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Walczak, A.P. (author), Kramer, E. (author), Hendriksen, P.J.M. (author), Tromp, P. (author), Helsper, J.P.F.G. (author), van der Zande, M. (author), Rietjens, I.M.C.M. (author), Bouwmeester, H. (author)
Intestinal translocation is a key factor for determining bioavailability of nanoparticles (NPs) after oral uptake. Therefore, we evaluated three in vitro intestinal cell models of increasing complexity which might affect the translocation of NPs: a mono-culture (Caco-2 cells), a co-culture with mucus secreting HT29-MTX cells and a tri-culture...
article 2015
document
Kloet, S.K. (author), Walczak, A.P. (author), Louisse, J. (author), van den Berg, H.H.J. (author), Bouwmeester, H. (author), Tromp, P. (author), Fokkink, R.G. (author), Rietjens, I.M.C.M. (author)
To obtain insight in translocation of nanoparticles across the placental barrier, translocation was studied for one positively and two negatively charged polystyrene nanoparticles (PS-NPs) of similar size in an in vitro model. The model consisted of BeWo b30 cells, derived from a human choriocarcinoma grown on a transwell insert forming a cell...
article 2015