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Asosingh, K. (author), Radl, J. (author), van Riet, I. (author), van Camp, B. (author), van der Kerken, K. (author), TNO Preventie en Gezondheid (author)
Chemicals/CAS: Cancer Vaccines; Myeloma Proteins; pristane, 1921-70-6; Terpenes; Vaccines, DNA
article 2000
document
Zhu, D. (author), van Arkel, C. (author), King, C.A. (author), van Meirvenne, S. (author), de Greef, C. (author), Thielemans, K. (author), Radl, J. (author), Stevenson, F.K. (author), TNO Preventie en Gezondheid (author)
The 5T series of multiple myelomas (MM) and Waldenstrsom's macroglobulinaemia-like lymphomas (WM), which developed spontaneously in ageing mice of the C57BL/KaLwRij strain, shows clinical and biological features that closely resemble their corresponding human diseases. In order to compare the patterns of somatic mutation in V(H) genes of mouse...
article 1998
document
Garrett, I.R. (author), Dallas, S. (author), Radl, J. (author), Mundy, G.R. (author), TNO Preventie en Gezondheid (author)
Myeloma causes a devastating and unique form of osteolytic bone disease. Although osteoclast activation is responsible for bone destruction, the precise mechanisms by which myeloma cells increase osteoclast activity have not been defined. An animal model of human myeloma bone disease mould help in clarification of these mechanisms. Multiple...
article 1997
document
van Arkel, C. (author), Nooij, F.J.M. (author), van der Sluijs-Gelling, A.J. (author), Radl, J. (author), TNO Preventie en Gezondheid (author)
The effects of age, genetic background, and neonatal thymectomy on the levels and the heterogeneity of the specific antibody response were investigated in an experimental mouse model. Both intact and neonatally thymectomized (NTx) C57BL/KaLwRij (C57BL) and CBA/BrARij (CBA) mice were immunized at the age of 3 ('young') or 22 months ('old')....
article 1997
document
Endo, T. (author), Radl, J. (author), Mestecky, J. (author), TNO Preventie en Gezondheid (author)
Asparagine-linked sugar chains were quantitatively released from chimpanzee, Rhesus monkey and rat IgA proteins as oligosaccharides by hydrazinolysis, converted to radioactive oligosaccharides by reduction with NaB3H4, and separated into neutral and two acidic fractions by paper electrophoresis. The acidic oligosaccharides were converted to...
article 1997
document
TNO Preventie en Gezondheid (author), van der Kerken, K. (author), de Raeve, H. (author), Goes, E. (author), van Meirvenne, S. (author), Radl, J. (author), van Riet, I. (author), Thielemans, K. (author), van Camp, B. (author)
The aim of this study was to evaluate the tissue infiltration and phenotypic adhesion profile of 5T2 multiple myeloma (MM) and 5T33 MM cells and to correlate it with that observed in human disease. For each line, 30 mice were intravenously inoculated with myeloma cells and at a clear-cut demonstrable serum paraprotein concentration; mice were...
article 1997
document
Mestecky, J. (author), Hamilton, R.G. (author), Magnusson, C.G.M. (author), Jefferis, R. (author), Vaerman, J.P. (author), Goodall, M. (author), de Lange, G.G. (author), Moro, I. (author), Aucouturier, P. (author), Radl, J. (author), Cambiaso, C. (author), Silvain, C. (author), Preud'homme, J.L. (author), Kusama, K. (author), Carlone, G.M. (author), Biewenga, J. (author), Kobayashi, K. (author), Skvaril, F. (author), Reimer, C.B. (author), Gaubius Instituut TNO (author)
51 monoclonal antibodies (McAb) with putative specificity for human IgA, the IgA subclasses, Am allotypes or secretory component (SC) were evaluated for immunoreactivity and specificity by nine laboratories employing immunodiffusion, agglutination, immunohistological assays, immunoblotting and direct binding and competitive inhibition enzyme...
article 1996
document
van den Akker, Th.W. (author), Radl, J. (author), Franken-Postma, E. (author), Hagemeijer, A. (author), Gaubius Instituut TNO (author)
Multiple myeloma (MM) and Waldenström's macroglobulinemia-like lymphoma (MW) appear spontaneously in C57BL/KaLwRij mice at a frequency of 0.5% and 0.2%, respectively. They can readily be propagated by intravenous transfer of mainly bone marrow or spleen cells into syngeneic recipients. Previous studies demonstrated that these mouse malignant...
article 1996
document
Radl, J. (author), van Arkel, C. (author), Hopstaken, C.M. (author), Hogenesch, H. (author), TNO Preventie en Gezondheid (author)
Persons undergoing maintenance immunosuppressive treatment (MIST) were shown to be at increased risk for the development of early malignancies, often of cells of the immune system. Very little is known about the late effects of MIST. Some clinical studies indicated an age-related increase in the incidence of plasma-cell disorders, in particular...
article 1996
document
TNO Preventie en Gezondheid (author), Vanderkerken, K. (author), Goes, E. (author), de Raeve, H. (author), Radl, J. (author), van Camp, B. (author)
The evolution of bone lesions in transplantable C57BL/KaLwRij 5T mouse myeloma (MM) has been followed in vivo. Mice were anaesthetised and a radiograph of the pelvis and hind legs was performed by a radiograph dedicated for mammography. This is the first description of an in vivo technique under experimental conditions whereby the development of...
article 1996
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