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Koeman, T. (author), Slottje, P. (author), Kromhout, H. (author), Schouten, L.J. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), Vermeulen, R. (author)
Objectives Although a study among utility workers found an increased risk for acute myocardial infarction and arrhythmia-related deaths associated with occupational extremely low-frequency magnetic fields (ELF-MF) exposure, later studies largely failed to replicate these findings. This study investigated the association between occupational ELF...
article 2013
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Molag, M.L. (author), de Vries, J.H.M. (author), Duif, N. (author), Ocké, M.C. (author), Dagnelie, P.C. (author), Goldbohm, R.A. (author), van 't Veer, P. (author), TNO Kwaliteit van Leven (author)
The authors automated the selection of foods in a computer system that compiles and processes tailored FFQ. For the selection of food items, several methods are available. The aim of the present study was to compare food lists made by MOM2, which identifies food items with highest between-person variance in intake of the nutrients of interest...
article 2010
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Lindeman, J.H.N. (author), Abdul-Hussien, H. (author), Schaapherder, A.F.M. (author), van Bockel, J.H. (author), von der Thüsen, J.H. (author), Roelen, D.L. (author), Kleemann, R. (author)
Inflammation plays a key role in the pathogenesis of an AAA (abdominal aortic aneurysm); however, the nature of the inflammatory factors and cellular response(s) involved in AAA growth is controversial. In the present study, we set out to determine the aortic levels of inflammatory cytokines in relation to downstream inflammatory transcription...
article 2008
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Beulens, J.W.J. (author), van den Berg, R. (author), Kok, F.J. (author), Helander, A. (author), Vermunt, S.H.F. (author), Hendriks, H.F.J. (author), TNO Kwaliteit van Leven (author)
Background and aims: To investigate the effect of moderate alcohol consumption on lipoprotein-associated phospholipase A2 activity, markers of inflammation and oxidative stress and whether these effects are modified by BMI. Methods and results: Eleven lean (BMI: 18.5-25 kg/m2) and 9 overweight (BMI > 27 kg/m2) men participated in a randomized...
article 2008
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Jansen, N.W.D. (author), Roosendaal, G. (author), Bijlsma, J.W.J. (author), de Groot, J. (author), Theobald, M. (author), Lafeber, F.P.J.G. (author), TNO Kwaliteit van Leven (author)
Background: Joint bleeds have a direct adverse effect on joint cartilage, leading to joint deterioration and, ultimately, to disability. Objective: To examine the hypothesis that because degenerated cartilage has a limited repair capacity, it is more susceptible than healthy cartilage to blood-induced cartilage damage. Methods: Healthy,...
article 2008
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Bergheanu, S.C. (author), Reijmers, T. (author), Zwinderman, A.H. (author), Bobeldijk, I. (author), Ramaker, R. (author), Liem, A.-H. (author), van der Greef, J. (author), Hankemeier, T. (author), Jukema, J.W. (author), TNO Kwaliteit van Leven (author)
Objective: Lipid profiling (lipidomics) may be useful in revealing detailed information with regard to the effects on lipid metabolism, the cardiovascular risk and to differentiate between therapies. The aims of the present study were to: (1) analyze in depth the lipid changes induced by rosuvastatin and atorvastatin at different dosages; (2)...
article 2008
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Norris, L.A. (author), Brosnan, J. (author), Bonnar, J. (author), Conard, J. (author), Kluft, C. (author), Hellgren, M. (author), TNO Kwaliteit van Leven (author)
Epidemiological studies have shown that hormone therapy (HT) increases the risk of venous thromboembolism in post menopausal women. The mechanism of this increased risk is unknown; however, activation of the haemostatic system is known to contribute to the pathogenesis of venous thromboembolism. In post-menopausal women the estrogen /progestogen...
article 2008
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van Uffelen, J.G.Z. (author), Chin A Paw, M.J.M. (author), Hopman-Rock, M. (author), van Mechelen, W. (author), TNO Kwaliteit van Leven (author)
Objective: To systematically review the effect of physical exercise on cognition in older adults with and without cognitive decline. Data sources: Randomized controlled trials were identified by literature searches in PubMed, EMBASE, CENTRAL, PsycINFO, and AgeLine. Study selection: Papers were included on the basis of predefined inclusion...
article 2008
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Sivan, S.S. (author), Tsitron, E. (author), Wachtel, E. (author), Roughley, P.J. (author), Sakkee, N. (author), van der Ham, F. (author), de Groot, J. (author), Roberts, S. (author), Maroudas, A. (author), TNO Kwaliteit van Leven (author)
We have used the racemization of aspartic acid as a marker for the "molecular age" of aggrecan components of the human intervertebral disc matrix (aggregating and non-aggregating proteoglycans as well as the different buoyant density fractions of aggrecan). By measuring the D/L Asp ratio of the various aggrecan species as a function of age and...
article 2006
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Koppes, L.L.J. (author), Dekker, J.M. (author), Hendriks, H.F.J. (author), Bouter, L.M. (author), Heine, R.J. (author), TNO Kwaliteit van Leven (author)
Aims/hypothesis: This systematic review examines the relationship between alcohol consumption and long-term complications of type 2 diabetes. Meta-analyses could only be performed for total mortality, mortality from CHD, and CHD incidence, because the availability of articles on other complications was too limited. Materials and methods: A...
article 2006
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Cho, E. (author), Smith-Warner, S.A. (author), Spiegelman, D. (author), Beeson, W.L. (author), van den Brandt, P.A. (author), Colditz, G.A. (author), Folsom, A.R. (author), Fraser, G.E. (author), Freudenheim, J.L. (author), Giovannucci, E. (author), Goldbohm, R.A. (author), Graham, S. (author), Miller, A.B. (author), Pietinen, P. (author), Potter, J.D. (author), Rohan, T.E. (author), Terry, P. (author), Toniolo, P. (author), Virtanen, M.J. (author), Willet, W.C. (author), Wolk, A. (author), Wu, K. (author), Yaun, S.-S. (author), Zeleniuch-Jacquotte, A. (author), Hunter, D.J. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)
Background: Studies in animals have suggested that calcium may reduce the risk of colorectal cancer. However, results from epidemiologic studies of intake of calcium or dairy foods and colorectal cancer risk have been inconclusive. Methods: We pooled the primary data from 10 cohort studies in five countries that assessed usual dietary intake by...
article 2004
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Männistö, S. (author), Smith-Warner, S.A. (author), Spiegelman, D. (author), Albanes, D. (author), Anderson, K. (author), van den Brandt, P.A. (author), Cerhan, J.R. (author), Colditz, G. (author), Feskanich, D. (author), Freudenheim, J.L. (author), Giovannucci, E. (author), Goldbohm, R.A. (author), Graham, S. (author), Miller, A.B. (author), Rohan, T.E. (author), Virtamo, J. (author), Willett, W.C. (author), Hunter, D.J. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)
Intervention trials with supplemental β-carotene have observed either no effect or a harmful effect on lung cancer risk. Because food composition databases for specific carotenoids have only become available recently, epidemiological evidence relating usual dietary levels of these carotenoids with lung cancer risk is limited. We analyzed the...
article 2004
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Sierksma, A. (author), Lebrun, C.E.I. (author), van der Schouw, Y.T. (author), Grobbee, D.E. (author), Lamberts, S.W.J. (author), Hendriks, H.F.J. (author), Bots, M.L. (author), TNO Voeding (author)
Objective-Moderate alcohol consumption has been postulated to be cardioprotective. Such an effect might be reflected in large-artery properties, such as arterial stiffness and wave reflections. Methods and Results-Three hundred seventy-one healthy postmenopausal women aged 50 to 74 years were sampled from a population-based study. Alcohol intake...
article 2004
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Sierksma, A. (author), Muller, M. (author), van der Schouw, Y.T. (author), Grobbee, D.E. (author), Hendriks, H.F.J. (author), Bots, M.L. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)
Objective: Moderate alcohol consumption has been proposed to be anti-atherogenic and protect against coronary heart disease. Arterial stiffness provides a summary measure of atherosclerotic arterial damage and cardiovascular risk. A vascular protective effect of moderate alcohol consumption would be reflected in an inverse association between...
article 2004
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Albers, R. (author), van der Wielen, R.P.J. (author), Brink, E.J. (author), Hendriks, H.F.J. (author), Dorovska-Taran, V.N. (author), Mohede, I.C.M. (author), TNO Voeding (author)
Objectives: To study the effects of two different mixtures of the main conjugated linoleic acid (CLA) isomers cis-9, trans-11 CLA and trans-10, cis-12 CLA on human immune function. Design: Double-blind, randomized, parallel, reference-controlled intervention study. Subjects and intervention: Seventy-one healthy males aged 31-69y received one of...
article 2003
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Witte, D.R. (author), Broekmans, W.M.R. (author), Kardinaal, A.F.M. (author), Klöpping-Ketelaars, I.A.A. (author), van Poppel, G. (author), Bots, M.L. (author), Kluft, C. (author), Princen, J.M.G. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)
Background: Flow mediated dilatation (FMD) of the brachial artery and soluble intercellular adhesion molecule 1 (sICAM-1) are measures of distinct functions of the endothelium, reflecting nitric oxide (NO)-mediated and pro-inflammatory status, respectively. The comparative value of the two measures in relation to cardiovascular risk is unknown....
article 2003
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Verhoef, P. (author), Pasman, W.J. (author), van Vliet, T. (author), Urgert, R. (author), Katan, M.B. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)
Background: A high plasma total homocysteine concentration is associated with increased risk of cardiovascular disease. Consumption of unfiltered or filtered coffee raises total homocysteine concentrations in healthy volunteers. The responsible compound, however, is unknown. Objective: The objective was to determine whether caffeine explains the...
article 2002
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Magos, L. (author), TNO BIBRA International Ltd, Woodmansterne Rd, Carshalton, Surrey SM5 4DS, United Kingdom Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)
Chemicals/CAS: Biological Products; Ethylmercury Compounds; Food Additives; Pharmaceutical Preparations; Preservatives, Pharmaceutical; Thimerosal, 54-64-8
article 2001
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Schuurman, A.G. (author), Goldbohm, R.A. (author), Dorant, E. (author), van den Brandt, P.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
In the Netherlands Cohort Study, the authors investigated whether anthropometry is associated with prostate cancer risk. At baseline in 1986, 58,279 men aged 55-69 years completed a self- administered questionnaire on diet, anthropometry, and other risk factors for cancer. After 6.3 years of follow-up, 681 cases were available with complete data...
article 2000
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Verzijl, N. (author), de Groot, J. (author), Thorpe, S.R. (author), Bank, R.A. (author), Shaw, J.N. (author), Lyons, T.J. (author), Bijlsma, J.W.J. (author), Lafeber, F.P.J.G. (author), Baynes, J.W. (author), TeKoppele, J.M. (author), Gaubius Instituut TNO (author)
Collagen molecules in articular cartilage have an exceptionally long lifetime, which makes them susceptible to the accumulation of advanced glycation end products (AGEs). In fact, in comparison to other collagen-rich tissues, articular cartilage contains relatively high amounts of the AGE pentosidine. To test the hypothesis that this higher AGE...
article 2000
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