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TNO BIBRA (author), Edwards, C.A. (author), Rumney, C. (author), Davies, M. (author), Parrett, A.M. (author), Dore, J. (author), Martin, F. (author), Schmitt, J. (author), Stahl, B. (author), Norin, E. (author), Midtvedt, T. (author), Rowland, I.R. (author), Heavey, P. (author), Köhler, H. (author), Stocks, B. (author), Schroten, H. (author)
Objectives: Bacterial colonization of the infant gut may have important influences on the development of gastrointestinal, respiratory, and allergic disease. Early diet is a major determinant of the gut microflora. It is very difficult to carry out studies in human infants that can investigate the interaction of diet, flora, and mucosa. In this...
article 2003
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Knippels, L.M.J. (author), Penninks, A.H. (author), TNO Voeding (author)
For the safety evaluation of genetically engineered crops, the potential allergenicity of the newly introduced protein(s) has become an important issue. There is, however, no universal and reliable test system for the evaluation of the allergic sensitizing ability of food proteins. Therefore, there is a growing interest in the development of...
article 2002
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Krul, C.A.M. (author), Luiten-Schuite, A. (author), Baan, R. (author), Verhagen, H. (author), Mohn, G. (author), Feron, V. (author), Havenaar, R. (author)
The TNO gastro-Intestinal tract Model (TIM) is a dynamic computer-controlled in vitro system that mimics the human physiological conditions in the stomach and small intestine. In the current TIM physiological parameters such as pH, temperature, peristaltic movements, secretion of digestion enzymes, bile and pancreatic juices, and absorption of...
article 2000
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Knippels, L.M.J. (author), Houben, G.F. (author), Spanhaak, S. (author), Penninks, A.H. (author)
We developed an oral sensitization protocol for food proteins for the rat. Young Brown Norway (BN) rats were exposed to 1 mg ovalbumin (OVA) by daily gavage dosing for 42 days without the use of an adjuvant. OVA-specific IgE and IgG responses were determined by ELISA. On an oral challenge with OVA some clinical symptoms of food allergy-like...
article 1999
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de Bie, A.T.H.J. (author), van Ommen, B. (author), Bär, A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The absorption, disposition, metabolism, and excretion of 14C-labeled γ-cyclodextrin ([14C]γ-CD) was examined in four separate experiments with Wistar rats. In experiment 1, [14C]γ-CD (25 μCi, 600 mg/kg body wt) was administered intravenously to four male and four female conventional rats. In experiment 2, [14C]γ- CD (25 μCi, 1000 mg/kg body wt)...
article 1998
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