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Virtanen, S.M. (author), van 't Veer, P. (author), Kok, F. (author), Kardinaal, A.F.M. (author), Aro, A. (author), EURAMIC Study Group (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Objective: To evaluate the levels of adipose tissue alpha-tocopherol, gamma-tocopherol, and toenail selenium and their determinants. Design: Control subjects from multicentre case-control study on antioxidants, myocardial infarction and cancer of the breast. Subjects and setting: 686 male and 339 female middle-aged and elderly subjects from...
article 1996
document
Brussaard, J.H. (author), van Dokkum, W. (author), van der Paauw, C.G. (author), de Vos, R.H. (author), de Kort, W.L.A.M. (author), Löwik, M.R.H. (author), TNO Voeding (author)
To assess the level of exposure to food contaminants (cadmium, lead, PCBs, DDT, hexachlorobenzene, nitrate and malathion) a total-diet study was carried out. A total of 226 food products were analysed individually; the concentration of contaminants in products not selected for analysis was estimated with the help of published data. The results...
article 1996
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Schifferstein, H.N.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The Equiratio Mixture Model predicts the psychophysical function for an equiratio mixture type on the basis of the psychophysical functions for the unmixed components. The model reliably estimates the sweetness of mixtures of sugars and sugar-alchohols, but is unable to predict intensity for aspartame/sucrose mixtures. In this paper, the...
article 1996
document
te Velthuis- Wierik, E.J.M. (author), van den Berg, H. (author), Weststrate, J.A. (author), van het Hof, K.H. (author), de Graaf, C. (author), TNO Voeding (author)
Objective: Dietary fat intake is higher than recommended in most western countries and is associated with the prevalence of cardiovascular diseases, obesity and cancer. The growing public concern about the adverse effects of a high fat intake has led to an increased availability of 'reduced-fat' products. Consumption of reduced-fat products...
article 1996
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Dorant, E. (author), van den Brandt, P.A. (author), Goldbohm, R.A. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)
The association between onion and leek consumption, garlic supplement use and colon and rectum carcinoma among men and women was evaluated in the Netherlands Cohort Study, a large-scale prospective cohort study on diet and cancer. Onions, leeks, and garlic belong to the Allium genus and contain large amounts of potentially chemopreventive...
article 1996
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Verhoeven, D.T.H. (author), Goldbohm, R.A. (author), van Poppel, G. (author), Verhagen, H. (author), van den Brandt, P.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
This paper gives an overview of the epidemiological data concerning the cancer-preventive effect of brassica vegetables, including cabbage, kale, broccoli, Brussels sprouts, and cauliflower. The protective effect of brassicas against cancer may be due to their relatively high content of glucosinolates. Certain hydrolysis products of...
article 1996
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Goldbohm, R.A. (author), Hertog, M.G.L. (author), Brants, H.A.M. (author), van Poppel, G. (author), van den Brandt, P.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Background: Tea is one of the most frequently consumed beverages in the world. Antioxidant polyphenol compounds (such as catechins and flavonols) are abundantly present in both green and black teas and have been observed to have anticarcinogenic properties in cell and animal model studies. In black tea, however, most of the catechins have been...
article 1996
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Löwik, M.R.H. (author), Hulshof, K.F.A.M. (author), Brussaard, J.H. (author), Brants, H.A.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
conference paper 1996
document
Brugman, E. (author), Meulmeester, J.F. (author), van der Spee-Wekke, A. (author), Beuker, R.J. (author), Zaadstra, B.M. (author), Radder, J.J. (author), Verloove-Vanhorick, P.S. (author), TNO Preventie en Gezondheid (author)
OBJECTIVE: To estimate the prevalence of dieting and the relationship between dieting, nutritional habits, and health among young adolescents in the Netherlands. METHODS: Out of 1359 secondary school children, aged 13 through 15 y, who were invited for a routine health assessment by school doctors or nurses as part of the Child Health Monitoring...
article 1997
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Botterweck, A.A.M. (author), van den Brandt, P.A. (author), Goldbohm, R.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The association between vegetable and fruit consumption and stomach cancer risk was investigated in the Netherlands Cohort Study among 120,852 men and women aged 55-69 years at the start in September 1986. Analyses were based on 282 incident stomach cancer cases after 6.3 years of follow-up. Age- and sex-adjusted rate ratios of stomach cancer in...
article 1998
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Su, L.C.J. (author), Bui, M. (author), Kardinaal, A. (author), Gomez-Aracena, J. (author), Martin-Moreno, J. (author), Martin, B. (author), Thamm, M. (author), Simonsen, N. (author), van 't Veer, P. (author), Kok, F. (author), Strain, S. (author), Kohlmeier, L. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Biomarkers of dietary exposure or nutritional status are sought actively to overcome limitations of traditional dietary methodology. We compared plasma and adipose tissue biomarkers for carotenoids and tocopherols. The data consisted of samples from 91 men and 122 women, ages 45-70 years, from the control group of the European Community...
article 1998
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van Dokkum, W. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
bookPart 1998
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Goldbohm, R.A. (author), Brants, H.A.M. (author), Hulshof, K.F.A.M. (author), van den Brandt, P.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
This study presents data on dietary intake of specific carotenoids in the Netherlands, based on a recently developed food composition database for carotenoids. Regularly eaten vegetables, the main dietary source of carotenoids, were sampled comprehensively and analysed with modern analytic methods. The database was complemented with data from...
article 1998
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Korst, A.E.C. (author), van der Sterre, M.L.T. (author), Gall, H.E. (author), Fichtinger-Schepman, A.M.J. (author), Vermorken, J.B. (author), van der Vijgh, W.J.F. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The pharmacokinetics of cisplatin was investigated in 13 patients receiving 18 courses of cisplatin alone or in combination with amifostine to investigate the influence of amifostine (WR 2721; Ethyol) on the pharmacokinetics of cisplatin. Cisplatin was administered as a 1-h i.v. infusion, whereas amifostine was given i.v. over 15 min just before...
article 1998
document
Weststrate, J.A. (author), van het Hof, K.H. (author), van den Berg, H. (author), te Velthuis-te-Wierik, E.J.M. (author), de Graaf, C. (author), Zimmermanns, N.J.H. (author), Westerterp, K.R. (author), Westerterp-Plantenga, M.S. (author), van de Verboeket-Venne, W.P.H.G. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Objectives: To compare the effects of free access to reduced fat products or their full fat equivalents on fat and energy intake, body weight, plasma lipids and fat-soluble antioxidants concentrations and haemostasis variables. Design: A multicentre open randomised controlled trial in which intervention and control groups were followed in...
article 1998
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Klipstein-Grobusch, K. (author), den Breeijen, J.H. (author), Goldbohm, R.A. (author), Geleijnse, J.M. (author), Hofman, A. (author), Grobbee, D.E. (author), Witteman, J.C.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Objective: The study was conducted to assess the relative validity of a 170-item semiquantitative food frequency questionnaire (SFFQ) adapted for use in the elderly. Design and subjects: The study was carried out in a sample of 80 men and women aged 55-75 y participating in a community based prospective cohort study in Rotterdam, The Netherlands...
article 1998
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Hendriks, H.F.J. (author), Veenstra, J. (author), van Tol, A. (author), Groener, J.E.M. (author), Schaafsma, G. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Moderate alcohol consumption is associated with a reduced risk of coronary heart disease. In this study, postprandial changes in plasma lipids, high-density lipoprotein (HDL) composition and cholesteryl ester transfer protein (CETP) and lecithin: cholesterol acyltransferase (LCAT) activity levels were investigated in response to moderate alcohol...
article 1998
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van Poppel, G. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Chemicals/CAS: Fatty Acids
article 1998
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Stouten, H. (author), Bessems, J.G.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
As part of a health-hazard survey on the health risk of hospital cleaning workers from exposure to Lyorthol, a hazard assessment of o-benzo-p-chlorophenol, one of the constituents of Lyorthol, has been prepared. In this paper, the physical and chemical characteristics, kinetics and effects of o-benzochlorophenol are described and discussed, and...
article 1998
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Sherratt, P.J. (author), Manson, M.M. (author), Thomson, A.M. (author), Hissink, E.A.M. (author), Neal, G.E. (author), van Bladeren, P.J. (author), Green, T. (author), Hayes, J.D. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
A characteristic feature of the class Theta glutathione S-transferase (GST) T1-1 is its ability to activate dichloromethane and dibromoethane by catalysing the formation of mutagenic conjugates. The level of the GSTT1 subunit within tissues is an important determinant of susceptibility to the carcinogenic effects of these dihaloalkanes. In the...
article 1998
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