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Pouwer, M.G. (author)
The thesis discussed several strategies that may contribute to further CVD risk reduction in the future. We described two novel lipid-lowering strategies, we unraveled (part of) the etiology of the cardiovascular safety issues of TKIs that are used for the treatment of CML, and we investigated the dose effects of PFOA on lipoprotein metabolism....
doctoral thesis 2020
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Kozijn, A.E. (author)
This thesis aimed to investigate how metabolic overload contributes to the pathophysiology of knee OA. We explored the role of these independent yet intertwined processes using state-of-the-art lipidomic and cellular approaches in mouse models of diet-induced OA. Chapter 2 presents an overview of twelve preclinical studies in which mice received...
doctoral thesis 2020
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Huijs, J.J.J.M. (author)
The objectives of this dissertation are to identify factors that influence prevention of sick leave and return to work (RTW), and to develop and evaluate interven-tions based on these factors.
doctoral thesis 2019
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Pot, M. (author)
doctoral thesis 2018
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Mulder, P.C.A. (author)
Non-alcoholic fatty liver disease (NAFLD) has rapidly become the most common cause of chronic liver disease, and its worldwide prevalence continues to increase in parallel of the obesity epidemic. NAFLD comprises a wide spectrum of liver damage ranging fat accumulation (steatosis) to steatosis with inflammation (non-alcoholic steatohepatitis,...
doctoral thesis 2017
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Hendriks, C. (author)
The studies presented in this thesis were performed to provide policy makers with more accurate information about the sources of air pollution and the possible consequences of future developments on air quality. This enables policy makers to make better informed decisions when formulating policies that have consequences for air quality. Harmful...
doctoral thesis 2017
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Oeij, P.R.A. (author)
Innovatieteams zijn succesvoller als hun werkomgeving 'mindful' is waardoor zij in staat zijn probleemsituaties op te lossen, zo blijkt uit het promotie-onderzoek van Peter Oeij. Hierdoor daalt de faalkans van innovatieprojecten en daarmee kunnen desinvesteringen worden verkleind. De slaagkans van innovatieprojecten neemt toe. Voor dit...
doctoral thesis 2017
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Schelvis, R.M.C. (author)
Good education advances our knowledge-based society. Good education will become excellent education if the general level of teaching is improved. And the level of teaching will more easily improve if the school organization is functioning well. However, this improvement in the level of teaching is challenged by the high level of work stress...
doctoral thesis 2017
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van de Ven, H.A. (author)
This thesis is the result of the ‘Shift Your Work’ study, which aims to contribute to a better understanding of sustainable employability of older shift workers by implementing new shift systems. This thesis builds on two premises. The first premise constitutes that shift work becomes more demanding with older age (Part I), the second premise...
doctoral thesis 2017
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van der Vijgh, B.H. (author)
doctoral thesis 2016
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Buist, H.E. (author)
doctoral thesis 2016
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Morrison, M.C. (author)
Over the past few decades it has become increasingly clear that inflammation – a normal and essential defense mechanism that protects the body from infection and injury – can also be triggered by nutrients and dietary surplus, an inflammatory state that is referred to as metabolic inflammation. This chronic low-grade inflammatory state is...
doctoral thesis 2016
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Sanders, J.M.A.S. (author)
Sustainable employability has recently become a topical issue in HR literature. Two major developments are responsible for this increased attention. The first is contextual change, requiring businesses to adapt to faster changing markets, causing rapid shifts in the demand for labour and skills. These shifts have severe consequences for the...
doctoral thesis 2016
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van Egmond, M.P. (author)
In Nederland krijgen jaarlijks 40.000 mensen in de werkende leeftijd een diagnose kanker. Uit onderzoek blijkt tevens dat het aantal mensen dat vanwege kanker een ziektewet- of WIA-uitkering aanvraagt, al jaren stijgt. Als je kanker krijgt heb je een kwetsbare positie op de arbeidsmarkt. Zelfs 1 op de 4 Nederlandse kankerpatiënten verliest zijn...
doctoral thesis 2016
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van Houtem, C.M.H.H. (author)
This thesis aimed to increase the knowledge about severe forms of anxiety, gagging and fainting in dentistry and to investigate whether these phenomena are overlapping or separate constructs. In Chapter 2 a literature review of twin studies showed that the estimated heritability of specific phobias and fears varied widely. In Chapter 3 a...
doctoral thesis 2016
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de Wind, A. (author)
Many developed countries are confronted with ageing populations, due to the increase in life expectancy and long-term decline in fertility rates. As a consequence, the ratio of the retired elderly to the active working population increases. This puts a pressure on the social security system, and causes tension in the solidarity between...
doctoral thesis 2016
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Döpp, C. (author)
Het proefschrift beschrijft een studie naar de implementatie van de effectief gebleken ergotherapie-interventie voor mensen met dementie en hun mantelzorgers (EDOMAH). Middels een cluster-RCT werd de huidige post-HBO cursus voor ergotherapeuten vergeleken met een multi-professionele strategie gericht op ergotherapeuten, artsen en managers. De...
doctoral thesis 2015
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Davydenko, I. (author)
The research presented in this PhD thesis has been motivated by the fact that the Netherlands, and the Randstad region in particular, are affected by the large transport flows and extensive operations of the logistics sector. These operations create welfare for those people who work in the sector, who own the companies, and for the Dutch and...
doctoral thesis 2015
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de Kluizenaar, Y. (author)
Road traffic is a prominent source of environmental noise exposure in urbanized areas. Because of its common presence, traffic is a source of exposure that is not easy to avoid. As a consequence, it is affecting a substantial proportion of residents in their homes, and in their living environment more in general. In view of reducing the number...
doctoral thesis 2015
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Liang, W. (author)
Overload of nutrients can lead to diet-induced inflammation, also called metabolic inflammation, which is thought to play an important role in many metabolic diseases, including the development of nonalcoholic fatty liver disease (NAFLD). NAFLD encompasses a spectrum of pathologies that range from simple hepatic steatosis to nonalcoholic...
doctoral thesis 2015
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