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von Lossonczy, T.O. (author), Ruiter, A. (author), Bronsgeest-Schoute, H.C. (author), van Gent, C.M. (author), Hermus, R.J.J. (author)
A cross-over study was done with 19 male and 23 female volunteers living in a monastery and a convent, respectively. The effect of a fat fish (mackerel) diet on the blood serum lipid composition was studied. As the normal diet of these volunteers was of the lacto-ovo-vegetarian type, a control diet in which the fish was replaced by full-fat...
article 1978
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Wolthuis, O. (author), Vanwersch, R.A.P. (author), van der Wiel, H.J. (author), Medisch Biologisch Laboratorium TNO (author)
Previous results had shown that bis-pyridinium oximes, particularly HI-6 are quite effective therapeutically in soman-poisoned rats and mice in vivo and in the rat diaphragm preparation in vitro. The aim of the present study was to investigate the efficacy of bis-pyridinium oximes on soman-inhibited neuromuscular transmission in muscle...
article 1981
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Brommer, E.J.P. (author), Leuven, J.A.G. (author), Barrett-Bergshoeff, M.M. (author), Schouten, J.A. (author), Gaubius instituut TNO (author)
Impairment of fibrinolysis is supposed to contribute to CVD. In 38 hyperlipoproteinemic patients, known to be at risk for early CVD, fibrinolytic activity was measured before and after stimulation with DDAVP. A negative correlation was found between serum triglyceride levels and fibrinolytic activity, both before and after DDAVP. A subnormal...
article 1982
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Tans, J.T.J. (author), Poortvliet, D.C.J. (author), Instituut voor Gezondheidstechniek TNO Medisch Biologisch Laboratorium TNO (author)
article 1984
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D'Angelo, A. (author), Kluft, C. (author), Verheijen, J.H. (author), Gaubius Instituut TNO (author)
In nine patients with non-malignant diseases undergoing major upper abdominal surgery, the mechanism of the postoperative fibrinolytic shut-down was investigated because of its potential significance for postoperative deep vein thrombosis by employing new and specific methods for assessing and stimulating the fibrinolytic system. The shut-down...
article 1985
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Gaubius instituut TNO (author), Boks, A.L. (author), Brommer, E.J.P. (author), Schalm, S.W. (author), van Vliet, H.H.D.M. (author)
In a study of severe, decompensated liver failure, we tried to find a correlation between hemorrhage and parameters of hemostasis and fibrinolysis. Three groups of patients were studied: alcoholic cirrhosis; nonalcoholic cirrhosis, and acute liver failure without known prior liver disease. The two cirrhotic groups did not differ significantly...
article 1986
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Engesser, L. (author), Brommer, E.J.P. (author), Kluft, C. (author), Briet, E. (author), Gaubius Instituut TNO (author)
Two hundred and three patients with venous thrombophilia were investigated in order to find out whether an elevated plasma concentration of plasminogen activator inhibitor (PAI) could be a cause of their tendency to thrombosis. The patients were studied in an asymptomatic period about 3 months after their last thromboembolic episode. PAI...
article 1989
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Lowik, M.R.H. (author), Schrijver, J. (author), Odink, J. (author), van den Berg, H. (author), Wedel, M. (author), Hermus, R.J.J. (author), TNO Kwaliteit van Leven (author)
In a nationwide survey the nutritional status was assessed of 539 apparently healthy, independently living elderly aged 65-79 years. Anthropometric data showed no energy deficits. The prevalence of anemia was 4 and 1% among men and women, respectively. Many elderly showed a low level of 25-hydroxyvitamin D in plasma (< 31 nmol/L: men 35%; women...
article 1990
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Korteling, J.E. (author)
Age-related differences in dual-task performance may be affected by factors such as skill integration and perceptual competition. Therefore these factors were examined in a dual-task experiment with young and older adults involving two one-dimensional compensatory tracking tasks. Single-task difficulty was individually adjusted for each subject....
article 1991
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Schaapveld, K. (author), van de Water, H.P.A. (author), van Ginneken, J.K.S. (author)
article 1991
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Gaubius Instituut TNO (author), de Knijff, P. (author), van den Maagdenberg, A.M.J.M. (author), Stalenhoef, A.F.H. (author), Leuven, J.A.G. (author), Demacker, P.N.M. (author), Kuyt, L.P. (author), Frants, R.R. (author), Havekes, L.M. (author)
By the careful screening of familial dysbetalipoproteinemic (FD) patients, five probands showing heterozygosity for the APOE*3-Leiden allele were found. Genealogical studies revealed that these probands share common ancestry in the 17th century. In a group of 128 family members, spanning three generations, 37 additional heterozygous APOE*3...
article 1991
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Instituut CIVO-Toxicologie en Voeding TNO (author), van Faassen, A. (author), van 't Veer, P. (author), Bausch-Goldbohm, R.A. (author), Sturmans, F. (author), Hermus, R.J.J. (author)
article 1992
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de Vries, A.C.J. (author), Cohen, L.H. (author), Gaubius Laboratory IVVO-TNO, P.O. Box 430, 2300 AK Leiden, Netherlands Instituut voor verouderings- en vaatziekten onderzoek TNO (author)
This study aimed to investigate the influence of the hypocholesterolemic drugs pravastatin and lovastatin on the cholesterol biosynthesis in the ocular lens. Two model systems were used: a human lens organ culture system and an in vivo rat lens system. For measurements of cholesterol and fatty acid synthesis rates, human lenses were incubated...
article 1993
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Korteling, J.E. (author)
When a dual-tracking task, consisting of two incoherent (uncorrelated) subtasks is partly integrated, such that it is characterized by incompatibility of similarity, or when axis similarity of subtasks is high, it may be difficult to map subtask stimuli to the proper responses. Especially for older adults, an increase in mapping demands may be a...
article 1993
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TNO Biomedical Instrumentation (author), Wesseling, K.H. (author), Jansen, J.R.C. (author), Settels, J.J. (author), Schreuder, J.J. (author)
We computed aortic flow pulsations from arterial pressure by simulating a nonlinear, time-varying three-element model of aortic input impedance. The model elements represent aortic characteristic impedance, arterial compliance, and systemic vascular resistance. Parameter values for the first two elements were computed from a published, age...
article 1993
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Feskens, E.J.M. (author), Havekes, L.M. (author), Kalmijn, S. (author), de Knijff, P. (author), Launer, L.J. (author), Kromhout, D. (author), TNO Preventie en Gezondheid (author)
Objectives - To determine whether polymorphism of apolipoprotein E - notably, the e4 allele - predicts cognitive deterioration in the general population. Design - Population based cohort investigated in 1990 and in 1993. Setting - Zutphen, the Netherlands. Subjects - Representative cohort of 538 Dutch men aged 70-89 at baseline. Main outcome...
article 1994
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Ganesh, S. (author), Sier, C.F.M. (author), Griffioen, G. (author), Vloedgraven, H.J.M. (author), de Boer, A. (author), Welvaart, K. (author), van de Velde, C.J.H. (author), van Krieken, J.H.J.M. (author), Verheijen, J.H. (author), Lamers, C.B.H.W. (author), Verspaget, H.W. (author), Instituut voor Verouderings- en Vaatziekten Onderzoek TNO (author)
Human colorectal carcinogenesis has been shown previously to be associated with impressive changes in the tissue levels of plasminogen activators and their inhibitors, exemplified by an increase in the urokinase-type plasminogen activator (u-PA) and the inhibitors PAI-1 and PAI-2, and a decrease in tissue-type plasminogen activator (t-PA). In...
article 1994
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Slagboom, P.E. (author), Droog, S. (author), Boomsma, D.I. (author), TNO Preventie en Gezondheid (author)
Reduction of telomere length has been postulated to be a causal factor in cellular aging. Human telomeres terminate in tandemly arranged repeat arrays consisting of the (TTAGGG) motif. The length of these arrays in cells from human mitotic tissues is inversely related to the age of the donor, indicating telomere reduction with age. In addition...
article 1994
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Kampman, E. (author), Bijl, A.J. (author), Kok, C. (author), van 't Veer, P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
We analysed data from a case-control study in the Netherlands in order to investigate whether reproductive events and hormonal factors are similarly related to colon cancer risk in men and women after adjustment for dietary factors. In total, 232 colon cancer cases (102 women, 130 men) and 259 controls (123 women, 136 men) were interviewed about...
article 1994
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Goldbohm, R.A. (author), van den Brandt, P.A. (author), van 't Veer, P. (author), Dorant, E. (author), Sturmans, F. (author), Hermus, R.J.J. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)
The association between alcohol consumption and cancer of the colon and rectum was investigated in a prospective cohort study, conducted in the Netherlands from 1986 onwards among 120,852 men and women, aged 55 to 69 years. During 3.3 years of follow-up, 312 and 166 cases of colon and rectal cancer had accumulated, respectively. After exclusion...
article 1994
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