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Pizzol, L. (author), Hristozov, D. (author), Zabeo, A. (author), Gianpietro, B. (author), Wohlleben, W. (author), Koivisto, A.J. (author), Jensen, K.A. (author), Fransman, W. (author), Stone, V. (author), Marcomini, A. (author)
The increasing use of engineered nanomaterials (ENMs) in nano-enabled products (NEPs) has raised societal concerns about their possible health and ecological implications. To ensure a high level of human and environmental protection it is essential to properly estimate the risks of these new materials and to develop adequate risk management...
article 2019
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Kuijpers, E. (author), Pronk, A. (author), Koivisto, A.J. (author), Jensen, K.A. (author), Vermeulen, R. (author), Fransman, W. (author)
Introduction. Knowledge on the exposure characteristics, including release of nanomaterials, is especially needed in the later stages of nano-enabled products’ life cycles to perform better occupational risk assessments. The objective of this study was to assess the concentrations during sawing and drilling in car bumpers containing multi-walled...
article 2019
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Semenzina, E. (author), Subramanian, V. (author), Pizzo, L. (author), Zabeo, A. (author), Fransman, W. (author), Oksel, C. (author), Hristozov, D. (author), Marcomini, A. (author)
The widespread use of engineered nanomaterials (ENMs) in consumer products and the overwhelming uncertainties in their ecological and human health risks have raised concerns regarding their safety among industries and regulators. There has been an ongoing debate over the past few decades on ways to overcome the challenges in assessing and...
article 2019
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Savic, N. (author), Gasic, B. (author), Schinkel, J. (author), Vernez, D. (author)
The Advanced REACH Tool (ART) is the most sophisticated tool used for evaluating exposure levels under the European Union's Registration, Evaluation, Authorisation and restriction of CHemicals (REACH) regulations. ART provides estimates at different percentiles of exposure and within different confidence intervals (CIs). However, its performance...
article 2018
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Koivisto, A.J. (author), Pizzol, L. (author), Basei, G. (author), Zabeo, A. (author), Mackevica, A. (author), Hansen, S.F. (author), Gosens, I. (author), Cassess, F.R. (author), de Jong, W. (author), Koivisto, A.J. (author), Neubauer, N. (author), Sanchaz, J.A. (author), Semenzin, E. (author), Subramanian, V. (author), Fransman, W. (author), Jensen, K.A. (author), Wohlleben, W. (author), Stone, V. (author), Marcomini, A. (author)
The use of nano-scale copper oxide (CuO) and basic copper carbonate (Cu2(OH)2CO3) in both ionic and micronized wood preservatives has raised concerns about the potential of these substances to cause adverse humans health effects. To address these concerns, we performed quantitative (probabilistic) human health risk assessment (HHRA) along the...
article 2018
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Goede, H.A. (author), Ploeg, D. (author), Schinkel, J.M. (author)
The development of a dermal exposure model is a challenge because of the complexity of dermal exposure processes on one hand, and the scarcity of good quality and contextually-rich dermal exposure measurements. Dermal exposure modelling is further complicated by the difficulty of measuring dermal exposure due to the lack of standardised methods ...
report 2018
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Bressot, C. (author), Shandilya, N. (author), Jayabalan, T. (author), Fayet, G. (author), Voetz, M. (author), Meunier, L. (author), Le Bihan, O. (author), Aguerre-Chariol, O. (author), Morgeneyer, M. (author)
Characterization of the exposition to nanoparticles and nano-objects at workplaces is a huge technical challenge. Workplace exposure during short durations is particularly difficult to detect due to the low performances of the samplers. This article proposes a solution allowing for characterizing emissions at workplaces and presents the results...
article 2018
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Pronk, A. (author), Stierum, R. (author)
Our health is impacted by the environment we grow up, live, work, sport, sleep and relax in. The combination of exposures during daily activities and over the lifetime constitutes a major risk factor for disease. Many common disorders are closely linked to these exposures ranging from lifestyle factors, to chemical exposures, social interactions...
other 2018
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Koivisto, A.J. (author), Kling, K.I. (author), Fonseca, A.S. (author), Brostrøm Bluhme, A. (author), Moreman, M. (author), Yu, M. (author), Costa, A.L. (author), Giovanni, B. (author), Ortelli, S. (author), Fransman, W. (author), Vogel, U. (author), Jensen, K.A. (author)
Nanoscale TiO2 (nTiO2) is manufactured in high volumes and is of potential concern in occupational health. Here, we measured workers exposure levels while ceramic honeycombs were dip coated with liquid photoactive nanoparticle suspension and dried with an air blade. The measured nTiO2 concentration levels were used to assess process specific...
article 2018
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Spaan, S. (author), Schinkel, J. (author)
report 2018
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Fonseca, A.S. (author), Kuijpers, E. (author), Kling, K.I. (author), Levin, M. (author), Koivisto, A.J. (author), Nielsen, S.H. (author), Fransman, W. (author), Fedutik, Y. (author), Jensen, K.A. (author), Koponen, I.K. (author)
Fume hoods are one of the most common types of equipment applied to reduce the potential of particle exposure in laboratory environments. A number of previous studies have shown particle release during work with nanomaterials under fume hoods. Here, we assessed laboratory workers’ inhalation exposure during synthesis and handling of CuO, TiO2...
article 2018
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Mazzucchelli, G. (author), Holzhauser, T. (author), Cirkovic Velickovic, T. (author), Diaz-Perales, A. (author), Molina, E. (author), Roncada, P. (author), Rodrigues, P. (author), Verhoeckx, K. (author), Hoffmann-Sommergruber, K. (author)
Food allergies are recognized as a global health concern. In order to protect allergic consumers from severe symptoms, allergenic risk assessment for well-known foods and foods containing genetically modified ingredients is installed. However, population is steadily growing and there is a rising need to provide adequate protein-based foods,...
article 2018
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Leist, M. (author), Ghallab, A. (author), Graepel, R. (author), Marchan, R. (author), Hassan, R. (author), Bennekou, S.H. (author), Limonciel, A. (author), Vinken, M. (author), Schildknecht, S. (author), Waldmann, T. (author), Danen, E. (author), van Ravenzwaay, B. (author), Kamp, H. (author), Gardner, I. (author), Godoy, P. (author), Bois, F.Y. (author), Braeuning, A. (author), Reif, R. (author), Oesch, F. (author), Drasdo, D. (author), Höhme, S. (author), Schwarz, M. (author), Hartung, T. (author), Braunbeck, T. (author), Beltman, J. (author), Vrieling, H. (author), Sanz, F. (author), Forsby, A. (author), Gadaleta, D. (author), Fisher, C. (author), Kelm, J. (author), Fluri, D. (author), Ecker, G. (author), Zdrazil, B. (author), Terron, A. (author), Jennings, P. (author), van der Burg, B. (author), Dooley, S. (author), Meijer, A.H. (author), Willighagen, E. (author), Martens, M. (author), Evelo, C. (author), Mombelli, E. (author), Taboureau, O. (author), Mantovani, A. (author), Hardy, B. (author), Koch, B. (author), Escher, S. (author), van Thriel, C. (author), Cadenas, C. (author), Kroese, D. (author), van de Water, B. (author), Hengstler, J.G. (author)
Adverse outcome pathways (AOPs) are a recent toxicological construct that connects, in a formalized, transparent and quality-controlled way, mechanistic information to apical endpoints for regulatory purposes. AOP links a molecular initiating event (MIE) to the adverse outcome (AO) via key events (KE), in a way specified by key event...
article 2017
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Spaan, S. (author), Meerstadt-Rombach, F. (author)
In allerlei werksituaties kunnen werknemers bewust of onbewust worden blootgesteld aan biologische agentia zoals bacteriën, virussen, parasieten of schimmels. Biologische agentia kunnen een infectie veroorzaken en zo een gezondheidsrisico voor de werknemer opleveren. Als besmetting plaatsvindt vanwege de arbeid spreken we van een...
other 2017
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Fransman, W. (author), Pronk, A. (author), Schelvis, R.M.C. (author), Moons, A.A.M. (author)
In Nederland overlijden jaarlijks zo’n 4.100 mensen aan beroepsziekten, waarvan ongeveer 2.700 aan werkgerelateerde kanker. Ondanks goede initiatieven in risicovolle sectoren als de bouw, metaal en de houtverwerkende industrie om een gezonde werksituatie te creëren, blijkt de blootstelling aan kankerverwekkende stoffen als respirabel kwarts,...
other 2017
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Birot, S. (author), Madsen, C.B. (author), Kruizinga, A.G. (author), Christensen, T. (author), Crépet, A. (author), Brockhoff, P.B. (author)
Food allergic subjects need to avoid the allergenic food that triggers their allergy. However, foods can also contain unintended allergens. Food manufacturers or authorities need to perform a risk assessment to be able to decide if unintended allergen presence constitutes a risk to food allergic consumers. One of the input parameters in risk...
article 2017
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Eendebak, P.T. (author), Schoen, E.D. (author)
We study the design of two-level experiments with N runs and n factors large enough to estimate the interaction model, which contains all the main effects and all the two-factor interactions. Yet, an effect hierarchy assumption suggests that main effect estimation should be given more prominence than the estimation of two-factor interactions....
article 2017
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van der Laan, J.W. (author), Duijndam, B. (author), van den Hoorn, T. (author), Woutersen, R. (author), van de Water, B. (author)
Lifetime testing for carcinogenicity of pharmaceuticals in rodents has been a controversial issue since the start of the International Conference on Harmonisation in 1990. Since 2010 the debate reached a new level following the proposal that a negative outcome of carcinogenicity studies can be predicted based upon the findings of 6 months...
article 2017
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Vaessen, S.F.C. (author), van Lipzig, M.M.H. (author), Pieters, R.H.H. (author), Krul, C.A.M. (author), Wortelboer, H.M. (author), van de Steeg, E. (author)
Intestinal transporter proteins and metabolizing enzymes play a crucial role in the oral absorption of a wide variety of drugs. The aim of the current study was to characterize better available intestinal in vitro models by comparing expression levels of these proteins and enzymes between porcine intestine, human intestine, and Caco-2 cells. We...
article 2017
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Buist, H.E. (author), Hischier, R. (author), Westerhout, J. (author), Brouwer, D.H. (author)
In this paper, we discuss the derivation of respiratory health effect factors (HEFs) for use in Life Cycle Impact Assessment (LCIA) for five nanoparticles: nanosilver, nano TiO2, carbon black, high-aspect ratio, rigid MWCNT and flexible MWCNT. For this purpose, we applied the methodology of USEtox™, a consensus model to calculate human toxicity...
article 2017
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