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document
Brouwer, D.H. (author), Aitken, R.J. (author), Oppl, R. (author), Cherrie, J.W. (author), TNO Kwaliteit van Leven (author)
This article proposes a common language for better understanding processes involved in dermal exposure and skin protection. A conceptual model has been developed that systematically describes the transport of agent mass from sources, eventually resulting in "loading" of the skin surface or the skin contaminant layer. In view of a harmonized...
article 2005
document
de Looze, M.P. (author), Urlings, I.J.M. (author), Vink, P. (author), van Rhijn, J.W. (author), Miedema, M.C. (author), Bronkhorst, R.E. (author), van der Grinten, M.P. (author)
Lifting, carrying, pushing and pulling at work are assumed to be related to increased risks of musculoskeletal injury, mainly in the low back and shoulder region. The implementation of products to reduce the physical load in heavy work is a well-known strategy to attack this problem. The success of these products depends not only on the product...
article 2001
document
Griffiths, R. (author), Grieve, A. (author), Scollon, J. (author), Scott, M. (author), Williams, C. (author), Meredith, C. (author), TNO Kwaliteit van Leven TNO Bibra (author)
Using primary cultures of mouse cerebellar granule cells as an in vitro model system, it has been demonstrated that different profiles of temporal expression of the c-fos proto-oncogene are observed under non-excitotoxic and excitotoxic conditions. A ratio has been derived previously for the steady- state level of c-fos mRNA after 30 min and 240...
article 2000
document
Maas, W.J.M. (author), de Graaf, I.A.M. (author), Schoen, E.D. (author), Koster, H.J. (author), van de Sandt, J.J.M. (author), Groten, J.P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
A number of studies on the cryopreservation of precision-cut liver slices using various techniques have been reported. However, the identification of important factors that determine cell viability following cryopreservation is difficult because of large differences between the various methods published. The aim of this study was to evaluate...
article 2000
document
Schultz, F.W. (author), Geleijns, J. (author), Holscher, H.C. (author), Weststrate, J. (author), Zonderland, H.M. (author), Zoetelief, J. (author), Instituut voor Toegepaste Radiobiologie en Immunologie TNO (author)
Micturating cystourethrography (MCU) examinations of paediatric patients in a major Dutch children's hospital (JKZ) were evaluated to generate quantitative information on effective dose (E). A standard examination involves three radiographs plus fluoroscopy. Observed total dose-area product (DAP) for 84 children increased, on average, with...
article 1999
document
Turnbull, D. (author), Frankos, V.H. (author), van Delft, J.H.M. (author), de Vogel, N. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Plant stanol esters from wood and vegetable oil sources were tested for genotoxicity in bacterial (Salmonella typhimurium) and mammalian cell (L5178Y) gene mutation assays and in a mammalian cell chromosome aberration assay (CHO cells). The two stanol ester formulations were tested separately at doses up to the limit of solubility, with and...
article 1999
document
Omboni, S. (author), Parati, G. (author), Castiglioni, P. (author), di Rienzo, M. (author), Imholz, B.P.M. (author), Langewouters, G.J. (author), Wesseling, K.H. (author), Mancia, G. (author), TNO Biomedical Instrumentation (author)
Portapres is a noninvasive, beat-to-beat finger blood pressure (BP) monitor that has been shown to accurately estimate 24-hour intra-arterial BP at normal and high BPs. However, no information is available on the ability of this device to accurately track ambulatory BP variability. In 20 ambulatory normotensive and hypertensive subjects, we...
article 1998
document
Theunissen, N.C.M. (author), Vogels, T.G.C. (author), Koopman, H.M. (author), Verrips, G.H.W. (author), Zwinderman, K.A.H. (author), Verloove-Vanhorick, S.P. (author), Wit, J.M. (author), TNO Preventie en Gezondheid (author)
This study evaluates the agreement between child and parent reports on children's health-related quality of life (HRQoL) in a representative sample of 1,105 Dutch children (age 8-11 years old). Both children and their parents completed a 56 item questionnaire (TACQOL). The questionnaire contains seven eight-item scales: physical complaints,...
article 1998
document
Vogels, T. (author), Verrips, G.H.W. (author), Verloove-Vanhorick, S.P. (author), Fekkes, M. (author), Kamphuis, R.P. (author), Koopman, H.M. (author), Theunissen, N.C.M. (author), Wit, J.M. (author), TNO Preventie en Gezondheid (author)
Health-related quality of life (HRQoL), conceptualized as patients' own evaluations of their health status, is an important criterion in evaluating health and health care and in the treatment of individual patients. Until now, few systematic attempts have been made to develop instruments to assess the HRQoL of children using such a...
article 1998
document
Imholz, B.P.M. (author), Wieling, W. (author), van Montfrans, G.A. (author), Wesseling, K.H. (author), TNO Biomedical Instrumentation (author)
We review the Finapres technology, embodied in several TNO-prototypes and in the Ohmeda 2300 and 2300e Finapres NIBP. Finapres is an acronym for FINger Arterial PRESsure, the device delivers a continuous finger arterial pressure waveform. Many papers report on the accuracy of the device in comparison with intra-arterial or with noninvasive but...
article 1998
document
van den Broek, P.J. (author), Haerkens, H.M.J. (author), van Weert, N.J.H.W. (author), Vermeij, P. (author), TNO Preventie en Gezondheid (author)
Objective. To determine whether intravenous home treatment with antimicrobial drugs of patients with an infection is feasible. Design. Descriptive. Setting. Academic Hospital, Leiden, the Netherlands. Method. In October 1992 a programme for intravenous home treatment of patients with infectious diseases was started. The programme was based on...
article 1997
document
van den Berg, H. (author), Hulshof, K.F.A.M. (author), Deslypere, J.P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Objective: To assess the distribution of dietary vitamin A intake among Dutch women aged 16-50 and among pregnant women, and to evaluate the effect of the use of a vitamin A (1200 RE) containing multivitamin supplement in terms of nutritional and teratogenic risk. Study design: Data from the 2nd Dutch national food consumption survey (1992) were...
article 1996
document
TNO Voeding (author), van Leeuwen, P. (author), Veldman, A. (author), Boisen, S. (author), Deuring, K. (author), van Kempen, G.J.M. (author), Derksen, G.B. (author), Verstegen, M.W.A. (author), Schaafsma, G. (author)
Two experiments were conducted to determine apparent ileal DM and crude-protein (CP) digestibilities in rations fed to pigs. An evaluation was made of Cr2O3 and HCl-insoluble ash as digestive markers. In addition, the effects of body weight (BW) on apparent ileal DM and CP (N x 6.25) digestibilities were studied. In Expt 1, thirteen barrows...
article 1996
document
Le Jeune, C. (author), Lonvaud-Funel, A. (author), ten Brink, B. (author), Hofstra, H. (author), van der Vossen, J.M.B.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
On the basis of the comparison of the nucleotide sequences of the histidine decarboxylase genes (hdcA) of Lactobacillus 30A and Clostridium perfringens and the amino acid sequences of these histidine decarboxylases and those of Lactobacillus buchneri and Micrococcus, oligonucleotides unique to the hdcA genes were synthesized and used in PCR. All...
article 1995
document
Draaisma, D. (author), Dam, J. (author), de Winter, C.R. (author), Nederlands Instituut voor Praeventieve Gezondheidszorg TNO (author)
In a debate on the desired occupational health service in The Netherlands all parties involved seemed to be rather unsatisfied with the current practice. Therefore a study was set out on the quality of the service to 51 client organizations as seen by the parties involved. In the first phase the viewpoint of the occupational health teams was...
article 1993
document
Steenwinkel, M.J.S.T. (author), Roggeband, R. (author), van Delft, J.H.M. (author), Baan, R.A. (author)
This contribution describes methodological modifications and improvements that may contribute to inter-assay reproducibility and more accurate adduct quantification for 32P-postlabelling. Firstly, an anion-exchange chromatography procedure was developed to determine the amount of DNA used per assay and to check its purity, in particular to...
bookPart 1993
document
Gaubius Instituut TNO (author), Atsma, D.E. (author), Kempen, H.J.M. (author), Nieuwenhuizen, W. (author), van 't Hooft, F.M. (author), Pauwels, E.K.J. (author)
Four 99mTc and three 123I labeling methods were evaluated for their suitability to label low density lipoproteins (LDL) for the purpose of scintigraphic biodistribution studies. For 99mTc these methods were: direct incorporation in LDL of 99mTcO4- using sodium dithionite (dithionite method); a method using first N,N-dimethylformamide to prepare...
article 1991
document
Speek, A.J. (author), van Agtmaal, E.J. (author), Saowakontha, S. (author), Schreurs, W.H.P. (author), van Haeringen, N.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
A fast and sensitive high-performance liquid chromatographic (HPLC) method for the determination of vitamin A (all-trans retinol) in 50 ??l human tear fluid is described. After deproteinization with ethanol and extraction with n-hexane, retinol is separated from the extract on a straight-phase HPLC column and detected fluorometrically. Vitamin A...
article 1986
document
Hagenbeek, A. (author), Martens, A.C.M. (author), Radiobiologisch Instituut TNO (author)
Results of three different regimens of extracorporeal irradiation of the blood (ECIB) are compared (1 X 20,2 X 10, and 4 X 5hr) in a rat model for human acute myelocytic leukemia. The D0 for X rays of leukemic cells in the blood was 68 cGy. The transit dose varied from 380 to 660 cGy. Evaluation was performed by follow-up of the number of...
article 1981
document
Polak, R.L. (author), Molenaar, P.C. (author), Medisch Biologisch Laboratorium TNO (author)
Demethylation by sodium benzenethiolate has been used to analyse mixtures of isotopic variants of acetylcholine (ACh) by gas chromatography/mass spectrometry (GC/MS). The present experiments show that demethylation by pyrolysis is also suitable for the simultaneous determination of deuterium labelled variants of ACh by means of GC/MS. However,...
article 1974
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