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Schuurman, A.G. (author), Goldbohm, R.A. (author), Dorant, E. (author), van den Brandt, P.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
In the Netherlands Cohort Study, the authors investigated whether anthropometry is associated with prostate cancer risk. At baseline in 1986, 58,279 men aged 55-69 years completed a self- administered questionnaire on diet, anthropometry, and other risk factors for cancer. After 6.3 years of follow-up, 681 cases were available with complete data...
article 2000
document
Lina, B.A.R. (author), Bos-Kuijpers, M.H.M. (author), Til, H.P. (author), Bär, A. (author)
The potential toxicity and carcinogenicity of erythritol, a low-calorie sugar substitute, were examined in Wistar Crl:(WI) WU BR rats. Groups of 50 rats of each sex consumed diets with 0, 2, 5, or 10% erythritol, or 10% mannitol, for a period of 104-107 weeks. To each of these main groups, two satellite groups of 20 males each were attached for...
article 1996
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Hissink, A.M. (author), Krüse, J. (author), Kulig, B.M. (author), Verwei, M. (author), Muijser, H. (author), Salmon, F. (author), Leenheers, L.H. (author), Owen, D.E. (author), Lammers, J.H.C.M. (author), Freidig, A.P. (author), McKee, R.H. (author), TNO Kwaliteit van Leven (author)
As part of a project designed to develop a framework for extrapolating acute central nervous system (CNS) effects of hydrocarbon solvents in animals to humans, experimental studies were conducted in rats and human volunteers in which acute CNS effects were measured and toxicokinetic data were collected. A complex hydrocarbon solvent, white...
article 2007
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Schouten, L.J. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)
Although obesity is an established risk factor for endometrial cancer, evidence linking risk to height, weight change since age 20, and physical activity is limited. In this case-cohort study, 62 573 women from The Netherlands Cohort Study on Diet and Cancer were followed up from 1986 to 1995, and 226 endometrial cancer case patients were...
article 2004
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Delsing, D.J.M. (author), Offerman, E.H. (author), van Duyvenvoorde, W. (author), van der Boom, H. (author), de Wit, E.C.M. (author), Gijbels, M.J.J. (author), van der Laarse, A. (author), Jukema, J.W. (author), Havekes, L.M. (author), Princen, H.M.G. (author), Gaubius Instituut TNO (author)
Background - The present study investigated whether the ACAT inhibitor avasimibe can reduce atherogenesis independently of its cholesterol-lowering effect in ApoE*3-Leiden mice. Methods and Results - Two groups of 15 female ApoE*3-Leiden mice were put on a high-cholesterol (HC) diet; 1 group received 0.01% (wt/wt) avasimibe mixed into the diet....
article 2001
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Visser, C.J.T. (author), van Garderen-Hoetmer, A. (author), Klijn, J.G.M. (author), Foekens, J.A. (author), Woutersen, R.A. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)
In a previous short-term study (4 months) we found that Sandostatin, when administered prophylactically, inhibited growth of putative pre-neoplastic ductular lesions induced in hamster pancreas by N-nitrosobis(2-oxopropyl)amine (BOP), but not of acinar lesions induced in rat pancreas by azaserine. The present long-term (12 months) study was...
article 1996
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Hambly, R.J. (author), Saunders, M. (author), Rijken, P.J. (author), Rowland, I.R. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)
Although there is much epidemiological evidence for an interaction between diet and colorectal cancer risk, the mechanisms by which diet might protect against colorectal cancer are still unclear. Here we report the significant up-regulation of carcinogen-induced apoptosis in the colon of rats fed a diet containing low-risk factors for colon...
article 2002
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Lina, B.A.R. (author), Bär, A. (author), TNO Voeding (author)
The toxicity of α-cyclodextrin (α-CD), a cyclic polymer of six α-1,4-linked glucopyranosyl units with potential applications as a food ingredient, more specifically a water-soluble dietary fiber, was examined in a 4-week range finding study and a 13-week oral toxicity study in rats. In the 4-week study, the test substance was administered to...
article 2004
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van de Vijver, L.P.L. (author), Kardinaal, A.F.M. (author), Charzewska, J. (author), Rotily, M. (author), Charles, P. (author), Maggiolini, M. (author), Ando, S. (author), Väänänen, K. (author), Wajszczyk, B. (author), Heikkinen, J. (author), Deloraine, A. (author), Schaafsma, G. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Several studies indicate that intake of calcium can inhibit iron absorption especially when taken simultaneously. In the CALEUR study, a cross-sectional study among girls (mean 13.5 y) and young women (mean 22.0 y) in six European countries, the association between calcium intake and iron status was studied. In 1,080 girls and 524 women,...
article 1999
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Rompelberg, C.J.M. (author), Steenwinkel, M.J.S.T. (author), van Asten, J.G. (author), van Delft, J.H.M. (author), Baan, R.A. (author), Verhagen, H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
To study the possible reduction by eugenol of the mutagenicity and genotoxicity of benzoja]pyrene (B[a]P) in vivo, the X-lacZ-transgenic mouse strain 40.6 (Muta(TM)Mouse) was used. Male mice were fed a diet containing 0.4% (w/w) eugenol or a control diet for 58 days. On day 10, half of the mice received an i.p. dose of 100 mg/kg b.w. B[a]P. The...
article 1996
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Muurling, M. (author), Jong, M.C. (author), Mensink, R.P. (author), Hornstra, G. (author), Dahlmans, V.E.H. (author), Pijl, H. (author), Voshol, P.J. (author), Havekes, L.M. (author), Gaubius Instituut TNO (author)
Previous studies have shown that energy restriction (ER) or low-fat (LF) diets have beneficial effects on high-fat (HF) diet-induced obesity and non-insulin-dependent diabetes. However, comparison between ER and low-fat diet regarding the effect on insulin resistance and lipid metabolism has not been reported. After inducing insulin resistance...
article 2002
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Lina, B. (author), Korte, H. (author), Nyman, L. (author), Unkila, M. (author), TNO Kwaliteit van Leven (author)
Plant lignan 7-hydroxymatairesinol (7-HMR) is a novel precursor of the mammalian lignan enterolactone. A 13 week toxicity study at dietary levels of 0, 0.25, 1, and 4% (w/w) of potassium acetate complex of 7-HMR (HMRlignan) was conducted in the Wistar rat. These dietary levels resulted in an average daily intake of 160, 640, and 2600 mg...
article 2005
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Gerrits, W.J.J. (author), Schrama, J.W. (author), Tamminga, S. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
A previous study showed that the marginal efficiency of utilization of digestible nitrogen for deposition in the body in preruminant calves is only ~30%. The study consisted of two similar experiments that were performed in two live weight ranges: 80-160 and 160-240 kg. In each experiment, 36 calves were allotted to one of twelve dietary...
article 1998
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Szabó, C. (author), Jansman, A.J.M. (author), Babinszky, L. (author), Kanis, E. (author), Verstegen, M.W.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The effects of four protein sources (soybean meal, sunflower meal, pea, and fish meal as the main protein source) and three apparent ileally digestible Lys:DE ratios (0.50, 0.43, 0.36 and 0.42, 0.36, 0.30 g Lys/MJ DE for 30 to 60 kg BW and 60 to 105 kg BW, respectively) in pig diets on growing-finishing performance, and carcass and meat quality...
article 2001
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Borghi, E. (author), de Onis, M. (author), Garza, C. (author), van den Broeck, J. (author), Frongillo, E.A. (author), Grummer-Strawn, L. (author), van Buuren, S. (author), Pan, H. (author), Molinari, L. (author), Martorell, R. (author), Onyango, A.W. (author), Martines, J.C. (author), Pinol, A. (author), Siyam, A. (author), Victoria, C.G. (author), Bhan, M.K. (author), Araújo, C.L. (author), Lartey, A. (author), Owusu, W.B. (author), Bhandari, N. (author), Norum, K.R. (author), Bjoerneboe, G.-E.Aa. (author), Mohamed, A.J. (author), Dewey, K.G. (author), Belbase, K. (author), Chumlea, C. (author), Cole, T. (author), Shrimpton, R. (author), Albernaz, E. (author), Tomasi, E. (author), de Cássia Fossati da Silveira, R. (author), Nader, G. (author), Sagoe-Moses, I. (author), Gomez, V. (author), Sagoe-Moses, C. (author), Taneja, S. (author), Rongsen, T. (author), Chetia, J. (author), Sharma, P. (author), Bahl, R. (author), Baerug, A. (author), Tufte, E. (author), Alasfoor, D. (author), Prakash, N.S. (author), Mabry, R.M. (author), Al Rajab, H.J. (author), Helmi, S.A. (author), Nommsen-Rivers, L.A. (author), Cohen, R.J. (author), Heinig, M.J. (author), TNO Kwaliteit van Leven (author)
The World Health Organization (WHO), in collaboration with a number of research institutions worldwide, is developing new child growth standards. As part of a broad consultative process for selecting the best statistical methods, WHO convened a group of statisticians and child growth experts to review available methods, develop a strategy for...
article 2006
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Hooftman, R.N. (author), Kuper, C.F. (author), Appelman, L.M. (author), Hoofdgroep Maatschappelijke Technologie TNO (author)
The sensitivity of different parameters for the determination of lung injury caused by nitrogen dioxide (NO2) was investigated. Male rats were exposed to concentrations of 0, 4, 10 or 25 ppm NO2 for 6 h/day, for 7, 14 or 21 days. Histopathology of the nasal cavity, larynx, trachea and lungs was compared with the changes in macrophage function...
article 1988
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Appel, M.J. (author), Kuper, C.F. (author), Woutersen, R.A. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)
A study was performed to provide data on the disposition, accumulation and toxicity of sodium iron EDTA in comparison with iron (II) sulfate in rats on administration via the diet for 31 and 61 days. Clinical signs, body weights, food consumption, food conversion efficiency, hematology, clinical chemistry and pathology of selected organs were...
article 2001
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Feron, V.J. (author), Kruysse, A. (author), Til, H.P. (author), Immel, H.R. (author), Centraal instituut voor voedingsonderzoek TNO (author)
The subacute inhalation toxicity of acrolein was examined in 4 groups of 20 hamsters, 12 rats and 4 rabbits each, exposed repeatedly to acrolein vapour at concentrations of 0, 0.4, 1.4 and 4.9 ppm (6 hr/day, 5 days/week) for a 13-week period. The most important effects found at the highest level included mortality in rats, ocular and nasal...
article 1978
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Bröde, P. (author), Havenith, G. (author), Wang, X. (author), Candas, V. (author), den Hartog, E.A. (author), Griefahn, B. (author), Holmér, I. (author), Kuklane, K. (author), Meinander, H. (author), Nocker, W. (author), Richards, M. (author), TNO Defensie en Veiligheid (author)
In order to assess the non-evaporative components of the reduced thermal insulation of wet clothing, experiments were performed with a manikin and with human subjects in which two layers of underwear separated by an impermeable barrier were worn under an impermeable overgarment at 20°C, 80% RH and 0.5 ms-1 air velocity. By comparing manikin...
article 2008
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Hooser, S.T. (author), van Dijk-Knijnenburg, C.M. (author), Waalkens-Berendsen, I.D.H. (author), Smits-van Prooije, A.E. (author), Snoeij, N.J. (author), Baan, R.A. (author), Fichtinger-Schepman, M.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Exposure of males to some genotoxic chemicals causes DNA damage in spermatozoa resulting in embryotoxicity and developmental defects in their offspring. This study demonstrates that cisplatin-DNA adducts could be measured in spermatozoa following treatment with the antineoplastic drug, cisplatin. The formation of spermatozoa cisplatin-DNA...
article 2000
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