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van den Berg, H. (author), Louwerse, E.S. (author), Bruinse, H.W. (author), Thissen, J.T.N.M. (author), Schrijver, J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The vitamin B6 status of women suffering from premenstrual symptoms (PMS, n = 19) and a group of matched controls (n = 19) has been investigated. The women volunteering in the study were selected on strictly defined criteria. Several biochemical parameters of the metabolism of vitamin B6 and tryptophan were studied in blood and urine samples...
article 1986
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Wertheim, A.H. (author), van Gelder, P. (author)
When the eyes pursue a fixation point that sweeps across a moving background pattern, and the fixation point is suddenly made to stop, the ongoing motion of the background pattern seems to accelerate to a higher velocity. Experiment I showed that this acceleration illusion is not caused by the sudden change in (i) the relative velocity between...
article 1990
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Smits, R.C.F. (author), Emmen, H.H. (author), Bertelmans, F.W. (author), Kulig, B.M. (author), van Loenen, A.C. (author), Polman, C.H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
4-Aminopyridine (4-AP) has a favorable effect on the disability of certain patients with MS. We investigated the effect of 4-AP on neuropsychological performance in 20 MS patients using a randomized, double-blind, placebo- controlled, crossover design. Although there was a trend for improved performance with 4-AP for two of the tests, we could...
article 1994
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te Koppele, J.M. (author), Beekman, B. (author), Bloemhoff, W. (author), Drijfhout, J.W. (author), TNO Preventie en Gezondheid (author)
article 1995
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de Maat, M.P.M. (author), de Bart, A.C.W. (author), Hennis, B.C. (author), Meijer, P. (author), Havelaar, A.C. (author), Mulder, P.G.H. (author), Kluft, C. (author), Gaubius Instituut TNO (author)
We compared intraindividual and interindividual variability in the plasma levels of fibrinogen, tissue-type plasminogen activator (TPA) antigen, plasminogen activator inhibitor (PAI) activity, and C-reactive protein (CRP) in 20 healthy, young individuals and 26 patients with stable angina pectoris (AP) who were at higher risk for cardiovascular...
article 1996
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Myrup, B. (author), Jensen, T. (author), Gram, J. (author), Kluft, C. (author), Jespersen, J. (author), Deckert, T. (author), Gaubius Instituut TNO (author)
OBJECTIVE - The high risk for cardiovascular disease in IDDM patients with nephropathy may be mediated by abnormal function of the vascular wall. We investigated whether heparin was able to modulate markers of vascular wall and hemostatic function in patients with incipient nephropathy. RESEARCH DESIGN AND METHODS - Thirty-five IDDM patients...
article 1997
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Bos, R. (author), van Leuven, C.J.M. (author), Stolk, J. (author), Hiemstra, P.S. (author), Ronday, H.K. (author), Nieuwenhuizen, W. (author), TNO Preventie en Gezondheid (author)
Upon stimulation, polymorphonuclear leucocytes (PMNs) release potent serine proteases, i.e. elastase, cathepsin C and proteinase 3, which contribute to the degradation of tissue and plasma components. Here, we describe the development of a plasma test to assess PMN-mediated fibrinogenolysis as a biochemical marker for actual PMN-derived...
article 1997
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Rosén, S. (author), Wejkum, L. (author), Billing-Claeson, S. (author), Ghosh, R. (author), Grdic, K. (author), Chmielewska, J. (author), Meijer, P. (author), Kluft, C. (author), Tengborn, L. (author), Conkie, J. (author), Walker, I. (author), Gaubius Instituut TNO (author)
A chromogenic bioimmunoassay method for determination of t-PA activities has been evaluated on plasmas from healthy individuals and from thromboembolic patients. The assay consists of an initial binding and washing step, whereby plasma t-PA is bound to a specific monoclonal t-PA antibody, which is coated on to microplate wells, followed by a...
article 1998
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Riese, H. (author), Hoedemaeker, M. (author), Brouwer, W.H. (author), Mulder, L.J.M. (author), Cremer, R. (author), Veldman, J.B.P. (author), TNO Arbeid (author)
In patients with very severe closed head injury (CHI), returning to work is often problematic. The present study focuses on a persistent complaint of these patients, viz. mental fatigue. To study this, the effect of sustained workload is assessed in a continuous dynamic divided attention task. Three types of measures are employed: performance...
article 1999
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Stemerdink, N.B.A. (author), van der Molen, M.W. (author), Kalverboer, A.F. (author), van der Meere, J.J. (author), Huisman, J. (author), de Jong, L.W. (author), Slijper, F.M.E. (author), Verkerk, P.H. (author), van Spronsen, F.J. (author), TNO Preventie en Gezondheid (author)
In this study, we tested the hypothesis that patients with early and continuously treated phenylketonuria (PKU) are selectively impaired in cognitive functions dependent on the prefrontal cortex (PFC) over a wide age range. Thirty-six patients with PKU between 8 and 20 years of age and 36 controls matched for age, sex, and educational level of...
article 1999
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Westhoff, M.H. (author), Stemmerik, L. (author), Boshuizen, H.C. (author), TNO Preventie en Gezondheid (author)
This study's purpose was to investigate whether a 10-week low-intensity strength-training program could improve strength of the knee extensors and functional ability. Participants 65 years and older with low knee-extensor muscle strength were randomized into an exercise (n = 11) and a control group (n = 10). Knee-extensor strength and functional...
article 2000
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van der Gaag, M.S. (author), Ubbink, J.B. (author), Sillanaukee, P. (author), Nikkari, S. (author), Hendriks, H.F.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Serum homocysteine increases after moderate consumption of red wine and spirits, but not after moderate consumption of beer. Vitamin B6 in beer seems to prevent the alcohol-induced rise in serum homocysteine. Chemicals/CAS: Homocysteine, 454-28-4; Pyridoxine, 65-23-6
article 2000
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Stemerdink, B.A. (author), Kalverboer, A.F. (author), van der Meere, J.J. (author), van der Molen, M.W. (author), Huisman, J. (author), de Jong, L.W.A. (author), Slijper, F.M.E. (author), Verkerk, P.H. (author), van Spronsen, F.J. (author), TNO Preventie en Gezondheid (author)
Thirty patients with early and continuously treated phenylketonuria (PKU) between 8 and 20 years of age were compared with 30 controls, matched individually for age, sex, and educational level of both parents, on behaviour rating scales for parents and teachers as well as a school achievement scale. PKU patients, as a group, demonstrated more...
article 2000
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Knippels, L.M.J. (author), van der Kleij, H.P.M. (author), Koppelman, S.J. (author), Houben, G.F. (author), Penninks, A.H. (author), Felius, A.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Background: No adequate enteral sensitization models are available to study food allergy and the allergenicity of food proteins. To further validate an enteral brown Norway (BN) rat sensitization model under development, we studied specific protein recognition to determine whether a comparable pattern of proteins is recognized by the rat immune...
article 2000
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Wang, X. (author), Bank, R.A. (author), teKoppele, J.M. (author), Mauli Agrawal, C. (author), Gaubius Instituut (author)
The hypothesis of this study was that collagen denaturation would lead to a significant decrease in the toughness of bone, but has little effect on the stiffness of bone. Using a heating model, effects of collagen denaturation on the biomechanical properties of human cadaveric bone were examined. Prior to testing, bone specimens were heat...
article 2001
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Verhoef, P. (author), Pasman, W.J. (author), van Vliet, T. (author), Urgert, R. (author), Katan, M.B. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)
Background: A high plasma total homocysteine concentration is associated with increased risk of cardiovascular disease. Consumption of unfiltered or filtered coffee raises total homocysteine concentrations in healthy volunteers. The responsible compound, however, is unknown. Objective: The objective was to determine whether caffeine explains the...
article 2002
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Theunissen, N.C.M. (author), Kamp, G.A. (author), Koopman, H.M. (author), Zwinderman, K.A.H. (author), Vogels, T. (author), Wit, J.-M. (author), TNO Preventie en Gezondheid (author)
Objective: Changes in health-related quality of life (HRQOL) and self-esteem were studied in children with idiopathic short stature (ISS) participating in a study on the effect of growth hormone treatment. Study design: Prepubertal children (n = 36) with ISS were randomly assigned to a treatment or control group. Children with ISS, their parents...
article 2002
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Konings, E.J.M. (author), Troost, F.J. (author), Castenmiller, J.J.M. (author), Roomans, H.H.S. (author), van den Brandt, P.A. (author), Saris, W.H.M. (author)
Our knowledge on the absorption of folate is incomplete. The deconjugation process as a possible limiting factor in the absorption of folates was investigated. The study also attempted to validate the use of the area under the serum response curve (AUC) from food compared with folic acid as a proxy variable for food folate bioavailability....
article 2002
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Lopatinskaya, L. (author), Boxel van-Dezaire, A.H.H. (author), Barkhof, F. (author), Polman, C.H. (author), Lucas, C.J. (author), Nagelkerken, L. (author)
In this longitudinal study, we examined the expression of Fas, FasL, CCR3, CCR5 and CXCR3 mRNA in peripheral blood mononuclear cells (PBMCs) of secondary progressive (SP) and relapsing-remitting (RR) multiple sclerosis (MS) patients. In RR patients, FasL, CCR3 and CCR5 mRNA levels were increased prior to the exacerbations, but these decreased...
article 2003
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Emmen, H.H. (author), Muijser, H. (author), Arts, J.H.E. (author), Prinsen, M.K. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)
The objective of this study was to establish the possible occurrence of eye irritation and subjective symptoms in human volunteers exposed to propylene glycol monomethyl ether (PGME) vapour at concentrations of 0, 100 and 150 ppm. Testing was conducted in 12 healthy male volunteers using a repeated measures design. Each subject was exposed for 2...
article 2003
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