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Schuurman, A.G. (author), Goldbohm, R.A. (author), Dorant, E. (author), van den Brandt, P.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
In the Netherlands Cohort Study, the authors investigated whether anthropometry is associated with prostate cancer risk. At baseline in 1986, 58,279 men aged 55-69 years completed a self- administered questionnaire on diet, anthropometry, and other risk factors for cancer. After 6.3 years of follow-up, 681 cases were available with complete data...
article 2000
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Botterweck, A.A.M. (author), van den Brandt, P.A. (author), Goldbohm, R.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The association between vegetable and fruit consumption and stomach cancer risk was investigated in the Netherlands Cohort Study among 120,852 men and women aged 55-69 years at the start in September 1986. Analyses were based on 282 incident stomach cancer cases after 6.3 years of follow-up. Age- and sex-adjusted rate ratios of stomach cancer in...
article 1998
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Albers, R. (author), van der Wielen, R.P.J. (author), Brink, E.J. (author), Hendriks, H.F.J. (author), Dorovska-Taran, V.N. (author), Mohede, I.C.M. (author), TNO Voeding (author)
Objectives: To study the effects of two different mixtures of the main conjugated linoleic acid (CLA) isomers cis-9, trans-11 CLA and trans-10, cis-12 CLA on human immune function. Design: Double-blind, randomized, parallel, reference-controlled intervention study. Subjects and intervention: Seventy-one healthy males aged 31-69y received one of...
article 2003
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van den Hout, A. (author), Fox, J.P. (author)
Longitudinal data can be used to estimate the transition intensities between healthy and unhealthy states prior to death. An illness-death model for history of stroke is presented, where time-dependent transition intensities are regressed on a latent variable representing cognitive function. The change of this function over time is described by...
article 2015
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Hopman-Rock, M. (author), Odding, E. (author), Hofman, A. (author), Kraaimaat, F.W. (author), Bijlsma, J.W.J. (author), TNO Preventie en Gezondheid (author)
Objective. To determine physical and psychosocial disability in subjects aged 55 to 74 years living in the community, in relation to pain in the hip and/or knee, and to explore the relationships between pain, physical and psychosocial disability, and selected background variables. Methods. A subsample from a community based study on pain,...
article 1996
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Westhoff, M.H. (author), Stemmerik, L. (author), Boshuizen, H.C. (author), TNO Preventie en Gezondheid (author)
This study's purpose was to investigate whether a 10-week low-intensity strength-training program could improve strength of the knee extensors and functional ability. Participants 65 years and older with low knee-extensor muscle strength were randomized into an exercise (n = 11) and a control group (n = 10). Knee-extensor strength and functional...
article 2000
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Feskens, E.J.M. (author), Havekes, L.M. (author), Kalmijn, S. (author), de Knijff, P. (author), Launer, L.J. (author), Kromhout, D. (author), TNO Preventie en Gezondheid (author)
Objectives - To determine whether polymorphism of apolipoprotein E - notably, the e4 allele - predicts cognitive deterioration in the general population. Design - Population based cohort investigated in 1990 and in 1993. Setting - Zutphen, the Netherlands. Subjects - Representative cohort of 538 Dutch men aged 70-89 at baseline. Main outcome...
article 1994
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Ganesh, S. (author), Sier, C.F.M. (author), Griffioen, G. (author), Vloedgraven, H.J.M. (author), de Boer, A. (author), Welvaart, K. (author), van de Velde, C.J.H. (author), van Krieken, J.H.J.M. (author), Verheijen, J.H. (author), Lamers, C.B.H.W. (author), Verspaget, H.W. (author), Instituut voor Verouderings- en Vaatziekten Onderzoek TNO (author)
Human colorectal carcinogenesis has been shown previously to be associated with impressive changes in the tissue levels of plasminogen activators and their inhibitors, exemplified by an increase in the urokinase-type plasminogen activator (u-PA) and the inhibitors PAI-1 and PAI-2, and a decrease in tissue-type plasminogen activator (t-PA). In...
article 1994
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Lowik, M.R.H. (author), Schrijver, J. (author), Odink, J. (author), van den Berg, H. (author), Wedel, M. (author), Hermus, R.J.J. (author), TNO Kwaliteit van Leven (author)
In a nationwide survey the nutritional status was assessed of 539 apparently healthy, independently living elderly aged 65-79 years. Anthropometric data showed no energy deficits. The prevalence of anemia was 4 and 1% among men and women, respectively. Many elderly showed a low level of 25-hydroxyvitamin D in plasma (< 31 nmol/L: men 35%; women...
article 1990
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Wopereis, S. (author), Stroeve, J.H.M. (author), Stafleu, A. (author), Bakker, G.C.M. (author), Burggraaf, J. (author), van Erk, M.J. (author), Pellis, L. (author), Boessen, R. (author), Kardinaal, A.A.F. (author), van Ommen, B. (author)
Background: A key feature of metabolic health is the ability to adapt upon dietary perturbations. Recently, it was shown that metabolic challenge tests in combination with the new generation biomarkers allow the simultaneous quantification of major metabolic health processes. Currently, applied challenge tests are largely non-standardized. A...
article 2017
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Lindeman, J.H.N. (author), Abdul-Hussien, H. (author), Schaapherder, A.F.M. (author), van Bockel, J.H. (author), von der Thüsen, J.H. (author), Roelen, D.L. (author), Kleemann, R. (author)
Inflammation plays a key role in the pathogenesis of an AAA (abdominal aortic aneurysm); however, the nature of the inflammatory factors and cellular response(s) involved in AAA growth is controversial. In the present study, we set out to determine the aortic levels of inflammatory cytokines in relation to downstream inflammatory transcription...
article 2008
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Su, L.C.J. (author), Bui, M. (author), Kardinaal, A. (author), Gomez-Aracena, J. (author), Martin-Moreno, J. (author), Martin, B. (author), Thamm, M. (author), Simonsen, N. (author), van 't Veer, P. (author), Kok, F. (author), Strain, S. (author), Kohlmeier, L. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Biomarkers of dietary exposure or nutritional status are sought actively to overcome limitations of traditional dietary methodology. We compared plasma and adipose tissue biomarkers for carotenoids and tocopherols. The data consisted of samples from 91 men and 122 women, ages 45-70 years, from the control group of the European Community...
article 1998
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Goldbohm, R.A. (author), van 't Veer, P. (author), van den Brandt, P.A. (author), van 't Hof, M.A. (author), Brants, H.A.M. (author), Sturmans, F. (author), Hermus, R.J.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Objectives: In studies on diet and cancer, diet assessment should address long-term intake. Therefore, the authors determined the 5-year reproducibility of a self-adminstered 150-item food frequency questionnaire (FFQ) used to assess dietary habits in the Netherlands Cohort Study on diet and cancer. Since the FFQ was repeated more than once, the...
article 1995
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Sprangers, M.A.G. (author), de Regt, E.B. (author), Andries, F. (author), van Agt, H.M.E. (author), Bijl, R.V. (author), de Boer, J.B. (author), Foets, M. (author), Hoeymans, N. (author), Jacobs, A.E. (author), Kempen, G.I.J.M. (author), Miedema, H.S. (author), Tijhuis, M.A.R. (author), de Haes, H.C.J.M. (author), NIA TNO (author)
The objective of the present study is to compare the QL of a wide range of chronic disease patients. Secondary analysis of eight existing data sets, including over 15,000 patients, was performed. The studies were conducted between 1993 and 1996 and included population-based samples, referred samples, consecutive samples, and/or consecutive...
article 2000
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Kampman, E. (author), Verhoeven, D. (author), Sloots, L. (author), van 't Veer, P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
To examine the relationship between colon cancer and food groups from vegetable or animal sources and their possible interactions with gender, we analyzed data from a Dutch case-control study. Dietary patterns were assessed for 232 colon cancer cases and 259 population controls. In multivariate analyses, the consumption of vegetables was...
article 1995
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Maasland, D.H.E. (author), van den Brandt, P.A. (author), Kremer, B. (author), Goldbohm, R.A. (author), Schouten, L.J. (author)
There is limited prospective data on the relationship between consumption of vegetables and fruits and the risk of head-neck cancer (HNC) subtypes [i.e., oral cavity cancer (OCC), oro-/hypopharyngeal cancer (OHPC) and laryngeal cancer (LC)]. Therefore, we investigated these associations within the Netherlands Cohort Study, in which 120,852...
article 2015
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Davidse, W. (author), Perenboom, R.J.M. (author), TNO Preventie en Gezondheid (author)
Objective. To increase the coverage of influenza vaccination by a programmatic approach in a large population, aimed at the general practitioners (GPs). Design. Intervention study (prospective). Setting. The region of central Brabant (Tilburg and some surrounding communities), the Netherlands. Method. The intervention was carried out in a...
article 1995
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Cho, E. (author), Smith-Warner, S.A. (author), Spiegelman, D. (author), Beeson, W.L. (author), van den Brandt, P.A. (author), Colditz, G.A. (author), Folsom, A.R. (author), Fraser, G.E. (author), Freudenheim, J.L. (author), Giovannucci, E. (author), Goldbohm, R.A. (author), Graham, S. (author), Miller, A.B. (author), Pietinen, P. (author), Potter, J.D. (author), Rohan, T.E. (author), Terry, P. (author), Toniolo, P. (author), Virtanen, M.J. (author), Willet, W.C. (author), Wolk, A. (author), Wu, K. (author), Yaun, S.-S. (author), Zeleniuch-Jacquotte, A. (author), Hunter, D.J. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)
Background: Studies in animals have suggested that calcium may reduce the risk of colorectal cancer. However, results from epidemiologic studies of intake of calcium or dairy foods and colorectal cancer risk have been inconclusive. Methods: We pooled the primary data from 10 cohort studies in five countries that assessed usual dietary intake by...
article 2004
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D'Angelo, A. (author), Kluft, C. (author), Verheijen, J.H. (author), Gaubius Instituut TNO (author)
In nine patients with non-malignant diseases undergoing major upper abdominal surgery, the mechanism of the postoperative fibrinolytic shut-down was investigated because of its potential significance for postoperative deep vein thrombosis by employing new and specific methods for assessing and stimulating the fibrinolytic system. The shut-down...
article 1985
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Bots, M.L. (author), van der Bom, J.G. (author), Haverkate, F. (author), Meijer, P. (author), Hofman, A. (author), Grobbee, D.E. (author), Kluft, C. (author), TNO Preventie en Gezondheid (author)
Background and objective. A low activated protein C (APC) response increases the risk of venous thrombosis, and possibly arterial disease. Apart from the factor V Leiden mutation, other factors may determine the level of APC response. In most studies on the association with arterial disease, cardiovascular risk factors were not appropriately...
article 1996
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