Searched for: +
(1 - 6 of 6)
document
van Delft, J.H.M. (author), van den Ende, A.M.C. (author), Keizer, H.J. (author), Ouwerkerk, J. (author), Baan, R.A. (author), Centraal Instituut voor Voedingsonderzoek TNO Medisch Biologisch Laboratorium TNO (author)
An ELISA method was used to determine N7-methylguanine (N7-MeGua) adducts in DNA of white blood cells from cancer patients treated with the methylating antitumor drug dacarbazine by i.v. administration. From four patients who received dacarbazine only, at dosages of 250, 400 or 800 mg/m2, the blood samples were collected before and several days...
article 1992
document
TNO Preventie en Gezondheid (author), Boomsma, D.I. (author), Beem, A.L. (author), van den Berg, M. (author), Dolan, C.V. (author), Koopmans, J.R. (author), Vink, J.M. (author), de Geus, E.J.C. (author), Slagboom, P.E. (author)
In a longitudinal study of Dutch adolescent and young adult twins, their parents and their siblings, questionnaire data were collected on depression, anxiety and correlated personality traits, such as neuroticism. Data were collected by mailed surveys in 1991, 1993, 1995 and 1997. A total of 13 717 individuals from 3344 families were included in...
article 2000
document
Gaubius Instituut TNO Preventie en Gezondheid (author), Hoekstra, C. (author), Meijer, P. (author), Kluft, C. (author), Heutink, P. (author), Smit, G. (author), de Geus, E. (author), Smit, J.H. (author), van Bruggen, A. (author), Montgomery, G.W. (author), Boomsma, D.I. (author)
To locate the genes that make a substantial contribution to variation in natural dizygotic twinning in humans, large-scale studies are needed. New studies should not stop at DNA genotyping, but collect material that allow gene-expression analysis, transcriptomics, proteomics and endocrinology. In this article we describe a pilot study to examine...
article 2004
document
Walker, L.C. (author), Overstreet, M.A. (author), Siddiqui, A. (author), de Paepe, A. (author), Ceylaner, G. (author), Malfait, F. (author), Symoens, S. (author), Atsawasuwan, P. (author), Yamauchi, M. (author), Ceylaner, S. (author), Bank, R.A. (author), Yeowell, H.N. (author), TNO Preventie en Gezondheid (author)
The clinical diagnosis of a patient with the phenotype of Ehlers-Danlos syndrome type VI was confirmed biochemically by the severely diminished level of lysyl hydroxylase (LH) activity in the patient's skin fibroblasts. A novel homozygous mutation, a single base change of T1360 → G in exon 13 of the LH1 gene, predicted to result in W446G, was...
article 2005
document
Schouten, L.J. (author), van Dijk, B.A.C. (author), Oosterwijk, E. (author), van Engeland, M. (author), van de Hulsbergen-Kaa, C.A. (author), Kiemeney, L.A.L.M. (author), Goldbohm, R.A. (author), Kester, A. (author), de Vogel, S. (author), Schalken, J.A. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)
Alcohol consumption has been associated with a decreased risk for renal cell cancer in several studies. We investigated whether alcohol is associated with (epi)genetic changes of the von Hippel-Lindau (VHL) gene in renal cell cancer. The Netherlands Cohort Study (NLCS) on Diet and Cancer started in 1986 (n = 120,852) and uses the case-cohort...
article 2008
document
Celis-Morales, C. (author), Livingstone, K.M. (author), Woolhead, C. (author), Forster, H. (author), O’Donovan, C.B. (author), Macready, A.L. (author), Fallaize, R. (author), Marsaux, C.F.M. (author), Tsirigoti, L. (author), Efstathopoulou, E. (author), Moschonis, G. (author), Navas-Carretero, S. (author), San-Cristobal, R. (author), Kolossa, S. (author), Klein, U.L. (author), Hallmann, J. (author), Godlewska, M. (author), Surwiłło, A. (author), Drevon, C.A. (author), Bouwman, J. (author), Grimaldi, K. (author), Parnell, L.D. (author), Manios, Y. (author), Traczyk, I. (author), Gibney, E.R. (author), Brennan, L. (author), Walsh, M.C. (author), Lovegrove, J.A. (author), Martinez, J.A. (author), Daniel, H. (author), Saris, W.H.M. (author), Gibney, M. (author), Mathers, J.C. (author)
In e-health intervention studies, there are concerns about the reliability of internet-based, self-reported (SR) data and about the potential for identity fraud. This study introduced and tested a novel procedure for assessing the validity of internet-based, SR identity and validated anthropometric and demographic data via measurements performed...
article 2015
Searched for: +
(1 - 6 of 6)