (author), de Vos, R.H. (author), de Kort, W.L.A.M. (author), Löwik, M.R.H. (author), TNO Voeding (author)
To assess the level of exposure to food contaminants (cadmium, lead, PCBs, DDT, hexachlorobenzene, nitrate and malathion) a total-diet study was carried out. A total of 226 food products were analysed individually; the concentration of contaminants in products not selected for analysis was estimated with the help of published data. The results...
article 1996
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Hunter, D.J. (author), Spiegelman, D. (author), Adami, H.O. (author), Beeson, L. (author), van den Brandt, P.A. (author), Folsom, A.R. (author), Fraser, G.E. (author), Goldbohm, R.A. (author), Graham, S. (author), Howe, G.R. (author), Kushi, L.H. (author), Marshall, J.R. (author), Mcdermott, A. (author), Miller, A.B. (author), Speizer, F.E. (author), Wolk, A. (author), Yaun, S.S. (author), Willett, W. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Background. Experiments in animals, international correlation comparisons, and case-control studies support an association between dietary fat intake and the incidence of breast cancer. Most cohort studies do not corroborate the association, but they have been criticized for involving small numbers of cases, homogeneous fat intake, and...
article 1996
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Schifferstein, H.N.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The Equiratio Mixture Model predicts the psychophysical function for an equiratio mixture type on the basis of the psychophysical functions for the unmixed components. The model reliably estimates the sweetness of mixtures of sugars and sugar-alchohols, but is unable to predict intensity for aspartame/sucrose mixtures. In this paper, the...
article 1996
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van Vliet, T. (author), van Schaik, F. (author), Schreurs, W.H.P. (author), van den Berg, H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
In view of controversies about assessment of the β-carotene cleavage activity, methodological aspects and problems of the dioxygenase assay are described. Using rat and hamster intestinal preparations the method was optimized on retinal formation, the only cleavage product we could demonstrate. It appeared that the cell fraction with the highest...
article 1996
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Verhagen, H. (author), Rauma, A.L. (author), Törrönen, R. (author), de Vogel, N. (author), Bruijntjes-Rozier, G.C.D.M. (author), Dreve, M.A. (author), Bogaards, J.J.P. (author), Mykkänen, H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
1. In order to study the potential beneficial effects of a vegan diet, a cross-sectional study was performed and several biomarkers of chemoprevention were measured in a population of female 'living food' eaters ('vegans'; n = 20) vs matched omnivorous controls (n = 20). 2. White blood cells obtained from fresh blood samples were subjected to...
article 1996
document
van 't Veer, P. (author), Strain, J.J. (author), Fernandez-Crehuet, J. (author), Martin, B.C. (author), Thamm, M. (author), Kardinaal, A.F.M. (author), Kohlmeier, L. (author), Huttunen, J.K. (author), Martin-Moreno, J.M. (author), Kok, F.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Antioxidants may protect against free radical mediated carcinogenesis. Epidemiological studies have not confirmed this hypothesis for breast cancer, possibly because of methodological limitations. Time-integrated exposure of α-tocopherol and β-carotene in adipose tissue, and selenium in toenails was investigated in a case-control study among...
article 1996
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van den Berg, H. (author), Hulshof, K.F.A.M. (author), Deslypere, J.P. (author), TNO Voeding (author)
Objective. To determine how much vitamin A is consumed through liver and liver products by non-pregnant and pregnant women aged 16-50 years, and to determine the implications for the use of multivitamin products. Design. Secondary analysis on data from representative database Dutch National Food Consumption Survey. Method. Data were obtained...
article 1996
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