Searched for: +
(1 - 20 of 355)

Pages

document
Mpofu, A. (author), Linnemann, A.R. (author), Sybesma, W. (author), Kort, R. (author), Nout, M.J.R. (author), Smid, E.J. (author)
A probiotic dairy product was developed on the basis of a traditional dish called mutandabota to enable resource-poor populations in southern Africa to benefit from a functional food. Mutandabota is widely consumed in rural southern Africa, making it an ideal food matrix to carry probiotics. First, a process to produce probiotic mutandabota was...
article 2014
document
Nowack, B. (author), David, R.M. (author), Fissan, H. (author), Morris, H. (author), Shatkin, J.A. (author), Stintz, M. (author), Zepp, R. (author), Brouwer, D. (author)
The expected widespread use of carbon nanotube (CNT)-composites in consumer products calls for an assessment of the possible release and exposure to workers, consumers and the environment. Release of CNTs may occur at all steps in the life cycle of products, but to date only limited information is available about release of CNTs from actual...
article 2013
document
Shandilya, N. (author), Morgeneyer, M. (author), Le Bihan, O. (author)
In this work, the particle aerosols emissions during the abrasion of three products – brick, wood and stainless steel – are measured. Owing to different material removal mechanisms in these three products during their abrasions, different quantities and generation rates of aerosols are observed with the brick producing the highest number at a...
article 2015
document
Ramirez, T. (author), Daneshian, M. (author), Kamp, H. (author), Bois, F.Y. (author), Clench, M.R. (author), Coen, M. (author), Donley, B. (author), Fischer, S.M. (author), Ekman, D.R. (author), Fabian, E. (author), Guillou, C. (author), Heuer, J. (author), Hogberg, H.T. (author), Jungnickel, H. (author), Keun, H.C. (author), Krennrich, G. (author), Krupp, E. (author), Luch, A. (author), Noor, F. (author), Peter, E. (author), Riefke, B. (author), Seymour, M. (author), Skinner, N. (author), Smirnova, L. (author), Verheij, E. (author), Wagner, S. (author), Hartung, T. (author), van Ravenzwaay, B. (author), Leist, M. (author)
Metabolomics, the comprehensive analysis of metabolites in a biological system, provides detailed information about the biochemical/physiological status of a biological system, and about the changes caused by chemicals. Metabolomics analysis is used in many fields, ranging from the analysis of the physiological status of genetically modified...
article 2013
document
Geerling, J.J. (author), Boon, M.R. (author), van der Zon, G.C. (author), van den Berg, S.A.A. (author), van den Hoek, A.M. (author), Lombès, M. (author), Princen, H.M.G. (author), Havekes, L.M. (author), Rensen, P.C.N. (author), Guigas, B. (author)
Metformin is the first-line drug for the treatment of type 2 diabetes. Besides its well-characterized antihyperglycemic properties, metformin also lowers plasma VLDL triglyceride (TG). In this study, we investigated the underlying mechanisms in APOE*3-Leiden.CETP mice, a well-established model for human-like lipoprotein metabolism. We found that...
article 2014
document
Shandilya, N. (author), Le Bihan, O. (author), Bressot, C. (author), Morgeneyer, M. (author)
In the present work, we investigate the effect of weathering duration on a commercial photocatalytic nanocoating on the basis of its nanoparticle emission tendency into two media, air and water. It is found that increased weathering duration results in stepwise structural deterioration of the nanocoating, which in turn decreases the nanocoating...
article 2015
document
Foti, M.J. (author), Médici, R. (author), Ruijssenaars, H.J. (author)
Pseudomonas putida S12 was engineered for the production of monoethanolamine (MEA) from glucose via the decarboxylation of the central metabolite l-serine, which is catalyzed by the enzyme l-serine decarboxylase (SDC).The host was first evaluated for its tolerance towards MEA as well as its endogenous ability to degrade this alkanolamine. Growth...
article 2013
document
Visser, H. (author), Joosten, V. (author), Punt, P.J. (author), Gusakov, A.V. (author), Olson, P.T. (author), Joosten, R. (author), Bartels, J. (author), Visser, J. (author), Sinitsyn, A.P. (author), Emalfarb, M.A. (author), Verdoes, J.C. (author), Wery, J. (author)
The filamentous fungus C1 was developed into an expression platform for screening and production of diverse industrial enzymes. C1 shows a lowviscosity morphology in submerged culture, enabling the use of complex growth and production media. This morphology furthermore allowed C1 to be used as a host for high-throughput robotic screening of gene...
article 2011
document
Blaauboer, M.E. (author), Emson, C.L. (author), Verschuren, L. (author), van Erk, M. (author), Turner, S.M. (author), Everts, V. (author), Hanemaaijer, R. (author), Stoop, R. (author)
Collagen deposition is a key process during idiopathic pulmonary fibrosis; however, little is known about the dynamics of collagen formation during disease development. Tissue samples of early stages of human disease are not readily available and it is difficult to identify changes in collagen content, since standard collagen analyses do not...
article 2013
document
Cobb, Z. (author), de Vries, R. (author), Spooner, N. (author), Williams, S. (author), Staelens, L. (author), Doig, M. (author), Broadhurst, R. (author), Barfield, M. (author), van de Merbel, N. (author), Schmid, B. (author), Siethoff, C. (author), Ortiz, J. (author), Verheij, E. (author), van Baar, B. (author), White, S. (author), Timmerman, P. (author)
Background: At the start of their work, the European Bioanalysis Forum dried blood spots microsampling consortium did not form a dedicated team to investigate the spot homogeneity. However, two teams performed experiments that produced results relating to sample homogeneity. Results: The data, which were produced via two different approaches (a...
article 2013
document
Gierman, L.M. (author), Kühnast, S. (author), Koudijs, A. (author), Pieterman, E.J. (author), Kloppenburg, M. (author), van Osch, G.J.V.M. (author), Stojanovic-Susulic, V. (author), Huizinga, T.W.J. (author), Princen, H.M.G. (author), Zuurmond, A.M. (author)
Objective Hypercholesterolaemia, a risk factor for atherosclerosis (ATH), has been suggested to have a role in the development of osteoarthritis (OA). To test this hypothesis, the effect of cholesterol and different cholesterol-lowering treatments on OA was investigated in a mouse model resembling human lipoprotein metabolism. Methods Female...
article 2014
document
Piersma, A.H. (author), Bosgra, S. (author), van Duursen, M.B.M. (author), Hermsen, S.A.B. (author), Jonker, L.R.A. (author), Kroese, E.D. (author), van der Linden, S.C. (author), Man, H. (author), Roelofs, M.J.E. (author), Schulpen, S.H.W. (author), Schwarz, M. (author), Uibel, F. (author), van Vugt-Lussenburg, B.M.A. (author), Westerhout, J. (author), Wolterbeek, A.P.M. (author), van der Burg, B. (author)
The application of alternative methods in developmental and reproductive toxicology is challenging in view of the complexity of mechanisms involved. A battery of complementary test systems may provide a better prediction of developmental and reproductive toxicity than single assays. We tested twelve compounds with varying mechanisms of toxic...
article 2013
document
Salek, R.M. (author), Neumann, S. (author), Schober, D. (author), Hummel, J. (author), Billiau, K. (author), Kopka, J. (author), Correa, E. (author), Reijmers, T. (author), Rosato, A. (author), Tenori, L. (author), Turano, P. (author), Marin, S. (author), Deborde, C. (author), Jacob, D. (author), Rolin, D. (author), Dartigues, B. (author), Conesa, P. (author), Haug, K. (author), Rocca-Serra, P. (author), O’Hagan, S. (author), Hao, J. (author), van Vliet, M. (author), Sysi-Aho, M. (author), Ludwig, C. (author), Bouwman, J. (author), Cascante, M. (author), Ebbels, T. (author), Griffin, J.L. (author), Moing, A. (author), Nikolski, M. (author), Oresic, M. (author), Sansone, S.A. (author), Viant, M.R. (author), Goodacre, R. (author), Günther, U.L. (author), Hankemeier, T. (author), Luchinat, C. (author), Walther, D. (author), Steinbeck, C. (author)
article 2015
document
Aguirre, M. (author), Ramiro-Garcia, J. (author), Koenen, M.E. (author), Venema, K. (author)
This study investigated the stability and the activity of the microbiota from a single and a pool of donors in the TNO in vitro model of the colon (TIM-2 system). Our findings demonstrate the suitability of the preparation of a pool of fecal sample to be used for fermentation experiments. Chemicals/CAS: isobutyric acid, 5711-69-3, 79-31-2;...
article 2014
document
Santoro, A. (author), Pini, E. (author), Scurti, M. (author), Palmas, G. (author), Berendsen, A. (author), Brzozowska, A. (author), Pietruszka, B. (author), Szczecinska, A. (author), Cano, N. (author), Meunier, N. (author), de Groot, C.P.G.M. (author), Feskens, E. (author), Fairweather-Tait, S. (author), Salvioli, S. (author), Capri, M. (author), Brigidi, P. (author), Franceschi, C. (author), Fabbri, C. (author), Bertarelli, C. (author), Izzi, M. (author), Mazzocchi, M. (author), Chardigny, J.M. (author), Morio, B. (author), Rossi, D. (author), Notarfonso, M. (author), O'Toole, P.W. (author), Cashman, K. (author), Carding, S.R. (author), Nicoletti, C. (author), Jacobs, D. (author), Xipsiti, M. (author), Fernandez, L. (author), Wills, J. (author), Irz, X. (author), Kuosmanen, N. (author), Gonos, E.S. (author), Voutetakis, K. (author), Salmon, M. (author), Toussaint, O. (author), Traill, B.W. (author), Nocella, G. (author), Caracciolo, B. (author), Xu, W. (author), Ikonen, M. (author), Tuure, T. (author), Brummer, R. (author), Kadi, F. (author), Breton, S. (author), Triomphe, M. (author), Magario, G. (author), Villani, F. (author), Pancrazio, A. (author), Teufner, B. (author), Stocker, J. (author), Echevarría, F.J. (author), Iglesias, J.R. (author), Smrž, F. (author), Krejcirova, L. (author), Koytsomitropoulou, E. (author), Georgakidis, K. (author), Yornuk, R. (author), Ucar, C. (author), van Ommen, B. (author), Bouwman, J. (author), Collino, S. (author), Jankovics, C. (author), Losó, A. (author), de Vos, W. (author), Fuentes, S. (author), Commelin, E. (author)
The development of a chronic, low grade, inflammatory status named "inflammaging" is a major characteristic of ageing, which plays a critical role in the pathogenesis of age-related diseases. Inflammaging is both local and systemic, and a variety of organs and systems contribute inflammatory stimuli that accumulate lifelong. The NU-AGE rationale...
article 2014
document
Sun, M. (author), Chang, W.T. (author), van Wijk, E. (author), He, M. (author), Koval, S. (author), Lin, M.K. (author), Van Wijk, R. (author), Hankemeier, T. (author), van der Greef, J. (author), Wang, M. (author)
Based on the traditional Chinese medicine theory, the Chinese pharmacopeia assigns a therapeutic description of “taste” to all herbs; thus, an herb's “taste” is valued in traditional Chinese medicine as a major ethnopharmacological category and reflects the herb's therapeutic properties. These properties guide the practitioner with respect to...
article 2017
document
Kort, R. (author)
article 2014
document
Gvaramia, D. (author), Blaauboer, M.E. (author), Hanemaaijer, R. (author), Everts, V. (author)
Fibrosis underlies the pathogenesis of numerous diseases and leads to severe damage of vital body organs and, frequently, to death. Better understanding of the mechanisms resulting in fibrosis is essential for developing appropriate treatment solutions and is therefore of upmost importance. Recent evidence suggests a significant antifibrotic...
article 2013
document
van den Hout, A. (author), Fox, J.P. (author)
Longitudinal data can be used to estimate the transition intensities between healthy and unhealthy states prior to death. An illness-death model for history of stroke is presented, where time-dependent transition intensities are regressed on a latent variable representing cognitive function. The change of this function over time is described by...
article 2015
document
Leist, M. (author), Ghallab, A. (author), Graepel, R. (author), Marchan, R. (author), Hassan, R. (author), Bennekou, S.H. (author), Limonciel, A. (author), Vinken, M. (author), Schildknecht, S. (author), Waldmann, T. (author), Danen, E. (author), van Ravenzwaay, B. (author), Kamp, H. (author), Gardner, I. (author), Godoy, P. (author), Bois, F.Y. (author), Braeuning, A. (author), Reif, R. (author), Oesch, F. (author), Drasdo, D. (author), Höhme, S. (author), Schwarz, M. (author), Hartung, T. (author), Braunbeck, T. (author), Beltman, J. (author), Vrieling, H. (author), Sanz, F. (author), Forsby, A. (author), Gadaleta, D. (author), Fisher, C. (author), Kelm, J. (author), Fluri, D. (author), Ecker, G. (author), Zdrazil, B. (author), Terron, A. (author), Jennings, P. (author), van der Burg, B. (author), Dooley, S. (author), Meijer, A.H. (author), Willighagen, E. (author), Martens, M. (author), Evelo, C. (author), Mombelli, E. (author), Taboureau, O. (author), Mantovani, A. (author), Hardy, B. (author), Koch, B. (author), Escher, S. (author), van Thriel, C. (author), Cadenas, C. (author), Kroese, D. (author), van de Water, B. (author), Hengstler, J.G. (author)
Adverse outcome pathways (AOPs) are a recent toxicological construct that connects, in a formalized, transparent and quality-controlled way, mechanistic information to apical endpoints for regulatory purposes. AOP links a molecular initiating event (MIE) to the adverse outcome (AO) via key events (KE), in a way specified by key event...
article 2017
Searched for: +
(1 - 20 of 355)

Pages